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Annales de Pathologie Mar 2024A 78-year-old woman with hypertrophic cardiomyopathy underwent a septal myomectomy and valve replacement. In the immediate postoperative period she developed shock of...
A 78-year-old woman with hypertrophic cardiomyopathy underwent a septal myomectomy and valve replacement. In the immediate postoperative period she developed shock of mixed etiology and died. At autopsy, hepatomegaly and splenomegaly were identified, with PAS and Giemsa positive intracellular ceroid granular deposits. Sea-blue histiocytosis is an extremely rare, chronic and benign deposit disease. It is characterized by hepatosplenomegaly, thrombocytopenia and lymphadenopathy. The presence of ceroid substance in granules in PAS and Giemsa stains should establish the diagnosis of suspicion.
Topics: Female; Humans; Aged; Sea-Blue Histiocyte Syndrome; Ceroid; Splenomegaly; Hepatomegaly
PubMed: 37865572
DOI: 10.1016/j.annpat.2023.10.001 -
Lancet (London, England) Oct 1970
Topics: Bone Marrow Diseases; Child; Histiocytes; Humans; Lipid Metabolism, Inborn Errors; Male
PubMed: 4195998
DOI: 10.1016/s0140-6736(70)90254-0 -
Leukemia & Lymphoma Feb 1998Clinical and hematological abnormalities can occur in patients receiving intravenous fat emulsions as part of a long-term parenteral nutrition; they consist of... (Review)
Review
Clinical and hematological abnormalities can occur in patients receiving intravenous fat emulsions as part of a long-term parenteral nutrition; they consist of hepatosplenomegaly and peripheral blood cytopenia(s). These abnormalities lead to bone marrow examination which revealed numerous macrophages laden with blue staining pigment granules and separate lipid vacuoles, presenting the typical histochemical characteristics of sea-blue histiocytes. Thus, long-term parenteral nutrition including fat-emulsion sources may represent a further condition in addition to the wide variety of disorders which can be associated with sea-blue histiocytosis. Moreover, in view of its clinical and morphological presentation, this storage pathological state could be compared with the so-called sea-blue histiocyte syndrome described by Silverstein and colleagues.
Topics: Bone Marrow; Bone Marrow Diseases; Fats; Humans; Parenteral Nutrition, Total; Sea-Blue Histiocyte Syndrome
PubMed: 9613982
DOI: 10.3109/10428199809058360 -
Internal Medicine (Tokyo, Japan) May 1996A 39-year-old male was admitted with fever, systemic lymph node swelling, liver dysfunction and mild splenomegaly. Liver biopsy specimen showed histiocytic aggregation... (Review)
Review
A 39-year-old male was admitted with fever, systemic lymph node swelling, liver dysfunction and mild splenomegaly. Liver biopsy specimen showed histiocytic aggregation in portal areas. These histiocytes were closely packed with granules, dyed sea-blue with May-Giemsa staining. Further microscopical examination of lymph nodes, gastro-intestinal tract and bone marrow also revealed the accumulation of sea-blue histiocytes. Activities of lipid metabolic enzymes were normal and hematopoietic diseases which are sometimes accompanied by secondary sea-blue histiocytosis were ruled out. We diagnosed this case as syndrome of the sea-blue histiocyte.
Topics: Adult; Humans; Leukocytes; Lipid Metabolism; Liver; Lymph Nodes; Male; Sea-Blue Histiocyte Syndrome
PubMed: 8797061
DOI: 10.2169/internalmedicine.35.419 -
Seminars in Hematology Jul 1972
Review
Topics: Adolescent; Adult; Aged; Child; Child, Preschool; Cytoplasmic Granules; Eye Manifestations; Female; Histiocytes; Humans; Infant; Leukocytes; Lipase; Lipids; Liver; Lung; Lymphatic Diseases; Male; Middle Aged; Molecular Biology; Neurologic Manifestations; Parasitic Diseases; Pigmentation; Splenomegaly; Staining and Labeling; Thrombocytopenia
PubMed: 4114368
DOI: No ID Found -
The New England Journal of Medicine May 1970
Topics: Adult; Black People; Carbon Isotopes; Histiocytes; Histocytochemistry; Humans; Lipidoses; Lipids; Male; Staining and Labeling; West Indies
PubMed: 4191343
DOI: 10.1056/nejm197005072821917 -
Lancet (London, England) Jul 1970
Topics: Bone Marrow; Bone Marrow Cells; Bone Marrow Examination; Child; Cytoplasmic Granules; Histiocytes; Histocytochemistry; Humans; Lipid Metabolism, Inborn Errors; Male; Pedigree; Staining and Labeling
PubMed: 4193362
DOI: 10.1016/s0140-6736(70)92642-5 -
Lancet (London, England) Aug 1971
Topics: Age Factors; Aged; Bone Marrow Examination; Cerebrosides; Chronic Disease; Female; Histiocytes; Humans; Myeloproliferative Disorders; Phosphatidylethanolamines; Triglycerides
PubMed: 4105006
DOI: 10.1016/s0140-6736(71)91365-1 -
Seminars in Hematology Jul 1972
Topics: Adult; Cytoplasmic Granules; Eye Manifestations; Female; Fundus Oculi; Glycolipids; Glycosaminoglycans; Histiocytes; Humans; Liver; Lymph Nodes; Lymphatic Diseases; Male; Phospholipids; Spleen; Staining and Labeling
PubMed: 4114369
DOI: No ID Found -
Lancet (London, England) Aug 1970
Topics: Anemia, Aplastic; Bone Marrow; Color; Histiocytes; Humans; Nervous System Diseases; Splenomegaly
PubMed: 4194379
DOI: No ID Found