-
European Journal of Gynaecological... 2002A 45-year-old white female presented a polypoid nodule in the vulva, one year after she was operated on for breast cancer. Histologic examination showed a poorly... (Review)
Review
A 45-year-old white female presented a polypoid nodule in the vulva, one year after she was operated on for breast cancer. Histologic examination showed a poorly differentiated carcinoma that closely resembled the primary breast tumor. Eight similar cases have been previously described in the literature. This very rare event should be differentiated from primary adenocarcinoma of the mammary-like glands of the vulva. The recognition of such a lesion as primary or metastatic is very important, since it greatly influences management and prognosis.
Topics: Breast Neoplasms; Carcinoma, Ductal, Breast; Diagnosis, Differential; Female; Humans; Mastectomy; Middle Aged; Neoplasm Metastasis; Neoplasms, Second Primary; Vulvar Neoplasms
PubMed: 12214743
DOI: No ID Found -
European Journal of Gynaecological... 2011A retrospective study aiming to assess the survival rate, recurrence rate and complications of patients with invasive squamous cell carcinoma of the vulva. (Review)
Review
PURPOSE
A retrospective study aiming to assess the survival rate, recurrence rate and complications of patients with invasive squamous cell carcinoma of the vulva.
METHODS
91 patients with invasive carcinoma of the vulva were included in the study. The following clinical factors were assessed: clinical stage, diameter of lesion, and degree of tumor differentiation. The Kaplan-Meier estimate for statistical analysis of survival was used.
RESULTS
Surgery was primary treatment for 76 patients. The 5-year survival for FIGO Stage I was 93.3%, Stage II 85%, Stage III 51% and for Stage IV it was zero as estimated by the Kaplan-Meier test. Of the 52 women who underwent inguinal lymphadenectomy, 11 or 21.1% had positive nodes and four patients underwent pelvic node resection. Patients with tumor size < or = 2 cm had 16.7% positive inguinal nodes, while patients with tumor size > 2.1 cm had 29.4% of positive nodes.
CONCLUSIONS
The right choice of surgical treatment after appropriate staging of the disease offers very good survival rates, while a more accurate assessment of the status of inguinal lymph nodes could reduce the extent of surgical treatment.
Topics: Aged; Carcinoma, Squamous Cell; Female; Humans; Lymph Node Excision; Lymphatic Metastasis; Neoplasm Grading; Neoplasm Invasiveness; Neoplasm Recurrence, Local; Neoplasm Staging; Retrospective Studies; Vulvar Neoplasms
PubMed: 22053662
DOI: No ID Found -
Klinicka Onkologie : Casopis Ceske a... 2013Review of revised staging system for vulva, explaining the changes of staging and their impact on the prognosis of disease is presented. (Review)
Review
BACKGROUND
Review of revised staging system for vulva, explaining the changes of staging and their impact on the prognosis of disease is presented.
AIM
The main objectives of a reliable staging system include an assessment of prognosis, planning treatment, and the evaluation of their outcomes. A good staging system must meet three basic characteristics: validity, reliability and practicality. Since medical research and practice in the field of oncology have shown explosive growth, the staging of vulvar cancer and some other cancers did not give a good spread of prognostic groupings. Changes based on new findings were proposed in 2008 by the FIGO Committee on Gynecologic Oncology, approved, and published a year later the changes in the staging system for carcinoma of the vulva. Stage 0 was deleted, since it represents preinvasive lesion. Stage IA remained unchanged and stage I and II were combined. The number and morphology of the involved nodes were taken into account, and the bilaterality of positive nodes has been discounted.
CONCLUSION
The purpose of a good staging system is to offer a classification of the extent of gynecological cancer, in order to provide a method of conveying ones clinical experience to others for the comparison of different treatment methods. As a result of the explosion of medical research in the field of oncology, the staging of some of the gynecological cancers became outdated and did not give a good spread of prognostic groupings. According to the revised staging for carcimona of the vulva, patients are divided to groups with similar prognosis. Therefore, exchange of relevant information between oncological centers is facilitated, thus disseminating knowledge and stimulating research in other parts of the world.
