-
Parasitology Research Jan 2022Trichuriasis is one of the most common soil-transmitted helminth (STH) infections, affecting populations globally. The condition is particularly prevalent in tropical... (Meta-Analysis)
Meta-Analysis Review
Trichuriasis is one of the most common soil-transmitted helminth (STH) infections, affecting populations globally. The condition is particularly prevalent in tropical and subtropical areas with low levels of sanitation and poor living conditions. The objective of this systematic review and meta-analysis was to evaluate the prevalence of Trichuris trichiura infection in Asia at the country and region level. Multiple databases/academic search engines (Web of Science, PubMed, ProQuest, Scopus, and Google Scholar) were searched for literature on T. trichiura prevalence in Asia published through January 2021. Pooled prevalence was determined using the meta-package in R (version 3.6.1). Out of 13,836 articles, 226 studies (5,439,500 individuals) from 26 countries met the inclusion criteria. Of the 226 studies, 151 were community-based studies that included individuals across the age spectrum, while 75 studies focused on school children (typically in the 5-16 years age range). The overall T. trichiura pooled prevalence was 15.3% (95% CI: 12.4-19.1%), with a pooled prevalence of 13.3% (95% CI: 10.0-17.1%) for the community studies and 20.9% (95% CI: 14.7-27.9%) for the studies only including school children. For studies including all age groups, individuals in the 1-15 years age group had the highest pooled prevalence at 23.4% (95% CI: 1.7-49.4%). There was a significant difference found in overall pooled prevalence by sex (p < 0.001) and community type (rural versus urban) (p < 0.001). Although prevalence appears to be decreasing, study findings suggest that T. trichiura infection continues to be a public health problem in Asia. Therefore, control programs focused on at-risk individuals in endemic areas are needed.
Topics: Adolescent; Animals; Ascariasis; Ascaris lumbricoides; Asia; Child; Child, Preschool; Feces; Helminthiasis; Humans; Infant; Prevalence; Sanitation; Soil; Trichuriasis; Trichuris
PubMed: 34993634
DOI: 10.1007/s00436-021-07365-8 -
Pathogens and Global Health Sep 2022The role of various parasitic infections in the occurrence of appendicitis is illustrated through cases recorded all over the world. The purpose of the current study was... (Meta-Analysis)
Meta-Analysis
The role of various parasitic infections in the occurrence of appendicitis is illustrated through cases recorded all over the world. The purpose of the current study was to estimate the global prevalence of parasite infestation (other than ) in appendectomy specimens.In the setting of the PRISMA guidelines, multiple databases (Science Direct, Scopus, Web of Science, PubMed, and Google Scholar) were explored in articles published until 28 September 2020. Totally, 62 studies (106 datasets) with 77, 619 participants were included in the analysis.The pooled prevalence of parasites in appendectomy samples was as follows; 0.012% (95% CI; 0.004-0.025) for , 0.004% (95% CI; 0.001-0.009) for , 0.025% (95% CI; 0.007-0.052) for , 0.002% (95% CI; 0.001-0.005) for spp., 0.061% (95% CI; 0.020-0.122) for and 0.034% (95% CI; 0.018-0.056) for .Our results demonstrated that the risk of appendicitis may increase in the presence of helminth and protozoan infections. As such, the most cases of parasites in appendectomy specimens were reported in developing countries. Regular screening plans for diagnosis, treatment and prevention are needed for prevention of parasitic infection as well as parasitic associated appendicitis, especially in endemic regions of the world.
Topics: Animals; Appendicitis; Ascaris lumbricoides; Feces; Humans; Intestinal Diseases, Parasitic; Parasites; Prevalence; Public Health
PubMed: 34842078
DOI: 10.1080/20477724.2021.2008701 -
Transactions of the Royal Society of... Jul 2022Toxocariasis is a neglected tropical disease caused by Toxocara canis and Toxocara cati. Toxocara species can involve many organs, such as the brain, heart and lungs,...
BACKGROUND
Toxocariasis is a neglected tropical disease caused by Toxocara canis and Toxocara cati. Toxocara species can involve many organs, such as the brain, heart and lungs, however, the urinary system involvement of toxocariasis is largely unknown.
METHODS
We performed a systematic review to identify cases infected with urinary tract toxocariasis.
