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Pakistan Journal of Biological Sciences... Nov 2010Thyrotoxicosis exhibit collective clinical manifestation, caused by excessive serum thyroid hormones particularity thyroxin. The clinical signs and symptoms included... (Review)
Review
Thyrotoxicosis exhibit collective clinical manifestation, caused by excessive serum thyroid hormones particularity thyroxin. The clinical signs and symptoms included general alteration of metabolic process leading to weight loss fatigue and weakness and some specific disorders such as cardiovascular, neuromuscular reproductive gastrointestinal dermatological and bone disorders. The diagnosis of thyrotoxicosis relay on the thyroid function test carried out by the laboratory serum measurement of thyroxin, triiodothyronine and thyroid stimulating hormones accompanied by other para-medical examinations suggested by clinicians and endociologicst. In thyrotoxicosis serum level of thyroid hormones and thyroxin in particular elevated accompanied by pituitary thyroid stimulating hormone suppression reaching to undetectable level in sever thyrotoxicosis. Among the most common cause of thyrotoxicosis are, thyroid autoimmunity diseases thyroid toxic, adenoma toxic nodular and multinodular hyperthyroidism. The main aim behind this review is to explore the clinical manifestation, the causative factors, diagnosis, metabolic disorder occur due to thyrotoxicosis.
Topics: Humans; Hyperthyroidism; Population Surveillance; Thyroid Neoplasms; Thyrotoxicosis
PubMed: 21313880
DOI: 10.3923/pjbs.2010.1066.1076 -
Journal of Pediatric Endocrinology &... Mar 2015Neonatal thyrotoxicosis is a rare condition caused by the transplacental passage of thyroid stimulating immunoglobulins from mothers with Graves' disease. We report a... (Review)
Review
Neonatal thyrotoxicosis is a rare condition caused by the transplacental passage of thyroid stimulating immunoglobulins from mothers with Graves' disease. We report a case of neonatal thyrotoxicosis with concurrent supraventricular tachycardia (SVT). The female infant, who was born by section due to breech delivery and meconium in the amniotic fluid at 36 weeks of gestation, presented with tachycardia on day 7. Her heart rate was between 260 and 300 beats/min, and an electrocardiogram revealed ongoing SVT. Sotalol was effective after two cardioversions in maintaining sinus rhythm. Thyroid function studies revealed hyperthyroidism in the infant, and her mother was found to have Graves' disease. Since symptoms and signs can vary, especially in preterm infants with neonatal hyperthyroidism, we want to emphasize the importance of prenatal care and follow-ups of Graves' disease associated pregnancies and management of newborns after birth.
Topics: Female; Humans; Infant, Newborn; Infant, Newborn, Diseases; Severity of Illness Index; Tachycardia, Supraventricular; Thyrotoxicosis
PubMed: 25153577
DOI: 10.1515/jpem-2014-0166 -
The Journal of the Association of... Jan 2011
Topics: Adrenergic beta-Antagonists; Antithyroid Agents; Humans; Severity of Illness Index; Thyroidectomy; Thyrotoxicosis; Thyroxine
PubMed: 21819001
DOI: No ID Found -
Journal of Medical Case Reports Oct 2023Acute suppurative thyroiditis is a rare and potentially life-threatening disease. A few cases of acute suppurative thyroiditis associated with thyrotoxicosis have been...
BACKGROUND
Acute suppurative thyroiditis is a rare and potentially life-threatening disease. A few cases of acute suppurative thyroiditis associated with thyrotoxicosis have been reported in adults. We report a case of acute suppurative thyroiditis that was associated with thyrotoxicosis.
CASE PRESENTATION
We report the case of a 49-year-old Iranian female presented with a painful neck swelling for a week. Computed tomography showed a well-defined gas-filled collection in the left thyroid lobe with an enhancing margin. The patient underwent two-phase surgery, first left thyroid abscess drainage and then total thyroidectomy. The result of histopathology examination was multinodular goiter with abscess formation without malignancy.
