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Actas Urologicas Espanolas 2002The retroperitoneum is one of the most complex regions of human anatomy as it contains a variety organs and structures from different systems, in particular those... (Review)
Review
The retroperitoneum is one of the most complex regions of human anatomy as it contains a variety organs and structures from different systems, in particular those belonging to the urinary and digestive tracts and the vascular systems. The emergence of different diagnostic imaging techniques has made easier to study the retroperitoneum. Thanks to ultrasonography, computerised tomography and magnetic resonance the assessment of retroperitoneal conditions has taken a great leap forwards permitting the anatomical connections and characteristics of the structures in this region to be reliably established. Owing to the location in the retroperitoneal space of the different organs of the digestive tract and the vascular system, a multidisciplinary approach is required involving the different surgical specialties. The urologist performs a large proportion of his surgical activity in this region and must, therefore, have a good knowledge of the different retroperitoneal organs belonging to the urinary tract and also the connections between these and other organs and structures of the retroperitoneal region.
Topics: Adult; Aged; Anti-Bacterial Agents; Antineoplastic Agents; Autoimmune Diseases; Chemotherapy, Adjuvant; Child; Combined Modality Therapy; Cysts; Diagnostic Imaging; Female; Humans; Immunosuppressive Agents; Male; Middle Aged; Neoplasm Staging; Radiotherapy, Adjuvant; Retroperitoneal Fibrosis; Retroperitoneal Neoplasms; Retroperitoneal Space; Retropharyngeal Abscess; Urologic Surgical Procedures
PubMed: 12224429
DOI: 10.1016/s0210-4806(02)72814-3 -
Acta Chirurgica Belgica 1987The clinical history, radiological investigations, pathologic findings and treatment of four patients affected by retroperitoneal leiomyosarcoma were compared with data...
The clinical history, radiological investigations, pathologic findings and treatment of four patients affected by retroperitoneal leiomyosarcoma were compared with data of the literature. These tumors have a great tendency to develop local recurrences after excision, but metastases to lymph nodes and distant organs usually occur lately. CT examination of the retroperitoneal space is a sensitive tool in the diagnosis and follow-up. Complete excision of the tumor followed by radiotherapy improves significantly the prognosis. Chemotherapy is advisable only when disseminated metastases appear. No correlation was found between the histologic appearance and the clinical behaviour.
Topics: Adult; Combined Modality Therapy; Female; Humans; Leiomyosarcoma; Male; Middle Aged; Neoplasm Metastasis; Neoplasm Recurrence, Local; Retroperitoneal Neoplasms; Tomography, X-Ray Computed
PubMed: 3661002
DOI: No ID Found -
Annals of Surgery Mar 1978A group of patients with retroperitoneal liposarcoma is presented and general guidelines of management reviewed. It is suggested that aggressive, radical total surgical...
A group of patients with retroperitoneal liposarcoma is presented and general guidelines of management reviewed. It is suggested that aggressive, radical total surgical excision followed by adjuvant postoperative irradiation be used as the treatment of choice. Although the management of recurrent disease may be discouraging in terms of ultimate cure, reasonable palliation and prolonged survival may result from aggressive therapy.
Topics: Abdominal Neoplasms; Aged; Female; Humans; Liposarcoma; Male; Middle Aged; Neoplasm Metastasis; Neoplasm Recurrence, Local; Retroperitoneal Neoplasms
PubMed: 637581
DOI: 10.1097/00000658-197803000-00008 -
Annals of the Royal College of Surgeons... May 2011The retroperitoneum can host a wide spectrum of pathologies, including a variety of rare benign tumours and malignant neoplasms that can be either primary or metastatic... (Review)
Review
INTRODUCTION
The retroperitoneum can host a wide spectrum of pathologies, including a variety of rare benign tumours and malignant neoplasms that can be either primary or metastatic lesions. Retroperitoneal tumours can cause a diagnostic dilemma and present several therapeutic challenges because of their rarity, relative late presentation and anatomical location, often in close relationship with several vital structures in the retroperitoneal space.