RESULTS
We identified seven cases that were eligible to be reviewed. Among the included citations, four studies reported bladder involvement and three reported kidney involvement. Fever, urinary, and abdominal presentations were amongst the most important clinical symptoms. Eosinophilic cystitis and nephrotic syndrome were the most common diagnoses.. The treatment regimen included a combination of anthelmintic drugs and steroids.
CONCLUSIONS
In cases of urinary tract presentations accompanied by eosinophilia or histopathologic findings suggestive of parasitic infection, toxocariasis should be included in the list of differential diagnoses, especially in endemic areas.
Topics: Animals; Anthelmintics; Eosinophilia; Humans; Neglected Diseases; Toxocara; Toxocara canis; Toxocariasis
PubMed: 34791477
DOI: 10.1093/trstmh/trab177 -
Veterinary Parasitology, Regional... Apr 2021Parasitic zoonoses despite of their potential threats to human health remain neglected especially in developing countries. Toxocara canis and Toxocara cati worms are... (Meta-Analysis)
Meta-Analysis
Parasitic zoonoses despite of their potential threats to human health remain neglected especially in developing countries. Toxocara canis and Toxocara cati worms are considered important zoonotic parasites and the ability of their infective ova to sustain longer in suitable edaphic environments poses constant risk of infection to humans. This systematic review and meta-analysis aims to highlight the burden and importance of soil borne toxocariasis in India. A total of 14 primary prevalence studies spanned over a period from 1985 to 2017 were included in this study. Due to expected variation between studies, a random-effects model was applied by using MetaXL add-on. The apparent prevalence based on the soil samples tested positive was found in the range of 2.11 to 31.0% while the weighted pooled prevalence was estimated as 11.26 (95% CI 07.59 - 15.54%). A high heterogeneity between studies (I = 93.39 and Q = 227.024, p = 0.00) confirmed the diversity of the populations under study. This meta-analysis highlights the need of more studies on soil transmission of zoonotic toxocariasis in India.
Topics: Animals; Soil; Toxocara; Toxocara canis; Toxocariasis; Zoonoses
PubMed: 34024376
DOI: 10.1016/j.vprsr.2021.100560 -
Ocular Immunology and Inflammation Nov 2021Ocular toxocariasis (OT) is a zoonotic infection caused by larval stages of and . The current review and meta-analysis aimed to evaluate the global prevalence of OT. (Meta-Analysis)
Meta-Analysis
PURPOSE
Ocular toxocariasis (OT) is a zoonotic infection caused by larval stages of and . The current review and meta-analysis aimed to evaluate the global prevalence of OT.
METHODS
Five English (PubMed, Scopus, Science Direct, Web of Science, and Google Scholar) databases were explored and 101 articles met the inclusion criteria.
RESULTS
The pooled prevalence (95% confidence interval) of OT was higher in immunological studies (9%. 6-12%) than in studies that applied ophthalmic examination (1%. 1-2%). The lower middle-income level countries had the highest prevalence (6%. 2-12%) as well as the African region (10%. 7-13%). The highest infection rate (4%. 2-7%) was detected in the 1-25 mean age group.
CONCLUSION
Regular anthelminthic treatment of cats and dogs, and removal of animal feces from public places must be considered.
Topics: Animals; Anthelmintics; Cat Diseases; Cats; Dog Diseases; Dogs; Eye Infections, Parasitic; Humans; Toxocara canis; Toxocariasis; Zoonoses
PubMed: 33909531
DOI: 10.1080/09273948.2021.1875007 -
Transactions of the Royal Society of... Oct 2021Toxocariasis is an important neglected disease that could have a role in the development of some neurological disorders, such as schizophrenia (SCZ). We performed the... (Meta-Analysis)
Meta-Analysis
Toxocariasis is an important neglected disease that could have a role in the development of some neurological disorders, such as schizophrenia (SCZ). We performed the first systematic review and meta-analysis on observational studies to evaluate the possible association between Toxocara infection/exposure and SCZ. Systematic searching (PubMed, Scopus, Web of Science and Google Scholar) was performed, up to 15 August 2020, to identify the relevant studies. We used a random effects meta-analysis model to generate the pooled OR and 95% CIs. The research process resulted in the identification of six studies related to the subject of interest entailing 411 SCZ patients and 2047 controls. Our results demonstrated that the SCZ patients (15%; 95% CI 6.8 to 29.9%) had higher pooled seroprevalence of Toxocara infection/exposure than the control group (3.3%; 95% CI 1.1 to 9.4%), showing a significant association (pooled OR, 4.06; 95% CI 1.14 to 14.43). Our findings suggested that Toxocara infection/exposure might have an important but neglected contribution to SCZ development. However, further well-designed and large-scale observational studies are needed to illuminate this association. Because many other environmental and genetic factors may be strong confounders, more mechanistic/experimental studies in animal models are also necessary to further define the mechanism of this association.
