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Acta Crystallographica. Section C,... Apr 2008The delta polymorph of sulfanilamide (or 4-aminobenzenesulfonamide), C(6)H(8)N(2)O(2)S, displays an overall three-dimensional hydrogen-bonded network that is dominated...
The delta polymorph of sulfanilamide (or 4-aminobenzenesulfonamide), C(6)H(8)N(2)O(2)S, displays an overall three-dimensional hydrogen-bonded network that is dominated by a two-dimensional substructure with R(2)(2)(8) rings; these result from dimeric N-H...O interactions between adjacent sulfonamide groups. This study shows how the polymorphism of sulfanilamide is linked to its versatile hydrogen-bonding capabilities.
Topics: Crystallization; Crystallography, X-Ray; Hydrogen Bonding; Molecular Structure; Sulfanilamide; Sulfanilamides
PubMed: 18391389
DOI: 10.1107/S0108270108005696 -
Naunyn-Schmiedebergs Archiv Fur... 1949
Topics: Sulfanilamide; Sulfanilamides; Sulfonamides
PubMed: 15405368
DOI: 10.1007/BF00244666 -
ACS Applied Bio Materials May 2024Carbon dots (CDs) were synthesized hydrothermally by mixing citric acid (CA) and an antifolic agent, sulfanilamide (SNM), employed for pH sensing and bacterial growth...
Carbon dots (CDs) were synthesized hydrothermally by mixing citric acid (CA) and an antifolic agent, sulfanilamide (SNM), employed for pH sensing and bacterial growth inactivation. Sulfanilamide is a prodrug; aromatic hetero cyclization of the amine moiety along with other chemical modifications produces an active pharmacological compound (chloromycetin and miconazole), mostly administered for the treatment of various microbial infections. On the other hand, the efficacy of the sulfanilamide molecule as a drug for antimicrobial activity was very low. We anticipated that the binding of the sulfanilamide molecule on the carbon dot (CD) surface may form antibacterial CDs. Citric acid was hybridized with sulfanilamide during the hydrothermal preparation of the CDs. The molecular fragments of bioactivated sulfanilamide molecule play a crucial role in bacterial growth inactivation for Gram-positive and Gram-negative bacteria. The functional groups of citric acid and sulfanilamide were conserved during the CD formation, facilitating the zwitterionic behavior of CDs associated with its photophysical activity. At low concentrations of CDs, the antibacterial activity was apparent for Gram-positive bacteria only. This Gram-positive bacteria selectivity was also rationalized by zeta potential measurement.
Topics: Carbon; Anti-Bacterial Agents; Hydrogen-Ion Concentration; Sulfanilamide; Microbial Sensitivity Tests; Particle Size; Biocompatible Materials; Materials Testing; Quantum Dots; Sulfanilamides; Gram-Positive Bacteria; Gram-Negative Bacteria
PubMed: 38662509
DOI: 10.1021/acsabm.3c01130 -
Northwest Medicine Dec 1946
Topics: Sulfanilamide; Sulfanilamides; Sulfonamides
PubMed: 20276624
DOI: No ID Found -
The Indian Medical Gazette Mar 1947
Topics: Sulfanilamide; Sulfanilamides; Sulfonamides
PubMed: 20343545
DOI: No ID Found -
The Indian Medical Gazette Feb 1947
Topics: Sulfanilamide; Sulfanilamides; Sulfonamides
PubMed: 20242781
DOI: No ID Found -
Annales Belges de Medecine Militaire.... 1946
Topics: Sulfanilamide; Sulfanilamides; Sulfonamides
PubMed: 21026067
DOI: No ID Found -
Journal of the American Chemical Society Dec 1945
Topics: Sulfanilamide; Sulfanilamides; Sulfonamides
PubMed: 21005696
DOI: 10.1021/ja01228a060 -
The New England Journal of Medicine Nov 1960
Topics: Sulfanilamide; Sulfanilamides; Sulfonamides
PubMed: 13783970
DOI: 10.1056/NEJM196011102631907 -
The New England Journal of Medicine Oct 1960
Topics: Sulfanilamide; Sulfanilamides; Sulfonamides
PubMed: 13783968
DOI: 10.1056/NEJM196010272631707