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The Journal of Obstetrics and... Dec 2011A case of a papillary squamotransitional cell carcinoma (PSTCC) of the vagina with a follow-up of 3 years is presented here. The characteristics of this case support a...
A case of a papillary squamotransitional cell carcinoma (PSTCC) of the vagina with a follow-up of 3 years is presented here. The characteristics of this case support a squamous rather than urothelial origin of this rare entity. Unlike its counterparts in the cervix uteri, the clinical behavior of vaginal PSTCC is more favorable than squamous cell carcinoma. Histological and clinical features are compared to those of previously described cases of vaginal and cervical PSTCC.
Topics: Adult; Carcinoma, Papillary; Carcinoma, Squamous Cell; Carcinoma, Transitional Cell; Female; Humans; Vagina; Vaginal Neoplasms
PubMed: 21917071
DOI: 10.1111/j.1447-0756.2011.01636.x -
Surgical Pathology Clinics Jun 2022A number of changes have been introduced into the 5th Edition of the World Health Organization (WHO) Classification of squamous and glandular neoplasms of the vulva and... (Review)
Review
A number of changes have been introduced into the 5th Edition of the World Health Organization (WHO) Classification of squamous and glandular neoplasms of the vulva and vagina. This review highlights the major shifts in tumor classification, new entities that have been introduced, recommendations for p16 immunohistochemical testing, biomarker use, molecular findings and practical points for pathologists which will affect clinical care. It also touches upon several issues that still remain answered in these rare but undeniably important women's cancers.
Topics: Carcinoma in Situ; Carcinoma, Squamous Cell; Female; Humans; Vagina; Vulva; Vulvar Neoplasms
PubMed: 35715167
DOI: 10.1016/j.path.2022.02.011 -
Revista Colombiana de Obstetricia Y... Dec 2019To present the case of a squamous carcinoma in the neovagina of a patient with Mayer-Rokitansky-Küster-Hauser syndrome and review of the literature related to treatment... (Review)
Review
OBJECTIVE
To present the case of a squamous carcinoma in the neovagina of a patient with Mayer-Rokitansky-Küster-Hauser syndrome and review of the literature related to treatment and prognosis of vaginal neoplasms or HPV infection in transgender women or with MRKH syndrome.
MATERIALS AND METHODS
A 56-year-old woman consulted to the Hospital Universitario of Sevilla (Spain). During the clinical examination, a exophytic tumor at the bottom of the vagina was found and the biopsy reported squamous carcinoma and positive nucleic acid amplification test for human papilloma (HPV) type 16. A literature search of case reports, case series and observational studies published from 2000 to October 2019 in English and Spanish was performed in Medline via PubMed, with the follow- ing terms: "congenital abnormalities"; "Mullerian aplasia"; "neovagina"; "Vaginal neoplasms"; "Squamous carcinoma"; "HPV infection" was performed.
RESULTS
14 studies were finally included; seven corresponded to squamous cell carcinoma, three to adenocarcinoma and four reported HPV infection only. All of the squamous cell carcinomas were at advanced stages due to local or lymphatic compro- mise and received radiotherapy with concomitant chemotherapy or radical surgery. The prognosis was bad in three of the cases. Patients with adenocarcinoma also presented with advanced lesions due to local extensión and received surgical treatment and two cases received concomitant chemotherapy. Only one patient was followed-up for five years or more. HPV infection is common in women who underwent neovagina reconstruction.
CONCLUSIONS
Patients with neovagina are susceptible to develope squamous carcinomas or adenocarcinomas depending if skin or intestinal tissue grafts are used. According to local compromise at the time of diagnosis, radical or combined treatments are required. Which screening strategies for HPV, squamous cell carcinomas and adenocarcinoma is to be investigated.
