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Minnesota Medicine Apr 1972
Topics: Aging; Diagnosis, Differential; Eye Diseases; Humans; Ophthalmoscopy; Retinal Diseases; Vision Disorders; Vitreous Body
PubMed: 5013958
DOI: No ID Found -
Vestnik Oftalmologii 2021Accumulations of pathological amyloid protein in the vitreous can be a pathognomonic morphological sign of systemic amyloidosis, which is characterized by deposition of...
Accumulations of pathological amyloid protein in the vitreous can be a pathognomonic morphological sign of systemic amyloidosis, which is characterized by deposition of insoluble fibrillar protein aggregates (amyloid) in various organs and tissues. The article describes a clinical case of a female 65-year-old patient with bilateral vitreous floaters and histologically confirmed vitreous amyloidosis on the right eye. The patient had undergone YAG laser vitreolysis of the right eye 3 years ago on the Ultra Q Reflex system («Ellex», Australia) to treat an atypical Weiss ring. Diagnosis of vitreous amyloidosis was confirmed using the following equipment: video slit lamp SL9900 («CSO», Italy), optical coherence tomography system Solix («Optovue», USA), B-scan Plus («Accutome», USA), microscope CX41RF («Olympus Corporation», Japan). Due to significant visual deterioration in the right eye, the patient underwent vitrectomy. Microscopic examination of the surgical sample showed the presence of amyloid deposits revealed by the brick-red specific staining with congo red dye and apple-green birefringence of the stained areas in polarized light.
Topics: Aged; Amyloidosis; Eye Diseases; Female; Humans; Lasers, Solid-State; Vitrectomy; Vitreous Body
PubMed: 34410063
DOI: 10.17116/oftalma202113704198 -
Medical Hypotheses Jun 2020At present, researchers are still debating the effect of blue light on the eyes.Studies have shown thatwhile blue lighthelpsto maintain normal biological...
At present, researchers are still debating the effect of blue light on the eyes.Studies have shown thatwhile blue lighthelpsto maintain normal biological rhythms,excessive blue light radiation mayinduce fundus lesions. The preliminary survey shows that the incidence of vitreous floaters is high among digital device users, electronic screens such as smart phones, iPad, and liquidcrystal displays (LCDs) emit blue light that may accelerates vitreous degeneration, resulting in vitreous opacity and increased floaters. Further research is needed to clarify the effects of blue light on the vitreous.
Topics: Fundus Oculi; Humans; Incidence; Light; Vision Disorders; Vitreous Body
PubMed: 32244150
DOI: 10.1016/j.mehy.2020.109698 -
BMC Ophthalmology Oct 2023To investigate the diagnostic sensitivity of Optos imaging for vision degrading myodesopsia (VDM).
BACKGROUND
To investigate the diagnostic sensitivity of Optos imaging for vision degrading myodesopsia (VDM).
METHODS
A total of 420 eyes from 345 patients with VDM were collected in this cross-sectional study. All eyes were classified as having posterior vitreous detachment (PVD) or not having PVD. The sensitivity of Optos imaging for the visibility of vitreous floaters was evaluated. The associated factors with the visibility of vitreous floaters on Optos images were analyzed in univariate and multivariate logistic regression analyses.
RESULTS
The mean age of all patients was 56.19 ± 13.89 years old, and 66.67% of patients were female. The vitreous floaters were visible on the ultrasound B scan in all eyes, but only in 47.62% of Optos images (55.29% in eyes with PVD and 15% in eyes without PVD). In the multiple binary logistic regression analysis, age (OR = 1.094, 95%CI = 1.063-1.125, P < 0.001), spherical equivalent (OR = 0.869, 95%CI = 0.791-0.955, P = 0.004) and the distance of the floaters from the retina (OR = 1.191, 95%CI = 1.059-1.339, P = 0.003) were significantly correlated with the visibility of vitreous floaters on Optos images. On Optos images, 25.71% of VDM eyes presented additional retinal abnormalities.
CONCLUSIONS
Optos imaging has a low sensitivity for vitreous floaters, particularly in eyes without PVD. On Optos imaging, floaters were more visible in older patients, eyes with greater myopia, and floaters that were further from the retina.
