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Brain Tumor Pathology Apr 2014We report the case of a 61-year-old man with supratentorial extraventricular anaplastic ependymoma who presented with repeated intratumoral hemorrhage. The patient was... (Review)
Review
We report the case of a 61-year-old man with supratentorial extraventricular anaplastic ependymoma who presented with repeated intratumoral hemorrhage. The patient was admitted with headache. Computed tomography and magnetic resonance imaging showed an enhancing mass with intratumoral hemorrhage in the right temporal lobe. Gross total resection was performed. The tumor was well demarcated from the brain tissue, and showed no continuity with the ventricular system. Histopathological examination revealed the features of anaplastic ependymoma. Therefore, additional radiation therapy and adjuvant chemotherapy were administered. Ten months later, the tumor recurred with hemorrhage in the spinal canal. This case showed rapid malignant progression and repeated intratumoral hemorrhage within a short period of time, both of which are characteristics of anaplastic ependymomas. Close observation of the central nervous system and adjuvant radiotherapy are mandatory, even if the ependymoma presents with repeated intratumoral hemorrhage.
Topics: Brain; Carotid Artery, Internal; Cerebral Angiography; Cerebral Hemorrhage; Combined Modality Therapy; Ependymoma; Headache; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Recurrence; Supratentorial Neoplasms; Tomography, X-Ray Computed
PubMed: 23546851
DOI: 10.1007/s10014-013-0146-0 -
Neurosurgical Focus Jun 2001A variety of mass lesions can arise within or in proximity to the ventricular system in children. These lesions are relatively uncommon, and they present a unique... (Review)
Review
A variety of mass lesions can arise within or in proximity to the ventricular system in children. These lesions are relatively uncommon, and they present a unique diagnostic and surgical challenge. The differential diagnosis is determined by tumor location in the ventricular system, clinical presentation, age of the patient, and the imaging characteristics of the lesion. In this report the authors provide an introduction to and an overview of the most common pediatric supratentorial intraventricular tumors. The typical radiographic features of each tumor and location preference within the ventricular system are reviewed. Management and treatment considerations are discussed. Examination of tissue samples to obtain diagnosis is usually required for accurate treatment planning, and resection without adjuvant therapies is often curative. The critical management decision frequently involves determining which lesions are appropriate for surgical therapy. Careful preoperative neuroimaging is extremely useful in planning surgery. Knowledge of the typical imaging characteristics of these tumors can help to determine the diagnosis with relative certainty when a tissue sample has not been obtained, because a small subset of these lesions can be managed expectantly.
Topics: Cerebral Ventricle Neoplasms; Child; Humans; Lateral Ventricles; Neurosurgical Procedures; Supratentorial Neoplasms; Third Ventricle
PubMed: 16724822
DOI: 10.3171/foc.2001.10.6.5 -
Journal of Neuro-oncology Jan 1998The authors report 11 patients with cerebral glioblastoma who lived at least 5 years after their initial diagnosis. There were 6 female and 5 male; the mean age was 39... (Review)
Review
The authors report 11 patients with cerebral glioblastoma who lived at least 5 years after their initial diagnosis. There were 6 female and 5 male; the mean age was 39 years (range 24-55 years). All patients were treated surgically and postoperatively received whole-brain radiotherapy and chemotherapy. Five patients (45%) presented local recurrences after an average interval of 3.9 years from treatment. At average follow-up of 9 years (range 5-14 years), 7 patients (64%) were alive after an average interval of 8.1 years; 4 patients (36%) died from local relapse. Survival was influenced by patient age and, to a lesser degree, by treatment. A review of the literature, together with our own series, suggest that death from recurrence disease is unusual in glioblastoma patients who survive more than 5 years.
Topics: Adult; Age Factors; Female; Follow-Up Studies; Glioblastoma; Humans; Male; Middle Aged; Prognosis; Retrospective Studies; Supratentorial Neoplasms; Survivors
PubMed: 9525826
DOI: 10.1023/a:1017926603341 -
Neuropathology : Official Journal of... Apr 2021We report a case of a 26-year-old Chinese man who had experienced three grand mal seizures in the past two months. Magnetic resonance imaging revealed a relatively...
