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Current Biology : CB Apr 2003
Topics: Biology
PubMed: 12725743
DOI: 10.1016/s0960-9822(03)00267-7 -
Lancet (London, England) Jul 2019
Topics: Health Status Disparities; History of Dentistry; History, 20th Century; History, 21st Century; Humans; Mouth Diseases; Oral Health; Public Health; Social Class
PubMed: 31327362
DOI: 10.1016/S0140-6736(19)31570-3 -
Science Progress Sep 2021The mode clamping mechanism is the most important part of forming section for the plastic injection molding machine. If this mechanism has double-toggle effects at the...
INTRODUCTION
The mode clamping mechanism is the most important part of forming section for the plastic injection molding machine. If this mechanism has double-toggle effects at the close position, it will get a larger clamping force and have higher safety. This study focuses on the optimal design of the Watt-chain mechanism with double-toggle effects at the close position.
METHODS
The Watt-chain double-toggle mechanism is chosen to be the mold clamping mechanism by referring to the existing patents. Then, the kinematic characteristics of the Watt-chain double-toggle mechanism are analyzed by the vector loop method. Finally, based on the kinematic requirements and the proposed optimal design process according to the objective function, the optimal design on Watt-chain double-toggle mechanism is accomplished in this study.
RESULTS
This study proposes an optimal design process on Watt-chain double-toggle mold clamping mechanism. By following the optimal design process, the optimal Watt-chain double-toggle mold clamping mechanism has a maximum acceleration 3418 mm/s ( = 3418 mm/s) and a force ratio is 2.24 (/ = 2.24).
DISCUSSION
According to the studies on the optimal designs of mechanisms, the optimal Watt-chain double-toggle mechanism, which is better than the multiple-joint double-toggle mold clamping mechanism in the existing patent by reducing 19.5% of acceleration and 30% of a driving force, is proposed. The results of this study could be the design reference in engineering when designing mold clamping mechanisms for plastic injection molding machines.
Topics: Biomechanical Phenomena; Constriction; Injections; Plastics
PubMed: 34606397
DOI: 10.1177/00368504211041488 -
CMAJ : Canadian Medical Association... Jan 2024
Topics: Humans; Alzheimer Disease; Canada; Antibodies, Monoclonal, Humanized
PubMed: 38286492
DOI: 10.1503/cmaj.230595-f -
British Medical Journal Dec 1960
Topics: History, 20th Century; Humans
PubMed: 14447302
DOI: No ID Found -
Seminars in Plastic Surgery Nov 2022
PubMed: 36544810
DOI: 10.1055/s-0042-1758694 -
Journal of the Royal Society of Medicine Feb 1981
Topics: Community Psychiatry; Epidemiology; History, 20th Century; United Kingdom
PubMed: 7009862
DOI: 10.1177/014107688107400202 -
Optics Letters May 2019A 10-watt-level mid-infrared supercontinuum (SC) spanning 0.8-4.7 μm with ultra-high-power conversion efficiency is generated in a piece of fluoroindate (InF) fiber....
A 10-watt-level mid-infrared supercontinuum (SC) spanning 0.8-4.7 μm with ultra-high-power conversion efficiency is generated in a piece of fluoroindate (InF) fiber. The pump laser is a master oscillator power amplifier system seeded by a mode-locked fiber laser operating at 1956 nm with pulse repetition rate and pulse duration of 33 MHz and 60 ps, respectively. A piece of InF fiber is fusion spliced to the output end of the pump light source with a low fusion splicing loss of 0.12 dB. An endcap made of multimode aluminum fluoride fiber is used to protect the fiber tip from possible optical or thermal damage. Benefiting from the fiber endcap as well as the low-loss splicing joint between silica and InF fiber, high-power SC generation is achieved with maximal output power of 11.3 W. Furthermore, the long wavelength edge of the obtained SC spectrum is extended to 4.7 μm. This Letter, to the best of our knowledge, not only demonstrates the first 10-watt-level SC generation in InF fibers, but also achieves record power conversion efficiency of 66.5% among reported 10-watt-level fluoride-fiber-based SC laser sources.
PubMed: 31042227
DOI: 10.1364/OL.44.002378 -
Frontiers in Psychiatry 2017The treatment of depression has been hampered by low efficacy of antidepressant medications and safety concerns with alternative modalities. Recent work demonstrated...
BACKGROUND
The treatment of depression has been hampered by low efficacy of antidepressant medications and safety concerns with alternative modalities. Recent work demonstrated that multi-Watt transcranial near-infrared light therapy (NILT) can effectively treat traumatic brain injury (TBI). The current objective is to explore multi-Watt NILT efficacy in a proof-of-concept study as a treatment for depression.
METHODS
Thirty-nine sequential patients treated for TBI between March 2013 and May 2017 provided depression self-assessment data and/or were administered the Hamilton depression rating scale. Each completed the Quick Inventory of Depression Symptomatology-Self Report (QIDS) before and after treatment. Patients received multi-Watt NILT using near-infrared lasers (810/980 nm at 8-15 W) applied to forehead and temporal regions bilaterally for 9-12 min to each area. Pre- and posttreatment scores were analyzed by paired -tests.
RESULTS
All met QIDS criteria for mild to severe depression and 69% had prior antidepressant trials. For 36 of the 39 patients, after 16.82 ± 6.26 treatments, QIDS scores indicated a robust response (decrease of QIDS total score by ≥50%). For 32 of 39 patients, posttreatment QIDS scores indicated a remission from depression (decrease of QIDS total score ≤5). Overall, the QIDS score fell from 14.10 ± 3.39 to 3.41 ± 3.30 SD ( = 6.29 × 10). With 12 or fewer treatments, QIDS score dropped from 14.83 ± 2.55 to 4.17 ± 3.93. Patients receiving ≥13 treatments showed a change in QIDS score from 13.67 ± 3.64 to 3.11 ± 3.14. Those ( = 15) who received the entire treatment course within ≤8 weeks (5.33 ± 1.72 weeks) showed a change in QIDS score from 13.86 ± 3.14 to 4.5 ± 3.94. Suicidal ideation resolved in all, but two patients. Patients remained in remission for up to 55 months after a single course of treatment.
CONCLUSION
This is the first report of high-powered NILT showing efficacy for depression. Multi-Watt NILT showed far greater efficacy and persistent benefit compared to low-power (<1 Watt) infrared light treatments. Patients saw benefit often within four treatments and resolution of depressive symptoms occurred within 4 weeks for some. These data raise an intriguing possibility-that multi-Watt NILT may be a safe, effective, and rapid treatment for depression comorbid with TBI and possibly primary major depression disorder. A double-blind, placebo controlled trial is warranted to verify these proof-of-concept data.
PubMed: 29033859
DOI: 10.3389/fpsyt.2017.00187 -
British Dental Journal Jul 2020
PubMed: 32710023
DOI: 10.1038/s41415-020-1935-6