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Toxicology Letters Oct 2019We investigate the long-term effect of very-low dose exposure to a mixture of six pesticides associated with hydrophilic vitamin deficiency on the neurobehavioral...
We investigate the long-term effect of very-low dose exposure to a mixture of six pesticides associated with hydrophilic vitamin deficiency on the neurobehavioral outcomes of rats. Two hundred Wistar rats were divided into four groups, two control groups, a vitamin sufficient control group and a vitamin deficiency control group and 2 test groups, a vitamin sufficient test group, and a vitamin deficiency group. The test groups were exposed for 9 months to a mixture of diquat, imazamox, imazethapyr, tepraloxydin, bentazone and acifluorfen in doses of 0.01xNOAEL (mg/kg bw/day). After 9 months of exposure, the behavior changes were evaluated by open field test and elevated plus maze test and the memory was assessed by passive avoidance test. Chronic vitamin deficiency decreased locomotor and special orientation activity and increased anxiety-like behavior in rats. Exposure to very low doses of a mixture of 6 pesticides caused central nervous effects, manifested as decreased locomotor activity, and increased anxiety levels. Vitamin deficiency and low dose chronic pesticides mixture exposure thus affected the central nervous system, especially long-term memory.
Topics: Animals; Avitaminosis; Avoidance Learning; Disease Models, Animal; Male; Maze Learning; Nervous System Diseases; Pesticides; Rats; Rats, Wistar
PubMed: 31386889
DOI: 10.1016/j.toxlet.2019.07.026 -
Military Medicine Nov 1991
Review
Topics: Humans; Middle East; Prisoners; United States; Vitamin A Deficiency; Vitamin B Deficiency; Warfare
PubMed: 1771019
DOI: No ID Found -
Quintessence International Jun 1970
Topics: Avitaminosis; Oral Manifestations
PubMed: 5268670
DOI: No ID Found -
Journal of Neural Transmission (Vienna,... 2007Pseudoexfoliation syndrome (PEX) is a systemic disorder characterized by the deposition of an abnormal fibrillar material in ocular and various extraocular tissues. It...
Pseudoexfoliation syndrome (PEX) is a systemic disorder characterized by the deposition of an abnormal fibrillar material in ocular and various extraocular tissues. It represents the most common identifiable cause of glaucoma (PEX glaucoma = PEXG). Due to similar pathogenetic mechanisms, glaucoma has been called "ocular Alzheimer's disease". PEXG and Alzheimer's disease share common associations such as the higher prevalence of hyperhomocysteinemia in both disorders. In order to investigate the cause of hyperhomocysteinemia in PEXG, we evaluated B-vitamin levels (folate, B12, B6) and their associations with homocysteine (Hcy) in plasma of 70 PEXG patients and 70 control subjects. Folate, vitamin B12 and B6 levels were significantly decreased and associated with elevated Hcy levels in PEXG. Low B-vitamin levels in PEX might also help explain, at least in part, the higher prevalence of B-vitamin deficiency in disorders associated with PEX such as Alzhemier's disease.
Topics: Aged; Case-Control Studies; Exfoliation Syndrome; Eye; Female; Folic Acid Deficiency; Glaucoma; Humans; Hyperhomocysteinemia; Male; Middle Aged; Prospective Studies; Vitamin B 12 Deficiency; Vitamin B 6 Deficiency; Vitamin B Deficiency
PubMed: 17238009
DOI: 10.1007/s00702-006-0598-z -
Brain and Nerve = Shinkei Kenkyu No... Oct 2022Vitamin deficiencies and excesses are known to cause various types of brain or peripheral nerve injuries. Improved nutritional status and dietary patterns have led to...
Vitamin deficiencies and excesses are known to cause various types of brain or peripheral nerve injuries. Improved nutritional status and dietary patterns have led to reduced prevalence, and at least some of these conditions are rare in recent times. However, delayed diagnosis (For example, in patients with Wernicke's encephalopathy) may worsen patient prognosis even in current times. Recent studies have reported an association between cognitive function and some vitamins. In this article, we summarize past and present research focused on neurological symptoms that occur secondary to vitamin deficiencies and excesses.