CONCLUSION
Abscess formation and thyrotoxicosis is a very rare condition that occurs at the same time in acute suppurative thyroiditis. Despite antibiotic therapy being the first line of treatment, surgery is also required when antibiotic therapy fails.
Topics: Adult; Humans; Female; Middle Aged; Thyroiditis, Suppurative; Abscess; Iran; Thyrotoxicosis; Anti-Bacterial Agents; Acute Disease
PubMed: 37833794
DOI: 10.1186/s13256-023-04119-1 -
Endocrinology and Metabolism Clinics of... Sep 1990Well-differentiated follicular carcinoma causing thyrotoxicosis is a rare entity. The age and sex distribution is no different from that of other patients with... (Review)
Review
Well-differentiated follicular carcinoma causing thyrotoxicosis is a rare entity. The age and sex distribution is no different from that of other patients with follicular carcinoma, with 87% older than the age of 40 and a female:male ratio of 3:1. The clinical presentation is similar to that of Graves' patients except that evidence of metastatic disease is often present (soft tissue masses, bone pain). The metastases are in the usual locations (bone, lung, mediastinum) and are often bulky. Despite the poor efficiency of iodine uptake and thyroid hormone production, the large tumor mass is capable of producing excessive hormone. Laboratory data confirm the hyperthyroid state, but the occurrence of T3 elevations with normal T4 levels is common, and T3 toxicosis may be missed if only T4 levels are measured. The role of thyroid stimulating immunoglobulins is still evolving, but such stimulators may support the growth of metastatic thyroid carcinoma and promote the development of hyperthyroidism. The treatment of these patients varied. Most had thyroidectomy followed by 131I therapy. Dosimetry allows for the administration of the largest dose of 131I with acceptable side effects. A good response to radioiodine predicted a more favorable outcome. The survival of patients with metastatic thyroid carcinoma causing hyperthyroidism does not differ from euthyroid patients with metastatic follicular disease (10-year survival, 59%).
Topics: Adult; Aged; Aged, 80 and over; Child; Female; Humans; Male; Middle Aged; Thyroid Gland; Thyroid Neoplasms; Thyrotoxicosis
PubMed: 2261908
DOI: No ID Found -
Current Problems in Cardiology Mar 2024The principal management of Amiodarone-induced-thyrotoxicosis (AIT) is balancing cardiac-thyroid conditions. However, the role of thyroidectomy is still contentious.... (Review)
Review
The principal management of Amiodarone-induced-thyrotoxicosis (AIT) is balancing cardiac-thyroid conditions. However, the role of thyroidectomy is still contentious. This systematic review aims to provide insights into the roles of thyroidectomy in the management of AIT. This systematic review encompasses 303 AIT patients who underwent thyroidectomy from 14 studies. The indication of thyroidectomy can be due to cardiac factors, thyrotoxicosis conditions, and patient-physician considerations. Thyroidectomy is more effective in improving thyroid hormone status, cardiac function, and mortality compared to optimal medical therapy, especially in those with left ventricular ejection fraction < 40 %. Thyroidectomy is effective in improving cardiac function and mortality due to shorter duration for achieving euthyroid. Thyroidectomy and medical therapy have comparable side effects. However, the identification of high-risk patients may reduce thyroidectomy complications. Thus, thyroidectomy should not be viewed as the last resource and should be performed immediately when indicated.
Topics: Humans; Amiodarone; Anti-Arrhythmia Agents; Thyroidectomy; Stroke Volume; Ventricular Function, Left; Thyrotoxicosis; Heart Diseases
PubMed: 38232922
DOI: 10.1016/j.cpcardiol.2024.102395 -
Pediatric Annals Jan 1992Evidence supports the presence of a genetic predisposition to an abnormality in immune surveillance, with environmental factors precipitating the development of Graves'...
Evidence supports the presence of a genetic predisposition to an abnormality in immune surveillance, with environmental factors precipitating the development of Graves' disease.
