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Otolaryngologic Clinics of North America Oct 1996Malignant tumors involving the structures of the temporal bone represent formidable diagnostic and therapeutic challenges for clinicians involved in the treatment of... (Review)
Review
Malignant tumors involving the structures of the temporal bone represent formidable diagnostic and therapeutic challenges for clinicians involved in the treatment of otologic disease. This article offers a perspective on the current understanding of the biology of malignancies involving the external auditory canal, middle ear space, and temporal bone, and reviews the often confusing and contradictory literature on this topic.
Topics: Adult; Aged; Carcinoma, Squamous Cell; Child, Preschool; Ear Neoplasms; Ear, External; Female; Humans; Male; Middle Aged; Neoplasm Staging; Petrous Bone; Skull Neoplasms; Temporal Bone
PubMed: 8893219
DOI: No ID Found -
Journal of Neurological Surgery. Part... Mar 2024Primary Ewing's sarcoma of the skull is a very rare malignant neoplasm, predominantly occurring in children and adolescents. We describe here the clinical,...
BACKGROUND AND OBJECTIVE
Primary Ewing's sarcoma of the skull is a very rare malignant neoplasm, predominantly occurring in children and adolescents. We describe here the clinical, neuroradiologic, and histopathologic features of a patient with primary Ewing's sarcoma of the skull and discuss the standards of therapy for this type of tumor.
CLINICAL PRESENTATION
This 18-year-old male patient presented with a primary Ewing's sarcoma of the skull, involving the dura of the frontal and parietal lobes of the left cerebral hemisphere. He was treated with gross total surgical excision of tumor, skull reconstruction, chemotherapy, and irradiation. Twelve years after the surgery, the patient has no evidence of local recurrence or distant metastases. Radical surgical excision of the primary tumor with safety margins is thought to play a role in the favorable clinical course.
CONCLUSION
The presented case is the longest surviving patient after treatment of primary Ewing's sarcoma of the skull bone. This rare type of tumor may allow better survival rates under adequate management than sarcoma elsewhere in the body.
Topics: Child; Male; Adolescent; Humans; Sarcoma, Ewing; Skull; Skull Neoplasms; Combined Modality Therapy; Survival Rate
PubMed: 37939826
DOI: 10.1055/s-0043-1776264 -
Cancer Treatment Reviews Dec 2015Temporal bone squamous cell carcinoma (TBSCC) is an uncommon malignancy with a distinctly poor prognosis in advanced cases. There is still much controversy surrounding... (Review)
Review
Temporal bone squamous cell carcinoma (TBSCC) is an uncommon malignancy with a distinctly poor prognosis in advanced cases. There is still much controversy surrounding the rational diagnostic/therapeutic approach to TBSCC. Diagnostic differences are due mainly to: the small number of cases reported (even in the largest available series); the inappropriate histological heterogeneity of several case series; the lack of an internationally-accepted staging system for TBSCC; the frequent absence of adequate radiological imaging to enable a malignancy's local, regional and distant extension to be studied in detail; and a non-standardized approach to final histological assessment of the surgical margins. As for the therapeutic approaches, several issues are still debated, including the choice between en bloc and piecemeal primary surgery for the tumor's removal, and the role of elective neck dissection. Although radiotherapy seems to be an effective adjuvant therapy in advanced cases, its role in low-stage tumors or as a primary treatment has yet to be established. The value of chemotherapy is also still unclear. The treatment strategy for TBSCC is often based on the combined experience of a given surgeon and institution, bearing the results reportedly achieved by other oncology centers in mind. To date, the optimal management of TBSCC is still elusive. We aimed to critically review the ongoing crucial issues concerning the management of TBSCC, analyzing how it is diagnosed, staged and treated, the management of recurrences, rational follow-up schedules, and prognostic factors for this disease.
Topics: Carcinoma, Squamous Cell; Chemotherapy, Adjuvant; Head and Neck Neoplasms; Humans; Neoplasm Recurrence, Local; Neoplasm Staging; Prognosis; Radiotherapy, Adjuvant; Skull Neoplasms; Squamous Cell Carcinoma of Head and Neck; Temporal Bone
PubMed: 26549119
DOI: 10.1016/j.ctrv.2015.10.007 -
Annals of the Royal College of Surgeons... Nov 2021A 62-year old woman presented with a 1-month history of left otalgia, facial palsy and hearing loss. She had a background of non-insulin-dependent diabetes mellitus and...
