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Journal of Cutaneous Medicine and... 2011
Topics: Humans; Lymph Node Excision; Melanoma; Mitotic Index; Neoplasm Staging; Sentinel Lymph Node Biopsy; Skin Neoplasms
PubMed: 22469203
DOI: 10.2310/7750.2011.00007 -
Annals of Surgical Oncology Nov 2004
Topics: DNA, Neoplasm; Humans; Lymphatic Metastasis; Melanoma; Neoplasm Staging; Prognosis; Reverse Transcriptase Polymerase Chain Reaction; Sentinel Lymph Node Biopsy; Skin Neoplasms
PubMed: 15525822
DOI: 10.1245/ASO.2004.09.914 -
Revue Medicale Suisse Apr 2020The dermatofibrosarcoma protuberans (DFSP) is the most common form of low-grade cutaneous sarcoma; its infiltrating growth occurs by fingerlike projections, which... (Review)
Review
The dermatofibrosarcoma protuberans (DFSP) is the most common form of low-grade cutaneous sarcoma; its infiltrating growth occurs by fingerlike projections, which explain the high rate of recurrence in case of inappropriate surgical procedure. Based on an extensive review of the existing literature, we propose here to discuss the actual criteria for early recognition, diagnosis and optimal take of care of DFSP.
Topics: Dermatofibrosarcoma; Early Detection of Cancer; Humans; Neoplasm Recurrence, Local; Skin Neoplasms
PubMed: 32239838
DOI: No ID Found -
Archives of Dermatology Jan 1991Ultraviolet exposure of human skin deletes the function of antigen-presenting Langerhans cells normally resident within the epidermis. Langerhans cells are capable of... (Review)
Review
Ultraviolet exposure of human skin deletes the function of antigen-presenting Langerhans cells normally resident within the epidermis. Langerhans cells are capable of activating T-lymphocytes by presenting antigens (such as nickel or tumor antigens) to T-lymphocytes. Such activated T-lymphocytes may be involved in the development of contact dermatitis and the immune surveillance of immunogenic skin cancers. Deletion of the function of Langerhans cells does not result in abrogated epidermal antigen presentation since ultraviolet irradiation simultaneously induces the appearance of another epidermal antigen-presenting cell population that is distinct from the Langerhans cell population and seems to induce suppression of the immune response. Suppression of the immune response following ultraviolet irradiation in murine models is critical for growth of immunogenic ultraviolet-induced skin neoplasm. Thus, ultraviolet irradiation of human skin may facilitate the growth of human neoplasms, and the spreading of skin-associated infections due to induction of suppressor T cells.
Topics: Animals; Antigen-Presenting Cells; Humans; Langerhans Cells; Neoplasms, Radiation-Induced; Skin; Skin Neoplasms; T-Lymphocytes, Regulatory; Ultraviolet Rays
PubMed: 1824747
DOI: No ID Found -
Geriatrics Jul 1985The pigmented acanthotic type of lesion may resemble malignant melanoma. When in doubt, a biopsy will usually resolve the question. Seborrheic keratoses may become...
The pigmented acanthotic type of lesion may resemble malignant melanoma. When in doubt, a biopsy will usually resolve the question. Seborrheic keratoses may become irritated or inflamed after trauma, biopsy, or exposure to irritants, causing transformation of the basaloid cell type to squamous cells. Such changes may be misinterpreted as diagnostic of basal or squamous epithelioma.
Topics: Diagnosis, Differential; Humans; Keratosis; Male; Middle Aged; Skin; Skin Neoplasms
PubMed: 4007500
DOI: No ID Found -
The Pan African Medical Journal 2022Pilomatricoma, formerly known as calcifying epithelioma of Malherbe, is a rare, benign, annexic skin tumor developed from the cells of the pilar matrix. The cure without...
Pilomatricoma, formerly known as calcifying epithelioma of Malherbe, is a rare, benign, annexic skin tumor developed from the cells of the pilar matrix. The cure without recurrence is the rule after complete surgical excision. Clinical diagnosis is challenging. Actually, differential diagnosis include malignant pilomatricoma or trichomatrical carcinoma with significant aggressive potential. However, the diagnosis of pilomatricoma must remain clinical and be confirmed histologically. We report the rare case of a pilomatricoma, in an unusual location in the thigh.