Topics: Animals; Bibliometrics; Humans; Risk Factors; Schizophrenia; Seroepidemiologic Studies; Toxocara; Toxocariasis
PubMed: 33822228
DOI: 10.1093/trstmh/trab056 -
Parasitology Research Nov 2020The infective stage of Anisakidae nematodes responsible for allergic reactions in humans is found in a variety of edible fish and cephalopods. The identification of...
The infective stage of Anisakidae nematodes responsible for allergic reactions in humans is found in a variety of edible fish and cephalopods. The identification of geographical regions that are high risk for infected seafood may help prevent allergic reactions in humans. Despite an abundance of published literature which has identified anisakid larvae in an array of edible seafood as well as scattered reports of human allergic anisakiasis, the relationship between the two has not been fully explored. Therefore, a systematic spatio-temporal study was conducted to determine the prevalence of Anisakis spp. in fish from January 2000 to August 2020 firstly to explore the relationship between fish infection and cases of allergic anisakiasis and secondly to use fish infection data to map potential allergic anisakiasis 'hot spots'. A systematic literature search for original English text articles was conducted through search engines, Web of Science, Scopus, PubMed, Science Direct and Google Scholar. Out of 3228 articles which describe anisakid infection in fish, 264 were used for data extraction. Of 904 articles describing allergic anisakiasis, 37 were used for data extraction. A qualitative summary of the extracted data was performed using equal interval method (ArcMap software) in order to compare the global distribution of Anisakis-infected fish. Of the 152-identified fish hosts, five families were most commonly infected with Anisakis spp. These included Lophiidae (86.9%), Trichiuridae (77.05%), Zeidae (70.9%), Merlucciidae (67.8%) and Gadidae (56.8%). The hot spot areas for allergic anisakiasis were North and northeast of Atlantic Ocean, southwest of USA, west of Mexico, south of Chile, east of Argentina, Norway, UK and west of Iceland (confidence 99%). The highest rate of allergic anisakiasis was in Portugal and Norway with the prevalence rate of 18.45-22.50%. Allergologists should consider allergic anisakiasis as a public health issue particularly in high-risk countries where high prevalences in fish have been demonstrated.
Topics: Animals; Anisakiasis; Anisakis; Fish Diseases; Fishes; Food Hypersensitivity; Global Health; Humans; Larva; Prevalence; Seafood
PubMed: 33025215
DOI: 10.1007/s00436-020-06892-0 -
Tropical Doctor Oct 2020Although human toxocariasis can lead to serious complications including neurological, ocular and visceral complications, there is a lack of comprehensive epidemiological...
Although human toxocariasis can lead to serious complications including neurological, ocular and visceral complications, there is a lack of comprehensive epidemiological information about the seroprevalence of species in humans. In the present study, we analysed and reviewed the overall seroprevalence of human toxocariasis in Iran. The data collection was systematically undertaken on published articles using the PubMed, Google Scholar, ScienceDirect and Scopus databases. A total of 27 studies from the past two decades reporting seroprevalence of human toxocariasis met our eligibility criteria. The pooled proportion of infection was estimated as 6.58% (95% confidence interval = 3.98-9.77). A wide variation between different studies was observed (Q statistic = 799.37, df = 26, < 0.0001, and I = 96.7%). The seroprevalence rate of toxocariasis in the Iranian population is relatively high; contamination of the environment by eggs from the host as well as from household dogs and cats should be blamed.
