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Archives of Otolaryngology--head & Neck... Nov 1989The movement of vocal cords while sniffing was observed by fiberscope and electromyogram. Nasal airflow rate was compared while sniffing and during normal respiration....
The movement of vocal cords while sniffing was observed by fiberscope and electromyogram. Nasal airflow rate was compared while sniffing and during normal respiration. Fiberscopic and electromyographic observations revealed that the vocal cords adduct while the subject is sniffing. The olfactory sense was not needed. It also was different from the defensive laryngeal reflex closure. The nasal airflow rate during sniffing was less during inspiration than during normal respiration. Inhalation while sniffing was different from that of respiration. It is concluded that the vocal cords adduct while sniffing, and that the nasal airflow rate might be less during sniffing than during normal respiration.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Child; Electromyography; Female; Fiber Optic Technology; Humans; Laryngoscopy; Male; Middle Aged; Naphazoline; Nose; Olfaction Disorders; Pulmonary Ventilation; Smell; Vocal Cords
PubMed: 2803719
DOI: 10.1001/archotol.1989.01860350096023 -
Pediatric and Developmental Pathology :... 1999Vocal cord basement membrane thickening (VCBMT) has been observed in children with sudden infant death syndrome (SIDS). It has been proposed that this lesion could be...
Vocal cord basement membrane thickening (VCBMT) has been observed in children with sudden infant death syndrome (SIDS). It has been proposed that this lesion could be used as a positive indicator of this syndrome in autopsies of children who have died unexpectedly. The present investigation aimed to analyze vocal cord basement membranes from autopsies of children 0 to 365 days old. A total of 134 larynges were analyzed. Histological sections of paraffin-embedded larynges stained with H&E and submitted to histochemical staining with periodic acid-Schiff (PAS), Masson's trichrome, syrius red, and Carstairs were used for light microscopy analysis. Immunohistochemistry with monoclonal anti-collagen IV antibody was used to determine the nature of VCBMT. The study was completed with morphometry of H&E- and PAS-stained sections and revision of the clinical information contained in the hospital files. VCBMT was found in 25 cases (18.7%) and showed characteristics of normal basement membrane, including immunoreactivity to collagen IV. Our data support the conclusions that VCBMT is frequently seen in pediatric autopsies, is seen in children in all age-groups studied whose deaths were due to causes other than SIDS, and is commonly associated with infectious diseases. Like SIDS, VCBMT occurs in the first year of life.
Topics: Basement Membrane; Death, Sudden; Female; Histocytochemistry; Humans; Immunohistochemistry; Infant; Infant Mortality; Infant, Newborn; Male; Sudden Infant Death; Vocal Cords
PubMed: 10441621
DOI: 10.1007/s100249900147 -
American Journal of Respiratory and... Feb 2012
Topics: Asthma; Female; Humans; Male; Vocal Cords
PubMed: 22298366
DOI: 10.1164/ajrccm.185.3.340a -
Lin Chuang Er Bi Yan Hou Tou Jing Wai... Dec 2019
Topics: Diagnostic Errors; Humans; Laryngeal Diseases; Myxoma; Polyps; Vocal Cords
PubMed: 31914276
DOI: 10.13201/j.issn.1001-1781.2019.12.022 -
Clinical Pediatrics Jan 1970
Topics: Child; Crying; Humans; Laryngeal Diseases; Vocal Cords; Voice Training
PubMed: 5410363
DOI: 10.1177/000992287000900105 -
Journal of the American Medical... Mar 1953
Topics: Humans; Vocal Cord Paralysis; Vocal Cords
PubMed: 13022339
DOI: No ID Found -
Advances in Oto-rhino-laryngology 2020Injection laryngoplasty as used in this chapter is synonymous with the term "injection augmentation." Injection augmentation is a technique designed to enhance glottic... (Review)
Review
Injection laryngoplasty as used in this chapter is synonymous with the term "injection augmentation." Injection augmentation is a technique designed to enhance glottic closure in patients with glottic insufficiency, or failure of glottic closure, by injecting material into the lateral aspect of the vocal fold to move the vibrating surface to the midline. This type of injection augments the vocal fold and improves glottic closure. Injection augmentation originated over 100 years ago. However, the current indications, techniques, and materials have changed significantly. Paralysis, defined as loss of function due to neu-rological injury, remains a common cause of glottic insufficiency. In cases of paralysis, nerve function to adduct the vocal folds for voice production and coughing is interrupted, bilaterally or unilaterally, and the glottis becomes insufficient. While unilateral vocal fold paralysis remains the most common indication for vocal fold injection augmentation, due to the development of newer injectable materials and less invasive injectable techniques, surgeons routinely perform injection augmentation for glottic insufficiency due to other causes such as vocal fold paresis, vocal fold atrophy, presbylarynx, vocal fold scar, and soft tissue loss. Additionally, there is an increasing performance of vocal fold injection in the awake patient. This allows for immediate feedback and reduced anesthetic risk. Outcomes assessment for injection augmentation remains varied by lack of consensus and large-scale studies to identify the factors most instrumental in documenting optimal results. We review the history of injection laryngoplasty, the indications for injection, choice of injectate, outcomes, complications, and future directions of injection laryngoplasty for augmentation.
