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QJM : Monthly Journal of the... Nov 2022
Topics: Humans; Purpura Fulminans; Rickettsia; Anti-Bacterial Agents; Purpura
PubMed: 35976146
DOI: 10.1093/qjmed/hcac188 -
Emerging Infectious Diseases Sep 2019During 2014-2017, we screened for Rickettsia japonica infection in Xinyang, China, and identified 20 cases. The major clinical manifestations of monoinfection were...
During 2014-2017, we screened for Rickettsia japonica infection in Xinyang, China, and identified 20 cases. The major clinical manifestations of monoinfection were fever, asthenia, myalgia, rash, and anorexia; laboratory findings included thrombocytopenia and elevated hepatic aminotransferase concentrations. Physicians in China should consider R. japonica infection in at-risk patients.
Topics: Adult; Aged; Animals; China; Female; Humans; Male; Middle Aged; Phylogeny; Rickettsia; Rickettsia Infections; Risk Factors; Tick Bites; Ticks
PubMed: 31441748
DOI: 10.3201/eid2509.171421 -
Emerging Infectious Diseases May 2019PCR amplification indicated the minimum infection rate of Rickettsia spp. was 0.66% in Haemaphysalis longicornis ticks collected from Shandong Province, China....
PCR amplification indicated the minimum infection rate of Rickettsia spp. was 0.66% in Haemaphysalis longicornis ticks collected from Shandong Province, China. Phylogenetic analysis based on the rrs, gltA, ompA, and ompB genes indicated that the ticks carried R. japonica, Candidatus Rickettsia longicornii, and a novel Rickettsia species related to R. canadensis.
Topics: Animals; China; DNA, Bacterial; Humans; Phylogeny; Polymerase Chain Reaction; Public Health Surveillance; Rickettsia; Ticks; Vector Borne Diseases
PubMed: 31002060
DOI: 10.3201/eid2505.171745 -
IDCases 2021Two patients from Huanggang, China, were diagnosed with spotted fever group (SFG) rickettsiosis-caused by ()-in 2021. This study aimed to investigate the clinical...
Two patients from Huanggang, China, were diagnosed with spotted fever group (SFG) rickettsiosis-caused by ()-in 2021. This study aimed to investigate the clinical symptoms, laboratory examinations, epidemiological factors, and therapeutic responses in patients with SFG rickettsiosis-an emerging disease in this region. The patients showed a variety of clinical signs and symptoms, such as acute febrile illness with severe headache, myalgia, asthenia, anorexia, eschar, lymphadenopathy, and rash on the trunk and extremities. They exhibited increased neutrophil ratio, mild thrombocytopenia, liver dysfunction, and increased C-reactive protein and procalcitonin levels. Following treatment with doxycycline, the patients recovered completely. This is the first report of infection in Huanggang City, Hubei Province, China. infection is a tick-borne disease, which can be effectively treated with doxycycline; however, it has a mortality rate of approximately 10% with delays in treatment. The Huanggang area is also a high-risk area for tick-borne severe fever with thrombocytopenia syndrome (SFTS). Therefore, SFTS and SFG rickettsiosis should be carefully diagnosed in this area and clinicians should be alert with respect to the possibility of infections with both SFTS and SFG rickettsiosis.
PubMed: 34712573
DOI: 10.1016/j.idcr.2021.e01309 -
Emerging Infectious Diseases Jun 2019We report a case of Rickettsia japonica infection in an 81-year-old man in central Japan. The patient had fever, rash, and an eschar but no evidence of a tick bite. His...
We report a case of Rickettsia japonica infection in an 81-year-old man in central Japan. The patient had fever, rash, and an eschar but no evidence of a tick bite. His symptoms began 8 days after a land leech bite. The land leech is a potential vector of R. japonica.
Topics: Aged, 80 and over; Animals; Biomarkers; Bites and Stings; Exanthema; Fluorescent Antibody Technique; Humans; Japan; Leeches; Male; Polymerase Chain Reaction; Rickettsia; Rickettsia Infections; Symptom Assessment
PubMed: 31107234
DOI: 10.3201/eid2506.181985 -
Infection and Drug Resistance 2022Severe complications may cause a fatal or disabling outcome in patients with infection but are poorly understood.
BACKGROUND
Severe complications may cause a fatal or disabling outcome in patients with infection but are poorly understood.
METHODS
We identified 11 patients with only infection with metagenomics next generation sequencing (mNGS) during April to November 2021 at Yichang Central People's Hospital, China. Clinical data were obtained through review of medical records.