Topics: Child; Diagnosis, Differential; Graves Disease; Humans; Infant, Newborn; Thyrotoxicosis
PubMed: 1549398
DOI: 10.3928/0090-4481-19920101-08 -
Archives of Disease in Childhood Aug 2004Thyrotoxicosis remains a frustrating condition for the young person, family, and health professionals involved. The associated symptoms do not always suggest thyroid... (Review)
Review
Thyrotoxicosis remains a frustrating condition for the young person, family, and health professionals involved. The associated symptoms do not always suggest thyroid disease and patients can be unwell for many months before the diagnosis is made. The antithyroid drug regimen used to treat children and adolescents with thyrotoxicosis varies from one unit to another and yet the potentially life threatening side effects and remission rates post-treatment may be related to the regimen used. Most patients with thyrotoxicosis will need many years of drug therapy if the thyroid gland is not removed surgically or destroyed by radioiodine. Even "definitive" treatment will typically necessitate thyroxine replacement for life.
Topics: Adolescent; Antithyroid Agents; Child; Humans; Iodine Radioisotopes; Recurrence; Thyroid Crisis; Thyroiditis, Autoimmune; Thyrotoxicosis; Treatment Outcome
PubMed: 15269076
DOI: 10.1136/adc.2003.035980 -
Thyroid : Official Journal of the... Oct 2008Cardiac arrhythmias associated with thyrotoxicosis tend to be supraventricular in nature with atrial fibrillation being the most common. Ventricular arrhythmias are...
BACKGROUND
Cardiac arrhythmias associated with thyrotoxicosis tend to be supraventricular in nature with atrial fibrillation being the most common. Ventricular arrhythmias are rarely associated with thyrotoxicosis and are considered to be secondary to intrinsic cardiac disease.
SUMMARY
We present three patients with thyrotoxicosis and stable coronary disease in whom the primary cardiac rhythm disturbance was ventricular tachycardia. In all of these patients, the ventricular arrhythmias terminated with achievement of a euthyroid state. We hypothesize that the thyrotoxic state contributed to the etiology of, or lowered the threshold for the ventricular arrhythmias.
CONCLUSION
Prompt attention to the management of thyrotoxicosis in patients with a history of significant heart disease is warranted in order to avoid potentially fatal arrhythmias.
Topics: Adult; Aged; Amiodarone; Fatal Outcome; Female; Humans; Male; Middle Aged; Tachycardia, Ventricular; Thyrotoxicosis
PubMed: 18816176
DOI: 10.1089/thy.2007.0307 -
Thyroid : Official Journal of the... Mar 2011The management of patients with severe thyrotoxicosis in the absence of a functional gastrointestinal tract represents an uncommon but significant clinical challenge... (Review)
Review
BACKGROUND
The management of patients with severe thyrotoxicosis in the absence of a functional gastrointestinal tract represents an uncommon but significant clinical challenge associated with a high mortality rate. This article offers a literature review and discussion of the available management options in this setting.
SUMMARY
Treatment of severe thyrotoxicosis in patients unable to ingest medications by the oral route should focus on normalization of thyroid hormone levels utilizing conventional medical therapy for thyrotoxicosis, administered via non-oral routes. This includes thionamides, beta-blockers, iodine containing solutions, and glucocorticoids. When conventional medical therapy fails, plasmapheresis should be considered as a temporary therapeutic bridge until conventional therapies can be instituted effectively or emergent surgery performed.
CONCLUSION
Although a rare scenario, the management of patients with severe thyrotoxicosis in the absence of a functional gastrointestinal tract represents a challenging clinical situation. Endocrinologists and critical care physicians should be apprised of the available treatment modalities which must be instituted swiftly in order to avoid a catastrophic outcome.
Topics: Adult; Diarrhea; Drug Administration Routes; Gastrointestinal Tract; Humans; Male; Phenylthiourea; Thyroid Crisis; Thyrotoxicosis; Vomiting
PubMed: 21254909
DOI: 10.1089/thy.2010.0159