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The Journal of Organic Chemistry May 2012A Veratrum piperidine chiron was prepared over 11 steps (7.9% yield) from (-)-citronellal. Three methods for the installation of the propargylic side chain onto a cyclic...
A Veratrum piperidine chiron was prepared over 11 steps (7.9% yield) from (-)-citronellal. Three methods for the installation of the propargylic side chain onto a cyclic enamide are presented.
Topics: Caprylates; Magnetic Resonance Spectroscopy; Molecular Structure; Piperidines; Stereoisomerism; Sulfonamides; Veratrum Alkaloids
PubMed: 22401662
DOI: 10.1021/jo2026228 -
Journal of Pharmaceutical Sciences May 1961
Topics: Organic Chemicals; Protoveratrines; Structure-Activity Relationship; Veratrum; Veratrum Alkaloids
PubMed: 13755215
DOI: 10.1002/jps.2600500505 -
Journal of Pharmaceutical Sciences Dec 1962
Topics: Aged; Animals; Antihypertensive Agents; Dogs; Emetics; Humans; Hypotension; Organic Chemicals; Protoveratrines; Veratrum; Veratrum Alkaloids
PubMed: 13999314
DOI: 10.1002/jps.2600511207 -
Journal of Medicinal and Pharmaceutical... Jan 1961
Topics: Esters; Hypotension; Protoveratrines; Structure-Activity Relationship; Veratrum; Veratrum Alkaloids
PubMed: 14460651
DOI: 10.1021/jm50014a008 -
Journal of Pharmaceutical Sciences Dec 1962
Topics: Antihypertensive Agents; Hypotension; Organic Chemicals; Protoveratrines; Structure-Activity Relationship; Veratrum; Veratrum Alkaloids
PubMed: 13927424
DOI: 10.1002/jps.2600511206 -
The Journal of Pharmacology and... Jan 1955
Topics: Animals; Central Nervous System; Mice; Veratrum Alkaloids
PubMed: 13234031
DOI: No ID Found -
Current Pharmaceutical Design 2016The natural steroidal alkaloid cyclopamine has been identified as the first inhibitor of the Hedgehog (Hh) signaling pathway, which is implicated in embryonic... (Review)
Review
The natural steroidal alkaloid cyclopamine has been identified as the first inhibitor of the Hedgehog (Hh) signaling pathway, which is implicated in embryonic development and tumorigenesis, as well as is hyperactivated in cancer stem cells (CSCs). The list of Hh-dependent tumors is steadily growing, and it has been estimated that about 25% of all cancer deaths show signs of aberrant Hh pathway activation. Notably, cyclopamine has been found to exert anticancer activity against several types of human cancer and to inhibit CSCs proliferation, thus highlighting the druggability of the Hh pathway and paving new opportunities in anticancer drug discovery. The aim of the present work is to review the main synthetic strategies to cyclopamine and its derivatives, with particular emphasis on the challenging chemical modifications aimed at improving the biological activity of the molecule.
Topics: Animals; Hedgehog Proteins; Humans; Molecular Structure; Neoplasms; Neoplastic Stem Cells; Signal Transduction; Veratrum Alkaloids
PubMed: 26759083
DOI: 10.2174/1381612822666160112130157 -
The Journal of Pediatrics Feb 1952
Topics: Veratrum; Veratrum Alkaloids
PubMed: 14908826
DOI: 10.1016/s0022-3476(52)80187-8 -
Journal of Toxicology. Clinical... Apr 1983Sneezing-powders containing pulverized root of veratrum album (white hellebore) have recently been marketed in the Scandinavian countries. The powder, imported from the...
Sneezing-powders containing pulverized root of veratrum album (white hellebore) have recently been marketed in the Scandinavian countries. The powder, imported from the Federal Republic of Germany, has caused severe intoxications.
Topics: Child; Child, Preschool; Humans; Infant; Male; Powders; Veratrum Alkaloids
PubMed: 6887310
DOI: 10.3109/15563658308990062 -
Annales Universitatis Saraviensis.... 1976
Review
Topics: Animals; Cevanes; Humans; Hydrogen-Ion Concentration; Muscles; Protein Binding; Serum Albumin; Veratrum Alkaloids
PubMed: 10826
DOI: No ID Found