A 62-year old woman presented with a 1-month history of left otalgia, facial palsy and hearing loss. She had a background of non-insulin-dependent diabetes mellitus and stage 2 endometrial adenocarcinoma, treated 18 months ago. Computed tomography scan showed erosion of the skull base and temporal bone. She was referred to the otolaryngology team with a diagnosis of necrotising otitis externa. On clinical examination, there was an exophytic, necrotic lesion in the ear canal arising from the posterior canal wall. A subsequent magnetic resonance imaging scan showed a lesion located in the left jugular foramen extending into the middle ear, with characteristics consistent with a glomus jugulo-tympanicum. Interestingly, histology of the lesion showed malignant cells with immunohistochemical staining suggestive of an adenocarcinoma. This is the first reported case of metastatic endometrial carcinoma involving the jugular foramen and temporal bone. Although a diagnosis is rare, it is important to consider it when other differential diagnoses are not fitting. Imaging should always be interpreted with caution, correlating to the clinical findings.
Topics: Adenocarcinoma; Endometrial Neoplasms; Female; Humans; Magnetic Resonance Imaging; Middle Aged; Neoplasm Recurrence, Local; Skull Base Neoplasms; Skull Neoplasms; Temporal Bone; Tomography, X-Ray Computed
PubMed: 34448403
DOI: 10.1308/rcsann.2021.0055 -
American Journal of Otolaryngology 2006Giant cell tumor is a bony tumor which primarily occurs in third to fourth decade after skeletal maturation. Usually, this tumor arises in the distal end of long bone... (Review)
Review
Giant cell tumor is a bony tumor which primarily occurs in third to fourth decade after skeletal maturation. Usually, this tumor arises in the distal end of long bone and is quite rare in the head and neck region. We had a elderly female patient with giant cell tumor at lateral skull base of the left temporal bone without classic symptoms. Team approach with neurosurgeon was used to eradicate the tumor. The detail of this case in conjunction with treatment of giant cell tumor was reported while reviewing pertinent papers.
Topics: Biopsy, Needle; Female; Follow-Up Studies; Giant Cell Tumors; Humans; Immunohistochemistry; Magnetic Resonance Imaging; Middle Aged; Neoplasm Staging; Neurosurgical Procedures; Risk Assessment; Skull Base; Skull Neoplasms; Treatment Outcome
PubMed: 16360828
DOI: 10.1016/j.amjoto.2005.05.021 -
Neurosurgical Review Jan 2006The preoperative diagnosis of a jugular foramen tumor may be challenging, since a large variety of unusual lesions may be located in this region. These tumors may be... (Review)
Review
The preoperative diagnosis of a jugular foramen tumor may be challenging, since a large variety of unusual lesions may be located in this region. These tumors may be classified as primary lesions (which are located in the jugular foramen or extend from the jugular foramen into the surrounding structures) and as secondary lesions (that extend from the surrounding structures into the jugular foramen). Primary tumors include glomus jugulare tumors, schwannomas, meningiomas and peripheral primitive neuroectodermal tumors, while secondary tumors comprise chordomas, chondrosarcomas, chondroblastomas, giant-cell tumors, cholesterol granulomas, giant cholesterol cyst, endolymphatic sac tumors, reactive myofibroblastic tumors, temporal bone carcinomas and metastases. Accurate preoperative radiological suspicion is of great value for preoperative patient counseling and has a direct impact on the surgical planning in these cases. The present study describes and discusses the main differentiating imaging features of lesions involving the jugular foramen, whose accurate preoperative radiological evaluation is essential for proper surgical planning.
Topics: Brain Neoplasms; Diagnosis, Differential; Glomus Jugulare Tumor; Humans; Magnetic Resonance Imaging; Neoplasm Invasiveness; Neurosurgical Procedures; Occipital Bone; Skull Base Neoplasms; Skull Neoplasms; Temporal Bone; Tomography, X-Ray Computed
PubMed: 16283211
DOI: 10.1007/s10143-005-0420-7 -
Journal of Neuro-oncology Dec 2013Giant cell tumors (GCTs) are generally benign, locally aggressive lesions mostly located in the metaphysis of long bones. GCTs of the skull are rare and the majority of...
Giant cell tumors (GCTs) are generally benign, locally aggressive lesions mostly located in the metaphysis of long bones. GCTs of the skull are rare and the majority of the cases have been presented as case reports. The authors retrospectively reported 18 patients with GCTs of the skull at a single institution from April 1994 to February 2012 and summarized the clinical, radiological, pathological characteristics and management of the disease. Meanwhile, a systematic review of 94 case reports of GCTs of the skull was performed. Headache and symptoms related to the involvement of intracranial nerves were the most common symptoms. Over 90 % of the tumors originated from sphenoid and temporal bones. On MRI, very low signal on T2-weighted images were found highly indicative of GCTs of the temporal bone. Univariate analysis revealed that extent of tumor resection and post-operative radiation therapy (RT) were prognostic factors significantly influencing the survival of the patients. We concluded that complete tumor resection is the optimal goal in treating this disease and adjuvant RT should be given once tumor residual is inevitable.
