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Plastic and Reconstructive Surgery Aug 1990Pilomatricoma is a common benign skin-appendage tumor. Surgeons should be on the alert for pilomatrical carcinoma, an aggressive variation of a usually benign skin...
Pilomatricoma is a common benign skin-appendage tumor. Surgeons should be on the alert for pilomatrical carcinoma, an aggressive variation of a usually benign skin neoplasm.
Topics: Adult; Head and Neck Neoplasms; Humans; Male; Neoplasm Recurrence, Local; Skin Neoplasms
PubMed: 2367584
DOI: 10.1097/00006534-199008000-00026 -
Journal of Cutaneous Pathology Jan 2018Pilomatrix carcinoma is a rare, locally aggressive tumor with a tendency to recur. Distant metastases have been reported, with pulmonary lesions being the most frequent... (Review)
Review
Pilomatrix carcinoma is a rare, locally aggressive tumor with a tendency to recur. Distant metastases have been reported, with pulmonary lesions being the most frequent manifestation. Similar to pilomatrixoma, pilomatrix carcinoma typically presents as a nontender, firm dermal swelling and is found most commonly in the head and neck region. Although pilomatrixomas and pilomatrix carcinoma are well-recognized lesions, clinically they are frequently misdiagnosed as other skin conditions. By reviewing the literature over the past 10 years, the aims of this review are to analyze the cause, clinical presentation, histopathologic features, management and outcomes of pilomatrix carcinoma amongst children and adults.
Topics: Adult; Carcinoma; Child; Female; Hair Diseases; Humans; Male; Pilomatrixoma; Skin Neoplasms
PubMed: 28914451
DOI: 10.1111/cup.13046 -
The American Journal of Dermatopathology Feb 2009Dermatofibroma or cutaneous fibrous histiocytoma is a common benign skin lesion with multiple, distinct histologic variants, including cellular, aneurismal, epithelioid,...
Dermatofibroma or cutaneous fibrous histiocytoma is a common benign skin lesion with multiple, distinct histologic variants, including cellular, aneurismal, epithelioid, atypical, lipidized "ankle-type," palisading, and cholesterotic. Although dermatofibromas are considered benign neoplasms, certain variants including cellular and aneurismal ones have shown to have a notable tendency to locally recur after excision. Indeed, although extremely rarely, metastases have been associated with the cellular and aneurysmal/atypical variants. Signet-ring cells are formed by cytoplasmic accumulations of various substances that push the nucleus toward the cellular border. The finding of signet-ring cells in a skin neoplasm always raises the suspicion of metastatic adenocarcinoma, although a number of reports have shown their occurrence in primitive cutaneous neoplasms as well. Signet-ring cell formation, however, has never been described in dermatofibroma. We present, for the first time, a new, distinctive variant of dermatofibroma, so-called signet-ring cell dermatofibroma, in a 16-year-old man with a slowly growing skin tumor on the lateral side of his right leg. Histologic examination demonstrated a striking signet-ring cell appearance of most of the cells in an otherwise fibrohistiocytic looking proliferation. Histochemical and immunohistochemical stainings confirmed the diagnosis of dermatofibroma. The phenomenon described in this case enlarges the histologic spectrum of cutaneous fibrous histiocytoma and may cause substantial differential diagnostic problems.
Topics: Adolescent; Cell Nucleus; Histiocytoma, Benign Fibrous; Humans; Male; Skin Neoplasms
PubMed: 19155733
DOI: 10.1097/DAD.0b013e31818981ff -
The American Journal of Dermatopathology Jun 2001This article summarizes Louis H. Winer's description of the dilated pore and some of the pertinent literature about the dilated pore. To better understand the discussion... (Review)
Review
This article summarizes Louis H. Winer's description of the dilated pore and some of the pertinent literature about the dilated pore. To better understand the discussion that follows, there is a brief review of the histology of the follicular infundibulum and isthmus, then a discussion of the architectural and cytologic differentiation of proliferations that reputedly differentiate toward the infundibulum. These other proliferations with their original photomicrographs are discussed rather extensively to support the argument that they do not differentiate either architecturally or cellularly toward the infundibulum. I then present evidence that contradicts those authors who claim that Winer's dilated pore is only a cyst and conclude that it is a neoplasm sui generis and the only neoplasm of the skin that differentiates architecturally and cytologically towards the infundibulum (the infundibuloma).
