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Zhong Nan Da Xue Xue Bao. Yi Xue Ban =... Nov 2022Although there is insufficient evidence supporting the link between septate uterus and infertility, there are many studies demonstrated the effect of spetal incision on...
Although there is insufficient evidence supporting the link between septate uterus and infertility, there are many studies demonstrated the effect of spetal incision on pregnancy in women diagnosed with septate uterus associated with infertility. Hysteroscopic metroplasty can significantly improve the reproductive performance of those with septate uterus. Some Müllerian malformations can be healed by surgery. The accurate diagnosis and appropriate therapeutic approch are fundamental for successful treatment. Any attempt at surgical correction of uterine abnormalities must be aimed at preserving or improving reproductive function. Among congenital uterine anomalies, septate uterus is the most amenable to simple hysteroscopic treatment. The resection of the septum is performed as standard treatment worldwide.
Topics: Female; Humans; Septate Uterus
PubMed: 36481626
DOI: 10.11817/j.issn.1672-7347.2022.220501 -
Clinical Case Reports Apr 2022The septate gallbladder is a rare congenital malformation. It is considered a risk factor of complications after laparoscopic cholecystectomy. We are reporting an image...
The septate gallbladder is a rare congenital malformation. It is considered a risk factor of complications after laparoscopic cholecystectomy. We are reporting an image in surgery of a septate gallbladder. It was discovered at an adult age. We are showing the difficulty of the diagnosis preoperatively on the radiological find.
PubMed: 35414909
DOI: 10.1002/ccr3.5666 -
Zhong Nan Da Xue Xue Bao. Yi Xue Ban =... Nov 2022The septate uterus is the most common structural uterine anomalies and it is associated with the poor reproductive outcome. It is believed to be the result of the...
The septate uterus is the most common structural uterine anomalies and it is associated with the poor reproductive outcome. It is believed to be the result of the failure in resorption of the tissue connecting the 2 paramesonephric ducts prior to the 20th embryonic week. The true prevalence of uterine septum is difficult to ascertain, as many uterine septal defects are asymptomatic. The septate uterus is usually diagnosed during an infertility evaluation and affects reproductive health by impairing fertility and increasing adverse pregnancy outcomes. The variations in uterine and cervical/vaginal anomalies collectively referred to as Müllerian anomalies. No consistent gold standard for the diagnosis of Müllerian anomalies exists. The preferred diagnostic method for Müllerian anomalies is two-dimensional ultrasound, other methods such as three-dimensional ultrasound, magnetic resonance imaging, hysterosalpingo contrast sonography, hysterosalpingography, hysteroscopy, and laparoscopy are also used to improve accuracy.
Topics: Female; Humans; Septate Uterus
PubMed: 36481625
DOI: 10.11817/j.issn.1672-7347.2022.220507 -
Cell Biochemistry and Biophysics 2006In most cell types, distinct forms of intercellular junctions have been visualized at the ultrastructural level. Among these, the septate junctions are thought to seal... (Review)
Review
In most cell types, distinct forms of intercellular junctions have been visualized at the ultrastructural level. Among these, the septate junctions are thought to seal the neighboring cells and thus to function as the paracellular barriers. The most extensively studied form of septate junctions, referred to as the pleated septate junctions, is ultrastructurally distinct with an electron-dense ladder-like arrangement of transverse septa present in invertebrates as well as vertebrates. In invertebrates, such as the fruit fly Drosophila melanogaster, septate junctions are present in all ectodermally derived epithelia, imaginal discs, and the nervous system. In vertebrates, septate junctions are present in the myelinated nerves at the paranodal interface between the myelin loops and the axonal membrane. In this review, we present an evolutionary perspective of septate junctions, especially their initial identification across phyla, and discuss many common features of their morphology, molecular organization, and functional similarities in invertebrates and vertebrates.
Topics: Animals; Drosophila melanogaster; Epithelial Cells; Evolution, Molecular; Intercellular Junctions; Myelin Sheath; Nervous System; Vertebrates
PubMed: 16943624
DOI: 10.1385/CBB:46:1:65 -
Obstetrics and Gynecology Clinics of... Sep 1995Reproductive results in women with a septate uterus include increased incidence of spontaneous abortion, premature birth, and abnormal fetal presentations. Septate... (Review)
Review
Reproductive results in women with a septate uterus include increased incidence of spontaneous abortion, premature birth, and abnormal fetal presentations. Septate uterus is seen most often in women with reproductive wastage. This article discusses the diagnosis, indications for surgery, surgical technique, results, and complications for treating patients with a septate uterus.
Topics: Abortion, Spontaneous; Endoscopes; Endoscopy; Female; Humans; Hysteroscopes; Hysteroscopy; Incidence; Infant, Newborn; Infant, Premature; Labor Presentation; Pregnancy; Pregnancy Outcome; Uterus
PubMed: 8524532
DOI: No ID Found -
Medicine Jan 2018A combination of Vaginal atresia and septate uterus as a novel genital malformation has been reported the first time. It offers a support for the bidirectional theory. (Review)
Review
RATIONALE
A combination of Vaginal atresia and septate uterus as a novel genital malformation has been reported the first time. It offers a support for the bidirectional theory.
PATIENT CONCERNS
A 23-year-old woman presented with the inability to perform intercourse. The unprecedented variant was misdiagnosed by magnetic resonance imaging and ultrasonography as low vaginal atresia associated with complete septate uterus with functional endometrium in both the cavities.
