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The Journal of Reproductive Medicine Jul 1989Three patients were treated for primary small cell carcinoma of the vagina. The light microscopic features were similar to those of small cell carcinoma of the lung,...
Three patients were treated for primary small cell carcinoma of the vagina. The light microscopic features were similar to those of small cell carcinoma of the lung, cervix and endometrium. Electron microscopy revealed occasional cytoplasmic, neurosecretory-type granules and cytoplasmic processes, features consistent with neuroendocrine cells. Radiotherapy appears to provide local control, but widespread disease at presentation or early metastases suggest the use of adjuvant chemotherapy in the initial management of the neoplasm.
Topics: Adult; Aged; Brachytherapy; Carcinoma, Small Cell; Cytoplasmic Granules; Female; Follow-Up Studies; Humans; Microscopy, Electron; Neoplasm Metastasis; Radiotherapy Dosage; Vagina; Vaginal Neoplasms
PubMed: 2549239
DOI: No ID Found -
Lancet (London, England) Jul 1990
Topics: Carcinoma; Female; Humans; Ultrasonography; Uterine Neoplasms; Vagina
PubMed: 1973811
DOI: 10.1016/0140-6736(90)91790-h -
Proceedings of the Royal Society of... May 1956
Topics: Carcinoma; Cytodiagnosis; Female; Humans; Uterine Neoplasms; Vagina; Vaginal Smears
PubMed: 13336011
DOI: No ID Found -
Gastroenterology Jun 1991A 33-year-old woman had undergone a radical surgical excision for carcinoma of the vagina at age 11. Vaginal reconstruction using a pedicled transplant of the sigmoid...
A 33-year-old woman had undergone a radical surgical excision for carcinoma of the vagina at age 11. Vaginal reconstruction using a pedicled transplant of the sigmoid colon was successfully accomplished at age 19. Fourteen years later she developed vaginal bleeding, and a biopsy of the neovagina revealed changes consistent with ulcerative colitis. Within 2 weeks the patient developed bleeding per ano, and a rectal biopsy also revealed changes consistent with ulcerative colitis. Symptoms responded to sulfasalazine. This is believed to be the first case report of ulcerative colitis developing in colonic tissue used for a neovagina. The etiology, natural history, and surveillance of ulcerative colitis in relation to this unique case are reviewed. This case argues against the hypothesis that chronic ulcerative colitis is causally related to direct exposure to alimentary antigens.
Topics: Adenocarcinoma; Adult; Colitis, Ulcerative; Colon, Sigmoid; Female; Humans; Surgery, Plastic; Time Factors; Transplantation, Autologous; Vagina; Vaginal Neoplasms
PubMed: 2019379
DOI: 10.1016/0016-5085(91)90679-f -
Obstetrics and Gynecology Mar 1987Congenital absence of the vagina is very rare, with one method of treatment being the split-thickness skin graft vaginoplasty. This is the ninth reported instance of...
Congenital absence of the vagina is very rare, with one method of treatment being the split-thickness skin graft vaginoplasty. This is the ninth reported instance of carcinoma arising in the neovagina and is apparently related to the type of tissue transplanted. The optimal therapy for this malignancy remains to be defined. A review of previously reported patients plus this patient suggests that reliance on radiotherapy as the primary means of treatment may result in a high percentage of failures.
Topics: Adolescent; Carcinoma, Squamous Cell; Female; Humans; Neoplasm Recurrence, Local; Postoperative Complications; Time Factors; Vagina; Vaginal Neoplasms
PubMed: 3808541
DOI: No ID Found -
Obstetrics and Gynecology Jul 1977Verrucous carcinoma is a well known and extensively reported entity in the English literature. It can occur in many tissues including vaginal mucosa. The first report of...
Verrucous carcinoma is a well known and extensively reported entity in the English literature. It can occur in many tissues including vaginal mucosa. The first report of this entity occuring in an artificial vagina, including typical gross and histologic features, is presented with a discussion of the literature. The best mode of therapy remains primary excision of the lesion, and prognosis is excellent if early surgical intervention is accomplished.
Topics: Carcinoma, Papillary; Female; Humans; Middle Aged; Neoplasms, Multiple Primary; Papilloma; Postoperative Complications; Radiotherapy Dosage; Rectum; Vagina; Vaginal Neoplasms; Vulvar Neoplasms
PubMed: 876534
DOI: No ID Found -
Obstetrics and Gynecology Aug 2011Pagetoid spread of adenocarcinoma in situ of the cervix into vaginal epithelium is a rare phenomenon, mimicking Paget's disease of the vulva.
BACKGROUND
Pagetoid spread of adenocarcinoma in situ of the cervix into vaginal epithelium is a rare phenomenon, mimicking Paget's disease of the vulva.
