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The Journal of Obstetrics and... May 2021A 78-year-old woman with the chief complaint of vaginal bleeding was referred to our institution. Pelvic magnetic resonance imaging showed a 2.1 cm × 2.0 cm soft... (Review)
Review
A 78-year-old woman with the chief complaint of vaginal bleeding was referred to our institution. Pelvic magnetic resonance imaging showed a 2.1 cm × 2.0 cm soft tissue mass in the left vaginal area with left inguinal lymph node enlargement. A positron emission tomography/computer tomography scan showed a focal hypermetabolic lesion in the left vaginal area with involvement of vulvar area. Pelvic examination showed a vaginal wall mass and the patient underwent surgical excision of the mass. The results of pathology indicated lymphoepithelioma-like carcinoma (LELC) in the vagina. The patient was admitted subsequently in the oncological department for additional chemoradiation treatment. LELC is extremely rare in the vagina, and only three cases have been reported in the literature. Here we report an extremely rare case of this tumor and review of the previous literature.
Topics: Aged; Carcinoma, Squamous Cell; Female; Humans; Magnetic Resonance Imaging; Positron-Emission Tomography; Vagina
PubMed: 33650156
DOI: 10.1111/jog.14722 -
BMJ Case Reports Oct 2022We report the case of a woman in her 70s with a stage IVA small cell neuroendocrine carcinoma of the vagina. The patient started chemotherapy with cisplatin and...
We report the case of a woman in her 70s with a stage IVA small cell neuroendocrine carcinoma of the vagina. The patient started chemotherapy with cisplatin and etoposide followed by concurrent chemoradiotherapy and adjuvant chemotherapy. Pelvic MRI after completion of treatment did not show residual disease. Three years and 8 months after definitive treatment, the patient remains on regular follow-up without evidence of disease.
Topics: Female; Humans; Antineoplastic Combined Chemotherapy Protocols; Neoplasm Staging; Chemoradiotherapy; Cisplatin; Chemotherapy, Adjuvant; Carcinoma, Neuroendocrine; Vagina
PubMed: 36316052
DOI: 10.1136/bcr-2022-252031 -
International Journal of Gynaecology... May 2023
Topics: Female; Humans; Carcinoma, Small Cell; Vagina; Carcinoma, Neuroendocrine; Vaginal Neoplasms
PubMed: 36453163
DOI: 10.1002/ijgo.14603 -
International Journal of Gynecological... Mar 2022Vaginal cancer is a rare cancer. A lot of the data used in the treatment of this cancer are extrapolated from cervical cancer data. Radiation therapy plays a significant... (Review)
Review
Vaginal cancer is a rare cancer. A lot of the data used in the treatment of this cancer are extrapolated from cervical cancer data. Radiation therapy plays a significant role in the treatment of vaginal cancer. The advances in radiation therapy in both external beam and brachytherapy have improved local control, survival, and toxicity. Brachytherapy plays an important role in treating vaginal cancer, but treatment should be individualized to each tumor. Imaging, particularly magnetic resonance imaging, plays an essential role in the management of patients with vaginal cancer, from diagnosis to staging to treatment management to surveillance.
Topics: Brachytherapy; Carcinoma in Situ; Female; Humans; Magnetic Resonance Imaging; Uterine Cervical Neoplasms; Vagina; Vaginal Neoplasms
PubMed: 35256422
DOI: 10.1136/ijgc-2021-002517 -
The Surgical Clinics of North America Feb 1978Squamous cell carcinoma of the vagina is one of the least understood malignant tumors arising from the female genital tract. Vital facts on its clinical and biologic... (Review)
Review
Squamous cell carcinoma of the vagina is one of the least understood malignant tumors arising from the female genital tract. Vital facts on its clinical and biologic behavior are difficult to collate in a cumulative way. Its intermediate position in the pelvis makes it a difficult site to which to apply conventional methods of treatment without associated morbidity; its rareness precludes developing expertise by no more than a few therapists and allows few the opportunity to test new ideas encased in research protocols; and its variegated presentations invite individualization as the only therapeutic approach. Squamous cell carcinoma of the vagina remains an enigma among gynecologic neoplasms.
Topics: Aged; Carcinoma, Squamous Cell; Female; Humans; Middle Aged; Neoplasm Metastasis; Neoplasm Staging; Radiation Injuries; Radiotherapy Dosage; Vagina; Vaginal Neoplasms
PubMed: 347602
DOI: 10.1016/s0039-6109(16)41431-3 -
Journal of Lower Genital Tract Disease Jan 2023Small cell carcinoma of the vagina (SmCCV) is an extremely rare disease. Evidence-based data and specific guidelines are lacking. We conducted the first systematic...
OBJECTIVES
Small cell carcinoma of the vagina (SmCCV) is an extremely rare disease. Evidence-based data and specific guidelines are lacking. We conducted the first systematic review of case reports to provide the most overall picture of SmCCV.
MATERIALS AND METHODS
Literature search in PubMed and Scopus was performed using the terms "small cell carcinoma" and "vagina." English-language case reports of primary SmCCV up to January 2022 were included.
