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BMJ Case Reports Oct 2023A primiparous woman in her mid-30s presented at 31 weeks of gestation with a large vaginal mass obstructing the cervix, initially concerning for malignancy. Pelvic MRI...
A primiparous woman in her mid-30s presented at 31 weeks of gestation with a large vaginal mass obstructing the cervix, initially concerning for malignancy. Pelvic MRI confirmed a vaginal lesion located on the lateral wall, and histopathology diagnosed a giant condyloma acuminatum. The vaginal lesion was surgically resected at 34 weeks of gestation, and the patient proceeded to have a successful vaginal birth. Our case report demonstrates an unusual presentation of a rare anogenital disease and highlights a differential diagnosis for cervical and vaginal lesions.
Topics: Pregnancy; Female; Humans; Buschke-Lowenstein Tumor; Condylomata Acuminata; Diagnosis, Differential; Vagina
PubMed: 37788919
DOI: 10.1136/bcr-2023-255996 -
Gynecologic Oncology Jun 1982
Topics: Adult; Age Factors; Aged; Carcinoma, Squamous Cell; Female; Humans; Lymph Node Excision; Lymphatic Metastasis; Middle Aged; Neoplasm Metastasis; Vagina; Vaginal Neoplasms; Vesicovaginal Fistula
PubMed: 7095576
DOI: 10.1016/0090-8258(82)90075-0 -
The Journal of Veterinary Medical... Jun 2016During artificial insemination of an 18-year-old female Japanese Black cow, a mass that was of a hen's egg size was found in the vagina. On necropsy, the firm mass,...
During artificial insemination of an 18-year-old female Japanese Black cow, a mass that was of a hen's egg size was found in the vagina. On necropsy, the firm mass, measuring approximately 3.5 × 3.5 × 3.0 cm, was located at the superior region of the vagina. The cut surface of the mass was gray-white in color with occasional necrotic or hemorrhagic areas. Histologically, the mass was composed of tumor cells arranged in solid nests of various sizes with an occasional tubular structure separated by a delicate fibrovascular stroma. The tumor cells had a hypochromatic nucleus and abundant, faintly eosinophilic cytoplasm. The tumor cells contained diastase-sensitive periodic acid-Schiff positive granules. Immunohistochemically, tumor cells were positive for cytokeratin AE1/AE3, CAM5.2 and carcinoembryonic antigen, but not for vimentin, p63, estrogen receptor-α, progesterone receptor, α-smooth muscle actin, neuron-specific enolase, S-100 protein and chromogranin A. On the basis of these findings, the tumor was diagnosed as a clear cell carcinoma of the vagina.
Topics: Adenocarcinoma, Clear Cell; Animals; Cattle; Cattle Diseases; Female; Vagina; Vaginal Neoplasms
PubMed: 26852732
DOI: 10.1292/jvms.15-0665 -
International Journal of Gynecological... Nov 2022Primary carcinomas of the vagina are uncommon and currently detailed recommendations for the reporting of resection specimens of these neoplasms are not widely...
Primary carcinomas of the vagina are uncommon and currently detailed recommendations for the reporting of resection specimens of these neoplasms are not widely available. The International Collaboration on Cancer Reporting (ICCR) is developing standardized, evidence-based reporting data sets for multiple cancer sites. We describe the development of a cancer data set by the ICCR expert panel for the reporting of primary vaginal carcinomas and present the core and noncore data elements with explanatory commentaries. This data set has incorporated the updates in the 2020 World Health Organization Classification of Female Genital Tumours, 5th edition. The data set addresses controversial issues such as tumor grading, margin assessment, and the role of ancillary studies. The adoption of this data set into clinical practice will help ensure standardized data collection across different countries, facilitate future research on vaginal carcinomas, and ultimately lead to improvements in patient care.
Topics: Female; Humans; Pathology, Clinical; Carcinoma; Neoplasm Grading; Vagina
PubMed: 35703457
DOI: 10.1097/PGP.0000000000000883 -
European Journal of Gynaecological... 2013Endometrial cancer is the most frequent malignancy of the female reproductive system, while cutaneous metastasis is extremely rare in endometrial cancer. The authors... (Review)
Review
Endometrial cancer is the most frequent malignancy of the female reproductive system, while cutaneous metastasis is extremely rare in endometrial cancer. The authors herein report a case ofendometrial adenocarcinoma (FIGO Stage IIIC2, Grade 2) with metastasis to the skin of right lower leg and vaginal orifice. The patient was treated with local excision and combination chemotherapy, but she did not respond to therapy and died within 11 months. The authors reviewed the clinico-pathologic features, treatment, and prognosis of such case with cutaneous metastasis.
Topics: Adenocarcinoma; Endometrial Neoplasms; Female; Humans; Leg; Middle Aged; Skin Neoplasms; Vagina
PubMed: 24020146
DOI: No ID Found -
International Journal of Gynecological... May 2017Very few cases of placental site trophoblastic tumor (PSTT) primarily involving extrauterine sites have been reported to date. We report a case of a 29-year-old female...
