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Journal of the Indian Medical... Jan 2003A two and half years old male child of sinus histiocytosis with massive lymphadenopathy, paraplegia and spinal cord involvement was treated with surgery and radiotherapy...
A two and half years old male child of sinus histiocytosis with massive lymphadenopathy, paraplegia and spinal cord involvement was treated with surgery and radiotherapy for the spinal cord compression and later with chemotherapy for his nodal disease in the neck. There was a significant improvement in his neurologic status as well as in his nodal status reiterating the role of combination therapy in this disease.
Topics: Child, Preschool; Histiocytosis, Sinus; Humans; Magnetic Resonance Imaging; Male; Spinal Cord Compression
PubMed: 12841504
DOI: No ID Found -
Pediatric Blood & Cancer Oct 2006Sinus histiocytosis with massive lymphadenopathy (SHML) or Rosai-Dorfman disease (RDD) is a rare but well-defined histiocytic proliferative disorder of unknown etiology...
Sinus histiocytosis with massive lymphadenopathy (SHML) or Rosai-Dorfman disease (RDD) is a rare but well-defined histiocytic proliferative disorder of unknown etiology that usually presents with cervical lymphadenopathy, fever, leukocytosis, and hypergammaglobulinemia in an otherwise healthy child. Although many patients undergo spontaneous remission, a subset of patients with systemic disease has a more serious course. For those patients with a poor outcome, steroids and chemotherapeutic agents such as etoposide or 6-mercaptopurine plus low dose methotrexate have been used. We present a child with a massive cervical lymphadenopathy treated with 2-chlorodeoxyadenosine (2-CdA, cladribine) after other approaches failed.
Topics: Child; Cladribine; Follow-Up Studies; Histiocytosis, Sinus; Humans; Male; Remission Induction; Treatment Outcome; X-Rays
PubMed: 16302214
DOI: 10.1002/pbc.20668 -
Internal Medicine Journal Apr 2012
Topics: Adult; Diagnosis, Differential; Head and Neck Neoplasms; Histiocytosis, Sinus; Humans; Lymph Nodes; Male
PubMed: 22498124
DOI: 10.1111/j.1445-5994.2012.02731.x -
Critical Reviews in Oncology/hematology May 2004
Review
Topics: Histiocytosis, Langerhans-Cell; Histiocytosis, Non-Langerhans-Cell; Histiocytosis, Sinus; Humans
PubMed: 15157664
DOI: 10.1016/j.critrevonc.2004.01.002 -
Skinmed 2017A 48-year-old Hispanic man presented with a nodule on the right cheek. The lesion had started as a papule 4 months previously that had slowly enlarged and then plateaued...
A 48-year-old Hispanic man presented with a nodule on the right cheek. The lesion had started as a papule 4 months previously that had slowly enlarged and then plateaued at its present size. The nodule was asymptomatic, and the patient denied bleeding, draining, or preceding trauma. Review of systems was negative for fevers, weight loss, night sweats, lymphadenopathy, or other skin findings. Past medical history was significant only for type 2 diabetes mellitus, hyperlipidemia, and hypertension.
Topics: Facial Dermatoses; Histiocytosis, Sinus; Humans; Male; Middle Aged
PubMed: 28859745
DOI: No ID Found -
The American Journal of Dermatopathology Jan 2020
Review
Topics: Aged, 80 and over; Biopsy, Needle; Drug Therapy, Combination; Histiocytosis, Sinus; Humans; Immunohistochemistry; Male; Methotrexate; Prednisone; Rare Diseases; Severity of Illness Index; Skin; Treatment Outcome
PubMed: 31880636
DOI: 10.1097/DAD.0000000000001293 -
Annals of Plastic Surgery Jun 2019Rosai-Dorfman disease (RDD), also known as sinus histiocytosis with massive lymphadenopathy, is a rare and benign proliferative disease that affects histiocytes. Its... (Review)
Review
Rosai-Dorfman disease (RDD), also known as sinus histiocytosis with massive lymphadenopathy, is a rare and benign proliferative disease that affects histiocytes. Its etiology remains unclear. Rosai-Dorfman disease primarily affects lymph nodes with many extranodal manifestations present, including cutaneous, pulmonary, ophthalmic, and gastrointestinal. Diagnosis is mainly histologic with the presence of Rosai-Dorfman cells, which demonstrate emperipolesis. We report a case of a 30-year-old man who presented with a facial cutaneous mass and was diagnosed with RDD; he underwent surgical excision. The patient experienced recurrent lesions on the surgical scar and parotid gland as well as the lower back. Treatment consisted of systemic steroids and surgical excision.
Topics: Adrenal Cortex Hormones; Adult; Follow-Up Studies; Histiocytosis, Sinus; Humans; Lymph Node Excision; Lymphadenopathy; Male; Parotid Gland; Positron-Emission Tomography; Rare Diseases; Recurrence; Risk Assessment; Severity of Illness Index; Skin; Treatment Outcome
PubMed: 30882409
DOI: 10.1097/SAP.0000000000001794 -
Virchows Archiv : An International... Jan 2004
Topics: Adolescent; Biopsy; Giant Cells; Hepatitis; Histiocytosis, Sinus; Humans; Liver; Lymph Nodes; Lymphatic Diseases; Male
PubMed: 14624361
DOI: 10.1007/s00428-003-0924-x -
Joint Bone Spine Dec 2011A 24-year-old woman who had sinus histiocytosis with massive lymphadenopathy (SHML, Rosai-Dorfman disease) also had oligoarthritis. We found only four previously...
A 24-year-old woman who had sinus histiocytosis with massive lymphadenopathy (SHML, Rosai-Dorfman disease) also had oligoarthritis. We found only four previously reported cases of SHML with clinical joint disease. The clinical picture may suggest rheumatoid arthritis or a spondylarthropathy with peripheral joint involvement. SHML should be considered routinely among the differential diagnoses in young patients with arthritis and large lymphadenopathies. There is no consensus regarding the treatment. In our patient, conventional disease-modifying antirheumatic drugs followed by 3 months of adalimumab then 3 months of etanercept had no effect on the symptoms.
Topics: Adalimumab; Adult; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis; Comorbidity; Diagnosis, Differential; Etanercept; Female; Histiocytosis, Sinus; Humans; Immunoglobulin G; Receptors, Tumor Necrosis Factor; Treatment Failure
PubMed: 21816647
DOI: 10.1016/j.jbspin.2011.05.024 -
Radiology Dec 1999Sinus histiocytosis with massive lymphadenopathy (SHML) is an uncommon disorder that typically manifests as systemic symptoms and lymphadenopathy. Extranodal,...
Sinus histiocytosis with massive lymphadenopathy (SHML) is an uncommon disorder that typically manifests as systemic symptoms and lymphadenopathy. Extranodal, intracranial disease is uncommon. The authors report on a 15-year-old adolescent girl who had a suprasellar mass at magnetic resonance imaging. Biopsy results demonstrated lymphophagocytosis consistent with a diagnosis of SHML. The clinical, radiologic, and histologic aspects of the disease are discussed.
Topics: Adolescent; Biopsy; Female; Histiocytosis, Sinus; Humans; Magnetic Resonance Imaging; Pituitary Diseases; Pituitary Gland
PubMed: 10580957
DOI: 10.1148/radiology.213.3.r99dc30808