RESULTS
Most patients realized that they had symptoms about one or two days after being bitten. Fever (91%), pulmonary effusion (91%), rash or erythema (100%), abnormal urine (100%), neutropenia (100%), lymphopenia (100%), and thrombocytopenia (100%) were the most common clinical signs. Six severely ill patients were admitted to the intensive care unit and five had mild symptoms. Systemic manifestations such as vomiting (83%), neurological manifestations (100%), and disseminated intravascular coagulation (100%) were more frequently observed in the severe cases, 33.3% of whom developed purpura fulminans requiring amputation or skin graft, and 16.6% died two days after admission. Some patients experienced sequelae.
CONCLUSION
Our study found that patients with critical infection complicating disseminated intravascular coagulation had high risk of poor outcome.
PubMed: 36386421
DOI: 10.2147/IDR.S383917 -
Microbiology and Immunology 1993
Review
Topics: Animals; Antibodies, Bacterial; Humans; Japan; Rickettsia; Rickettsia Infections
PubMed: 8502180
DOI: 10.1111/j.1348-0421.1993.tb03185.x -
Emerging Infectious Diseases Nov 2018We investigated 16 Japanese spotted fever cases that occurred in southeastern China during September-October 2015. Patients had fever, rash, eschar, and lymphadenopathy....
We investigated 16 Japanese spotted fever cases that occurred in southeastern China during September-October 2015. Patients had fever, rash, eschar, and lymphadenopathy. We confirmed 9 diagnoses and obtained 2 isolates with high identity to Rickettsia japonica strain YH. R. japonica infection should be considered for febrile patients in China.
Topics: Adult; Aged; Animals; Anti-Bacterial Agents; Azithromycin; China; Doxycycline; Female; Humans; Lymphadenopathy; Male; Middle Aged; Rickettsia; Rickettsia Infections; Spotted Fever Group Rickettsiosis; Ticks; Treatment Outcome
PubMed: 30334710
DOI: 10.3201/eid2411.170044 -
Tropical Biomedicine Mar 2022Ticks are important vectors of arthropod-borne diseases and they can transmit a wide variety of zoonotic pathogens to humans, domestic and wild animals. Rickettsia...
Ticks are important vectors of arthropod-borne diseases and they can transmit a wide variety of zoonotic pathogens to humans, domestic and wild animals. Rickettsia japonica is a member of SFG rickettsiae causing Japanese spotted fever (JSF) and can transmit to humans via infected ticks. In this study, we report the first case of Rickettsia japonica in Haemaphysalis hystricis tick collected from a roadkill Burmese ferret-badger ( Melogale personata ) in Loei province, northeastern Thailand. According to the DNA sequences and phylogenetic analyses of the outer membrane protein A and B genes ( ompA and ompB), the detected R. japonica was identical to those found in JSF patients in Korea, Japan, and China, and closely related to Rickettsia detected by ompA in a tick from Thailand. Further study on the prevalence of R. japonica and diversity of mammalian reservoir hosts will be useful to gain a better understanding of JSF epidemiology.
Topics: Animals; Ferrets; Humans; Ixodidae; Mustelidae; Phylogeny; Rickettsia; Thailand; Ticks
PubMed: 35507925
DOI: 10.47665/tb.39.1.007 -
Infectious Disease Reports Dec 2020(1) Background. () infection induces severe inflammation, and the disappearance of eosinophil in the acute stage is one of the phenomena. (2) Materials and Methods. In...
(1) Background. () infection induces severe inflammation, and the disappearance of eosinophil in the acute stage is one of the phenomena. (2) Materials and Methods. In the current study, we measured the serum concentrations of Th1, Th2, and Th17 cytokines in the acute and recovery stages. (3) Results. In the acute phase, IL-6 and IFN-γ levels were elevated and we speculated that they played a role as a defense mechanism against . The high concentration of IFN-γ suppressed the differentiation of eosinophil and induced apoptosis of eosinophil, leading to the disappearance of eosinophil. On day 7, IL-6 and IFN-γ concentrations were decreased, and Th2 cytokines such as IL-5 and IL-9 were slightly increased. On day 14, eosinophil count recovered to the normal level. The transition of serum cytokine concentration in infection was presented. (4) Conclusions. IL-6 and IFN-γ seem to be critical cytokines as defense mechanism against in the acute phase, and this may deeply connect to the decrease of eosinophil.
PubMed: 33322277
DOI: 10.3390/idr12030023