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Current Problems in Surgery Dec 1987
Review
Topics: Gastrectomy; History, 15th Century; History, 16th Century; History, 17th Century; History, 18th Century; History, 19th Century; History, Ancient; Humans; Stomach Ulcer; Vagotomy
PubMed: 3319433
DOI: 10.1016/0011-3840(87)90018-9 -
Khirurgiia 2001
Review
Topics: Duodenal Ulcer; Humans; Prognosis; Reproducibility of Results; Vagotomy
PubMed: 11247026
DOI: No ID Found -
Current Surgery 1983
Review
Topics: Duodenal Ulcer; Humans; Peptic Ulcer Perforation; Postoperative Complications; Recurrence; Stomach Ulcer; Vagotomy; Vagotomy, Proximal Gastric
PubMed: 6342979
DOI: No ID Found -
Surgery Annual 1989
Review
Topics: Humans; Hydrogen-Ion Concentration; Intraoperative Care; Premedication; Staining and Labeling; Vagotomy; Vagotomy, Proximal Gastric
PubMed: 2470158
DOI: No ID Found -
Annals of Surgery Jul 1996The authors compared open and laparoscopic proximal gastric vagotomies for efficacy of acid reduction and preservation of gastric emptying. (Comparative Study)
Comparative Study
OBJECTIVE
The authors compared open and laparoscopic proximal gastric vagotomies for efficacy of acid reduction and preservation of gastric emptying.
SUMMARY BACKGROUND DATA
Laparoscopic methods have been used to perform vagotomy in patients with duodenal ulcer; however, no direct comparisons are available of laparoscopic and open surgical procedures regarding acid reduction and gastric emptying.
METHODS
Thirty-one consecutive dogs were randomized to open proximal gastric vagotomy (OPGV; n = 11), laparoscopic anterior seromyotomy and posterior truncal vagotomy (ASPTV; n = 10), or laparoscopic proximal gastric vagotomy (LPGV; n = 10). Intraoperative endoscopic Congo red testing assured complete vagotomy. Basal acid output (BAO) and maximal acid output (MAO) during pentagastrin and insulin-induced hypoglycemia were measured with marker dilution techniques, and gastric emptying was assessed with radionuclide-labelled solid and liquid markers before and 5 weeks after operation.
RESULTS
Operative time (mean +/- standard error of the mean) for OPGV was shorter compared with ASPTV and LPGV (86 +/- 7 minutes vs. 124 +/- 7 minutes and 115 +/- 7 minutes; p < 0.002). Postoperative BAO did not decrease in any group. Open proximal gastric vagotomy and LPGV, but not ASPTV, decreased MAO (p < 0.05); (after pentagastrin, OPGV from 26.4 +/- 1.7 mEq/hour to 11.3 +/- 0.1 mEq/hour, LPGV from 21.4 +/- 1.0 mEq/hour to 6.4 +/- 0.5 mEq/hour; after insulin-induced hypoglycemia, OPGV from 9.9 +/- 0.5 mEq/hour to 2.2 +/- 0.3 mEq/hour, LPGV from 7.9 +/- 0.5 mEq/hour to 1.9 +/- 0.4 mEq/hour). Gastric emptying of liquids and solids, as quantitated by the time for one half of the marker to empty (T 1/2) and the shape of the emptying curve, were similar before and after all three surgical procedures.
CONCLUSIONS
Laparoscopic proximal gastric vagotomy was comparable to OPGV in decreasing stimulated gastric acid production without significantly altering gastric emptying. Anterior seromyotomy and posterior truncal vagotomy was less effective in decreasing MAO and required more operative time. Laparoscopic proximal gastric vagotomy has the potential to become accepted therapy for patients with duodenal ulcer managed presently with OPGV.
Topics: Animals; Congo Red; Dogs; Evaluation Studies as Topic; Female; Gastric Acid; Gastric Emptying; Laparoscopy; Male; Random Allocation; Time Factors; Vagotomy, Proximal Gastric; Vagotomy, Truncal
PubMed: 8678617
DOI: 10.1097/00000658-199607000-00007 -
The American Journal of the Medical... Jun 1989The present study investigated the integrity of the rat gastric mucosa after 6 hours of vagotomy without drainage. Transection vagotomy was employed to ensure complete...
The present study investigated the integrity of the rat gastric mucosa after 6 hours of vagotomy without drainage. Transection vagotomy was employed to ensure complete gastric vagal denervation. Vagotomy without drainage produced gastric distension and mucosal injury confined to the glandular part. Anterior truncal vagotomy produced injury in 70% of rats, whereas truncal or transection vagotomy produced injury in all rats. The injury score with transection vagotomy was significantly higher than that with anterior truncal (21.2 mm2 +/- 1.6 vs. 8 mm2 +/- 2.7, mean +/- SEM, n = 10, p less than .01) or truncal vagotomy (21.2 mm2 +/- 1.6 vs. 15.6 mm2 +/- 1.4, mean +/- SEM, n = 10, p less than .05). Histologic examination of the mucosal injury revealed necrosis involving the epithelium and lamina propria. Cholestyramine, pyloroplasty, or gastric diversion protected the stomach against the vagotomy-induced mucosal injury. The results demonstrate in the rat that vagotomy without drainage produces within 6 hours injury of the gastric mucosa, which increases as vagal denervation is rendered more complete. Because cholestyramine protects the rat stomach against vagotomy-induced acute gastric mucosal injury, reflux of duodenal contents appears to be the principal factor behind this injury. Pyloroplasty prevents gastric distension but probably not duodenal contents refluxing, suggesting that this distention also may have a role in the mechanism of the said injury.
Topics: Animals; Cholestyramine Resin; Drainage; Female; Gastric Acid; Gastric Emptying; Gastric Mucosa; Male; Pylorus; Rats; Rats, Inbred Strains; Stomach; Vagotomy; Vagotomy, Truncal
PubMed: 2735340
DOI: 10.1097/00000441-198906000-00002 -
Science (New York, N.Y.) Aug 1981The site where peripherally administered cholecystokinin-8 elicits satiety was investigated by injecting rats with cholecystokinin-8 (1 to 8 micrograms per kilogram of...
The site where peripherally administered cholecystokinin-8 elicits satiety was investigated by injecting rats with cholecystokinin-8 (1 to 8 micrograms per kilogram of body weight, intraperitoneally) after they had received bilateral lesions of the ventromedial hypothalamus or after they had undergone bilateral abdominal vagotomy or selective vagotomies. Abdominal vagotomy or gastric vagotomy abolished or reduced the satiety effect of cholecystokinin, but lesions of the ventromedial hypothalamus did not. These results demonstrate that peripherally administered cholecystokinin acts in the abdomen through gastric vagal fibers and not directly on the brain to produce satiety in the rat.
Topics: Afferent Pathways; Animals; Brain; Cholecystokinin; Efferent Pathways; Rats; Satiation; Stomach; Vagotomy
PubMed: 7268408
DOI: 10.1126/science.7268408 -
Lancet (London, England) Dec 1976
Comparative Study
Topics: Esophagus; Humans; Nerve Regeneration; Pyloric Antrum; Recurrence; Stomach Ulcer; Vagotomy
PubMed: 63777
DOI: 10.1016/s0140-6736(76)92067-5 -
Nihon Heikatsukin Gakkai Zasshi Dec 1976
Topics: Animals; Cryosurgery; Dogs; Vagotomy
PubMed: 1035773
DOI: No ID Found -
MMW, Munchener Medizinische... Jun 1976
Topics: Duodenal Ulcer; Humans; Vagotomy
PubMed: 819803
DOI: No ID Found