Topics: Humans; Female; Aged; Adult; Middle Aged; Male; Cross-Sectional Studies; Vitreous Body; Eye Diseases; Vitreous Detachment; Ophthalmoscopes; Lasers
PubMed: 37864149
DOI: 10.1186/s12886-023-03166-y -
Future Oncology (London, England) Jun 2019ALK inhibitors are a new group of tyrosine kinase inhibitors, highly efficient in the treatment of non-small-cell lung carcinoma. However, these targeted therapies can... (Meta-Analysis)
Meta-Analysis Review
ALK inhibitors are a new group of tyrosine kinase inhibitors, highly efficient in the treatment of non-small-cell lung carcinoma. However, these targeted therapies can induce various adverse effects, including ocular toxicity. To date, few articles reporting ophthalmological side effects of ALK inhibitors have been published. In this review, we aim to describe the different side effects and to collect information regarding the causes behind the discrepancy between the reported rates of visual disorders. Frequent ocular side effects of ALK inhibitors included flashes, post-flashbulb effect, stripes, photopsia, accommodation disorder, presbyopia, reduced visual acuity and blurred vision. Optic neuropathy, vitreous floaters, diplopia, cataract and macular edema were also reported.
Topics: Anaplastic Lymphoma Kinase; Antineoplastic Agents; Carcinoma, Non-Small-Cell Lung; Eye Diseases; Humans; Lung Neoplasms; Molecular Targeted Therapy; Orbital Diseases; Protein Kinase Inhibitors
PubMed: 31140869
DOI: 10.2217/fon-2018-0608 -
Vestnik Oftalmologii 2018To develop methods for evaluating effectiveness of YAG-laser vitreolysis of vitreous floaters.
PURPOSE
To develop methods for evaluating effectiveness of YAG-laser vitreolysis of vitreous floaters.
MATERIAL AND METHODS
The study included 144 patients (173 eyes) who had underwent YAG-laser vitreolysis and were under observation from 01.09.16 to 31.01.18. The patients were 34 to 86 years old (mean age 62.7±10.2 years), 28 (19.4%) patients were male, 116 (80.6%) - female. All patients underwent standard and additional examination: ultrasonography (Accutome B-scan plus, U.S.A.), optic biometry (Lenstar 900, Haag-Streit, Switzerland), spectral optical coherence tomography using RTVue XR Avanti scanner (Optovue, U.S.A.) in modes Enhanced HD Line, 3D Retina, 3D Widefield MCT, Cross Line, Angio Retina, and scanning laser ophthalmoscopy (SLO) using Navilas 577s system. Laser vitreolysis was performed using the Ultra Q Reflex laser (Ellex, Australia).
RESULTS
This paper presents methods of objective quantitative and qualitative assessment of artifactual shadows of vitreous floaters with spectral optical coherence tomographic scanner RTVue xR Avanti employing an algorithm of automatic detection of non-perfusion zones in modes Angio Retina, HD Angio Retina, as well as foveal avascular zone (FAZ) measurement with Angio Analytics® software. SLO performed with Navilas 577s was used as method of visualizing floaters and artifactual shadows in retinal surface layers prior to surgical treatment and after YAG-laser vitreolysis.
CONCLUSION
Suggested methods of quantitative and qualitative assessment of artifactual shadows of the floaters in retinal layers are promising and may prove to be highly relevant for clinical monitoring of patients, optimization of treatment indications and evaluating effectiveness of YAG-laser vitreolysis. Further research of laser vitreolysis effectiveness in patients with vitreous floaters is necessary.
Topics: Adult; Aged; Aged, 80 and over; Eye Diseases; Female; Humans; Laser Therapy; Lasers, Solid-State; Male; Middle Aged; Vitrectomy; Vitreous Body
PubMed: 29543200
DOI: 10.17116/oftalma2018134156-62 -
Eye (London, England) Jan 2003
Topics: Eye Diseases; Humans; Laser Therapy; Vitreous Body; Vitreous Detachment
PubMed: 12579192
DOI: 10.1038/sj.eye.6700356 -
Retina (Philadelphia, Pa.) Nov 2016To evaluate the safety and efficacy of posterior continuous curvilinear capsulorhexis through the pars plana and 23-gauge vitrectomy in surgical management of dense...
SURGICAL REMOVAL OF DENSE POSTERIOR CAPSULE OPACIFICATION AND VITREOUS FLOATERS IN ADULTS BY POSTERIOR CONTINUOUS CURVILINEAR CAPSULORHEXIS THROUGH THE PARS PLANA AND 23-GAUGE VITRECTOMY.