Topics: Avitaminosis; Humans; Prevalence; Prognosis; Thiamine; Vitamins; Wernicke Encephalopathy
PubMed: 36198646
DOI: 10.11477/mf.1416202210 -
Pediatric Nephrology (Berlin, Germany) Jul 2018Pediatric dialysis patients are at risk of nutritional illness secondary to deficiencies in water-soluble vitamins and trace elements. Unlike 25-OH vitamin D, most other... (Review)
Review
Pediatric dialysis patients are at risk of nutritional illness secondary to deficiencies in water-soluble vitamins and trace elements. Unlike 25-OH vitamin D, most other vitamins and trace elements are not routinely monitored in the blood and, consequently, the detection of any deficiency may not occur until significant complications develop. Causes of vitamin and trace element deficiency in patients on maintenance dialysis patient are multifactorial, ranging from diminished nutritional intake to altered metabolism as well as dialysate-driven losses of water-soluble vitamins and select trace elements. In this review we summarize the nutritional sources of key water-soluble vitamins and trace elements with a focus on the biological roles and clinical manifestations of their respective deficiency to augment awareness of potential nutritional illness in pediatric patients receiving maintenance dialysis. The limited pediatric data on the topic of clearance of water-soluble vitamins and trace elements by individual dialysis modality are reviewed, including a brief discussion on clearance of water-soluble vitamins and trace elements with continuous renal replacement therapy.
Topics: Avitaminosis; Child; Dialysis Solutions; Humans; Kidney Failure, Chronic; Nutritional Requirements; Nutritional Status; Renal Dialysis; Trace Elements; Vitamins
PubMed: 28752387
DOI: 10.1007/s00467-017-3751-z -
The Punjab Medical Journal May 1946
Topics: Avitaminosis; Deficiency Diseases; Female; Humans; Pregnancy; Pregnancy Complications
PubMed: 20281990
DOI: No ID Found -
World Journal of Gastroenterology Mar 2019Symptoms of gastroenteropancreatic located neuroendocrine neoplasms (GEP-NENs) are often related to food intake and manifest as abdominal pain or diarrhoea which can... (Review)
Review
Symptoms of gastroenteropancreatic located neuroendocrine neoplasms (GEP-NENs) are often related to food intake and manifest as abdominal pain or diarrhoea which can influence patients nutritional status. Malnutrition is common in cancer patients and influences quality of life, treatment options and survival but is also present in up to 40% of patients with GEP-NENs. As part of malnutrition there are often deficiencies in fat-soluble vitamins, mainly vitamin D. Little knowledge exists on trace elements. Several factors influence the development of malnutrition such as size and localisation of the primary tumour as well as metastases, side effects from treatment but also hormone production of the tumour itself. One of the main influencing factors leading to malnutrition is diarrhoea which leads to dehydration and electrolyte disturbances. Treatment of diarrhoea should be guided by its cause. Screening for malnutrition should be part of routine care in every GEP-NEN patient. Multidisciplinary treatment including dietician support is necessary for all malnourished patients with GEP-NENs.
Topics: Avitaminosis; Diarrhea; Gastrointestinal Neoplasms; Humans; Malnutrition; Neuroendocrine Tumors; Nutritional Status; Prognosis; Quality of Life; Trace Elements; Vitamins
PubMed: 30886501
DOI: 10.3748/wjg.v25.i10.1171 -
Recent Progress in Psychiatry 1950
Topics: Avitaminosis; Humans; Mental Disorders; Nervous System; Psychotic Disorders; Vitamins
PubMed: 24539442
DOI: No ID Found -
International Journal For Vitamin and... 1984
Review
Topics: Animals; Avitaminosis; General Adaptation Syndrome; Humans; Stress, Psychological
PubMed: 6434483
DOI: No ID Found