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BMJ Case Reports Feb 2020Genital tuberculosis (TB) in women is a chronic disease with low-grade symptoms. Genital tract tuberculosis is usually secondary to extragenital TB. The fallopian tubes...
Genital tuberculosis (TB) in women is a chronic disease with low-grade symptoms. Genital tract tuberculosis is usually secondary to extragenital TB. The fallopian tubes are most commonly affected, and along with endometrial involvement, it causes infertility in such patients. Involvement of the cervix and the vulva is very rare. We present one such rare case of vulvar tuberculosis presented with a large ulcer diagnosed on histopathology and treated with antitubercular chemotherapy.
Topics: Aged; Antitubercular Agents; Female; Humans; Tuberculosis, Female Genital; Vulva
PubMed: 32051158
DOI: 10.1136/bcr-2019-232880 -
The British Journal of Dermatology Jun 1972
Review
Topics: Animals; Cattle; Crohn Disease; Edema; Ehlers-Danlos Syndrome; Female; Genital Diseases, Female; Humans; Microscopy, Electron; Pemphigus; Peutz-Jeghers Syndrome; Skin Diseases; Testosterone; Vulva; Vulvar Neoplasms; Vulvovaginitis
PubMed: 4558233
DOI: 10.1111/j.1365-2133.1972.tb05083.x -
Cell Jul 1995
Review
Topics: Animals; Caenorhabditis elegans; Female; Morphogenesis; Signal Transduction; Vulva
PubMed: 7628006
DOI: 10.1016/0092-8674(95)90302-x -
Aesthetic Surgery Journal May 2022
Topics: Body Image; Female; Humans; Vulva
PubMed: 34606564
DOI: 10.1093/asj/sjab353 -
WormBook : the Online Review of C.... Dec 2005C. elegans hermaphrodites are self-fertile, and their rate and temporal pattern of egg-laying are modulated by diverse environmental cues. Egg-laying behavior has served... (Review)
Review
C. elegans hermaphrodites are self-fertile, and their rate and temporal pattern of egg-laying are modulated by diverse environmental cues. Egg-laying behavior has served as an important phenotypic assay for the genetic dissection of neuronal signal transduction mechanisms. This chapter reviews our current understanding of the neuronal and neurochemical mechanisms underlying the control of egg-laying in C. elegans. The roles of specific neurons in the egg-laying motor circuit, which release multiple neurotransmitters affecting distinct parameters of egg-laying muscle activity, and the possible mechanisms for sensory control of egg-laying behavior, are discussed.
Topics: Animals; Caenorhabditis elegans; Disorders of Sex Development; Female; Oviposition; Uterus; Vulva
PubMed: 18050396
DOI: 10.1895/wormbook.1.38.1 -
Reproduction in Domestic Animals =... Oct 2022The aim of this study was to assess whether vulvar morphometric changes occurring in female pigs during proestrus and oestrus could be objective, accurate and predictive...
The aim of this study was to assess whether vulvar morphometric changes occurring in female pigs during proestrus and oestrus could be objective, accurate and predictive indicators of the onset to oestrus and thus performed artificial inseminations at the most appropriate time. For that purpose, pictures of vulvas from 60 hyperprolific females (30 gilts and 30 sows) during proestrus and oestrus were taken once a day. Vulva measurements (area, perimeter, length and width) on these pictures were performed using the image processing ImageJ software. Gilts and sows showed statistical differences (p < .01) in all vulvar morphometric measurements between proestrus and oestrus. Statistical differences in vulvar metrics were detected 24 h before the onset to oestrus, affecting all vulvar measurements in gilts, whereas only vulvar width was affected in sows. The image analysis used in this study may contribute to the development of smart technology in swine farming.
Topics: Animals; Estrus; Female; Insemination, Artificial; Proestrus; Sus scrofa; Swine; Vulva
PubMed: 35689465
DOI: 10.1111/rda.14178 -
CMAJ : Canadian Medical Association... Mar 2021
Topics: Adult; Crohn Disease; Female; Humans; Vulva
PubMed: 33722830
DOI: 10.1503/cmaj.190112 -
Anticancer Research Apr 2023The expression of the cyclin-dependent kinase inhibitor p16 correlates with the presence of human papillomavirus. The purpose of this investigation was to assess the...
Positive p16 Immunostaining Is an Independent Prognostic Variable for Disease-free Survival and Overall Survival in Patients With Squamous Cell Carcinoma of the Vulva Treated With Radical Surgery and Inguinofemoral Lymphadenectomy: An Italian Single Center Retrospective Study.
BACKGROUND/AIM
The expression of the cyclin-dependent kinase inhibitor p16 correlates with the presence of human papillomavirus. The purpose of this investigation was to assess the prognostic relevance of p16 expression in patients with vulvar squamous cell carcinoma (VSCC) treated with radical surgery followed by adjuvant (chemo) radiation in selected cases.
PATIENTS AND METHODS
Seventy-eight patients were analyzed retrospectively.
RESULTS
Positive p16 immunostaining was detected in 19 (24.4%) patients. Five-year disease-free survival (DFS) and 5-year overall survival (OS) were better in p16-positive compared to p16-negative patients (83.9% versus 37.3% p=0.002 and 91.7% versus 57.6%, p=0.003, respectively). p16 expression retained prognostic relevance at multivariate analysis for both DFS and OS.
CONCLUSION
p16 expression was detected in 24.4% of patients with VSCC and was found to be an independent prognostic variable for both DFS and OS.
Topics: Female; Humans; Prognosis; Retrospective Studies; Disease-Free Survival; Papillomavirus Infections; Vulva; Vulvar Neoplasms; Cyclin-Dependent Kinase Inhibitor p16; Carcinoma, Squamous Cell; Lymph Node Excision
PubMed: 36974801
DOI: 10.21873/anticanres.16315 -
Henry Ford Hospital Medical Bulletin Sep 1963
Topics: Biopsy; Female; Humans; Leukoplakia; Pathology; Precancerous Conditions; Terminology as Topic; Vulva; Vulvar Lichen Sclerosus; Vulvar Neoplasms
PubMed: 14056321
DOI: No ID Found -
Cell Systems Feb 2017It is a fundamental open question as to how embryos develop into complex adult organisms with astounding reproducibility, particularly because cells are inherently...
It is a fundamental open question as to how embryos develop into complex adult organisms with astounding reproducibility, particularly because cells are inherently variable on the molecular level. During C. elegans vulva induction, the anchor cell induces cell fate in the vulva precursor cells in a distance-dependent manner. Surprisingly, we found that initial anchor cell position was highly variable and caused variability in cell fate induction. However, we observed that vulva induction was "canalized," i.e., the variability in anchor cell position and cell fate was progressively reduced, resulting in an invariant spatial pattern of cell fates at the end of induction. To understand the mechanism of canalization, we quantified induction dynamics as a function of anchor cell position during the canalization process. Our experiments, combined with mathematical modeling, showed that canalization required a specific combination of long-range induction, lateral inhibition, and cell migration that is also found in other developmental systems.
Topics: Animals; Body Patterning; Caenorhabditis elegans; Caenorhabditis elegans Proteins; Cell Movement; Embryonic Induction; Female; Ligands; Models, Theoretical; Receptors, Notch; Signal Transduction; Vulva
PubMed: 28215526
DOI: 10.1016/j.cels.2017.01.009