Topics: Adolescent; Adult; Combined Modality Therapy; Female; Follow-Up Studies; Giant Cell Tumors; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Neoplasm Recurrence, Local; Neoplasm Staging; Prognosis; Retrospective Studies; Review Literature as Topic; Skull Neoplasms; Survival Rate; Young Adult
PubMed: 24043601
DOI: 10.1007/s11060-013-1242-z -
Pediatric Neurosurgery 1992Three cases of melanotic neuroectodermal tumors of infancy are presented. Two were localized on the midline, involving the skull and extending subdurally. One was... (Review)
Review
Three cases of melanotic neuroectodermal tumors of infancy are presented. Two were localized on the midline, involving the skull and extending subdurally. One was located on the inner aspect of the dura and developed intracranially. Two had a benign course following gross total removal. One had a malignant course, recurring locally and spreading within the brain. The difficulties of removing these tumors when they are implanted on the midline are stressed. Histological features of prognostic value are pointed out. Further support for neural crest origin of these tumors is given.
Topics: Child, Preschool; Craniotomy; Female; Follow-Up Studies; Frontal Bone; Humans; Infant; Meningeal Neoplasms; Meninges; Microscopy, Electron; Neoplasm Recurrence, Local; Neoplasm Seeding; Neoplasms, Germ Cell and Embryonal; Parietal Bone; Reoperation; Skull Neoplasms; Tomography, X-Ray Computed
PubMed: 1329922
DOI: 10.1159/000120636 -
Journal of Neuro-oncology 2004We report a rare case of skull metastasis from ampulla of Vater adenocarcinoma in a patient with controlled primary neoplasm. This 65-year-old Korean man presented with...
We report a rare case of skull metastasis from ampulla of Vater adenocarcinoma in a patient with controlled primary neoplasm. This 65-year-old Korean man presented with headache and painful parietal scalp swelling, but he did not show any neurological deficits. Computed tomography revealed an osteolytic mass that invaded and expanded through the skull tables in full-thickness. On magnetic resonance images following Gadolinium injection, the mass appeared slightly hypointense signal on all sequences and intense heterogeneous enhancement. He underwent surgical excision with artificial grafting of calvaria and dura. Postoperative radiation therapy was ensued for metastatic adenocarcinoma, and he was well for the follow-up period of 3 months. To the best of our knowledge, this is the first such case that involved the skull.
Topics: Adenocarcinoma; Aged; Ampulla of Vater; Common Bile Duct Neoplasms; Humans; Magnetic Resonance Imaging; Male; Skull Neoplasms; Tomography, X-Ray Computed
PubMed: 15072455
DOI: 10.1023/b:neon.0000021775.60688.2d -
Current Problems in Cancer 2018Plexiform neurofibroma (PNF) is a rare variant of neurofibromatosis type1 (NF-1), which histopathologically, is a subtype of benign nerve sheath tumors, neurofibromas...
Plexiform neurofibroma (PNF) is a rare variant of neurofibromatosis type1 (NF-1), which histopathologically, is a subtype of benign nerve sheath tumors, neurofibromas (NF). It develops as a result of proliferation in all parts of peripheral nervous system and can cause the functional damage, deformities, pain, considerable mortality, and morbidity and even the increasing risk of malignant transformation in some critical cases. Currently, the surgical intervention is the treatment of choice for PNF patients, which due to the tumor invasion, massive growth, and the chance of postoperative regrowth is not possible. The diagnosis of isolated tumor is an uncommon event. Considering the rarity of this neoplasm, herein, we describe a case of isolated PNF, so the purpose of this presenting is the rarity of recording. We describe a case of isolated plexiform neurofibroma presented with 7-year history of a slowly growing postauricular soft subcutaneous mass in a 14-year-old boy, which caused the right auricular deformity. After initial evaluation by imaging studies, the patient underwent to surgical resection of the mass and the diagnosis of plexiform neurofibroma was confirmed by histopathologic examination. Surgical excision of the mass had been done before which concluded the satisfactory result and based on oncologist diagnosis, further intervention such as radiotherapy or chemotherapy was not needed. The patient left the hospital with a clinical stability and was suggested to continue the regular follow-up. In conclusion, considering neurofibroma (NF) as differential diagnosis for subcutaneous masses in head and neck area is critical for early diagnosis and treatment procedure.
Topics: Adolescent; Diagnosis, Differential; Humans; Male; Neurofibroma, Plexiform; Skull Neoplasms
PubMed: 29449010
DOI: 10.1016/j.currproblcancer.2018.01.007