Topics: 46, XX Disorders of Sex Development; Adenocarcinoma; Biopsy; Carcinoma, Squamous Cell; Congenital Abnormalities; Female; Humans; Middle Aged; Mullerian Ducts; Nucleic Acid Amplification Techniques; Papillomavirus Infections; Surgically-Created Structures; Vagina; Vaginal Neoplasms
PubMed: 32142241
DOI: 10.18597/rcog.3328 -
Radiology Feb 1951
Topics: Carcinoma; Female; Humans; Vagina
PubMed: 14816559
DOI: 10.1148/56.2.193 -
Gynecologic Oncology Jan 2002Carcinoma of the vagina is a rare disease, and it is even more rare in the neovagina. Nevertheless, it has been well described. The aim of this report was to analyze the... (Review)
Review
BACKGROUND
Carcinoma of the vagina is a rare disease, and it is even more rare in the neovagina. Nevertheless, it has been well described. The aim of this report was to analyze the reported cases and to add observations concerning a risk profile for this rare occurrence of carcinoma.
CASE REPORT
The 29-year-old patient's history included congenital absence of vagina as a result of Rokitansky-Kuster syndrome. In 1987, when the patient was 17 years old, a neovagina was constructed by dissection between the bladder and the rectum, according to the Warthon method, and the apex of the neovagina was covered with Dura-mater. In 1990 the patient underwent radiation treatment with brachytherapy three times in combination with surgical treatment, because of granulation tissue in the neovagina. In 1999 several specimens of the granulation tissue were removed and histological examination showed intermediate differentiated squamous cell carcinoma. Total exenteration with pelvic and lower paraaortic lymph node dissection was performed, and the patient received a continent neobladder (Mainz Pouch I), colostoma, and sigma neovagina. Two months later in January 2000 the patient showed local recurrence and after local excision the patient received radiotherapy. The follow-up to June 2001 showed no evidence of disease.
CONCLUSION
All patients with vaginoplasty should undergo regular 1-year follow-ups, including smear analysis because of the possibility of the development of carcinoma. Granulation tissue arising in a neovagina should be biopsied and no prosthesis should be used until lesions have healed completely. Patients who have undergone radiation of the neovagina carry an additional risk.
Topics: Adult; Carcinoma, Squamous Cell; Female; Humans; Surgically-Created Structures; Vagina; Vaginal Neoplasms
PubMed: 11748997
DOI: 10.1006/gyno.2001.6417 -
Acta Obstetricia Et Gynecologica... 1989Neoplastic lesions of the vagina account for 1% of all gynecologic malignancies. The overall 5-year survival rate for this disease is poor. This study comprised 58...
Neoplastic lesions of the vagina account for 1% of all gynecologic malignancies. The overall 5-year survival rate for this disease is poor. This study comprised 58 patients with diagnosis of squamous cell carcinoma of the vagina treated between 1960 and 1984. Median age at diagnosis was 70 years. The lesions were staged according to FIGO. The numbers of patients in various stages were: I/13, II/24, III/12 and IV/9 and according to histologic differentiation: low grade/11, medium grade/17 and high grade/25; not recorded, 5. Twenty patients were treated with primary surgery and irradiation, 30 were treated with intracavitary and/or external irradiation only. The 5-year corrected survival rates were: St I/50%, St II/30%, St III/17% and St IV/10%; grade I/57%, grade 2/32% and grade 3/17%, younger than 70 years of age/43% and older than or 70 years of age/21%. The incidence of rectovaginal or vesicovaginal fistulas amounted to 17%. The treatment results of primary carcinoma of the vagina are poor. Prognostic factors for survival should be considered at treatment planning.
Topics: Aged; Carcinoma, Squamous Cell; Combined Modality Therapy; Female; Humans; Neoplasm Staging; Prognosis; Radiotherapy, High-Energy; Survival Rate; Vagina; Vaginal Neoplasms
PubMed: 2520784
DOI: 10.3109/00016348909021012 -
Journal of Lower Genital Tract Disease Jul 2015Creation of a neovagina is uncommon, but it may be performed for congenital absence or anomaly, after exenterative cancer surgery, or in male-to-female transsexuals. A... (Review)
Review
Creation of a neovagina is uncommon, but it may be performed for congenital absence or anomaly, after exenterative cancer surgery, or in male-to-female transsexuals. A variety of tissues may be used to create the neovagina. Lesions of the neovagina are uncommon and probably not well known to most practitioners. A review of these lesions will be helpful if such a patient presents.
