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Bulletin of Experimental Biology and... Aug 2023Molecular genetic analysis of polymorphic variants of serotonin receptor genes (HTR2C and HTR2A) was performed in 89 healthy medical students and regulatory and adaptive...
Molecular genetic analysis of polymorphic variants of serotonin receptor genes (HTR2C and HTR2A) was performed in 89 healthy medical students and regulatory and adaptive capacities were determined by cardiorespiratory synchronism. The relationship of serotonin receptor gene polymorphisms and the regulatory and adaptive capabilities of the body were revealed. The highly active *G allele and *G/*G genotype of the serotonin receptor HTR2C gene and the heterozygous *A/*G genotype of the serotonin receptor HTR2A gene are associated with "good" regulatory and adaptive capacities. The low-active *C allele of the serotonin receptor HTR2C gene is associated with "low" regulatory and adaptive capacities.
Topics: Humans; Alleles; Genotype; Polymorphism, Genetic; Polymorphism, Single Nucleotide; Receptor, Serotonin, 5-HT2A; Receptor, Serotonin, 5-HT2C; Receptors, Serotonin; Students, Medical; Adaptation, Psychological
PubMed: 37768455
DOI: 10.1007/s10517-023-05878-z -
Proceedings of the National Academy of... Dec 1998
Review
Topics: Animals; Anti-Anxiety Agents; Emotions; Humans; Mice; Mice, Knockout; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Serotonin; Serotonin Receptor Agonists
PubMed: 9860934
DOI: 10.1073/pnas.95.26.15153 -
Current Topics in Medicinal Chemistry 2010
Topics: Chemistry, Pharmaceutical; Drug Discovery; Humans; Ligands; Receptors, Serotonin; Serotonin Agents
PubMed: 20374191
DOI: 10.2174/156802610791111579 -
Clinical Neuropharmacology 1993Serotonin (5-HT) neuroendocrine tests are a valid and acceptable means of measuring 5-HT neurotransmission in humans. Recently, the availability of selective 5-HT... (Review)
Review
Serotonin (5-HT) neuroendocrine tests are a valid and acceptable means of measuring 5-HT neurotransmission in humans. Recently, the availability of selective 5-HT receptor ligands has allowed the assessment of specific 5-HT receptor subtype function using neuroendocrine methods. Studies with selective antagonists have shown that the endocrine responses to the 5-HT precursor L-tryptophan (LTP) are mediated via postsynaptic 5-HT1A receptors, whereas endocrine responses produced by the 5-HT-releasing agent d-fenfluramine involve postsynaptic 5-HT2/1C receptors. Endocrine responses to both LTP and fenfluramine are consistently decreased in depressive illness. In contrast, endocrine responses to direct 5-HT1A and 5-HT2/1C receptor agonists are not consistently attenuated in depressed patients. The current data suggest that depressive illness is associated with an impairment of 5-HT neurotransmission that involves decreased 5-HT release rather than altered sensitivity of postsynaptic 5-HT receptors.
Topics: Depression; Humans; Neurosecretory Systems; Receptors, Serotonin; Serotonin; Serotonin Receptor Agonists; Selective Serotonin Reuptake Inhibitors
PubMed: 8131155
DOI: No ID Found -
Clinical Neuropharmacology Feb 1991The effects of 5-HT are varied and widely distributed throughout the human body. At this time, 5-HT research is a field ripe for "plucking." Not only is there a great... (Review)
Review
The effects of 5-HT are varied and widely distributed throughout the human body. At this time, 5-HT research is a field ripe for "plucking." Not only is there a great demand for more selective agonists and antagonists, but there is more than enough work needed in receptor binding studies to keep pharmacologists employed for years to come. The clinical benefits of 5-HT receptor pharmacology are just starting to be developed and explored. Novel treatments for hypertension, migraine headaches, anxiety, and depression using 5-HT are just the beginning. It will be exciting to see what the future holds for 5-HT clinically.
