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Acta Obstetricia Et Gynecologica... 1972
Comparative Study
Topics: Adult; Age Factors; Aged; Electrocoagulation; Female; Humans; Lymph Node Excision; Lymphatic Metastasis; Middle Aged; Neoplasm Recurrence, Local; Vulvar Neoplasms
PubMed: 5049377
DOI: 10.3109/00016347209154003 -
Obstetrical & Gynecological Survey Oct 1995Vulvar melanoma is an unusual tumor with a poor prognosis. Most surgeons have abandoned radical vulvectomy as the treatment of choice. The role of elective node... (Review)
Review
Vulvar melanoma is an unusual tumor with a poor prognosis. Most surgeons have abandoned radical vulvectomy as the treatment of choice. The role of elective node dissection is controversial. Currently effective adjuvant therapy is lacking. In this paper 51 sources concerning melanoma and/or melanoma of the vulva were reviewed, 43 of these sources were considered to be pertinent and current enough to include in this review. The objective was to describe current knowledge about the natural history, staging, pathology, and treatment of melanoma of the vulva. It has been found that melanoma continues to be difficult to treat when in advanced stages. Microstaging systems offer clinicians the best prognostic information. In many patients, less radical surgical treatment offers equal cure rates with decreased morbidity.
Topics: Age Distribution; Aged; Aged, 80 and over; Female; Humans; Lymph Node Excision; Melanoma; Middle Aged; Neoplasm Staging; Prognosis; Survival Rate; Treatment Outcome; Vulvar Neoplasms
PubMed: 8524524
DOI: 10.1097/00006254-199510000-00021 -
International Journal of... Jun 2015Malignant tumors of the female reproductive system are a serious health and social problem, as they are the second most common cause of death among women, after breast... (Review)
Review
Malignant tumors of the female reproductive system are a serious health and social problem, as they are the second most common cause of death among women, after breast cancer. Vulvar tumors represent only 4% of all gynecological neoplasms, and they are fourth in frequency after tumors of the cervix, uterus, and ovary. Ninety-eight percent of all vulvar tumors are benign and only 2% are malignant. Sarcomas of the vulva comprise approximately 1-3% of all vulvar cancers. They are characterized by rapid growth, high metastatic potential, frequent recurrences, aggressive behavior, and high mortality rate. In Part 1 of this paper, we presented the most common forms of sarcoma of the vulva: leiomyosarcoma, epithelioid sarcoma, malignant rhabdoid tumor, and rhabdomyosarcoma. The second part of this review will focus mainly on the rarest variants of vulvar sarcoma: low-grade fibromyxoid sarcoma, synovial sarcoma, monophasic synovial sarcoma, carcinosarcoma, Ewing sarcoma, myeloid sarcoma, dermatofibrosarcoma protuberans, malignant fibrous histiocytoma, angiomatoid fibrous histiocytoma, liposarcoma, malignant peripheral nerve sheath tumor, and malignant mesothelioma.
Topics: Female; Humans; Neoplasm Recurrence, Local; Sarcoma; Vulvar Neoplasms
PubMed: 25816393
DOI: 10.1177/0394632015575977 -
American Journal of Obstetrics and... Jan 1974
Topics: Age Factors; Carcinoma, Squamous Cell; Female; Humans; Lymph Nodes; Lymphatic Metastasis; Middle Aged; Neoplasm Metastasis; Prognosis; Recurrence; Vulva; Vulvar Neoplasms
PubMed: 4809402
DOI: 10.1016/0002-9378(74)90542-0 -
Archives of Gynecology and Obstetrics Jun 2008Aggressive angiomyxoma (AA) is a rare vulvovaginal mesenchymal neoplasm with a marked tendency to local recurrence but which usually does not metastasize. (Review)
Review
BACKGROUND
Aggressive angiomyxoma (AA) is a rare vulvovaginal mesenchymal neoplasm with a marked tendency to local recurrence but which usually does not metastasize.
CASE REPORT
We describe a case of AA in the left labium majus pudendi in a 47-year-old woman who underwent incomplete surgical excision. Follow-up 2years later revealed no recurrence.
CONCLUSION
In the past, most authors advocated wide excision even if genitourinary and digestive tract resection were necessary. These days, a less radical surgery is recommended, but the significance of hormonal treatment and/or radiation therapy is not clear yet. Further investigation is necessary.
Topics: Female; Humans; Middle Aged; Myxoma; Ultrasonography; Vulvar Neoplasms
PubMed: 18214507
DOI: 10.1007/s00404-008-0561-3 -
Obstetrics and Gynecology Jun 1986Bartholin gland tumors are rare and management recommendations have been based on limited information. This report summarizes a 30-year clinical experience involving...
Bartholin gland tumors are rare and management recommendations have been based on limited information. This report summarizes a 30-year clinical experience involving Bartholin gland carcinoma in 36 patients whose five-year survival rate was 84%. FIGO stages of the 36 tumors were stage I, nine; stage II, 15; stage III, ten; and stage IV, two. Cell types were: squamous, 27 (three nonkeratinizing with areas of a transitional component); adenomatous, six; adenoid cystic, two; and adenosquamous, one. Fourteen of 30 (47%) patients with lymph node dissections had nodal metastases and 11 remain disease-free. Disease recurred in nine patients (six local, two distant, one local and distant) and four were treated successfully. One of 14 (7%) patients receiving radiation and six of 22 (27%) patients not receiving radiation developed local recurrences. Wide excision (often necessitating a radical hemivulvectomy), ipsilateral inguinal lymphadenectomy, and adjunctive irradiation to the vulva and regional lymph nodes produced excellent results.