CASE
We report a case of in situ squamous cell and in situ adenocarcinoma of the cervix in a 44-year-old woman who underwent total abdominal hysterectomy, bilateral salpingo-oophorectomy, and upper vaginectomy. Pathologic evaluation showed pagetoid endocervical adenocarcinoma in situ spreading into the vagina with positive margins. Malignant cells were positive for mucin, P16, CK-7, and carcinoembryonic antigen.
CONCLUSION
The asymptomatic occult finding of pagetoid changes in the vagina should raise the suspicion of vaginal extension of pagetoid genital or urothelial carcinoma in situ; however, it can be mistaken as vaginal dysplasia or primary Paget's disease. Immunohistochemical profiling may help in the differential diagnosis.
Topics: Adult; Carcinoembryonic Antigen; Carcinoma in Situ; Carcinoma, Squamous Cell; Cyclin-Dependent Kinase Inhibitor p16; Female; Gynecologic Surgical Procedures; Humans; Keratin-7; Mucins; Neoplasm Invasiveness; Paget Disease, Extramammary; Treatment Outcome; Uterine Cervical Neoplasms; Vagina
PubMed: 21768854
DOI: 10.1097/AOG.0b013e3182164af8 -
The Journal of Family Practice Jan 1995Because primary vaginal cancer is rare, many experts discourage routine cytologic sampling of the vaginal vault following hysterectomy for benign circumstances. The... (Review)
Review
Because primary vaginal cancer is rare, many experts discourage routine cytologic sampling of the vaginal vault following hysterectomy for benign circumstances. The following report describes a case of vaginal intraepithelial neoplasia III (VAIN III) detected by a vaginal vault Papanicolaou smear obtained from an asymptomatic 57-year-old woman 23 years after she had a total abdominal hysterectomy for a benign condition. As VAIN III is a true vaginal cancer precursor, the innocent disregard of recommended screening practices averted significant morbidity and possibility mortality for this otherwise healthy woman.
Topics: Carcinoma in Situ; Chronic Disease; Female; Humans; Hysterectomy; Middle Aged; Papanicolaou Test; Postoperative Complications; Risk Factors; Uterine Cervicitis; Vagina; Vaginal Neoplasms; Vaginal Smears
PubMed: 7807042
DOI: No ID Found -
Akusherstvo I Ginekologiia 2000
Review
Topics: Bulgaria; Carcinoma; Female; Humans; Middle Aged; Ovarian Neoplasms; Risk Factors; Ultrasonography; Vagina
PubMed: 11288632
DOI: No ID Found -
Archives of Gynecology and Obstetrics Mar 2024This systematic review aims to provide a data synthesis about the risk of neovaginal cancer in women with Müllerian anomalies and to investigate the association between... (Review)
Review
PURPOSE
This systematic review aims to provide a data synthesis about the risk of neovaginal cancer in women with Müllerian anomalies and to investigate the association between the adopted reconstructive technique and the cancer histotype.
METHODS
PubMed, MEDLINE, Embase, Scopus, ClinicalTrials.gov and Web of Science databases were searched from inception to March 1st, 2023. Studies were included if: (1) only women affected by Müllerian malformations were included, (2) the congenital defect and the vaginoplasty technique were clearly reported, (3) the type of malignancy was specified.
RESULTS
Literature search yielded 18 cases of squamous cell carcinoma and two cases of vaginal intraepithelial neoplasia 3 (VAIN 3). Of these, 3 had been operated on according to the Wharton technique, 8 according to the McIndoe technique, 3 with a split-skin graft vaginoplasty, 2 according to the Davydov technique, 2 with a simple cleavage technique, 1 according to the Vecchietti technique and 1 with a bladder flap vaginoplasty. A total of 17 cases of adenocarcinoma and 1 case of high-grade polypoid dysplasia were also described. Of these, 15 had undergone intestinal vaginoplasty, 1 had been operated on according to the McIndoe technique and 1 had undergone non-surgical vaginoplasty. Finally, 1 case of verrucous carcinoma in a woman who had undergone a split-skin graft vaginoplasty, was reported.
CONCLUSION
Although rare, neovaginal carcinoma is a definite risk after vaginal reconstruction, regardless of the adopted technique. Gynaecologic visits including the speculum examination, the HPV DNA and/or the Pap smear tests should be scheduled on an annual basis.
Topics: Humans; Female; Vagina; Plastic Surgery Procedures; Vaginal Neoplasms; Carcinoma, Squamous Cell; Adenocarcinoma; Mullerian Ducts; 46, XX Disorders of Sex Development; Congenital Abnormalities; Gynecologic Surgical Procedures; Treatment Outcome
PubMed: 37466686
DOI: 10.1007/s00404-023-07086-6