Topics: Carcinoma; Disease Progression; Female; Humans; Neoplasm Staging; Practice Guidelines as Topic; Prognosis; Vulvar Neoplasms; Women's Health
PubMed: 24107153
DOI: 10.14735/amko2013319 -
Gynecologic Oncology Nov 2001Only two previous cases of villoglandular adenocarcinoma of the vulva, an entity morphologically similar to tumors found in the uterine cervix and colorectum, have been...
BACKGROUND
Only two previous cases of villoglandular adenocarcinoma of the vulva, an entity morphologically similar to tumors found in the uterine cervix and colorectum, have been reported. This paper communicates the first complete immunohistochemical study in villoglandular adenocarcinoma in order to determine its phenotype and histogenesis.
CASE
A 69-year-old woman had a 1.5-cm nodule in the right labium majus. Histologically, it corresponded to a minimally atypical, villoglandular adenocarcinoma with a small microinvasion. Immunohistochemically, it was positive to OC125, CEA, and OC19.9 and coexpressed cytokeratins 7 and 20. Chromogranin, nuclear estrogen, and progesterone receptors were negative.
CONCLUSION
Phenotypic expression was more consistent with a papillary mucinous ovarian or cervical neoplasm than of a colonic one. Its behavior was similar to that of its morphologic counterpart in the cervix, since the patient had no recurrence 3 years after a wide local excision.
Topics: Adenocarcinoma; Aged; Female; Humans; Immunohistochemistry; Mixed Tumor, Mullerian; Vulvar Neoplasms
PubMed: 11606106
DOI: 10.1006/gyno.2001.6372 -
Gynecologic Oncology Dec 2004Aggressive angiomyxoma is a rare soft tissue tumour that carries a high risk of local relapse. It is a slowly growing and locally infiltrating tumour.
BACKGROUND
Aggressive angiomyxoma is a rare soft tissue tumour that carries a high risk of local relapse. It is a slowly growing and locally infiltrating tumour.
CASE
We describe the case of an aggressive pelvic-perineal angiomyxoma arising in a 36-year-old woman. The patient had a mass that grew before, during and after her pregnancy. Transperineal surgery was performed. The resection margins were free of disease.
CONCLUSION
Our case confirms what has previously been published concerning the possible hormone-dependence of this neoplasm. Given the positive estrogen and progesterone receptor status of this tumour, we will consider hormonal treatments in the case of a future relapse.
Topics: Adult; Female; Humans; Myxoma; Neoplasm Invasiveness; Pregnancy; Pregnancy Complications, Neoplastic; Vulvar Neoplasms
PubMed: 15581991
DOI: 10.1016/j.ygyno.2004.07.051 -
Acta Obstetricia Et Gynecologica... Jul 2004
Topics: Adult; Dermatofibrosarcoma; Female; Humans; Immunohistochemistry; Neoplasm Metastasis; Neoplasm Recurrence, Local; Prognosis; Skin Neoplasms; Treatment Outcome; Vulvar Neoplasms
PubMed: 15225196
DOI: 10.1111/j.0001-6349.2004.0226b.x -
Pathology May 1997The clinical and pathological features of a nonulcerated desmoplastic melanoma in the vulva of a 52-year-old woman are presented. Pleomorphic neoplastic spindle cells,... (Review)
Review
The clinical and pathological features of a nonulcerated desmoplastic melanoma in the vulva of a 52-year-old woman are presented. Pleomorphic neoplastic spindle cells, fibroblasts and collagen formed a poorly demarcated 18 mm dermal mass. No adjacent intraepidermal component was seen. Immunoreactivity was demonstrated for S100 protein, vimentin, neuron-specific enolase and actin, but not for HMB-45, CAM 5.2, cytokeratin, epithelial membrane antigen, desmin or CD34. Electron microscopic examination was noncontributory. Treatment included a left hemivulvectomy with ipsilateral groin node dissection followed by radiotherapy. The tumor recurred six weeks later and was unresectable. The patient is alive with symptoms nine months after presentation. This is the first case report of a vulvar desmoplastic melanoma without neural involvement or an intraepidermal component. The variable tumor cytomorphology, nonspecific immunohistochemical and ultrastructural features render a diagnosis more difficult than with other primary cutaneous melanomas.
