-
Journal of the National Comprehensive... Mar 2009
Topics: Humans; Lymph Node Excision; Melanoma; Neoplasm Recurrence, Local; Skin Neoplasms
PubMed: 19401060
DOI: 10.6004/jnccn.2009.0020 -
Surgical Oncology Clinics of North... Apr 2015
Topics: Humans; Melanoma; Neoplasm Staging; Skin Neoplasms
PubMed: 25769720
DOI: 10.1016/j.soc.2015.01.001 -
The Medical Clinics of North America Nov 2009Skin cancers may be derived from any part of the skin, and the classification of all variants is extensive. Overall they are the most common cancers of the body, and... (Review)
Review
Skin cancers may be derived from any part of the skin, and the classification of all variants is extensive. Overall they are the most common cancers of the body, and include those that are highly mortal and those that are associated with an increased morbidity. In this review the most common skin cancers confronted by the clinician and their management are discussed. New associations are highlighted, as well as new information that can help the clinician to better understand the pathogenesis of many of these entities.
Topics: Humans; Melanoma; Neoplasm Metastasis; Skin Neoplasms
PubMed: 19932329
DOI: 10.1016/j.mcna.2009.08.011 -
Transplantation Proceedings 2018Maintenance hemodialysis (HD) patients are potential transplant recipients. One of the most common cancers in the population of kidney recipients is skin neoplasm. Skin...
INTRODUCTION
Maintenance hemodialysis (HD) patients are potential transplant recipients. One of the most common cancers in the population of kidney recipients is skin neoplasm. Skin infections are also of a particular importance. In this population, especially in patients on the transplant waiting list, full dermatological examination, including dermatoscopy, should be carried out routinely.
MATERIALS AND METHODS
The research was comprised of 105 HD patients (57 men, 48 women) with a mean age of 60.8 (range 25-94) years. The patients' skin condition was assessed and a dermatoscopic examination was performed. We compared the incidence of skin diseases in the two subpopulations: HD patients (n = 89) and HD patients active on the transplant waiting list (n = 16).
RESULTS
Bacterial, fungal, and viral infections in the group of HD patients occurred in 24.7%, 14.6%, and 6.7% of patients, respectively. In HD patients on the waiting list, bacterial skin diseases were reported in 12.5% of patients, and neither fungal nor viral infections were noticed. Malignant skin lesions and precancerous conditions, such as basal cell carcinoma and keratosis actinic, developed in 4.5% and 3.4% of the HD patients. These malignancies did not occur in HD patients on the waiting list. The results show proper qualification for transplantation in maintenance HD patients before the waiting list. In the group of dialysis patients, 67.4% required dermatological care, while in the HD waiting group only 12.5% required dermatological care.
CONCLUSIONS
The presented results prove the necessity of performing dermatological examinations on HD patients. Some dermatological skin lesions, if not diagnosed and treated, could progress to cancer after organ transplantation.
Topics: Adult; Aged; Aged, 80 and over; Female; Humans; Incidence; Kidney Diseases; Kidney Transplantation; Male; Middle Aged; Renal Dialysis; Risk Factors; Skin Diseases, Bacterial; Skin Diseases, Infectious; Skin Neoplasms; Waiting Lists
PubMed: 30056869
DOI: 10.1016/j.transproceed.2018.02.133 -
BMJ Open May 2023Skin cancer is Australia's most common and costly cancer. We examined the frequency of Australian general practice consultations for skin cancer-related conditions, by...
OBJECTIVE
Skin cancer is Australia's most common and costly cancer. We examined the frequency of Australian general practice consultations for skin cancer-related conditions, by patient and general practitioner (GP) characteristics and by time period.
DESIGN
Nationally representative, cross-sectional survey of general practice clinical activity.
SETTING, PARTICIPANTS
Patients aged 15 years or older having a skin cancer-related condition managed by GPs in the Bettering the Evaluation And Care of Health study between April 2000 and March 2016.
PRIMARY OUTCOME MEASURES
Proportions and rates per 1000 encounters.
RESULTS
In this period, 15 678 GPs recorded 1 370 826 patient encounters, of which skin cancer-related conditions were managed 65 411 times (rate of 47.72 per 1000 encounters, 95% CI 46.41 to 49.02). Across the whole period, 'skin conditions' managed were solar keratosis (29.87%), keratinocyte cancer (24.85%), other skin lesion (12.93%), nevi (10.98%), skin check (10.37%), benign skin neoplasm (8.76%) and melanoma (2.42%). Over time, management rates increased for keratinocyte cancers, skin checks, skin lesions, benign skin neoplasms and melanoma; but remained stable for solar keratoses and nevi. Skin cancer-related encounter rates were higher for patients aged 65-89 years, male, living in Queensland or in regional or remote areas, with lower area-based socioeconomic status, of English-speaking background, Veteran card holders and non-healthcare card holders; and for GPs who were aged 35-44 years or male.