Topics: Darier Disease; Humans; Neoplasms, Basal Cell; Skin; Skin Neoplasms
PubMed: 11391113
DOI: 10.1097/00000372-200106000-00020 -
Oncology Reports Sep 2007Erlotinib is an inhibitor of the tyrosine-kinase domain of the epidermal growth factor receptor-1 (EGFR). This drug is used to treat some solid cancers, particularly...
Erlotinib is an inhibitor of the tyrosine-kinase domain of the epidermal growth factor receptor-1 (EGFR). This drug is used to treat some solid cancers, particularly advanced non-small-cell lung carcinoma. Similar to other EGFR inhibitors, erlotinib is responsible for a series of skin adverse reactions, particularly acneiform lesions. We described the incidental effect of erlotinib on actinic keratoses which became markedly inflamed and showed partial regression. Inflammation appeared to spontaneously decrease while on erlotinib treatment. This reaction in the skin neoplasm is perhaps a visible and accessible model for predicting the effect in the deep-seated neoplasm targeted by the drug.
Topics: Carcinoma, Squamous Cell; ErbB Receptors; Erlotinib Hydrochloride; Humans; Inflammation; Keratosis; Male; Protein Kinase Inhibitors; Quinazolines; Radionuclide Imaging; Skin Neoplasms; Sunlight
PubMed: 17671704
DOI: No ID Found -
ANZ Journal of Surgery Oct 2021Spiradenocarcinoma is a rare skin adnexal neoplasm that may behave aggressively. It is often associated with a benign slow-growing spiradenoma that has undergone... (Review)
Review
BACKGROUND
Spiradenocarcinoma is a rare skin adnexal neoplasm that may behave aggressively. It is often associated with a benign slow-growing spiradenoma that has undergone malignant transformation. Given the paucity of cases in the literature, there is a lack of consensus on treatment.
METHODS
The terms 'malignant spiradenoma' or 'spiradenocarcinoma' were systematically used to search the PubMed, MEDLINE and Google Scholar databases. A total of 182 cases of spiradenocarcinoma were identified as eligible for this comprehensive literature review.
RESULTS
Spiradenocarcinoma was commoner in older age and Caucasian race. In most cases, surgical excision for local disease is the mainstay of treatment. Lymph node dissection is usually reserved for those with suspected or confirmed lymph node metastases. High rates of local recurrence (20.8%), metastasis (37.4%) and mortality (19.1%) were identified, prompting some authors to suggest regular follow up including chest X-rays and liver function tests.
CONCLUSIONS
Patients with spiradenocarcinoma may benefit from a magnetic resonance imaging and fluorodeoxyglucose-positron emission tomography/computed tomography to establish the extent of disease. We recommend wide local excision as the treatment of choice to achieve surgical margins of ≥1 cm, with node resection to be determined on a case-to-case basis. Regular follow up is important given the high rate of local recurrence, metastasis and mortality. This should include an examination of the regional lymph nodes. Further research is required to refine an evidence-based approach to spiradenocarcinoma.
Topics: Aged; Humans; Lymph Nodes; Lymphatic Metastasis; Neoplasm Recurrence, Local; Skin Neoplasms; Sweat Gland Neoplasms
PubMed: 33522696
DOI: 10.1111/ans.16626 -
The European Journal of Health... Apr 2018In this paper, we analyze how a nationwide population-based skin cancer screening program (SCS) implemented in Germany in 2008 has impacted the number of hospital...
