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Obstetrics and Gynecology Oct 1990A retrospective review was conducted of 53 women with invasive carcinoma of the vagina and without documented exposure to diethylstilbestrol who were seen at the...
A retrospective review was conducted of 53 women with invasive carcinoma of the vagina and without documented exposure to diethylstilbestrol who were seen at the University of California Irvine Medical Center, Long Beach Memorial Medical Center, and Saddleback Memorial Medical Center from 1976-1988. Forty-seven (89%) had squamous cell carcinoma and six (11%) adenocarcinoma. Thirty-seven (70%) were treated with whole-pelvis irradiation and brachytherapy, nine with surgery alone, and the other seven with a combination of treatments. The crude and corrected 2-year survival rates for the entire group were 47 and 69%, respectively. Those with previous pelvic surgery were more likely to develop serious treatment-related complications. There was a statistically significant correlation between previous hysterectomy and the diagnosis of primary invasive carcinoma of the vagina after the onset of symptoms. Women diagnosed during routine examination, before symptom onset, tended to have a survival advantage. All women, including those who have had hysterectomy, should be counseled to continue gynecologic cancer surveillance regardless of age.
Topics: Adenocarcinoma; California; Carcinoma, Squamous Cell; Combined Modality Therapy; Female; Humans; Hysterectomy; Middle Aged; Retrospective Studies; Survival Rate; Vagina; Vaginal Neoplasms
PubMed: 2216195
DOI: No ID Found -
European Journal of Gynaecological... 2014Multifocal microinvasive squamous cell carcinoma (SCC) with extensive spread of squamous cell carcinoma in situ (CIS) into the uterine corpus, salpinx, and vagina is...
Multifocal microinvasive squamous cell carcinoma with extensive spread of squamous cell carcinoma in situ (CIS) into the uterine corpus, vagina, and left salpinx diagnosed five years after conization of cervical CIS.
BACKGROUND
Multifocal microinvasive squamous cell carcinoma (SCC) with extensive spread of squamous cell carcinoma in situ (CIS) into the uterine corpus, salpinx, and vagina is extremely unusual.
CASE
The authors present a case of 69-year-old woman with hydrometra who was found to have multifocal microinvasive SCC in the endometrium. The CIS had spread superficially throughout the entire endometrium up to the fundus, completely replacing the epithelium. The uterine cervix, vaginal surface and left salpingeal mucosa were involved. She had previously undergone conization due to cervical CIS five years prior. The pathologic reports showed clear resection margins at that time.
CONCLUSION
The present case suggests that CIS in the endometrium spread back to the cervix and vagina, although the definite origin of the first CIS was not determined.
Topics: Aged; Carcinoma in Situ; Carcinoma, Squamous Cell; Fallopian Tubes; Female; Humans; Neoplasm Invasiveness; Uterine Cervical Neoplasms; Uterus; Vagina
PubMed: 25423715
DOI: No ID Found -
International Journal of Gynecological... Jul 2023Under 10% of gynaecological cancers are diagnosed in the vulva and vagina, mostly squamous cell carcinomas. Melanoma, Paget disease, basal cell carcinomas, and other...
Under 10% of gynaecological cancers are diagnosed in the vulva and vagina, mostly squamous cell carcinomas. Melanoma, Paget disease, basal cell carcinomas, and other cancers can present with vulval/vaginal symptoms. The pathology information system of a tertiary referral center for vulvo-vaginal cancers was searched for cancers of the vulva and vagina from 1996 to 2019. Squamous carcinomas were excluded, and the remaining entities were catalogued. A total of 221 nonsquamous cancers were found, including 135 vaginal and 86 vulval cases. One hundred eight cases of metastatic carcinomas from the endometrium, cervix, ovary, bowel, bladder, kidney, and breast formed the largest category. Basal cell carcinomas constituted the second largest category. Others included melanomas, Paget disease, and adenoid cystic carcinomas. Primary adenocarcinomas included porocarcinoma, mammary type carcinoma, enteric type carcinoma, clear cell carcinoma, Bartholin gland adenocarcinoma and malignant transformation of hidradenoma papilliferum. The vulva and vagina can harbor a wide range of nonsquamous malignancies. The most challenging of these are adenocarcinomas which can be metastatic from other sites. The dominance of metastatic carcinomas in this series is likely to reflect consultation practice of specialist pathologists.
