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Chemosphere Nov 2022Seeking effective methods to degrade organic pollutants has always been a hot research field. In this work, MoS/FeO catalyst was synthesized by hydrothermal method with...
Seeking effective methods to degrade organic pollutants has always been a hot research field. In this work, MoS/FeO catalyst was synthesized by hydrothermal method with MoS as carrier to construct an advanced oxidation system of electrochemical enhanced MoS/FeO-activated peroxymonosulfate (E/MoS/FeO/PMS). The materials were characterized by X-ray diffraction, transmission electron microscopy and X-ray photoelectron spectroscopy. The degradation efficiency of sulfamerazine (SM1) by E/MoS/FeO/PMS system was investigated and reaction mechanism was explored. The results showed that the removal rates of SM1 within 30 min were 31%, 20% and 89% with FeO, MoS and MoS/FeO as catalysts, respectively. The characterization results revealed that Fe(III) on the surface of FeO was reduced to Fe(II) and Mo(IV) was oxidized to Mo(VI) in the presence of MoS. The synergistic effect between FeO and MoS enhanced the PMS decomposition and improved the SM1 removal efficiency. Free radical quenching experiments showed that SO⋅, ·OH, O· and O were all involved in the degradation of SM1, and the effect of O was more significant than other active substances. Low concentrations of Cl and humic acid (HA) had no significant inhibitory effect on the degradation of SM1, while HCO had a significant inhibitory effect on the E/MoS/FeO/PMS system. In addition, catalyst cycling experiments showed that MoS/FeO maintained good stability before and after the catalytic reaction process.
Topics: Environmental Pollutants; Ferric Compounds; Ferrous Compounds; Free Radicals; Humic Substances; Molybdenum; Peroxides; Sulfamerazine
PubMed: 36030935
DOI: 10.1016/j.chemosphere.2022.136198 -
Heliyon Apr 2019Cobalt (Co(II)) and copper (Cu(II)) complexes of sulfamerazine-salicylaldehyde (SS) ligand intercalated Mg/Al-layered double hydroxide [Co-SS-LDH/Cu-SS-LDH] were...
Cobalt (Co(II)) and copper (Cu(II)) complexes of sulfamerazine-salicylaldehyde (SS) ligand intercalated Mg/Al-layered double hydroxide [Co-SS-LDH/Cu-SS-LDH] were prepared for the antimicrobial application. Sulfamerazine and salicylaldehyde were mixed together and dissolved in methanol for the synthesis of SS ligand and modified further by the complexation with Co(II) and Cu(II) metal ions [Co-SS/Cu-SS]. The delaminating/restacking method was used to intercalate the Mg/Al-NO-LDH with the metal complexed ligands (Co-SS/Cu-SS). The obtained materials were analyzed using different characterization techniques to prove their successful synthesis and preparation. The antibacterial activity of the synthesized Co-SS-LDH/Cu-SS-LDH were checked by the inhibition zone method. The prepared hybrid materials showed good antimicrobial activity against both gram negative () and gram positive () bacteria.
PubMed: 31049432
DOI: 10.1016/j.heliyon.2019.e01521 -
Biomolecules Apr 2024This scientific study employs the Taylor dispersion technique for diffusion measurements to investigate the interaction between sulfamerazine (NaSMR) and macromolecular...
This scientific study employs the Taylor dispersion technique for diffusion measurements to investigate the interaction between sulfamerazine (NaSMR) and macromolecular cyclodextrins (-CD and HP--CD). The results reveal that the presence of -CD influences the diffusion of the solution component, NaSMR, indicating a counterflow of this drug due to solute interaction. However, diffusion data indicate no inclusion of NaSMR within the sterically hindered HP--CD cavity. Additionally, toxicity tests were conducted, including pollen germination () and growth curve assays in BY-2 cells. The pollen germination tests demonstrate a reduction in sulfamerazine toxicity, suggesting potential applications for this antimicrobial agent with diminished adverse effects. This comprehensive investigation contributes to a deeper understanding of sulfamerazine-cyclodextrin interactions and their implications for pharmaceutical and biological systems.
Topics: Sulfamerazine; Diffusion; Cyclodextrins; Toxicity Tests; beta-Cyclodextrins; 2-Hydroxypropyl-beta-cyclodextrin
PubMed: 38672478
DOI: 10.3390/biom14040462 -
Chemosphere Oct 2021Most metal-organic frameworks (MOFs) are synthesized from carboxylate and metal precursors by hydrothermal process, which will consume a large amount of solvent and...