Topics: 46, XX Disorders of Sex Development; Carcinoma; Chronic Disease; Congenital Abnormalities; Female; Humans; Male; Mullerian Ducts; Plastic Surgery Procedures; Sex Reassignment Procedures; Sexually Transmitted Diseases; Vagina; Vaginal Diseases; Vaginal Neoplasms
PubMed: 26111041
DOI: 10.1097/LGT.0000000000000110 -
Journal of Obstetrics and Gynaecology :... Jan 2017Carcinoma of the vagina is a rare disease, and it is even more rare when it appears in a neovagina, having its incidence and optimum treatment constantly discussed. The... (Review)
Review
Carcinoma of the vagina is a rare disease, and it is even more rare when it appears in a neovagina, having its incidence and optimum treatment constantly discussed. The aim of this article was to review the cases described in the currently available literature and describe the second documented case of carcinoma in a neovagina created with peritoneal flaps, and also list the possible pathways and risk factors for its development. The case we present is a 49-year-old female who after undergoing a laparoscopic colpectomy of the upper two-thirds of the vagina, with an immediate reconstruction with peritoneal flaps by laparoscopy, at a 4 months follow up presented a focal microinvasive squamous carcinoma in the vault of the neovagina. After reviewing the literature, we conclude that excisional treatment is the preferable option to avoid the progression to an invasive carcinoma. However, this case demonstrates the importance of the necessity to do regular cito-vulvovaginoscopic examinations after the complete surgical treatment because of the chance of persistent or recurrent lesions on the transplanted tissue.
Topics: Carcinoma, Squamous Cell; Colposcopy; Female; Humans; Laparoscopy; Middle Aged; Neoplasm Invasiveness; Peritoneum; Surgical Flaps; Vagina; Vaginal Neoplasms
PubMed: 27866418
DOI: 10.1080/01443615.2016.1234445 -
International Urogynecology Journal Nov 2011We present here the case report of a postmenopausal woman who complained of recurrent pus-like vaginal discharge and perianal pain 1 year after Le Fort colpocleisis,...
We present here the case report of a postmenopausal woman who complained of recurrent pus-like vaginal discharge and perianal pain 1 year after Le Fort colpocleisis, which was subsequently identified as a primary invasive carcinoma of the vagina. Biopsy confirmed a squamous cell carcinoma in the vagina, and the disease was classified as stage III according to FIGO staging. The patient received pelvic radiotherapy. This case emphasizes that differential diagnosis of recurrent vaginal discharge that presents remote from obliterative procedure for pelvic organ prolapse should consider not only pyometra, but also other causes.
Topics: Aged; Carcinoma, Squamous Cell; Diagnosis, Differential; Female; Humans; Pelvic Organ Prolapse; Pyometra; Vagina; Vaginal Discharge; Vaginal Neoplasms
PubMed: 21562914
DOI: 10.1007/s00192-011-1439-7 -
Radiologic Clinics of North America May 2002The imaging evaluation of female lower genital tract cancers has undergone dramatic changes in the last two decades. Technical improvements and increased availability of... (Review)
Review
The imaging evaluation of female lower genital tract cancers has undergone dramatic changes in the last two decades. Technical improvements and increased availability of cross-sectional modalities (US, CT, MR) have increased their use to such an extent that they have largely replaced more conventional imaging techniques. US is of limited value in the staging of vaginal and vulvar malignancies. CT is most useful for staging more advanced disease of the vagina and vulva. It is widely available and provides quick imaging time. CT is used in the detection and biopsy of suspected lymph nodes and metastases. MRI provides the best soft tissue contrast and is the most useful imaging modality available to evaluate carcinomas of the vagina and vulva. Future advancements in the imaging evaluation of vaginal and vulvar cancers will likely focus on functional imaging.
Topics: Diagnostic Imaging; Female; Humans; Vagina; Vaginal Diseases; Vulva; Vulvar Diseases
PubMed: 12117197
DOI: 10.1016/s0033-8389(01)00010-0