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Der Ophthalmologe : Zeitschrift Der... Jul 2015The vitreous body is the largest component of the eye. It is a colorless, gelatinous, highly hydrated matrix that fills the posterior segment of the eye between the...
BACKGROUND AND PURPOSE
The vitreous body is the largest component of the eye. It is a colorless, gelatinous, highly hydrated matrix that fills the posterior segment of the eye between the lens, the ciliary body and the retina. Changes in vitreal structure that occur with aging, such as vitreous liquefaction and fiber aggregation (vitreous syneresis) are important in the pathogenesis of many vitreoretinal diseases. During senescence, the vitreous volume is reduced, the vitreous body collapses and the vitreal fibers are continuously thickened, become more tortuous and surrounded by liquefied vitreous. This sequence of age-related changes results from a progressive reorganization of the hyaluronic acid and collagen molecular networks.
RESULTS AND DISCUSSION
Although the vitreous body may at first glance appear to be a redundant tissue than can be removed and almost normal ocular function will still be maintained, the vitreous body and the vitreoretinal interface have a crucial influence on the physiology and pathophysiology of the eye. Age-related liquefaction and vitrous syneresis play an essential pathogenetic role in the development of posterior vitreous detachment, retinal breaks and retinal detachment.
Topics: Aging; Animals; Humans; Models, Biological; Retinal Diseases; Vitreous Body
PubMed: 26002378
DOI: 10.1007/s00347-015-0031-9 -
Developments in Ophthalmology 2008Imaging vitreous has long been a quest to view what is, by design, invisible. This chapter will review important historical aspects, past and present imaging... (Review)
Review
PURPOSE
Imaging vitreous has long been a quest to view what is, by design, invisible. This chapter will review important historical aspects, past and present imaging methodologies, and new technologies that are currently in development for future research and clinical applications.
METHODS
Classic and modern histologic techniques, dark-field slit microscopy, clinical slit lamp biomicroscopy, standard and scanning laser ophthalmoscopy (SLO), ultrasonography, optical coherence tomography (OCT), combined OCT-SLO, magnetic resonance and Raman spectroscopies, and dynamic light scattering methodologies are presented.
RESULTS
The best available histologic techniques for imaging vitreous are those that avoid rapid dehydration of vitreous specimens. Dark-field slit microscopy enables in vitro imaging without dehydration or tissue fixatives. OCT enables better in vivo visualization of the vitreoretinal interface than SLO and ultrasonography, but does not adequately image the vitreous body. The combination of OCT with SLO has provided useful new imaging capabilities, but only at the vitreoretinal interface. Dynamic light scattering can evaluate the vitreous body by determining the average sizes of vitreous macromolecules in aging, disease, and as a means to assess the effects of pharmacologic vitreolysis. Raman spectroscopy can detect altered vitreous molecules, such as glycated collagen and other proteins in diabetic vitreopathy and possibly other diseases.
CONCLUSIONS
A better understanding of normal vitreous physiology and structure and how these change in aging and disease is needed to develop more effective therapies and prevention. The quest to adequately image vitreous will likely only succeed through the combined use of more than one technique to provide better vitreous imaging for future research and clinical applications.
Topics: Collagen; Coloring Agents; Diagnostic Imaging; Diagnostic Techniques, Ophthalmological; Eye Diseases; Humans; Hyaluronic Acid; Vitreous Body
PubMed: 18535377
DOI: 10.1159/000138754 -
Archives D'ophtalmologie 1977
Review
Topics: Animals; Cataract; Corneal Diseases; Eye Diseases; Hemorrhage; Humans; Infant, Newborn; Infant, Premature; Inflammation; Intraocular Pressure; Lens, Crystalline; Retinal Diseases; Vitreous Body
PubMed: 141267
DOI: No ID Found -
Journal Francais D'ophtalmologie Jan 2017
Topics: Amyloidosis; Eye Diseases; Fundus Oculi; Humans; Male; Middle Aged; Vitrectomy; Vitreous Body
PubMed: 28065461
DOI: 10.1016/j.jfo.2016.04.006 -
Documenta Ophthalmologica. Advances in... 1987The vitreous body of a fresh human eye removed post-mortem was suspended in water after stripping off the corneo-scleral coat, the choroid and the retina. Coloured ink...
The vitreous body of a fresh human eye removed post-mortem was suspended in water after stripping off the corneo-scleral coat, the choroid and the retina. Coloured ink was injected into the vitreous specimen from different points. Individual spaces (cisterns), transitions between cisterns and specialized structures like the bursa premacularis and the canal of Cloquet became visible when partial filling had taken place. SEM-examination of the individual cisternal walls of the bursa premacularis area showed networks of different density and texture and a considerable variation in the length of the individual fibres, some of which extended from the ciliary body (Retzius bundles) to the rim of the Bursa premacularis.
Topics: Humans; Microscopy, Electron, Scanning; Vitreous Body
PubMed: 3428097
DOI: 10.1007/BF00142712 -
Bulletin de La Societe Belge... 1987
Review
Topics: Animals; Contusions; Eye Injuries; Humans; Vitreous Body; Wounds, Penetrating
PubMed: 3307964
DOI: 10.1007/978-1-4757-1901-7_12 -
Journal Francais D'ophtalmologie Jun 2018
Topics: Child; Fundus Oculi; Humans; Male; Morocco; Retina; Retinoschisis; Tomography, Optical Coherence; Vitreous Body
PubMed: 29908649
DOI: 10.1016/j.jfo.2017.09.023 -
Ophthalmology Feb 1996
Review
Topics: Diabetic Retinopathy; Eye Diseases; Humans; Ultrasonography; Vitreous Body; Vitreous Hemorrhage
PubMed: 8594502
DOI: 10.1016/s0161-6420(96)30716-1 -
Retina (Philadelphia, Pa.) 1998
Review
Topics: Animals; Endopeptidases; Fibrinolysin; Fibrinolytic Agents; Humans; Hyaluronoglucosaminidase; Vitrectomy; Vitreous Body
PubMed: 9502274
DOI: 10.1097/00006982-199801000-00001 -
Bulletin de La Societe Belge... 1995