Most metal-organic frameworks (MOFs) are synthesized from carboxylate and metal precursors by hydrothermal process, which will consume a large amount of solvent and carboxylate. To address this issue, a new strategy for Cu-based MOFs was developed, in which the Cu-based MOFs was obtained by using abundant natural polymer (tannic acid) as one of the precursors and using high-energy ball milling to achieve a self-assembly of tannic acid and copper sulfate. Based on this strategy, a novel Cu-based MOFs derivative (CuO@C composite) was synthesized by high-temperature sintering of Cu-based MOFs and used for sulfamerazine (SMR) removal via O activation. The BET specific surface area and average pore size of CuO@C composite were 110.34 m g and 21.06 nm, respectively, which made CuO@C composite had the maximum adsorption capacity (Q) for SMR of 104.65 mg g and favored the subsequent degradation of SMR. The results from XRD and XPS indicated that CuO@C composite contained a lot of Cu and CuO with the sizes of 76.6 nm and 9.8 nm, respectively, which led to its high performance of O activation. The removal efficiency of SMR and 90.2% TOC achieved 100% and 90.2%, respectively in the CuO@C/air system at initial pH of 4.0, air flow rate of 100 mL min, CuO@C dosage of 1 g L and reaction time of 30 min. Reactive species, including HO, OH and O radicals were detected in the CuO@C/air system, and OH and O were mainly responsible for the degradation of SMR.
Topics: Adsorption; Hydrogen Peroxide; Metal-Organic Frameworks; Sulfamerazine
PubMed: 33971422
DOI: 10.1016/j.chemosphere.2021.130678 -
Analytica Chimica Acta Aug 2022A novel strategy utilizing the quartz crystal microbalance (QCM) was developed for the in situ discrimination of polymorphic nucleation (form-I and form-II) and phase...
A novel strategy utilizing the quartz crystal microbalance (QCM) was developed for the in situ discrimination of polymorphic nucleation (form-I and form-II) and phase transformation of sulfamerazine (SMZ) in cooling crystallization. According to Ostwald's rule of stages, metastable form-I of SMZ is first nucleated and then shifted to stable form-II by solution-mediated phase transformation. Through surface modification with the self-assembled monolayer technique of a functional group, QCM distinctively detects the formation of the two polymorphs. The results indicated that -NH (among the several functional groups tested) selectively accommodated stable form-II on the QCM sensor's surface and completely prevented the adsorption of metastable form-I on the surface. Therefore, the-NH-terminated QCM detected the formation of form-I only using the solution viscosity variation on the surface. However, it monitored the nucleation and growth of form-II via the solid mass change on the surface during the phase transformation of form-I to form-II. This strategy suggests a new and precise solution for in situ discrimination of SMZ polymorphs and their phase transformation.
Topics: Crystallization; Quartz; Quartz Crystal Microbalance Techniques; Sulfamerazine
PubMed: 35934408
DOI: 10.1016/j.aca.2022.340137 -
Journal of Pharmaceutical Sciences Apr 2002A bulk powder of sulfamerazine polymorph II in a narrow distribution of particle size was prepared for the first time. The two known sulfamerazine polymorphs, I and II,...
A bulk powder of sulfamerazine polymorph II in a narrow distribution of particle size was prepared for the first time. The two known sulfamerazine polymorphs, I and II, were physically characterized by optical microscopy, powder X-ray diffractometry, differential scanning calorimetry, carbon-13 solid-state nuclear magnetic resonance spectroscopy, and measurements of aqueous solubility and density. The thermodynamics and kinetics of the transition between the polymorphs was examined under various pharmaceutically relevant conditions, such as heating, cooling, milling, compaction, and contact with solvents. The two polymorphs were found to be enantiotropes with slow kinetics of interconversion. The thermodynamic transition temperature lies between 51 and 54 degrees C, with polymorph II stable at lower temperatures. Ostwald's Rule of Stages explains the crystallization of the polymorphs from various solvents and may account for the delay in the discovery of polymorph II.
Topics: Anti-Infective Agents; Calorimetry, Differential Scanning; Crystallization; Drug Stability; Powders; Solubility; Sulfamerazine; Temperature; Thermogravimetry; X-Ray Diffraction
PubMed: 11948548
DOI: 10.1002/jps.10100 -
Journal of Environmental Management Jan 2019Understanding the dynamics of veterinary antibiotic and related antibiotic resistance genes (ARGs) during swine manure composting is crucial in assessing the...
Understanding the dynamics of veterinary antibiotic and related antibiotic resistance genes (ARGs) during swine manure composting is crucial in assessing the environmental risk of antibiotics, which could effectively reduce their impact in natural environments. This study investigated the dissipation of oxytetracycline (OTC), sulfamerazine (SM1) and ciprofloxacin (CIP) as well as the behaviour of their corresponding ARGs during swine manure composting. These antibiotics were added at two concentration levels and two different methods of addition (single/mixture). The results indicated that the removal efficiency of antibiotics by composting were ≥85%, except for the single-SM1 treatment. The tetracycline resistance genes (TRGs) encoding ribosomal protection proteins (RPP) and efflux pump (EFP) and fluoroquinolone resistance genes (FRGs) could be effectively removed after 42 days. On the contrary, the TRGs encoding enzymatic inactivation (EI) and sulfonamide resistance genes (SRGs) were enriched up to 31-fold (sul 2 in single-low-SM1). Statistical analyses indicated that the behaviour of these class antibiotics and ARGs were controlled by microbial activity and significantly influenced by environmental factors (mainly C/N, moisture and pH) throughout the composting process.
