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British Medical Journal Apr 1950
Topics: Carcinoma; Neoplasms; Peptic Ulcer; Stomach
PubMed: 15414332
DOI: 10.1136/bmj.1.4660.973 -
International Journal of Molecular... Dec 2018Gastric cancer has reduced prevalence, but poor prognoses. To improve treatment, better knowledge of carcinogenesis and cells of origin should be sought. Stomach cancers... (Review)
Review
Gastric cancer has reduced prevalence, but poor prognoses. To improve treatment, better knowledge of carcinogenesis and cells of origin should be sought. Stomach cancers are typically localized to one of the three mucosae; cardial, oxyntic and antral. Moreover, not only the stem cell, but the ECL cell may proliferate and give rise to tumours. According to Laurén, the classification of gastric carcinomas seems to reflect biological important differences and possible different cell of origin since the two subtypes, intestinal and diffuse, do not transform into the other and show different epidemiology. The stem cell probably gives rise to the intestinal type, whereas the ECL cell may be important in the diffuse type. Elevation of gastrin may be the carcinogenic factor for as well as the recently described increased risk of gastric cancer due to proton pump inhibitor treatment. Therefore, it is essential to determine the role of the gastrin target cell, the ECL cell, in gastric carcinogenesis. Clinical trials with gastrin antagonists could improve prognoses in those with gastrin receptor positive tumours. However, further studies on gastric carcinomas applying relative available methods and with the highest sensitivity are warranted to improve our knowledge of gastric carcinogenesis.
Topics: Carcinogenesis; Carcinoma; Cell Proliferation; Gastric Mucosa; Gastrins; Helicobacter Infections; Helicobacter pylori; Humans; Stomach Neoplasms
PubMed: 30567376
DOI: 10.3390/ijms19124109 -
Diagnostic Pathology Feb 2021The majority of gastrointestinal tumors are adenocarcinomas. Rarely, there are other types of tumors, such as acinar cell carcinoma, and these are often called... (Review)
Review
BACKGROUND
The majority of gastrointestinal tumors are adenocarcinomas. Rarely, there are other types of tumors, such as acinar cell carcinoma, and these are often called pancreatic-type acinar cell carcinomas. Among these tumors, some are differentiated into neuroendocrine components. A few of them are MiNENs.
CASE PRESENTATION
The patient was an 80-year-old male who was referred to our hospital for treatment of a pedunculated gastric tumor. It was 5 cm in diameter and detected in the upper gastric body with upper GI endoscopy conducted to investigate anemia. In the biopsy, although hyperplasia of gastric gland cells was noted, no tumor cells were found. Retrospectively, the diagnosis was misdiagnosed. An operation was arranged because bleeding from the tumor was suspected as a cause of anemia and because surgical resection was considered to be desirable for accurate diagnosis. Hence, laparoscopic and endoscopic cooperative surgery was performed. In the pathological examination, several types of epithelial cells that proliferated in the area between the mucosa and deep inside the submucosa were observed. These consisted of acinar-glandular/trabecular patterns and solid. A diagnosis of pancreatic-type acinar cell carcinoma of the stomach with NET G2 and G3 was made based on characteristic cellular findings and the results of immunostaining tests. Each of them consisted of more than 30% of the lesion; a diagnosis of pancreatic-type mixed acinar neuroendocrine carcinoma (pancreatic-type MiNEN) of the stomach or a type of gastric MiNEN was obtained. Anemia was resolved after the operation, and the patient was discharged from the hospital without perioperative complications.
CONCLUSIONS
Pancreatic-type ACC of the stomach that is differentiated into neuroendocrine tumors is very rare. Hence, we report this case along with a literature review.