DIAGNOSES
The correct diagnosis was made and confirmed intraoperatively as a genital malformation, vaginal atresia and cervical agenesis associated with septate uterus.
INTERVENTION
laparoscopic and hysteroscopic diagnosis the novel malformation never been reported and a vaginal stent was recommended postoperatively.
OUTCOMES
This rare clinical variant made misdiagnosis. Intraoperatively, unprecedented genital malformation was confirmed. There are no vaginal atresia cases in the literature with a septate functional uterus and single agenesis cervix.
LESSONS
Confirmed diagnosed by operation instead of depending on the imaging should be used for rare genital anomaly.
Topics: Abnormalities, Multiple; Cervix Uteri; Female; Humans; Uterus; Vagina; Young Adult
PubMed: 29505013
DOI: 10.1097/MD.0000000000009674 -
Facts, Views & Vision in ObGyn Sep 2021Septate uterus is the most common uterine malformation found in women presenting poor reproductive history. Hysteroscopic septoplasty (HS) restores the uterine anatomy...
BACKGROUND
Septate uterus is the most common uterine malformation found in women presenting poor reproductive history. Hysteroscopic septoplasty (HS) restores the uterine anatomy in a safe procedure.
OBJECTIVES
The goal of our study is to determine the reproductive outcomes after HS of symptomatic septate uterus.
MATERIALS AND METHODS
In a retrospective observational single centre study the reproductive outcomes and complications after HS were evaluated in 31 women with symptomatic septate uterus. The patients were separated into two groups according to the symptoms - infertility or recurrent pregnancy loss (RPL).
MAIN OUTCOME MEASURES
were the pregnancy and live birth rate and secondarily the complication rate. Furthermore, the results were analysed depending on the need of assisted reproductive techniques (ART).
RESULTS
The treatment has resulted in an overall pregnancy rate of 71% for both groups. The spontaneous pregnancy rate is 45% and 8 pregnancies resulted from ART (26%). The overall first live birth rate is 51.6%. A decrease has been noticed in the miscarriage rate from 95.24% to 24% (p<0.001) in the overall population.
CONCLUSIONS
In patients with a symptomatic septate uterus hysteroscopic septoplasty is a safe and effective procedure. The favourable results pointing out the benefits of surgery on the reproductive outcomes as well as the relatively simple and safe technique of HS make the intervention attractive.
PubMed: 34555879
DOI: 10.52054/FVVO.13.3.032 -
Taiwanese Journal of Obstetrics &... May 2024To discuss several techniques of hysteroscopic surgery for complete septate uterus. (Review)
Review
OBJECTIVE
To discuss several techniques of hysteroscopic surgery for complete septate uterus.
CASE REPORT
A 40-year-old female with unexplained primary infertility was diagnosed with complete septate uterus with septate cervix. Hysteroscopic incision of complete septate uterus was performed by using ballooning technique. The patient conceived naturally shortly after the operation and delivered a healthy, term infant.
CONCLUSION
Hysteroscopic incision of complete septate uterus is a safe and prompt way of metroplasty. With the knowledge obtained from a pre-operative MRI, it can be completed without laparoscopy and the need for hospitalization.
Topics: Humans; Female; Adult; Hysteroscopy; Pregnancy; Cervix Uteri; Uterus; Infertility, Female; Term Birth; Urogenital Abnormalities; Septate Uterus
PubMed: 38802207
DOI: 10.1016/j.tjog.2024.05.001 -
BJOG : An International Journal of... Sep 2019Little is known about the pathophysiology underlying the increased risk for impaired reproductive outcomes in women with a septate uterus.
BACKGROUND
Little is known about the pathophysiology underlying the increased risk for impaired reproductive outcomes in women with a septate uterus.
OBJECTIVES
We explored the available evidence on the pathophysiology of the septate uterus in an attempt to find a biological basis for these effects.
SEARCH STRATEGY
We performed a systematic literature search in OVID MEDLINE and OVID EMBASE from inception to January 2018.
SELECTION CRITERIA
We selected studies that investigated the pathophysiology of the septate uterus. Case reports or reviews without original data were excluded.
DATA COLLECTION AND ANALYSIS
Two reviewers independently evaluated potentially eligible papers.
MAIN RESULTS
Thirty-eight studies were included for analysis. The overall findings were that the intrauterine septum consists of endometrium and myometrium similar to the uterine wall. All five imaging studies that evaluated vascularity found that most of the intrauterine septa were vascularised. Histological studies found that the intrauterine septum consisted of myometrium and was covered by endometrium (n = 9). The endometrium covering the septum showed differences in histological composition in four studies and in gene expression in three studies compared with the normal uterine wall.
CONCLUSIONS
We found no clear biological basis for the impaired reproductive outcomes in women with a septate uterus. Either the gross anatomy of the septum itself or differences in histology or gene expression of the septum could account for the increased risk of reproductive waste observed after implantation in the septum.
TWEETABLE ABSTRACT
In women with a septate uterus differences in histology or gene expression could account for impaired reproductive outcome.
Topics: Abortion, Habitual; Female; Humans; Hysteroscopy; Infertility; Pregnancy; Uterine Diseases; Uterus
PubMed: 31004459
DOI: 10.1111/1471-0528.15798