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Archivio "E. Maragliano" Di Patologia E... Feb 1956
Topics: Animals; Growth Hormone; Human Growth Hormone; Immunity; Lagomorpha; Rabbits; Typhoid Fever
PubMed: 13328348
DOI: No ID Found -
Polski Tygodnik Lekarski May 1959
Topics: Growth Hormone; Human Growth Hormone; Surgical Procedures, Operative
PubMed: 13674978
DOI: No ID Found -
Clinical Interventions in Aging 2008Although advanced age or symptoms of aging are not among approved indications for growth hormone (GH) therapy, recombinant human GH (rhGH) and various GH-related... (Review)
Review
Although advanced age or symptoms of aging are not among approved indications for growth hormone (GH) therapy, recombinant human GH (rhGH) and various GH-related products are aggressively promoted as anti-aging therapies. Well-controlled studies of the effects of rhGH treatment in endocrinologically normal elderly subjects report some improvements in body composition and a number of undesirable side effects in sharp contrast to major benefits of GH therapy in patients with GH deficiency. Controversies surrounding the potential utility of GH in treatment of a geriatric patient are fueled by increasing evidence linking GH and cancer and by remarkably increased lifespan of GH-resistant and GH-deficient mice. Conservation of cellular signaling mechanisms that influence aging in organisms ranging from worms to mammals suggests that at least some of the results obtained in mutant mice are applicable to the human. We suggest that the normal, physiological functions of GH in promoting growth, sexual maturation and fecundity involve significant costs in terms of aging and life expectancy. Natural decline in GH levels during aging likely contributes to concomitant alterations in body composition and vigor but also may be offering important protection from cancer and other age-associated diseases.
Topics: Age Factors; Aging; Animals; Growth Hormone; Human Growth Hormone; Humans
PubMed: 19281058
DOI: 10.2147/cia.s3697 -
Archivio Per Le Scienze Mediche Dec 1954
Topics: Growth Hormone; Human Growth Hormone; Humans; Tuberculosis
PubMed: 13249778
DOI: No ID Found -
Growth Hormone & IGF Research :... Aug 2009
Topics: Athletes; Athletic Performance; Doping in Sports; Human Growth Hormone; Humans; Substance Abuse Detection
PubMed: 19535276
DOI: 10.1016/j.ghir.2009.04.002 -
Science of Aging Knowledge Environment... Jul 2004
Topics: Aged; Animals; Growth Hormone; Human Growth Hormone; Humans; Mice
PubMed: 15282369
DOI: 10.1126/sageke.2004.30.ns5 -
Minnesota Medicine Apr 1956
Topics: Growth Hormone; Human Growth Hormone; Humans; Minnesota
PubMed: 13309143
DOI: No ID Found -
Bailliere's Best Practice & Research.... Oct 1999Knowledge of the interaction between growth hormone (GH) and the growth hormone receptor (GHR) has led to the rational design of a GHR antagonist. An analogue of GH able... (Review)
Review
Knowledge of the interaction between growth hormone (GH) and the growth hormone receptor (GHR) has led to the rational design of a GHR antagonist. An analogue of GH able to block the action of GH at the cellular level offers greater specificity of effect compared with current medical therapies and is not dependent on tumour characteristics. This chapter reviews the interaction between GH and the GHR, and discusses the outstanding issues regarding GHR antagonist therapy in acromegaly.
Topics: Acromegaly; Animals; Dimerization; Drug Design; Human Growth Hormone; Humans; Receptors, Somatotropin; Signal Transduction
PubMed: 10909433
DOI: 10.1053/beem.1999.0032 -
Hospital Practice (1995) Jan 1997Adults with hypopituitarism and documented growth hormone deficiency are now eligible for replacement therapy. What are the guidelines for diagnosis and treatment? More... (Review)
Review
Adults with hypopituitarism and documented growth hormone deficiency are now eligible for replacement therapy. What are the guidelines for diagnosis and treatment? More broadly, what are the implications for other adults with hyposomatotropism-namely, the elderly? And is there a therapeutic role for the hormone in patients with disease states such as osteoporosis, heart failure, and acute catabolic illness?
Topics: Adult; Aging; Cardiomyopathies; Female; Growth Disorders; Human Growth Hormone; Humans; Insulin-Like Growth Factor I; Male; Osteoporosis
PubMed: 9006584
DOI: 10.1080/21548331.1997.11443405 -
Journal of Pediatric Endocrinology &... Dec 2002Estimates of the frequency of growth hormone deficiency (GHD) range from 1:4,000 to 1:10,000. Most cases are sporadic and presumed to be secondary to one of a wide... (Review)
Review
Estimates of the frequency of growth hormone deficiency (GHD) range from 1:4,000 to 1:10,000. Most cases are sporadic and presumed to be secondary to one of a wide variety of causes. However, in families with consanguinity, or when a second case occurs in the same family, a genetic cause may be suspected. Four distinct familial types of isolated GHD (IGHD) have been well differentiated on the basis of inheritance, hormonal deficiencies, and molecular analyses. Two forms are inherited autosomal recessively (IGHD type IA and IB); one is inherited autosomal dominantly (IGHD type II); and one is inherited in an X-linked manner. This review focuses on the secretory pathway of GH and the possible mechanisms causing IGHD type II. In IGHD type II, the apparently same phenotype results from several distinct GH-1 gene alterations leading to different blockades within the secretory pathway. This type of IGHD, in addition to some other specific GH-1 gene mutations, provides the most important opportunity for shedding light on cellular biological mechanisms beyond its description at the DNA/RNA level.
Topics: Human Growth Hormone; Humans; Mutation; Protein Folding
PubMed: 12510984
DOI: No ID Found