Topics: Aged, 80 and over; Biopsy; Carcinoma, Acinar Cell; Carcinoma, Neuroendocrine; Cell Differentiation; Diagnostic Errors; Endoscopy, Digestive System; Humans; Laparoscopy; Male; Neuroendocrine Tumors; Pancreas; Pancreatic Neoplasms; Stomach; Stomach Neoplasms
PubMed: 33531019
DOI: 10.1186/s13000-021-01070-x -
Zhonghua Bing Li Xue Za Zhi = Chinese... Nov 2021
Topics: Biomarkers, Tumor; Carcinoma; Humans; Stomach; Stomach Neoplasms
PubMed: 34719168
DOI: 10.3760/cma.j.cn112151-20210415-00294 -
Zhonghua Bing Li Xue Za Zhi = Chinese... Oct 2022
Topics: Carcinoma; Humans; Stomach; Stomach Neoplasms
PubMed: 36207928
DOI: 10.3760/cma.j.cn112151-20220315-00183 -
British Medical Journal Jul 1950
Topics: Carcinoma; Humans; Stomach
PubMed: 15434370
DOI: 10.1136/bmj.2.4673.262 -
Diagnostic Pathology Nov 2013A lymphoepithelioma-like carcinoma (LLC), characterized by a carcinoma with stromal heavy lymphocyte infiltration, is one of the histological patterns observed in... (Review)
Review
UNLABELLED
A lymphoepithelioma-like carcinoma (LLC), characterized by a carcinoma with stromal heavy lymphocyte infiltration, is one of the histological patterns observed in patients with Epstein-Barr virus (EBV)-associated gastric carcinoma. Although this entity is hard to be recognized in the biopsy specimens, pathologists and clinicians should acknowledge this subset of gastric cancer because it generally has a better prognosis than other forms of EBV-associated gastric carcinomas and conventional gastric carcinomas. This might be due to the fact that the patient's inflammatory response may prevent the spread of tumor through the gastric wall and to the lymph nodes or remote organs.We report a case of EBV-positive, microsatellite stable LLC as a rare morphologic variant of gastric carcinoma.
VIRTUAL SLIDES
The virtual slides for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/1360498724104351.
Topics: Aged; Biopsy; Carcinoma; Epstein-Barr Virus Infections; Herpesvirus 4, Human; Humans; Male; Microsatellite Repeats; Prognosis; Stomach; Stomach Neoplasms
PubMed: 24188515
DOI: 10.1186/1746-1596-8-184 -
Digestive Diseases and Sciences Apr 1990Small cell carcinoma of the stomach is an unusual and rare neoplasm with only eight reported cases in the world literature. Like small cell carcinomas elsewhere, they... (Review)
Review
Small cell carcinoma of the stomach is an unusual and rare neoplasm with only eight reported cases in the world literature. Like small cell carcinomas elsewhere, they possess rapid growth ability and high propensity to metastasize with short survival. Clinically, small cell carcinoma is indistinguishable from adenocarcinoma. Because of the rarity of gastric small cell carcinoma, there is minimal information available on the optimal treatment. Herein, we report on a patient with metastatic pure small cell carcinoma of the stomach. He underwent palliative surgery and postoperative combination chemotherapy with transient partial response. He died 10 months after diagnosis with progressive widespread disease.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Small Cell; Combined Modality Therapy; Gastrectomy; Humans; Lymphatic Metastasis; Male; Postoperative Care; Stomach; Stomach Neoplasms; Tomography, X-Ray Computed
PubMed: 2156662
DOI: 10.1007/BF01536928 -
The Journal of International Medical... Apr 2024Ovarian cancer is a common tumor among women. It is often asymptomatic in the early stages, with most cases already at stage III to IVE at the time of diagnosis. Direct... (Review)
Review
Ovarian cancer is a common tumor among women. It is often asymptomatic in the early stages, with most cases already at stage III to IVE at the time of diagnosis. Direct spread and lymphatic metastasis are the primary modes of metastasis, whereas hematogenous spread is rare. An initial diagnosis of ovarian cancer that has metastasized to the stomach is also uncommon. Therefore, clear treatment methods and prognostic data for such metastasis are lacking. In our hospital, we encountered a patient with an initial imaging diagnosis of a gastric tumor and a history of an ovarian tumor with endoscopic abdominal metastasis. Based on the characteristics of the case, the two tumors were considered to be the same. After chemotherapy, a partial response was observed in the stomach and pelvic lesions, suggesting the effectiveness of the treatment. Through three treatments of recurrence, gastroscopy confirmed the stomach to be a metastatic site. Therefore, determining the primary source of advanced tumors is crucial in guiding treatment decisions. Clinicians must approach this comprehensively, relying on thorough evaluation and personal experience.
Topics: Female; Humans; Carcinoma, Ovarian Epithelial; Cystadenocarcinoma, Serous; Ovarian Neoplasms; Prognosis; Stomach Neoplasms; Stomach
PubMed: 38635893
DOI: 10.1177/03000605241245000 -
Canadian Medical Association Journal Dec 1950
Topics: Carcinoma; Humans; Lip; Stomach; Tongue
PubMed: 14792444
DOI: No ID Found