MATERIALS AND METHODS
A comprehensive literature search was conducted using PubMed. Relevant international articles published in the last ten years were assessed. The keywords for search purposes included: retroperitoneum, benign, sarcoma, neoplasm, diagnosis and surgery, radiotherapy, chemotherapy. The search was limited to articles published in English. All articles were read in full by the authors and selected for inclusion based on relevance to this article.
RESULTS
Tumours usually present late and cause symptoms or become palpable once they have reached a significant size. Retroperitoneal tumours are best evaluated with good quality cross-sectional imaging and preoperative histology by core needle biopsy is required when imaging is non-diagnostic. Sarcomas comprise a third of retroperitoneal tumours. Other retroperitoneal neoplasms include lymphomas and epithelial tumours or might represent metastatic disease from known or unknown primary sites. The most common benign pathologies encountered in the retroperitoneum include benign neurogenic tumours, paragangliomas, fibromatosis, renal angiomyolipomas and benign retroperitoneal lipomas.
CONCLUSIONS
Complete surgical resection is the only potential curative treatment modality for retroperitoneal sarcomas and is best performed in high-volume centres by a multidisciplinary sarcoma team. The ability completely to resect a retroperitoneal sarcoma and tumour grade remain the most important predictors of local recurrence and disease-specific survival.
Topics: Chemotherapy, Adjuvant; Humans; Neoplasm Recurrence, Local; Retroperitoneal Neoplasms; Sarcoma; Tomography, X-Ray Computed; Treatment Outcome
PubMed: 21944791
DOI: 10.1308/003588411X571944 -
Current Opinion in Oncology Jul 2023Retroperitoneal soft-tissue sarcomas (RPS) are a group of rare, histologically distinct tumours with variable recurrence patterns depending on histological type. This... (Review)
Review
PURPOSE OF REVIEW
Retroperitoneal soft-tissue sarcomas (RPS) are a group of rare, histologically distinct tumours with variable recurrence patterns depending on histological type. This review will discuss the growing body of evidence supporting histology-specific, multidisciplinary management and highlight areas of future research for patients with RPS.
RECENT FINDINGS
Histology-tailored surgery is the cornerstone of management in patients with localized RPS. Further efforts to develop resectability criteria and identify patients who will benefit from neoadjuvant treatment strategies will help standardize the treatment of patients with localized RPS. Surgery for local recurrence is well tolerated in selected patients and re-iterative surgery in liposarcoma (LPS) may be beneficial at the time of local recurrence. The management of advanced RPS holds promise with several trials currently investigating systemic treatment beyond conventional chemotherapy.
SUMMARY
The management of RPS has made significant progress over the past decade owing to international collaboration. Ongoing efforts to identify patients who will derive the most benefit from all treatment strategies will continue to advance the field of RPS.
Topics: Humans; Sarcoma; Neoadjuvant Therapy; Retroperitoneal Neoplasms; Soft Tissue Neoplasms; Neoplasm Recurrence, Local
PubMed: 37222202
DOI: 10.1097/CCO.0000000000000954 -
Annals of Surgical Oncology Feb 2023
Topics: Humans; Liposarcoma; Sarcoma; Retroperitoneal Neoplasms; Neoplasm Recurrence, Local; Prognosis
PubMed: 36287347
DOI: 10.1245/s10434-022-12666-y -
Journal of Surgical Oncology Jan 2014Approximately 15% of soft tissue sarcomas are retroperitoneal. The occult location and anatomic complexity results in local recurrences in the majority of patients.... (Review)
Review
Approximately 15% of soft tissue sarcomas are retroperitoneal. The occult location and anatomic complexity results in local recurrences in the majority of patients. Predictors of recurrence include histological subtype, completeness of resection, and the hospital case volume. The most significant predictor of outcome following local recurrence is the resectability of the recurrent disease. An understanding of the implication of tumor biology on outcomes is essential in determining optimal management for patients with recurrent retroperitoneal sarcoma.