We report a case of a 26-year-old Chinese man who had experienced three grand mal seizures in the past two months. Magnetic resonance imaging revealed a relatively well-circumscribed lesion in the left frontal lobe. A craniotomy with total excision of the tumor was performed. Histopathological investigations confirmed a grade 2 ependymoma according to the World Health Organization classification. Genetic analysis revealed a tumor harboring FAM118B fusion to YAP1, and no other genetic alterations or methylation of the O -methylguanine-DNA methyltransferase gene promoter were detected. This is the second case report of ependymoma with YAP1:FAM118B fusion.
Topics: Adaptor Proteins, Signal Transducing; Adult; Ependymoma; Frontal Lobe; Humans; Magnetic Resonance Imaging; Male; Seizures; Supratentorial Neoplasms; Transcription Factor RelA; Transcription Factors; YAP-Signaling Proteins
PubMed: 33480048
DOI: 10.1111/neup.12712 -
Rays 1996Pediatric supratentorial tumors represent about 50% of all intracranial neoplasms. The most frequent tumors of the cerebral hemispheres are gliomas that arise from... (Review)
Review
Pediatric supratentorial tumors represent about 50% of all intracranial neoplasms. The most frequent tumors of the cerebral hemispheres are gliomas that arise from astrocytes, oligodendrocytes or ependymal cells. The incidence of the different histologic types is difficult to be established as many tumors have a mixed cellularity, thus classification is based on the prevalent oncotype or the most malignant component. Choroid plexus papillomas and ependymomas are the most common ventricular neoplasms. However, subependymal giant cell astrocytomas, subependymomas, teratomas are also observed. The parasellar region is a frequent site of pediatric tumors as craniopharyngiomas, optic pathway gliomas and germinomas. Pinealomas are less common. Signs and symptoms related to increased intracranial pressure are often reported and vary according to the patient's age. Macrocrania and a bulging fontanel can be observed in infants and toddlers, whereas headache, papilledema and vomiting are present in the older children. A tumor hindering CSF circulation may cause hydrocephalus. Focal signs include epilepsy and neurological deficits characteristic of tumor location. Total removal of the tumor is the ideal surgical therapy. When eloquent areas are involved, partial exeresis is indicated. Radiotherapy is usually administered to malignant tumors even if in younger children its use in markedly limited by the possible severe side-effects on the developing brain. Chemotherapy seems effective in some brain neoplasms, however most suitable drugs and dose need to be established. It may represent an alternative to radiotherapy in children less than three years of age.
Topics: Child; Child, Preschool; Humans; Infant; Supratentorial Neoplasms
PubMed: 8677342
DOI: No ID Found -
Journal of Neurosurgical Sciences Sep 2005The radiologic modality that most likely provides the imaging information needed in a patient suspected of having a brain tumors is magnetic resonance imaging. A brain... (Review)
Review
The radiologic modality that most likely provides the imaging information needed in a patient suspected of having a brain tumors is magnetic resonance imaging. A brain tumors can be reliably ruled out, if the standard magnetic resonance examination is performed properly and experts interpret the results as negative for tumor. In this paper we will illustrate morphological aspects of low-grade supratentorial neoplasms, including tumors of neuroepithelial tissue, such as low-grade diffuse fibrillary astrocytomas, and circumscribed astrocytic lesions (pilocytic astrocytoma, pleomorphic xantoastrocytoma and subependymal giant cell astrocytoma). Then the main practical applications of functional imaging in neurosurgery will be also debated.
Topics: Brain; Glioma; Humans; Magnetic Resonance Imaging; Radiography; Supratentorial Neoplasms
PubMed: 16288189
DOI: No ID Found -
Cephalalgia : An International Journal... Nov 2015
Topics: Female; Headache; Humans; Meningeal Neoplasms; Meningioma; Middle Aged; Supratentorial Neoplasms
PubMed: 25667301
DOI: 10.1177/0333102415570763 -
Der Radiologe Nov 2003In Germany about 400 children are diagnosed of having a brain tumour each year. About half of them are located in the supratentorial region. Despite the fact, that brain... (Review)
Review
In Germany about 400 children are diagnosed of having a brain tumour each year. About half of them are located in the supratentorial region. Despite the fact, that brain tumours are the most common solid tumour in childhood, they are very heterogeneous, regarding clinical symptoms, pathology, treatment and prognosis. Imaging studies play an important role for diagnosis and follow-up.
