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Mycopathologia 1983The in vitro activity of ribostamycin against algae of the genus Prototheca was evaluated by minimum inhibitory concentration (MIC) studies on solid media.... (Comparative Study)
Comparative Study
The in vitro activity of ribostamycin against algae of the genus Prototheca was evaluated by minimum inhibitory concentration (MIC) studies on solid media. Concentrations of 4 mcg/ml were required to inhibit 100% of the P. zopfii strains; 16 mcg/ml inhibited 100% of the P. stagnora strains and 95% of the P. wickerhamii strains. These values are inferior to plasma concentrations obtained after injection of ribostamycin. It is likely that this antibiotic could be effective in the treatment of protothecosis in man.
Topics: Anti-Bacterial Agents; Dose-Response Relationship, Drug; Prototheca; Ribostamycin; Species Specificity
PubMed: 6633631
DOI: 10.1007/BF00437408 -
The Journal of Antibiotics Dec 1972
Topics: Amino Sugars; Anti-Bacterial Agents; Chromatography, Gel; Chromatography, Ion Exchange; Drug Resistance, Microbial; Escherichia coli; Kanamycin; Neomycin; Phosphorylase Kinase; Spectrum Analysis
PubMed: 4568694
DOI: 10.7164/antibiotics.25.748 -
Minerva Medica Feb 1980Results in the treatment of mostly Gram-negative infections of the respiratory apparatus (30 subjects) and the urinary apparatus (20 subjects) with ribostamycin are...
Results in the treatment of mostly Gram-negative infections of the respiratory apparatus (30 subjects) and the urinary apparatus (20 subjects) with ribostamycin are reported. These were regarded as good overall, as shown by the bacteriological findings. An extremely high sensitivity to the antibiotic was noted in isolated germs from both types of infection. This good response in vitro was matched by an equally encouraging bacteriological result in vivo.
Topics: Adult; Aged; Anti-Bacterial Agents; Bacteria; Bacterial Infections; Female; Humans; Male; Microbial Sensitivity Tests; Middle Aged; Respiratory Tract Infections; Ribostamycin; Urinary Tract Infections
PubMed: 7354947
DOI: No ID Found -
Journal of Medicinal Chemistry Jan 19802',3'-Epimino analogues of neamine, ribostamycin, and kanamycin B possessing little or no intrinsic antimicrobial activity were designed to enhance the activity of...
2',3'-Epimino analogues of neamine, ribostamycin, and kanamycin B possessing little or no intrinsic antimicrobial activity were designed to enhance the activity of kanamycin A against bacterial strains that elaborate aminoglycoside 3'-phosphotransferases. Routes were devised for their synthesis from the parent antibiotics and the 2'',3''-epimino analogue of kanamycin B also was prepared. None of these analogues was active against phosphotransferase-producing bacteria, although the kanamycin B derivatives showed very weak activity against nonresistant strains. At 8 and 32 microgram/mL, the 2',3'-epimino analogue of neamine produced a small synergistic effect on the activity of kanamycin A against a strain of Escherichia coli that produces aminoglycoside 3'-phosphotransferase II. The N3-(carbobenzyloxy) derivative of this analogue produced a small effect against the same strain, and it, as well as the 2'',3''-epimino analogue of kanamycin B, slightly enhanced the activity of kanamycin A against a strain of Proteus rettgeri that elaborates a similar enzyme.
Topics: Anti-Bacterial Agents; Escherichia coli; Kanamycin; Microbial Sensitivity Tests; Neomycin; Phosphotransferases; Proteus; Pseudomonas aeruginosa; Ribostamycin; Structure-Activity Relationship
PubMed: 6244410
DOI: 10.1021/jm00175a009 -
Antimicrobial Agents and Chemotherapy 1970
Topics: Amino Sugars; Anti-Bacterial Agents; Chromatography; Magnetic Resonance Spectroscopy; Methods; Optical Rotatory Dispersion; Oxidation-Reduction; Spectrophotometry
PubMed: 5521353
DOI: No ID Found -
The Journal of Antibiotics Dec 1972
Topics: Amino Sugars; Anti-Bacterial Agents; Chemical Phenomena; Chemistry; Kanamycin; Pseudomonas aeruginosa; Spectrum Analysis
PubMed: 4631344
DOI: 10.7164/antibiotics.25.746 -
Antimicrobial Agents and Chemotherapy Jan 1974It was found that the 5''-hydroxy group of ribostamycin was preferentially phosphorylated by a cell-free extract from Pseudomonas aeruginosa GN 573, a clinical isolate.