Topics: Animals; Anti-Bacterial Agents; Ciprofloxacin; Composting; Drug Resistance, Microbial; Manure; Oxytetracycline; Sulfamerazine; Swine
PubMed: 30278273
DOI: 10.1016/j.jenvman.2018.09.074 -
Environmental Research Sep 2022Heteroatom-doped carbon materials can effectively activate HO into •OH during the metal-free electro-Fenton (EF) process. However, information on bifunctional...
Heteroatom-doped carbon materials can effectively activate HO into •OH during the metal-free electro-Fenton (EF) process. However, information on bifunctional catalysts for the simultaneous generation and activation of HO is scarce. In this study, O- and F-doped porous carbon cathode materials (PPCs) were prepared by the direct carbonization of polyvinylidene fluoride (PVDF) for sulfamerazine (SMR) removal in a metal-free EF process. The porous structure and chemical composition of the PPCs were regulated by the carbonization temperature. PPC-6 (carbonized at 600 °C) exhibited optimal electrocatalytic performance in terms of electrochemical HO generation and activation owing to its high specific surface area, mesoporous structure, and optimum fractions of doped O and F. Excellent performance of the 2e oxygen reduction reaction was found with an HO selectivity of 93.5% and an average electron transfer number of 2.13. An HO accumulative concentration of 103.9 mg/L and an SMR removal efficiency of 90.1% were achieved during the metal-free EF process. PPC-6 was able to stably remove SMR over five consecutive cycles, retaining 92.6% of its original performance. Quantitative structure-activity relationship analysis revealed that doped oxygen functional groups contributed substantially to HO generation, and semi-ionic C-F bonds with high electronegativity were the cause of the activation of HO to •OH. These findings suggest that the PVDF-derived carbonaceous catalysts are feasible and desirable for metal-free EF processes.
Topics: Carbon; Fluorocarbon Polymers; Hydrogen Peroxide; Metals; Oxidation-Reduction; Oxygen; Polyvinyls; Porosity; Sulfamerazine; Water Pollutants, Chemical
PubMed: 35613635
DOI: 10.1016/j.envres.2022.113508 -
The Science of the Total Environment Aug 2023Sulfamerazine (SM) is a commonly used antibiotic and have been widely used to control various bacterial infectious diseases. The structural composition of colored...
Sulfamerazine (SM) is a commonly used antibiotic and have been widely used to control various bacterial infectious diseases. The structural composition of colored dissolved organic matter (CDOM) is known to be a major factor that influences the indirect photodegradation of SM, yet the influence mechanism remains unknown. In order to understand this mechanism, CDOM from different sources was fractionated using ultrafiltration and XAD resin, and characterized using UV-vis absorption and fluorescence spectroscopy. The indirect photodegradation of SM in these CDOM fractions was then investigated. Humic acid (JKHA) and Suwannee River natural organic matter (SRNOM) were used in this study. The results showed that CDOM could be divided into four components (three humic-like components and one protein-like component), and terrestrial humic-like components C1 and C2 were found to be the main components that promote SM indirect photodegradation due to their high aromaticity. The indirect photodegradation of SM was much faster in low molecular weight (MW) solutions, whose structures were dominated by greater aromaticity and terrestrial fluorophores in JKHA and higher terrestrial fluorophores in SRNOM. The HIA and HIB fractions of SRNOM contained large aromaticity and high fluorescence intensities of C1 and C2, resulting in a greater indirect photodegradation rate of SM. The HOA and HIB fractions of JKHA had abundant terrestrial humic-like components and contributed more to SM indirect photodegradation.
Topics: Sulfamerazine; Dissolved Organic Matter; Organic Chemicals; Photolysis; Anti-Bacterial Agents; Rivers; Spectrometry, Fluorescence; China
PubMed: 37201832
DOI: 10.1016/j.scitotenv.2023.164231 -
Molecular Pharmaceutics Oct 2015Understanding the polymorphism exhibited by organic active-pharmaceutical ingredients (APIs), in particular the relationships between crystal structure and the...
Understanding the polymorphism exhibited by organic active-pharmaceutical ingredients (APIs), in particular the relationships between crystal structure and the thermodynamics of polymorph stability, is vital for the production of more stable drugs and better therapeutics, and for the economics of the pharmaceutical industry in general. In this article, we report a detailed study of the structure-property relationships among the polymorphs of the model API, Sulfamerazine. Detailed experimental characterization using synchrotron radiation is complemented by computational modeling of the lattice dynamics and mechanical properties, in order to study the origin of differences in millability and to investigate the thermodynamics of the phase equilibria. Good agreement is observed between the simulated phonon spectra and mid-infrared and Raman spectra. The presence of slip planes, which are found to give rise to low-frequency lattice vibrations, explains the higher millability of Form I compared to Form II. Energy/volume curves for the three polymorphs, together with the temperature dependence of the thermodynamic free energy computed from the phonon frequencies, explains why Form II converts to Form I at high temperature, whereas Form III is a rare polymorph that is difficult to isolate. The combined experimental and theoretical approach employed here should be generally applicable to the study of other systems that exhibit polymorphism.
Topics: Crystallization; Crystallography, X-Ray; Molecular Structure; Sulfamerazine; Synchrotrons; Thermodynamics
PubMed: 26317333
DOI: 10.1021/acs.molpharmaceut.5b00504