Topics: Adolescent; Brain; Child; Child, Preschool; Humans; Image Enhancement; Image Processing, Computer-Assisted; Infant; Infant, Newborn; Magnetic Resonance Imaging; Prognosis; Supratentorial Neoplasms; Tomography, X-Ray Computed
PubMed: 14628122
DOI: 10.1007/s00117-003-0981-9 -
Journal of Neurosurgical Anesthesiology Jan 2024Preoperative anxiety is common among patients, particularly in neurosurgical patients. The aim of the study was to evaluate the incidence and predictive factors of... (Observational Study)
Observational Study
BACKGROUND
Preoperative anxiety is common among patients, particularly in neurosurgical patients. The aim of the study was to evaluate the incidence and predictive factors of preoperative anxiety using the state anxiety scale of the State-Trait Anxiety Inventory (STAI-S) among patients undergoing elective craniotomy for a supratentorial neoplasm. This study also determined the optimal Amsterdam Preoperative Anxiety and Information Scale (APAIS) score for the identification of preoperative anxiety in this cohort.
METHODS
Sixty patients aged 18 to 65 years with American Society of Anesthesiologists physical status score I/II scheduled for elective craniotomy for a supratentorial neoplasm were recruited into this prospective, observational study. Preoperative anxiety was assessed using STAI-S and APAIS questionnaires. Using STAI-S ≥37 to define preoperative anxiety, the optimal APAIS to identify preoperative anxiety was determined using receiver operating characteristic curve analysis. Logistic regression was performed to identify independent predictive factors for preoperative anxiety.
RESULTS
Sixty percent of patients had preoperative anxiety (STAI-S ≥37). An APAIS score of 10 identified preoperative anxiety with a sensitivity, specificity, and positive predictive value of 97%, 96%, and 97%, respectively. Right-sided tumor location ( P =0.047) and need-for-information on surgery ( P =0.007) were independent predictors of preoperative anxiety.
CONCLUSIONS
Patients with supratentorial neoplasms have a high incidence of preoperative anxiety; an APAIS score of 10 is the optimal cutoff to identify anxious patients in the preoperative period. Need-for-information about surgery and right-sided tumor laterality are independent predictors of preoperative anxiety.
Topics: Humans; Prevalence; Prospective Studies; Anxiety; Brain Neoplasms; Supratentorial Neoplasms
PubMed: 36418242
DOI: 10.1097/ANA.0000000000000896 -
Child's Nervous System : ChNS :... Oct 2009Supratentorial ependymomas are rare neoplasms accounting for just ten to 15 new cases in the UK per year. This article discusses the surgical management of these tumours. (Review)
Review
INTRODUCTION
Supratentorial ependymomas are rare neoplasms accounting for just ten to 15 new cases in the UK per year. This article discusses the surgical management of these tumours.
MATERIALS AND METHODS
We present our experience over the past 12 years looking, in particular, at the location, histological grading, postoperative complications, survival and progression-free survival. A literature review of publications discussing the surgical management of ependymoma over the past 10 years is then presented.
RESULTS
The data shows that complete surgical resection confers a significant survival advantage. There appears to be conflicting data with respect to prognosis when comparing supratentorial to infratentorial ependymoma.
CONCLUSION
The authors suggest complete excision and advocate, where appropriate, the use of pre and intra-operative functional mapping and second-look surgery. The trade off neurological deficit in the pursuit of complete surgical excision in some instances should be considered.
Topics: Adolescent; Brain; Child; Child, Preschool; Ependymoma; Female; Follow-Up Studies; Humans; Infant; Infratentorial Neoplasms; Male; Neoplasm Staging; Prognosis; Supratentorial Neoplasms; Treatment Outcome
PubMed: 19357853
DOI: 10.1007/s00381-009-0881-z