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North Carolina Medical Journal Apr 1952
Topics: North Carolina; Veratrum; Veratrum Alkaloids
PubMed: 14941483
DOI: No ID Found -
Ceskoslovenska Farmacie Dec 1953
Topics: Veratrum Alkaloids
PubMed: 13127020
DOI: No ID Found -
Zeitschrift Fur Die Gesamte Innere... Jun 1954
Topics: Veratrum Alkaloids
PubMed: 24543266
DOI: No ID Found -
Quarterly Bulletin. Northwestern... 1954
Topics: Female; Pre-Eclampsia; Pregnancy; Veratrum Alkaloids
PubMed: 13215750
DOI: No ID Found -
Zeitschrift Fur Naturforschung. C,... 2010Twelve steroidal alkaloids were isolated from four populations of Veratrum lobelianum Bernh. and Veratrum nigrum L. Full NMR data for veralosinine (1), and extensive 1H...
Twelve steroidal alkaloids were isolated from four populations of Veratrum lobelianum Bernh. and Veratrum nigrum L. Full NMR data for veralosinine (1), and extensive 1H NMR data for veralosine (3) and teinemine (5) are presented here for the first time. (+/-)-15-O-(2-Methylbutyroyl)germine (10) is undescribed up to now. The antiproliferative activities of veranigrine, veralosinine, and neogermitrine have shown that they are a perspective for further studies.
Topics: Animals; Bulgaria; Cell Division; Leukemia L5178; Magnetic Resonance Spectroscopy; Medicine, Traditional; Mice; Models, Molecular; Mongolia; Phytosterols; Veratrum; Veratrum Alkaloids
PubMed: 20469637
DOI: 10.1515/znc-2010-3-405 -
Phytotherapy Research : PTR Jun 2010Ten steroidal alkaloids - cyclopamine, veratramine, jervine, 3, 15-diangyloylgermine, 3-angyloylzygadenine, 3-veratroyl zygadenine, 15-veratroylgermine, germine,...
Ten steroidal alkaloids - cyclopamine, veratramine, jervine, 3, 15-diangyloylgermine, 3-angyloylzygadenine, 3-veratroyl zygadenine, 15-veratroylgermine, germine, veratrosine and pseudojervine - from Veratrum dahuricum, together with the ethanol extract and total alkaloids, were evaluated for their antitumor and antiplatelet activities. Cyclopamine, veratramine and germine significantly inhibited the hedgehog pathway in NIH/3T3 cells. Cyclopamine exerted a potent inhibitory effect against the growth of PANC-1 tumors in mice, with inhibition rates of 40.64%, 44.37%, 46.77% at doses of 5.0, 15.0 and 50.0 mg kg-1, respectively. Veratroylgermine was found to produce the strongest inhibition against the platelet aggregation induced by arachidonic acid, with inhibition rate of 92.0% at 100 microM.
Topics: Animals; Antineoplastic Agents, Phytogenic; Drug Screening Assays, Antitumor; Female; Male; Mice; Mice, Inbred BALB C; Molecular Structure; Plant Extracts; Platelet Aggregation Inhibitors; Rabbits; Veratrum; Veratrum Alkaloids
PubMed: 20013819
DOI: 10.1002/ptr.3022 -
British Journal of Pharmacology and... Dec 1951
Topics: Blood Pressure; Blood Pressure Determination; Veratrum Alkaloids
PubMed: 14904893
DOI: 10.1111/j.1476-5381.1951.tb00679.x -
Physiological Reviews Jul 1946
Topics: Veratrum; Veratrum Alkaloids
PubMed: 20993555
DOI: 10.1152/physrev.1946.26.3.383 -
Acta Medica Scandinavica 1955
Topics: Alkaloids; Cardiovascular Agents; Hexamethonium; Hypertension; Muscle Relaxants, Central; Salts; Veratrum; Veratrum Alkaloids
PubMed: 14398136
DOI: 10.1111/j.0954-6820.1955.tb10317.x -
Journal of Medicinal and Pharmaceutical... Jul 1962
Topics: Alkaloids; Chemical Phenomena; Chemistry; Research; Veratrine; Veratrum; Veratrum Alkaloids
PubMed: 14056401
DOI: 10.1021/jm01239a002