Topics: Female; Humans; Vulva; Vagina; Vulvar Neoplasms; Carcinoma, Squamous Cell; Adenocarcinoma; Melanoma; Carcinoma, Basal Cell; Skin Neoplasms
PubMed: 36731045
DOI: 10.1097/PGP.0000000000000924 -
The Journal of Obstetrics and... Aug 1950
Topics: Abdomen; Carcinoma; Female; Humans; Neoplasms, Second Primary; Vagina
PubMed: 14779213
DOI: No ID Found -
British Journal of Cancer Jul 2004Protein patterns in six samples from primary vaginal cancers, in five from normal vaginal tissue and in five primary cervical cancers, were analysed using... (Comparative Study)
Comparative Study
Protein patterns in six samples from primary vaginal cancers, in five from normal vaginal tissue and in five primary cervical cancers, were analysed using two-dimensional polyacrylamide gel electrophoresis (2-DE). Protein expression profile was evaluated by computer-assisted image analysis (PDQUEST) and proteins were subsequently identified using matrix-assisted laser desorption/ionisation mass spectrometry. The aim was to analyse the protein expression profiles using the hierarchical clustering method in vaginal carcinoma and to compare them with the protein pattern in cervical carcinoma in order to find a helpful tool for correct classification and for increased biomedical knowledge. Protein expression data of a distinct set of 33 protein spots were differentially expressed. These differences were statistically significant (Mann-Whitney signed-Ranked Test, P<0.05) between normal tissue, vaginal and cervical cancer. Furthermore, protein profiles of pairs of primary vaginal and cervical cancers were found to be very similar. Some of the protein spots that have so far been identified include Tropomyosin 1, cytokeratin 5, 15 and 17, Apolipoprotein A1, Annexin V, Glutathione-S-transferase. Others are the stress-related proteins, calreticulin, HSP 27 and HSP 70. We conclude that cluster analysis of proteomics data allows accurate discrimination between normal vaginal mucosa, primary vaginal and primary cervical cancer. However, vaginal and cervical carcinomas also appear to be relatively homogeneous in their gene expression, indicating similar carcinogenic pathways. There might, further, be a possibility to identify tumour-specific markers among the proteins that are differentially expressed. The results from this study have to be confirmed by more comprehensive studies in the future.
Topics: Adenocarcinoma; Biomarkers, Tumor; Carcinoma, Squamous Cell; Electrophoresis, Gel, Two-Dimensional; Female; Humans; Neoplasm Proteins; Peptide Mapping; Proteome; Proteomics; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Uterine Cervical Neoplasms; Vagina; Vaginal Neoplasms
PubMed: 15199389
DOI: 10.1038/sj.bjc.6601944 -
Radiographics : a Review Publication of... 2008Primary vaginal malignancies are rare, accounting for only 1%-2% of all gynecologic malignancies. Squamous cell carcinoma makes up about 85% of primary vaginal... (Review)
Review
Primary vaginal malignancies are rare, accounting for only 1%-2% of all gynecologic malignancies. Squamous cell carcinoma makes up about 85% of primary vaginal malignancies. This tumor characteristically arises from the posterior wall of the upper third of the vagina. The main patterns of disease are an ulcerating or fungating mass or an annular constricting lesion. At magnetic resonance (MR) imaging, squamous cell carcinoma has intermediate signal intensity on T2-weighted images and low signal intensity on T1-weighted images. The tumors that account for the remaining 15% of primary vaginal malignancies are adenocarcinoma, melanoma, and sarcomas. The signal intensity characteristics on MR images correlate with the histologic subtypes and reflect the MR imaging appearances of these histologic subtypes elsewhere in the body. Secondary malignancy of the vagina is far more frequent than primary vaginal malignancy. Most vaginal metastases occur by means of direct local spread from the cervix, uterus, or rectum. The MR imaging appearances of these metastases reflect the MR imaging appearances of the primary tumor.
Topics: Adenocarcinoma; Carcinoma, Squamous Cell; Female; Humans; Image Enhancement; Magnetic Resonance Imaging; Practice Guidelines as Topic; Practice Patterns, Physicians'; Vagina; Vaginal Neoplasms
PubMed: 18203930
DOI: 10.1148/rg.281075065 -
American Journal of Obstetrics and... Feb 1977
Topics: Adult; Carcinoma in Situ; Female; Humans; Skin Transplantation; Transplantation, Autologous; Vagina; Vaginal Neoplasms; Vulva; Vulvar Neoplasms
PubMed: 319668
DOI: 10.1016/0002-9378(77)90479-3 -
Journal of the American Academy of... Aug 1984Epidermotropic carcinomas are neoplasms with an unusual but specific propensity for invading and intimately associating with the epidermis. A unique case of squamous...
Epidermotropic carcinomas are neoplasms with an unusual but specific propensity for invading and intimately associating with the epidermis. A unique case of squamous cell carcinoma of the vagina with epidermotropic cutaneous metastases is described.
Topics: Aged; Carcinoma, Squamous Cell; Combined Modality Therapy; Female; Humans; Skin Neoplasms; Uterine Cervical Neoplasms; Vagina; Vaginal Neoplasms; Vulvar Neoplasms
PubMed: 6480941
DOI: 10.1016/s0190-9622(84)70171-x -
Gynecologic Oncology Jan 1987A patient who developed squamous cell carcinoma in situ in a split-thickness skin graft neovagina is presented. This is the third reported case in the English literature...
A patient who developed squamous cell carcinoma in situ in a split-thickness skin graft neovagina is presented. This is the third reported case in the English literature of a patient previously treated for carcinoma in situ of the vagina who later developed an identical lesion in the graft. Management of this neoplasm is discussed, and follow-up for patients with neovaginas is emphasized.
Topics: Carcinoma in Situ; Female; Humans; Middle Aged; Neoplasm Recurrence, Local; Skin Transplantation; Vagina; Vaginal Neoplasms
PubMed: 3539716
DOI: 10.1016/0090-8258(87)90075-8 -
Obstetrics and Gynecology Annual 1980
Topics: Adenocarcinoma; Adult; Carcinoma, Squamous Cell; Child; Child, Preschool; Diethylstilbestrol; Female; Humans; Melanoma; Prognosis; Vagina; Vaginal Neoplasms
PubMed: 7402504
DOI: No ID Found