RESULTS
Twenty-nine articles describing 44 cases met our inclusion criteria. We report a new case of our hospital. The global median overall survival (mOS) was 12.00 months (95% CI = 9.31-14.69). The mOS was not reached for stage I, and it was 12.00, 12.00, 9.00, and 8.00 months for stages II, III, IVA, and IVB, respectively (statistically significant differences between stage I and stages II, III, or IVA [log rank p = .003-.017]). Thirty-five cases received local treatments (77.8%). The mOS of patients treated with surgery ± complementary chemotherapy, radiotherapy ± complementary chemotherapy, chemoradiation ± complementary chemotherapy, and surgery + radiotherapy ± complementary chemotherapy were 11.00, 12.00, 17.00, and 29.00 months, respectively. The use of adjuvant or neoadjuvant chemotherapy (64.5%, mostly platinum + etoposide) showed longer mOS (77.00 vs 15.00 months). Four of 5 tested cases presented human papillomavirus infection, 3 of them presenting type 18.
CONCLUSIONS
Small cell carcinoma of the vagina shows dismal prognosis. Multimodal local management plus complementary chemotherapy seems to achieve better outcomes. Human papillomavirus could be related to the development of SmCCV. A diagnostic-therapeutic algorithm is proposed.
Topics: Female; Humans; Algorithms; Carcinoma; Neoadjuvant Therapy; Neoplasm Staging; Prognosis; Vagina
PubMed: 36282979
DOI: 10.1097/LGT.0000000000000712 -
Asian Journal of Surgery Feb 2024
Topics: Female; Humans; Carcinoma, Squamous Cell; Vagina; Pelvis
PubMed: 38008629
DOI: 10.1016/j.asjsur.2023.11.012 -
BMJ Case Reports Apr 2022Primary vaginal neuroendocrine tumours are extremely rare but aggressive. We report a case of primary poorly differentiated vaginal carcinoma with focal neuroendocrine...
Primary vaginal neuroendocrine tumours are extremely rare but aggressive. We report a case of primary poorly differentiated vaginal carcinoma with focal neuroendocrine differentiation. The clinical stage was cT3N1M0, FIGO stage III. The patient received six cycles of cisplatin-based concurrent chemoradiation therapy (CCRT) followed by six cycles of adjuvant chemotherapy (IEP protocol: ifosfomide, epirubicin and cisplatin). Pelvic MRI scans obtained after treatment completion revealed no residual tumour in the vagina. However, the patient experienced severe dyspnoea 2 months later. Chest X-ray revealed a reticulonodular interstitial pattern over bilateral lungs with suspicion of lymphangitic carcinomatosis. Further chest, abdominal and pelvic CT scans showed bilateral lung metastases with multiple mediastinal, left lower neck and left axilla, intra-abdominal and pelvic lymphadenopathies. For this rare tumour, cisplatin-based CCRT followed by IEP protocol adjuvant chemotherapy may have a limited treatment effect. Further studies are necessary to provide more information on clinical management.
Topics: Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Neuroendocrine; Chemoradiotherapy; Chemotherapy, Adjuvant; Cisplatin; Female; Humans; Neoplasm Staging; Neoplasms, Glandular and Epithelial; Vagina
PubMed: 35396236
DOI: 10.1136/bcr-2021-247554 -
Journal of Obstetrics and Gynaecology :... May 2016Carcinoma of the recto-vaginal septum is an extremely rare entity. We performed a MEDLINE-based search on recto-vaginal septum carcinoma, focussing on its management, in... (Review)
Review
Carcinoma of the recto-vaginal septum is an extremely rare entity. We performed a MEDLINE-based search on recto-vaginal septum carcinoma, focussing on its management, in order to clarify which are the best treatment options for this disease. In addition an unpublished case report has been added to the review. 34 case reports were included in our review. Surgery and adjuvant chemoradiation therapy seem to be the most common treatment option. However, since primary surgical treatment leads to mutilation by removing a large portion of the vagina and the anal sphincter with a permanent terminal colostomy, primary platinum-based chemoradiation therapy could be considered. In case of extragastrointestinal stromal tumours primary surgical treatment seems to be the best option. Due to the rarity of this entity only limited data is available. Therefore further investigation is necessary.
Topics: Adult; Anal Canal; Carcinoma; Chemoradiotherapy, Adjuvant; Combined Modality Therapy; Female; Humans; Rectal Neoplasms; Vagina; Vaginal Neoplasms
PubMed: 26467428
DOI: 10.3109/01443615.2015.1065234 -
Surgery, Gynecology & Obstetrics Jan 1983Carcinoma of the vagina remains a problem for the clinician. The experience of The Ohio State University Gynecologic Oncology section confirms that careful consideration... (Review)
Review
Carcinoma of the vagina remains a problem for the clinician. The experience of The Ohio State University Gynecologic Oncology section confirms that careful consideration of urinary complaints is important in patient evaluation. In our experience, a fourth of the patients in our series with primary carcinoma of the vagina presented with urinary complaints with or without associated pain or bleeding. Vaginal bleeding was the most common complaint. Radical surgery may result in equally successful therapy, as does radiation for early stage disease. The disease stage was the single most important prognostic factor. Finally, careful screening of the vagina for a neoplasm is important, especially in patients in the postmenopausal period with histories of other neoplasms.
Topics: Adenocarcinoma; Adult; Aged; Carcinoma in Situ; Carcinoma, Squamous Cell; Female; Humans; Hysterectomy; Melanoma; Middle Aged; Neoplasm Staging; Vagina; Vaginal Neoplasms
PubMed: 6336629
DOI: No ID Found