Topics: Humans; Injections; Laryngoplasty; Patient Selection; Vocal Cord Paralysis; Vocal Cords
PubMed: 33166968
DOI: 10.1159/000456684 -
Clinical Otolaryngology and Allied... Apr 1980This study was undertaken to determine whether brief periods of vocal cord paralysis might commonly occur as a result of tracheal intubation. The vocal cords of 100...
This study was undertaken to determine whether brief periods of vocal cord paralysis might commonly occur as a result of tracheal intubation. The vocal cords of 100 patients were examined prior to and after intubation for operation. Although soft tissue trauma was observed in nearly all patients none had evidence of vocal cord paralysis.
Topics: Humans; Intubation, Intratracheal; Laryngoscopy; Vocal Cord Paralysis; Vocal Cords
PubMed: 7371211
DOI: 10.1111/j.1365-2273.1980.tb01635.x -
Trials Oct 2022Surgery and radiotherapy are well-established standards of care for unilateral stage 0 and I early-stage glottic cancer (ESGC). Based on comparative studies and... (Randomized Controlled Trial)
Randomized Controlled Trial
VoiceS: voice quality after transoral CO laser surgery versus single vocal cord irradiation for unilateral stage 0 and I glottic larynx cancer-a randomized phase III trial.
BACKGROUND
Surgery and radiotherapy are well-established standards of care for unilateral stage 0 and I early-stage glottic cancer (ESGC). Based on comparative studies and meta-analyses, functional and oncological outcomes after both treatment modalities are similar. Historically, radiotherapy (RT) has been performed by irradiation of the whole larynx. However, only the involved vocal cord is being treated with recently introduced hypofractionated concepts that result in 8 to 10-fold smaller target volumes. Retrospective data argues for an improvement in voice quality with non-inferior local control. Based on these findings, single vocal cord irradiation (SVCI) has been implemented as a routine approach in some institutions for ESGC in recent years. However, prospective data directly comparing SVCI with surgery is lacking. The aim of VoiceS is to fill this gap.
METHODS
In this prospective randomized multi-center open-label phase III study with a superiority design, 34 patients with histopathologically confirmed, untreated, unilateral stage 0-I ESGC (unilateral cTis or cT1a) will be randomized to SVCI or transoral CO-laser microsurgical cordectomy (TLM). Average difference in voice quality, measured by using the voice handicap index (VHI) will be modeled over four time points (6, 12, 18, and 24 months). Primary endpoint of this study will be the patient-reported subjective voice quality between 6 to 24 months after randomization. Secondary endpoints will include perceptual impression of the voice via roughness - breathiness - hoarseness (RBH) assessment at the above-mentioned time points. Additionally, quantitative characteristics of voice, loco-regional tumor control at 2 and 5 years, and treatment toxicity at 2 and 5 years based on CTCAE v.5.0 will be reported.
DISCUSSION
To our knowledge, VoiceS is the first randomized phase III trial comparing SVCI with TLM. Results of this study may lead to improved decision-making in the treatment of ESGC.
TRIAL REGISTRATION
ClinicalTrials.gov NCT04057209. Registered on 15 August 2019. Cantonal Ethics Committee KEK-BE 2019-01506.
Topics: Humans; Laryngeal Neoplasms; Voice Quality; Vocal Cords; Carbon Dioxide; Retrospective Studies; Prospective Studies; Laser Therapy; Treatment Outcome
PubMed: 36303192
DOI: 10.1186/s13063-022-06841-5 -
CMAJ : Canadian Medical Association... Mar 2014
Topics: Female; Hoarseness; Humans; Vocal Cord Paralysis; Vocal Cords
PubMed: 24639324
DOI: 10.1503/cmaj.114-0018