CONCLUSION
These findings show the spectrum and burden of skin cancer-related conditions managed in general practice in Australia, which can guide GP education, policy and interventions to optimise skin cancer prevention and management.
Topics: Humans; Male; Cross-Sectional Studies; Australia; General Practice; General Practitioners; Skin Neoplasms; Nevus; Melanoma; Keratosis, Actinic
PubMed: 37142316
DOI: 10.1136/bmjopen-2022-067744 -
Photodermatology, Photoimmunology &... Mar 2023
Topics: Humans; Critical Pathways; Skin Neoplasms; Melanoma; Biopsy; Skin
PubMed: 36583286
DOI: 10.1111/phpp.12862 -
Dermatologic Surgery : Official... Dec 1998
Review
Topics: Dermatologic Surgical Procedures; Diagnosis, Differential; Humans; Neoplasm Recurrence, Local; Risk; Skin; Skin Neoplasms; Survival Rate
PubMed: 9865191
DOI: 10.1111/j.1524-4725.1998.tb00001.x -
Neoplasia (New York, N.Y.) Sep 2023Cutaneous melanoma is the deadliest form of skin neoplasm and its high mortality rates could be averted by early accurate detection. While the detection of melanoma is...
Cutaneous melanoma is the deadliest form of skin neoplasm and its high mortality rates could be averted by early accurate detection. While the detection of melanoma is currently reliant upon melanin visualisation, research into melanosome biogenesis, as a key driver of pathogenesis, has not yielded technology that can reliably distinguish between atypical benign, amelanotic and melanotic lesions. The endosomal-lysosomal system has important regulatory roles in cancer cell biology, including a specific functional role in melanosome biogenesis. Herein, the involvement of the endosomal-lysosomal system in melanoma was examined by pooled secondary analysis of existing gene expression datasets. A set of differentially expressed endosomal-lysosomal genes was identified in melanoma, which were interconnected by biological function. To illustrate the protein expression of the dysregulated genes, immunohistochemistry was performed on samples from patients with cutaneous melanoma to reveal candidate markers. This study demonstrated the dysregulation of Syntenin-1, Sortilin and Rab25 may provide a differentiating feature between cutaneous melanoma and squamous cell carcinoma, while IGF2R may indicate malignant propensity in these skin cancers.
Topics: Humans; Melanoma; Skin Neoplasms; Carcinoma, Squamous Cell; Lysosomes; rab GTP-Binding Proteins; Melanoma, Cutaneous Malignant
PubMed: 37562257
DOI: 10.1016/j.neo.2023.100924 -
Actas Dermo-sifiliograficas 2019
Topics: Antineoplastic Agents, Immunological; Humans; Immunotherapy; Neoplasm Staging; Skin Neoplasms
PubMed: 29548489
DOI: 10.1016/j.ad.2017.10.020 -
American Family Physician Jul 2000The incidence of skin cancer is increasing by epidemic proportions. Basal cell cancer remains the most common skin neoplasm, and simple excision is generally curative.... (Review)
Review
The incidence of skin cancer is increasing by epidemic proportions. Basal cell cancer remains the most common skin neoplasm, and simple excision is generally curative. Squamous cell cancers may be preceded by actinic keratoses-premalignant lesions that are treated with cryotherapy, excision, curettage or topical 5-fluorouracil. While squamous cell carcinoma is usually easily cured with local excision, it may invade deeper structures and metastasize. Aggressive local growth and metastasis are common features of malignant melanoma, which accounts for 75 percent of all deaths associated with skin cancer. Early detection greatly improves the prognosis of patients with malignant melanoma. The differential diagnosis of pigmented lesions is challenging, although the ABCD and seven-point checklists are helpful in determining which pigmented lesions require excision. Sun exposure remains the most important risk factor for all skin neoplasms. Thus, patients should be taught basic "safe sun" measures: sun avoidance during peak ultraviolet-B hours; proper use of sunscreen and protective clothing; and avoidance of suntanning.
Topics: Carcinoma, Basal Cell; Carcinoma, Squamous Cell; Diagnosis, Differential; Humans; Melanoma; Patient Education as Topic; Skin Neoplasms; Sunburn; Teaching Materials
PubMed: 10929700
DOI: No ID Found