It was found that the 5''-hydroxy group of ribostamycin was preferentially phosphorylated by a cell-free extract from Pseudomonas aeruginosa GN 573, a clinical isolate.
Topics: Aminoglycosides; Anti-Bacterial Agents; Cell-Free System; Chromatography, Thin Layer; Oxidative Phosphorylation; Pseudomonas aeruginosa
PubMed: 4209071
DOI: 10.1128/AAC.5.1.92 -
Chemistry (Weinheim An Der Bergstrasse,... Mar 2010
Topics: Aminoglycosides; Anti-Bacterial Agents; Base Sequence; Binding Sites; Carbohydrate Sequence; Chimera; Kanamycin; Ligands; Molecular Sequence Data; Oligosaccharides; RNA; Ribostamycin
PubMed: 20162651
DOI: 10.1002/chem.200903003 -
Minerva Chirurgica20 patients have been treated, 10 with ribostamycin sulphate, 5 with gentamycin and 5 with sodium cephalotin. Patients were selected at random from those who had... (Clinical Trial)
Clinical Trial Comparative Study
20 patients have been treated, 10 with ribostamycin sulphate, 5 with gentamycin and 5 with sodium cephalotin. Patients were selected at random from those who had undergone abdominal, thoracic or cervical operations. Doses were 1000-2000 mg i.m. for ribostamycin, 4-8 g i.v. for cephalotin, and 160-240 mg i.m. for gentamycin. Mean treatment time was 12.5 days. Indices of therapeutic activity, parameters of liver and renal function and otovestibular function are indicated. The therapeutic activity of ribostamycin was very good and no side-effects were observed.
Topics: Adult; Aged; Anti-Bacterial Agents; Bacterial Infections; Cephalothin; Female; Gentamicins; Humans; Male; Middle Aged; Postoperative Complications; Ribostamycin; Surgical Procedures, Operative
PubMed: 7290416
DOI: No ID Found -
The Journal of Antibiotics Oct 2000Fourteen different aminoglycoside antibiotics (AGs) were challenged with aminoglycoside acetyltransferases (AACs) of actinomycete origin in order to examine their...
Fourteen different aminoglycoside antibiotics (AGs) were challenged with aminoglycoside acetyltransferases (AACs) of actinomycete origin in order to examine their 'double stage activity' that is arbitrarily defined as antibiotic activity retainable after enzymatic modification. In kanamycin (KM)-group AGs tested [KM, dibekacin (DKB), amikacin and arbekacin (ABK)], ABK retained activity after acetylations by AAC(3), AAC(2') and AAC(6'). DKB also retained a weak activity after acetylation by AAC(2'). In gentamicin (GM)-group AGs tested [GM, micronomicin, sisomicin (SISO), netilmicin (NTL) and isepamicin], GM, SISO and NTL retained activites after acetylation by AAC(2'). In neomycin (NM)-group AGs tested [ribostamycin, NM, paromomycin], NM retained activity after acetylation by AAC(6') and AAC(2'). None of astromicin (ASTM)-group AGs tested (ASTM and istamycin B) retained activity after acetylation by AAC(2') and AAC(6'). The activities of acetylated ABK derivatives by AAC(3) and AAC(2') were distinctively high, compared to the others. Streptomyces lividans TK21 containing the cloned aac genes were markedly sensitive to AGs that retained activities after acetylation, indicating the substantial effect of 'double stage activity'.
Topics: Acetylation; Acetyltransferases; Actinomycetales; Aminoglycosides; Anti-Bacterial Agents; Bacillus subtilis; Carbohydrate Sequence; Chromatography, Thin Layer; Drug Resistance, Microbial; Microbial Sensitivity Tests; Molecular Sequence Data; Streptomyces
PubMed: 11132963
DOI: 10.7164/antibiotics.53.1168