Topics: Humans; Pilomatrixoma; Thigh; Skin Neoplasms; Hair Diseases; Diagnosis, Differential; Carcinoma
PubMed: 36942146
DOI: 10.11604/pamj.2022.43.208.34861 -
Der Hautarzt; Zeitschrift Fur... Jun 2008
Topics: Combined Modality Therapy; Humans; Melanoma; Neoplasm Staging; Skin Neoplasms
PubMed: 18463839
DOI: 10.1007/s00105-008-1578-z -
Veterinary Pathology Sep 2021With increasing numbers of pet rabbits living out their natural lifespan, rabbit oncology is stepping more and more into the limelight. On the other hand, rabbit tumors... (Review)
Review
With increasing numbers of pet rabbits living out their natural lifespan, rabbit oncology is stepping more and more into the limelight. On the other hand, rabbit tumors are less covered in recent editions of textbooks of veterinary pathology than before. We present 1238 cases with neoplastic and non-neoplastic masses in rabbit tissue, submitted from 2008 to 2019, supplemented by a review of the literature on neoplasms in rabbits. Cutaneous masses comprised 47% of submissions. Trichoblastoma was by far the most common skin neoplasm, and nodular suppurative panniculitis was the second most frequent skin nodule in this series. Epithelial as well as mesenchymal cutaneous neoplasms can be virally induced in rabbits (eg, Shope papilloma, myxomatosis) but were infrequent in the current cases. Mammary neoplasms comprised 21% of submitted masses and 94% of these had histologic features of malignancy. Tumors of the female reproductive tract were responsible for 9% of biopsies and were predominantly uterine adenocarcinoma. Polypoid proliferation of rectal mucosa was the most common lesion in the alimentary tract. A broad spectrum of other neoplasms was described, including sarcomas at vaccination sites and ocular posttraumatic sarcomas, comparable to lesions described in cats.
Topics: Adenocarcinoma; Animals; Biopsy; Cat Diseases; Cats; Female; Rabbits; Sarcoma; Skin Neoplasms; Uterine Neoplasms
PubMed: 33874811
DOI: 10.1177/03009858211002190 -
Journal of the American Academy of... Aug 2021Skin cancer is the most common cancer worldwide.
BACKGROUND
Skin cancer is the most common cancer worldwide.
OBJECTIVE
To evaluate the burden of skin cancer in the US from 1990 to 2019.
METHODS
Age-standardized incidence, prevalence, disability-adjusted life years (DALY), and mortality rates from skin cancer in the US were evaluated from the Global Burden of Disease 2019.
RESULTS
Incidence, prevalence, DALY, and mortality rates for melanoma per 100,000 persons in 2019 were 17.0, 138, 64.8, and 2.2, respectively; for squamous cell carcinoma, rates were 262, 314, 26.6, and 0.8, respectively; and for basal cell carcinoma, rates were 525, 51.2, 0.2, and zero, respectively. Incidence and prevalence rates of melanoma and non-melanoma skin cancer (NMSC) have increased since 1990, while mortality rates have remained fairly stable. Males have had higher incidence, prevalence, DALY, and mortality rates from melanoma and NMSC every year since 1990. Incidence and prevalence of melanoma was relatively higher in the northern half of the US than in the southern half.
LIMITATIONS
Global Burden of Disease is derived from estimation and mathematical modeling.
CONCLUSIONS
Health care professionals can utilize differences and trends noted in this study to guide allocation of resources to reduce incidence and morbidity from skin cancer.
Topics: Adult; Aged; Aged, 80 and over; Carcinoma, Basal Cell; Carcinoma, Squamous Cell; Cost of Illness; Disability Evaluation; Female; Humans; Incidence; Male; Melanoma; Middle Aged; Prevalence; Quality-Adjusted Life Years; Skin Neoplasms; Time Factors; United States
PubMed: 33852922
DOI: 10.1016/j.jaad.2021.03.109 -
Open Veterinary Journal Jan 2024Cutaneous neoplastic disorders are often observed in small mammal pets, such as dogs, regardless of their gender.
BACKGROUND
Cutaneous neoplastic disorders are often observed in small mammal pets, such as dogs, regardless of their gender.
AIM
An important objective of this work was to give a full account of the clinical, pathological, and immune-histochemical features of several skin tumors in dogs.
METHODS
This study was a case series in the hospital clinic, Faculty of Veterinary Medicine, Zagazig University, Egypt. Twenty-five dogs (14 males and 11 females) were examined clinically during the period from March 2022 to October 2023. The skin swelling was collected from affected animals and then subjected to a detailed histopathological study to record the different gross and microscopic findings and confirm the diagnosis by immunohistochemistry.
RESULTS
Skin neoplasia in dogs was exposed to various clinical signs, and the dogs' ages ranged between 3 and 11 years. Concerning tumor features, the majority of neoplasms were malignant (65.52%) more than benign (34.48%). The study revealed the presence of 29 cases of dogs showed neoplasia with different prevalence rates including squamous cell carcinoma (13.79%), mast cell tumor (6.89%), basal cell tumors (10.34%), histiocytoma (6.89%), trichoepithelioma (10.34%), transmissible venereal tumor (10.34%), trichilemmoma (3.44%), scalp paraganglioma (3.44%), pilomatricoma (10.34%), malignant melanomas (17.24%), and miscellaneous cases as fat necrosis (6.89%), in males and females dogs with different histopathological lesions and immunohistochemistry expressions for pan-cytokeratin (CK), melanocyte-differentiation antigens (S100 protein), and synaptophysin.
CONCLUSION
Malignant melanomas (17.24%) are the extremely common cutaneous tumors diagnosed in this study. Meanwhile, benign tumors such as trichilemmoma, trichoepithelioma, pilomatricoma, and paraganglioma are less frequent in dogs.
Topics: Humans; Male; Female; Dogs; Animals; Melanoma; Pilomatrixoma; Egypt; Skin Neoplasms; Paraganglioma; Mammals; Dog Diseases
PubMed: 38633166
DOI: 10.5455/OVJ.2024.v14.i1.44