Topics: Humans; Neoplasm Recurrence, Local; Retroperitoneal Neoplasms; Sarcoma
PubMed: 24155163
DOI: 10.1002/jso.23463 -
Journal of Surgical Oncology Mar 1996Two cases of retroperitoneal cystic lymphangioma (CL) are presented; the current literature on this rare, benign neoplasm of the lymphatic system is reviewed. This tumor... (Review)
Review
Two cases of retroperitoneal cystic lymphangioma (CL) are presented; the current literature on this rare, benign neoplasm of the lymphatic system is reviewed. This tumor consists of various numbers of cyst-like cavities filled with a serous, serosanguineous or chylous fluid. The histogenesis of CL is still uncertain. Most commonly CL occurs in the neck and in the axillary region, whereas it is rare in the retroperitoneum. Although retroperitoneal CL is a benign lesion, it may cause significant morbidity due to its large size, and its often invasive character with a strong tendency to secondary infection. The treatment of choice is surgical excision.
Topics: Adult; Chyle; Exudates and Transudates; Follow-Up Studies; Humans; Lymphangioma, Cystic; Male; Middle Aged; Neoplasm Invasiveness; Plasma; Retroperitoneal Neoplasms
PubMed: 8637214
DOI: 10.1002/(SICI)1096-9098(199603)61:3<234::AID-JSO14>3.0.CO;2-7 -
Khirurgiia 2021The problem of retroperitoneal neoplasm management is still relevant despite certain achievements in diagnosis, anesthetic care and surgical techniques. These patients...
The problem of retroperitoneal neoplasm management is still relevant despite certain achievements in diagnosis, anesthetic care and surgical techniques. These patients often admit to specialized hospitals with a widespread malignant process and/or complications due to no specific symptoms. Resection is preferred for malignant inorganic retroperitoneal tumors. A feature of these neoplasms is frequent local relapses, which seriously limit the possibility of redo surgery. The authors report successful surgical treatment of recurrent malignant inorganic retroperitoneal myxolipoma with giant baseline dimensions.
Topics: Humans; Neoplasm Recurrence, Local; Retroperitoneal Neoplasms; Retrospective Studies
PubMed: 34786923
DOI: 10.17116/hirurgia202111196 -
Gynecologic and Obstetric Investigation 2016The aim of this study was to perform a systematic review on primary retroperitoneal cystoadenocarcinoma (PRC), which is an extremely rare disease. (Review)
Review
BACKGROUND/AIMS
The aim of this study was to perform a systematic review on primary retroperitoneal cystoadenocarcinoma (PRC), which is an extremely rare disease.
METHODS
According to PRISMA guidelines, all the literature about PRC from 1977 to 2015 was reviewed. Thirty articles were selected; characteristics of the patients were collected and described; time to recurrence and overall survival (OS) were investigated when available.
RESULTS
Thirty seven patients were included of whom 33 were females; the median age at presentation was 43. PRC was more common in postmenopausal women. Surgery was the standard therapy; the role of chemotherapy and/or radiotherapy was uncertain. Thirty percent of the patients relapsed after 58 months from the surgery; the rupture of the cyst occurred in 13% of the cases and it was associated with poor prognosis as well as premenopausal status. At 125 months from the diagnosis, 72% of the patients were alive and the median OS was not reached.
CONCLUSIONS
The present systematic review about PRC is the first performed until the date of drafting this paper. We described some clinical features of PRC and their possible prognostic value. No conclusive data can be presented due to the small population analyzed and to publication bias.
Topics: Cystadenocarcinoma; Humans; Neoplasm Recurrence, Local; Prognosis; Retroperitoneal Neoplasms
PubMed: 27309542
DOI: 10.1159/000446954