Topics: Adenocarcinoma; Adult; Aged; Bartholin's Glands; Carcinoma, Adenoid Cystic; Carcinoma, Squamous Cell; Carcinoma, Transitional Cell; Combined Modality Therapy; Diagnosis, Differential; Female; Humans; Lymphatic Metastasis; Middle Aged; Neoplasm Metastasis; Neoplasm Recurrence, Local; Vulva; Vulvar Neoplasms
PubMed: 3010205
DOI: 10.1097/00006250-198606000-00009 -
Archives of Pathology & Laboratory... Apr 2008Synovial sarcomas most commonly arise in the soft tissue of the extremities. Less commonly, these tumors present in the head and neck, abdominal wall, and other sites.... (Review)
Review
Synovial sarcomas most commonly arise in the soft tissue of the extremities. Less commonly, these tumors present in the head and neck, abdominal wall, and other sites. However, synovial sarcoma occurring in the vulvar area is extremely rare. Only 2 previous cases of biphasic synovial sarcoma of the vulva have been reported, but no case of vulvar monophasic synovial sarcoma has been described in the English literature. We report the third case of synovial sarcoma and apparently the first case of monophasic synovial sarcoma arising in soft tissues of the vulva. The patient was a 33-year-old woman who presented for evaluation of a painless vulvar mass. The tumor was located in the deep fibroadipose tissue of the right vulva (6.5 x 4.2 x 3.5 cm). The histology of the lesion was that of a monophasic synovial sarcoma with a hemangiopericytic vascular pattern. A subsequent molecular analysis revealed SYT-SSX2 gene fusion, which confirmed the diagnosis of synovial sarcoma. After an initial wide local excision, the patient developed a recurrence in the right groin and received chemotherapy and additional surgery. The patient is currently disease free, on adjuvant chemotherapy, and being followed up closely.
Topics: Adult; Biopsy, Fine-Needle; Female; Gene Fusion; Humans; Neoplasm Proteins; Proto-Oncogene Proteins; Repressor Proteins; Sarcoma, Synovial; Vulva; Vulvar Neoplasms
PubMed: 18384223
DOI: 10.5858/2008-132-698-MSSAIT -
Obstetrics and Gynecology Sep 1990Primary adenocarcinoma of ectopic breast tissue in the vulva has been reported in only four instances. A fifth case, in which estrogen and progesterone receptors were... (Review)
Review
Primary adenocarcinoma of ectopic breast tissue in the vulva has been reported in only four instances. A fifth case, in which estrogen and progesterone receptors were present, is described. Estrogen and progesterone receptor studies may be helpful in identifying adenocarcinoma of uncertain origin.
Topics: Adenocarcinoma; Aged; Breast; Choristoma; Diagnosis, Differential; Female; Humans; Lymphatic Metastasis; Neoplasm Invasiveness; Receptors, Estrogen; Receptors, Progesterone; Vulvar Neoplasms
PubMed: 2199874
DOI: No ID Found -
Critical Reviews in Oncology/hematology Jan 2024Gynecological neuroendocrine neoplasms are rare entities and can be divided into two groups: carcinoids and neuroendocrine carcinomas. Due to their rarity their... (Review)
Review
Gynecological neuroendocrine neoplasms are rare entities and can be divided into two groups: carcinoids and neuroendocrine carcinomas. Due to their rarity their management is not standardized. The aim of this work is to summarize and discuss the current literature evidence on this pathology. A scoping literature review was performed in multiple databases. Thirty-one studies were included: 30 case reports and one case series. Patients' age ranged between 28 and 92 years. Surgery was the most used treatment and the surgical approach included local excision (N = 16/31; 51.6%) with (N = 5/16; 31.25%) or without (N = 11/16; 68.75%) inguinal lymphadenectomy. Adjuvant radiotherapy was delivered in 12 (38.7%) cases; instead, platinum-based therapies were frequently used when chemotherapy was chosen for adjuvant treatment. The overall survival ranged between 20 days to 4 years. However, further research is needed; currently, multimodal approach including surgery, chemotherapy and radiotherapy appeared safe and feasible for the treatment of these rare and aggressive diseases.
Topics: Female; Humans; Adult; Middle Aged; Aged; Aged, 80 and over; Vulvar Neoplasms; Neoplasm Staging; Vulva; Neuroendocrine Tumors; Lymph Node Excision
PubMed: 37977312
DOI: 10.1016/j.critrevonc.2023.104201 -
Gynecologic Oncology Dec 2004Microinvasive squamous cell carcinoma of the vulva is defined as stromal invasion < or =1 mm and is treated by wide local resection. Whether criteria for microinvasive...
BACKGROUND
Microinvasive squamous cell carcinoma of the vulva is defined as stromal invasion < or =1 mm and is treated by wide local resection. Whether criteria for microinvasive squamous cell carcinoma can be applied to Paget's disease of the vulva is unknown because of the rarity of that disease.
CASES
We initially evaluated three cases of microinvasive Paget's disease by using sentinel lymph node (SLN) analysis. The SLNs in two patients were negative; and these patients had no recurrence of invasive or metastatic Paget's disease. The other patient had a positive SLN (the only positive lymph node) and subsequently received complete lymph node dissection of the groin bilaterally.
CONCLUSION
Evaluation of SLNs may be valid for evaluating microinvasive Paget's disease.
Topics: Aged; Female; Humans; Middle Aged; Neoplasm Invasiveness; Paget Disease, Extramammary; Sentinel Lymph Node Biopsy; Vulvar Neoplasms
PubMed: 15581999
DOI: 10.1016/j.ygyno.2004.09.008