In this paper, we analyze how a nationwide population-based skin cancer screening program (SCS) implemented in Germany in 2008 has impacted the number of hospital discharges following malignant skin neoplasm diagnosis and the malignant melanoma mortality rate per 100,000 inhabitants. Our panel data, drawn from the Eurostat database, cover subregions in 22 European countries, measured at the lowest nomenclature of territorial units for statistics (NUTS) level for 2000-2013. Applying fixed effects methods, we find a significantly positive and robust effect of the German SCS on the number of patients diagnosed with malignant skin neoplasm. However, the program does not significantly influence the melanoma mortality rate. This finding conflicts with the decreased melanoma mortality rate found for the pilot SCS program in northern Germany. Our results indicate that Germany's nationwide SCS program is effective in terms of a higher diagnosis rate for malignant skin neoplasms and thus may contribute to an improvement in the early detection of skin cancer.
Topics: Adult; Aged; Early Detection of Cancer; Female; Germany; Humans; Incidence; Male; Mass Screening; Melanoma; Middle Aged; Skin Neoplasms
PubMed: 28353004
DOI: 10.1007/s10198-017-0888-4 -
Journal of Cutaneous Pathology Jul 2016Keratoacanthoma (KA) is a common keratinocytic skin neoplasm that typically develops rapidly and undergoes complete spontaneous regression. As the pro-apoptotic p53...
BACKGROUND
Keratoacanthoma (KA) is a common keratinocytic skin neoplasm that typically develops rapidly and undergoes complete spontaneous regression. As the pro-apoptotic p53 protein may be involved in the lifecycle of KA, we studied the p53 status throughout the main stages of KA that include proliferation, maturation and regression in a large series of lesions.
METHODS
One-hundred and twenty-four KAs were characterized with respect to age of the lesions both clinically and histopathologically, in addition to phenotypic characteristics such as cellular atypia, infiltration, inflammation and fibrosis. Tp53 mutations were detected by capillary electrophoresis, and p53 protein levels were assessed by immunohistochemistry.
RESULTS
Tp53 mutations were detected in 49 cases (39.5%) and were associated with high p53 protein levels (p = 0.007) and histopathologic age of the lesions (p = 0.044). Significant association was also seen between high p53 protein levels and atypia (p = 0.036), whereas the association with infiltration showed borderline significance (p = 0.057). High p53 protein levels were significantly associated with gene mutations in transplanted, but not in non-transplanted patients.
CONCLUSION
We show a high frequency of Tp53 mutations in KAs that is associated with increased p53 levels. The results indicate a role for the p53 protein in KA development.
Topics: Adult; Aged; DNA Mutational Analysis; Electrophoresis, Capillary; Female; Humans; Immunohistochemistry; Keratoacanthoma; Male; Middle Aged; Mutation; Skin Neoplasms; Tumor Suppressor Protein p53
PubMed: 27020606
DOI: 10.1111/cup.12713 -
Praxis Apr 2017
Review
Topics: Early Diagnosis; Early Medical Intervention; General Practice; Guideline Adherence; Humans; Interdisciplinary Communication; Intersectoral Collaboration; Neoplasm Staging; Skin Neoplasms
PubMed: 28443706
DOI: 10.1024/1661-8157/a002660 -
Facial Plastic Surgery Clinics of North... Feb 2013The incidence of cutaneous malignant melanoma continues to increase worldwide. It is the deadliest form of skin malignancy. This article focuses on the epidemiology,... (Review)
Review
The incidence of cutaneous malignant melanoma continues to increase worldwide. It is the deadliest form of skin malignancy. This article focuses on the epidemiology, diagnosis, prevention, and new staging criteria of melanoma. The author delves into standards of treatment and highlights new strategies, including but not limited to noninvasive imaging techniques and immunotherapy.
Topics: Humans; Incidence; Melanoma; Neoplasm Staging; Risk Factors; Skin Neoplasms
PubMed: 23369587
DOI: 10.1016/j.fsc.2012.11.007