Topics: Animals; Humans; Receptors, Serotonin
PubMed: 2029690
DOI: No ID Found -
Nihon Rinsho. Japanese Journal of... Jul 1991
Review
Topics: Brain Chemistry; Humans; Receptors, Serotonin; Tomography, Emission-Computed
PubMed: 1886250
DOI: No ID Found -
Signal Transduction and Targeted Therapy Jun 2021
Topics: Apoenzymes; Crystallography, X-Ray; Humans; Ligands; Protein Conformation; Receptors, Serotonin; Serotonin; Serotonin Receptor Agonists
PubMed: 34145221
DOI: 10.1038/s41392-021-00668-3 -
Neuroscience Letters Mar 2016Taste cells release neurotransmitters to gustatory neurons to transmit chemical information they received. Sweet, umami, and bitter taste cells use ATP as a...
Taste cells release neurotransmitters to gustatory neurons to transmit chemical information they received. Sweet, umami, and bitter taste cells use ATP as a neurotransmitter. However, ATP release from sour taste cells has not been observed so far. Instead, they release serotonin when they are activated by sour/acid stimuli. Thus it is still controversial whether sour taste cells use ATP, serotonin, or both. By reverse transcription-polymerase chain reaction and subsequent in situ hybridization (ISH) analyses, we revealed that of 14 serotonin receptor genes only 5-HT3A and 5-HT3B showed significant/clear signals in a subset of neurons of cranial sensory ganglia in which gustatory neurons reside. Double-fluorescent labeling analyses of ISH for serotonin receptor genes with wheat germ agglutinin (WGA) in cranial sensory ganglia of pkd1l3-WGA mice whose sour neural pathway is visualized by the distribution of WGA originating from sour taste cells in the posterior region of the tongue revealed that WGA-positive cranial sensory neurons rarely express either of serotonin receptor gene. These results suggest that serotonin receptors expressed in cranial sensory neurons do not play any role as neurotransmitter receptor from sour taste cells.
Topics: Animals; Ganglia, Sensory; Gene Expression; Male; Mice, Inbred C57BL; Mice, Transgenic; Receptors, Purinergic P2X2; Receptors, Serotonin; Receptors, Serotonin, 5-HT3; Sensory Receptor Cells; Skull; Taste
PubMed: 26854841
DOI: 10.1016/j.neulet.2016.01.050 -
Current Opinion in Investigational... Sep 2004Pulmonary hypertension (PHT) results from compromised pulmonary vasoconstriction and vascular remodeling. Serotonin (5-hydroxytryptamine/5-HT) is one of the important... (Review)
Review
Pulmonary hypertension (PHT) results from compromised pulmonary vasoconstriction and vascular remodeling. Serotonin (5-hydroxytryptamine/5-HT) is one of the important vasomotor agents, and its importance in the pathogenesis of PHT is currently being investigated. In most mammalian species, PHT can result from numerous serotonergic drugs, demonstrating that various 5-HT receptor subtypes and the 5-HT transporter (5-HTT) contribute to PHT. Both are therefore potential therapeutic targets for the treatment of the disorder. This review describes current awareness of the roles of 5-HT, the 5-HT receptor and the 5-HTT in PHT.
Topics: Animals; Drug Synergism; Humans; Hypertension, Pulmonary; Membrane Glycoproteins; Membrane Transport Proteins; Nerve Tissue Proteins; Receptor, Serotonin, 5-HT1B; Receptors, Serotonin; Serotonin; Serotonin Plasma Membrane Transport Proteins
PubMed: 15503652
DOI: No ID Found -
Current Opinion in Neurobiology Apr 1997The serotonergic system appears to play a role in behaviors that involve a high cognitive demand and in memory improvement or recovery from impaired cognitive... (Review)
Review
The serotonergic system appears to play a role in behaviors that involve a high cognitive demand and in memory improvement or recovery from impaired cognitive performance, as made evident after administration of serotonin 5-HT2A/5-HT2C or 5-HT4 receptor agonists or 5-HT1A or 5-HT3 receptor antagonists. These serotonin receptor subtypes are localized on 'cognitive' pathways, with the hippocampus and frontal cortex as the main target structures. A better understanding of the role played by these and other serotonin receptor subtypes in cognition is likely to result from the recent availability of new specific ligands and new molecular tools, such as gene knock-out and transgenic mice.
Topics: Animals; Behavior, Animal; Cognition; Mice; Receptors, Serotonin
PubMed: 9142756
DOI: 10.1016/s0959-4388(97)80013-x