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Journal of Surgical Oncology May 2013
Topics: Breast Neoplasms; Female; Humans; Mastectomy; Mastectomy, Segmental; United States
PubMed: 23592498
DOI: 10.1002/jso.23340 -
The Breast Journal Nov 2016
Topics: Breast Neoplasms; Female; Health Knowledge, Attitudes, Practice; Humans; Mastectomy; Mastectomy, Segmental; Prophylactic Mastectomy
PubMed: 27870336
DOI: 10.1111/tbj.12654 -
Breast Cancer (Tokyo, Japan) Jul 2020The present review evaluated health-related quality of life (HR-QoL) outcomes in surgical breast cancer survivors who received breast reconstruction (BR),... (Comparative Study)
Comparative Study Meta-Analysis
Health-related quality of life following breast reconstruction compared to total mastectomy and breast-conserving surgery among breast cancer survivors: a systematic review and meta-analysis.
The present review evaluated health-related quality of life (HR-QoL) outcomes in surgical breast cancer survivors who received breast reconstruction (BR), breast-conservation surgery (BCS) or mastectomy (M), and whether HR-QoL domains across generic and disease/surgery-specific questionnaires are compatible. Six electronic databases were searched for appropriate observational studies. Standardized scores for different HR-QoL domains in the BR, BCS, and M treatment groups were extracted from each study for the purpose of a meta-analysis. Using Stata version 14.0, a random-effects meta-analysis model was adopted for each outcome variable to estimate the effect size, 95% CI-confidence intervals, and statistical significance. Sixteen of the 18 eligible studies with BR (n = 1474) and BCS (n = 2612) or M (n = 1458) groups were included in the meta-analysis. The BR group exhibited a better physical health (k = 12; 0.1, 95% CI 0.04, 0.24) and body image (k = 12; 0.50, 95% CI 0.10, 0.89) than the M group. However, the two groups exhibited comparable social health (k = 13; 0.1, 95% CI -0.07, 0.37), emotional health (k = 13; -0.08, 95% CI - 0.41, 0.25), global health (k = 7; 0.1, 95% CI - 0.01, 0.27), and sexual health (k =11; 0.2, 95% CI - 0.02,0.57). There was no clear evidence of the superiority of BR to BCS for all the six domains. These results suggest that HR-QoL outcomes in BR and BCS groups are better than the M group. Therefore, women opting for BR or BCS are likely to report fairly better HR-QoL outcomes than M. However, due to the significant heterogeneity observed in most BR versus BCS outcomes, developing a unified questionnaire incorporating both breast/surgery-specific and generic HR-QoL domains is warranted.
Topics: Body Image; Breast; Breast Neoplasms; Cancer Survivors; Female; Humans; Mammaplasty; Mastectomy, Segmental; Mastectomy, Simple; Quality of Life; Surveys and Questionnaires
PubMed: 32162181
DOI: 10.1007/s12282-020-01076-1 -
International Journal of Radiation... Jan 2019
Comparative Study
Topics: Breast Neoplasms; Female; Humans; Mastectomy; Mastectomy, Segmental
PubMed: 30563667
DOI: 10.1016/j.ijrobp.2018.07.2021 -
Archives of Pathology & Laboratory... Feb 2016
Topics: Breast Neoplasms; Female; Humans; Mastectomy, Segmental; Practice Guidelines as Topic; Radiation Oncology
PubMed: 26910213
DOI: 10.5858/arpa.2015-0355-LE -
European Journal of Surgical Oncology :... Sep 2001In women with breast cancer for whom breast-conserving therapy (BCT) is not the best option, a nipple and areola complex-(NAC) sparing mastectomy with immediate... (Review)
Review
BACKGROUND
In women with breast cancer for whom breast-conserving therapy (BCT) is not the best option, a nipple and areola complex-(NAC) sparing mastectomy with immediate reconstruction has been proposed as a good and safe alternative to conventional, more radical mastectomy. Surgeons hesitate to perform this operation for fear of recurrence of tumour in the NAC due to undetected nipple involvement (NI) of the tumour. In order to determine whether a NAC-sparing mastectomy is a viable option, the frequency and predictive factors of NI by the tumour were studied in the literature.
METHODS
A literature survey was performed by searching the Medline database. Other references were derived from the material perused.
RESULTS AND CONCLUSIONS
NI is found in up to 58% of mastectomy specimens and correlates with tumour size, tumour-areola or tumour-nipple distance, positive lymph nodes and clinical suspicion. Best candidates for NAC-sparing mastectomy are patients with a small tumour (T1) at a large distance (>4-5 cm) from the nipple. However, in these patients BCT has excellent results with low complications and recurrence rates. Considering the incidence of NI in larger tumours (T2 average 33%, T3 average >50%) a NAC-sparing mastectomy may carry an unacceptable high risk for local relapse and should therefore not be advocated.
Topics: Breast Neoplasms; Female; Humans; Mastectomy, Segmental; Nipples; Postoperative Complications; Preoperative Care; Prognosis; Sensitivity and Specificity; Survival Analysis; Treatment Outcome
PubMed: 11520082
DOI: 10.1053/ejso.2001.1130 -
The American Journal of Nursing Jul 1994
Topics: Female; Humans; Mastectomy, Modified Radical; Mastectomy, Segmental
PubMed: 8017490
DOI: No ID Found -
Lancet (London, England) Nov 2016
Topics: Breast Neoplasms; History, 20th Century; History, 21st Century; Humans; Italy; Mastectomy, Segmental; Pathology; Sentinel Lymph Node Biopsy; Surgical Oncology
PubMed: 28452323
DOI: 10.1016/S0140-6736(16)32230-9 -
Annals of Surgery Dec 2018
Topics: Breast Neoplasms; Female; Humans; Mastectomy, Segmental; Nipples; Postoperative Complications; Retrospective Studies
PubMed: 29995680
DOI: 10.1097/SLA.0000000000002941 -
Current Oncology (Toronto, Ont.) Mar 2024Breast cancer is diagnosed in nearly 3 million people worldwide. Radiation therapy is an integral component of disease management for patients with breast cancer, and is... (Review)
Review
Breast cancer is diagnosed in nearly 3 million people worldwide. Radiation therapy is an integral component of disease management for patients with breast cancer, and is used after breast-conserving surgery or a mastectomy to reduce the risk of a local recurrence. The following review describes the methods used to personalize radiation therapy by optimizing patient selection, using advanced treatment techniques to lessen the radiation dose to normal organs, and using hypofractionation in order to shorten the duration of radiation treatment.
Topics: Humans; Female; Breast Neoplasms; Mastectomy; Mastectomy, Segmental
PubMed: 38534954
DOI: 10.3390/curroncol31030121