Very few cases of placental site trophoblastic tumor (PSTT) primarily involving extrauterine sites have been reported to date. We report a case of a 29-year-old female who presented with a vaginal nodule 9 months after delivery at an outside hospital which was initially diagnosed as a poorly differentiated squamous cell carcinoma. Subsequently she was referred to our institute, and on the basis of histology, mildly elevated serum β-HCG level, and immunohistochemistry, PSTT was diagnosed. After the completion of chemotherapy, the vaginal nodule completely regressed and serum β-hCG returned to baseline. Her follow-up has been unremarkable. This case highlights the importance of the fact that PSTT can be easily misdiagnosed at extrauterine sites in the absence of proper clinical, histologic, and immunohistochemical correlation.
Topics: Adult; Chorionic Gonadotropin, beta Subunit, Human; Diagnostic Errors; Female; Humans; Hysterectomy; Immunohistochemistry; Pregnancy; Trophoblastic Tumor, Placental Site; Uterine Neoplasms; Vagina
PubMed: 27513078
DOI: 10.1097/PGP.0000000000000318 -
Differentiation; Research in Biological... Oct 2011In mammals, the female reproductive tract (FRT) develops from a pair of paramesonephric or Müllerian ducts (MDs), which arise from coelomic epithelial cells of... (Review)
Review
In mammals, the female reproductive tract (FRT) develops from a pair of paramesonephric or Müllerian ducts (MDs), which arise from coelomic epithelial cells of mesodermal origin. During development, the MDs undergo a dynamic morphogenetic transformation from simple tubes consisting of homogeneous epithelium and surrounding mesenchyme into several distinct organs namely the oviduct, uterus, cervix and vagina. Following the formation of anatomically distinctive organs, the uniform MD epithelium (MDE) differentiates into diverse epithelial cell types with unique morphology and functions in each organ. Classic tissue recombination studies, in which the epithelium and mesenchyme isolated from the newborn mouse FRT were recombined, have established that the organ specific epithelial cell fate of MDE is dictated by the underlying mesenchyme. The tissue recombination studies have also demonstrated that there is a narrow developmental window for the epithelial cell fate determination in MD-derived organs. Accordingly, the developmental plasticity of epithelial cells is mostly lost in mature FRT. If the signaling that controls epithelial differentiation is disrupted at the critical developmental stage, the cell fate of MD-derived epithelial tissues will be permanently altered and can result in epithelial lesions in adult life. A disruption of signaling that maintains epithelial cell fate can also cause epithelial lesions in the FRT. In this review, the pathogenesis of cervical/vaginal adenoses and uterine squamous metaplasia is discussed as examples of such incidences.
Topics: Adenocarcinoma, Clear Cell; Animals; Cell Differentiation; Cervix Uteri; Diethylstilbestrol; Epithelial Cells; Estrogens, Non-Steroidal; Female; Humans; Mesoderm; Metaplasia; Mullerian Ducts; Organogenesis; Uterine Neoplasms; Uterus; Vagina
PubMed: 21612855
DOI: 10.1016/j.diff.2011.04.008 -
Gynecologic Oncology Feb 1994The development of carcinoma in a neovagina is a rare occurrence. A case of mucinous adenocarcinoma of a neovagina is presented. A neovagina was formed in 1945 to... (Review)
Review
The development of carcinoma in a neovagina is a rare occurrence. A case of mucinous adenocarcinoma of a neovagina is presented. A neovagina was formed in 1945 to correct a congenital anomaly. Subsequently the patient developed a chronic rectovaginal fistula. It is thought that the mucinous adenocarcinoma developed as a result of chronic inflammation secondary to the fistula. Although rare, development of a malignancy in ectopic tissue can occur. Clinicians need to be aware of this as they follow these patients.
Topics: Adenocarcinoma, Mucinous; Adult; Female; Humans; Postoperative Complications; Surgery, Plastic; Vagina; Vaginal Neoplasms
PubMed: 8314151
DOI: 10.1006/gyno.1994.1045 -
Obstetrics and Gynecology Clinics of... Mar 1993Both epithelial and structural abnormalities of the lower genital tract are known to occur in women exposed in utero to DES with greater frequency than in the general... (Review)
Review
Both epithelial and structural abnormalities of the lower genital tract are known to occur in women exposed in utero to DES with greater frequency than in the general population. These changes are usually easily identified by pelvic and colposcopic examination. In general, no treatment is suggested for benign changes. DES-exposed women, however, must be carefully followed-up because of the potential, although rare, of the development of clear cell adenocarcinoma and the increased incidence of squamous intraepithelial neoplasia. With rare exception, screening at yearly intervals is sufficient.
Topics: Adenocarcinoma; Adolescent; Adult; Biopsy; Carcinoma in Situ; Carcinoma, Squamous Cell; Cervix Uteri; Colposcopy; Diethylstilbestrol; Female; Genital Neoplasms, Female; Genitalia, Female; Humans; Maternal-Fetal Exchange; Metaplasia; Pregnancy; Prenatal Exposure Delayed Effects; Vagina
PubMed: 8332308
DOI: No ID Found -
American Journal of Obstetrics and... Dec 1950
Topics: Carcinoma; Female; Humans; Pregnancy; Vagina
PubMed: 14789908
DOI: 10.1016/0002-9378(50)90027-5