PURPOSE
To evaluate the safety and efficacy of posterior continuous curvilinear capsulorhexis through the pars plana and 23-gauge vitrectomy in surgical management of dense posterior capsule opacification and vitreous floaters.
METHODS
Fifteen pseudophakic eyes of 15 patients with dense posterior capsule opacification and vitreous floaters between September 2012 and June 2014 were included; after vitrectomy, posterior continuous curvilinear capsulorhexis through the pars plana was performed. Data were collected, including baseline preoperative characteristics, postoperative outcomes, complications, and a modified quality-of-life survey that patients completed.
RESULTS
No intraoperative or postoperative complications were encountered in any of the 15 cases. Mean Snellen best-corrected visual acuity was 20/250 preoperatively and improved to 20/32 postoperatively (P < 0.001). All patients showed normal intraocular pressure 7 days after the procedure. The mean overall corneal endothelial cell loss at postoperative Month 3 was 1.2%. Approximately 80% of the patients had no complaint of vitreous floaters after the procedure. Except for 1 patient (7%) diagnosed with age-related macular degeneration, the rest of the patients (93%) were satisfied with the procedure and would recommend it to friends with dense posterior capsule opacification and vitreous floaters.
CONCLUSION
Posterior continuous curvilinear capsulorhexis through the pars plana combined with 23-gauge vitrectomy may be used to remove dense posterior capsule opacification and vitreous floaters in pseudophakic eyes.
Topics: Aged; Capsule Opacification; Capsulorhexis; Eye Diseases; Female; Humans; Lens Implantation, Intraocular; Male; Microsurgery; Middle Aged; Phacoemulsification; Posterior Capsule of the Lens; Prospective Studies; Pseudophakia; Treatment Outcome; Visual Acuity; Vitrectomy; Vitreous Body
PubMed: 27078801
DOI: 10.1097/IAE.0000000000001037 -
Quality of Life Research : An... Aug 2013To assess the time trade-off (TTO) utility values in patients with persistent visually disabling vitreous floaters (DVF) and to determine the reliability and validity of...
PURPOSE
To assess the time trade-off (TTO) utility values in patients with persistent visually disabling vitreous floaters (DVF) and to determine the reliability and validity of TTO methods in DVF patients.
METHODS
Prospective cross-sectional questionnaire survey: Eligible patients with persistent DVF referred to the Shanghai First People's Hospital outpatient service between January 2006 and February 2010, and randomly selected normal vision general population residents, were enrolled. All participants underwent TTO utility value evaluation. After 4-5 weeks, the patients were asked to undergo second TTO utility value evaluation during the follow-up interview.
RESULTS
The mean initial utility values of the 107 persistent DVF patients were 0.904 ± 0.054. Regression analyses revealed that length of education, visual acuity in the poorer-vision eye and employment status were associated with utility values (all P < 0.01). All patients took part in the follow-up interview; the intra-class correlation coefficient for TTO utility values at the initial and follow-up interviews was 0.855. In the 91 general population residents, the mean utility value was 0.923 ± 0.032, which was statistically higher than that of active study patients (t = 3.01, P < 0.01).
CONCLUSIONS
Persistent DVF can substantially diminish the patients' perception of their life, and can be measured by TTO utility values with high reliability and construct validity.
Topics: Adult; Aged; China; Cross-Sectional Studies; Disability Evaluation; Eye Diseases; Female; Health Status; Health Status Indicators; Humans; Male; Middle Aged; Predictive Value of Tests; Prospective Studies; Quality of Life; Regression Analysis; Reproducibility of Results; Severity of Illness Index; Sickness Impact Profile; Surveys and Questionnaires; Time Factors; Visual Acuity
PubMed: 23054488
DOI: 10.1007/s11136-012-0256-x -
Clinical Ophthalmology (Auckland, N.Z.) 2014A case of Staphylococcus caprae endophthalmitis in a young patient following pars plana vitrectomy for symptomatic vitreous floaters is reported here. Recent literature...
A case of Staphylococcus caprae endophthalmitis in a young patient following pars plana vitrectomy for symptomatic vitreous floaters is reported here. Recent literature suggests that there is an increasing trend of performing pars plana vitrectomy for symptomatic floaters. Although rare, the potential risk of endophthalmitis should be explicitly discussed with patients considering surgical intervention for vitreous floaters.
PubMed: 25210434
DOI: 10.2147/OPTH.S67855