Topics: Biomarkers; Female; Humans; Immunohistochemistry; Melanoma; Middle Aged; Neoplasm Recurrence, Local; Vulvar Neoplasms
PubMed: 9213352
DOI: 10.1080/00313029700169974 -
Gynecologic and Obstetric Investigation 2012Granular cell tumors (GCTs) are uncommon soft tissue tumors of neural derivation, as supported by immunohistochemical and ultrastructural evidence. Vulvar involvement... (Review)
Review
Granular cell tumors (GCTs) are uncommon soft tissue tumors of neural derivation, as supported by immunohistochemical and ultrastructural evidence. Vulvar involvement has been reported in 7-16%. This paper presents the cases of a 60-year-old woman and her 32-year-old niece with a strong family history of cancer, both presenting with an enlarging mass on their left labia majora. The lesions were treated by simple surgical excision. Histopathological examination revealed a benign vulvar GCT in both lesions. This is the first reported case of GCT of the vulva in the same family. The possible familial component of GCT needs further investigation. A systematic review of the literature on vulvar GCTs is carried out, the most complete one to date. This review unexpectedly reveals that there have been more than 130 cases of GCT of the vulva reported to date, only 7 of which were malignant. Since 5-25% of patients have multiple lesions, before planning treatment, clinicians should exclude multicentric lesions. After surgical treatment, if there is any evidence of tumor in the surgical margin, wider local excision should be performed. Regular follow-up is important for diagnosing a possible recurrence or a new lesion.
Topics: Adult; Female; Granular Cell Tumor; Humans; Immunohistochemistry; MEDLINE; Middle Aged; Neoplasm Recurrence, Local; S100 Proteins; Vulvar Neoplasms
PubMed: 22517025
DOI: 10.1159/000336256 -
International Journal of Surgical... Feb 2022We present the case of a 31-year-old woman who underwent surgical excision for a polypoid, vulvar lesion. Histopathological analysis showed a diffuse myxoid stroma...
We present the case of a 31-year-old woman who underwent surgical excision for a polypoid, vulvar lesion. Histopathological analysis showed a diffuse myxoid stroma admixed with scant collagen fibrils. Thin-walled and branching blood vessels were prominent, with a mild perivascular lymphocytic infiltrate. Cytologically bland spindle cells with inconspicuous nucleoli were immersed in a loose myxoid stroma. This combination of histopathological features along with multinodularity in the subcutaneous fat raised concern for deep angiomyxoma, a locally destructive neoplasm. Among our differential of myxoid lesions of the vulva, we ultimately favored the diagnosis of vulvar cutaneous myxoma. Upon further investigation, we learned that our patient was indeed known for the Carney complex. We highlight that vulvar cutaneous myxomas arising in the context of the Carney complex pose a significant diagnostic challenge for pathologists and should not be overdiagnosed as aggressive lesions such as deep angiomyxoma or other malignant stromal neoplasms.
Topics: Adult; Biomarkers, Tumor; Carney Complex; Female; Humans; Skin Neoplasms; Vulvar Neoplasms
PubMed: 34029148
DOI: 10.1177/10668969211020504 -
International Journal of Gynecological... Jan 1995Vulvar sarcomas are uncommon, comprising only approximately 2% of all vulvar malignancies. Consequently, most reported series contain only a few cases. We add to the...
Vulvar sarcomas are uncommon, comprising only approximately 2% of all vulvar malignancies. Consequently, most reported series contain only a few cases. We add to the literature 10 cases of various primary sarcomas of the vulva, including previously unreported cases of angiosarcoma and a neoplasm resembling Ewing's sarcoma. The only histologic feature helpful in determining prognosis was tumor necrosis.
Topics: Adult; Aged; Aged, 80 and over; Female; Follow-Up Studies; Humans; Immunohistochemistry; Middle Aged; Necrosis; Prognosis; Retrospective Studies; Sarcoma; Vulvar Neoplasms
PubMed: 7883427
DOI: 10.1097/00004347-199501000-00010