Topics: Animals; Cats; Dogs; Humans; Iran; Larva Migrans, Visceral; Seroepidemiologic Studies; Toxocara; Toxocariasis; Zoonoses
PubMed: 32998656
DOI: 10.1177/0049475520931545 -
BMC Infectious Diseases Jul 2020Tuberculosis and intestinal parasites are mostly affecting poor people. They are in a vicious since one is the risk factor for the other. However, the comprehensive... (Meta-Analysis)
Meta-Analysis
BACKGROUND
Tuberculosis and intestinal parasites are mostly affecting poor people. They are in a vicious since one is the risk factor for the other. However, the comprehensive report on the burden and co-incidence of intestinal parasites and tuberculosis in Ethiopia is scant. This systematic review and meta-analysis aimed to provide abridge conclusive evidence on the intestinal parasite-tuberculosis co-infection in Ethiopia.
METHODS
A total of 414 articles published in English were searched from both electronic databases (CINAHL, DOAJ, Embase, Emcare, Medline, ProQuest, and PubMed, Science Direct, and Web of Science) and other sources. The qualities of the included studies were assessed using the Joanna Briggs Institute Critical Appraisal tools and the publication bias was measured using the funnel plot and Eggers regression test. Comprehensive meta-analysis (CMA) Version 3.3.07 and Review Manager software were used to estimate pooled prevalence and associations of intestinal parasites and tuberculosis infection.
RESULTS
Eleven articles with a total of 3158 tuberculosis patients included in the analysis based on the eligibility criteria. The estimated pooled prevalence of intestinal parasites co-infection was 33% (95% CI: 23.3, 44.3) using the random-effects model. The most common intestinal parasites were Ascaris lumbricoides 10.5% (95% CI: 6.0, 17.5), Hookworm 9.5% (95% CI: 6.10, 14.4), Giardia lamblia 5.7% (95% CI: 2.90, 10.9) and Strongyloides sterocoralis 5.6% (95% CI: 3.3, 9.5). The odds of intestinal parasites infection was higher among tuberculosis patients compared to tuberculosis free individuals (OR = 1.76; 95% CI: 1.17, 2.63). A significant difference was observed among TB patients for infection with intestinal helminths (OR = 2.01; 95% CI: 1.07, 3.80) but not for intestinal protozoans when compared with their counterparts. The odds of multiple parasitic infections was higher among tuberculosis patients (OR = 2.59, 95% CI: 1.90, 3.55) compared to tuberculosis free individuals. However, intestinal parasites co-infection was not associated with HIV status among tuberculosis patients (OR = 0.97; 95% CI: 0.71, 1.32).
CONCLUSION
One-third of tuberculosis patients are co-infected with one or more intestinal parasites, and they are more likely to be infected with intestinal helminths and multiple intestinal parasitic infections compared to TB free individuals. We recommend routine screening of tuberculosis patients for intestinal parasites. The effect of mass deworming on tuberculosis incidence would be important to be considered in future researches.
TRIAL REGISTRATION
Registered on PROSPERO with reference number ID: CRD42019135350 .
Topics: Ancylostomatoidea; Animals; Ascaris lumbricoides; Coinfection; Ethiopia; Feces; Female; Giardia lamblia; Humans; Intestinal Diseases, Parasitic; Male; Prevalence; Risk Factors; Tuberculosis
PubMed: 32664873
DOI: 10.1186/s12879-020-05237-7 -
Advances in Parasitology 2020Toxocariasis is a neglected parasitic zoonosis. Although some studies have reported the Toxocara prevalence in dogs and cats in mainland China, there is a lack of...
Toxocariasis is a neglected parasitic zoonosis. Although some studies have reported the Toxocara prevalence in dogs and cats in mainland China, there is a lack of comprehensive analysis of these data. Here, we conducted the first systematic review based on relevant literatures published in Web of Science, PubMed and CNKI from January 2000 to July 2019 to assess the prevalence of Toxocara infection in dogs and cats in mainland China. A total of 68 eligible papers were retrieved, including 24,490 dogs and 844 cats, with 17.34% (4246/24,490) Toxocara canis prevalence in dogs and 22.04% (186/844) Toxocara cati prevalence in cats by faecal floatation method. The prevalence and risk factors of T. canis and T. cati infection in different geographical regions, years, breeds, ages and genders were estimated in this review. This review indicates that there was high prevalence of Toxocara infection in dogs and cats in China. This finding calls for measures to reduce the potential risk of Toxocara infection and toxocariasis in humans and animals.
Topics: Animals; Cats; China; Dogs; Prevalence; Risk Factors; Toxocara; Toxocara canis; Toxocariasis
PubMed: 32381229
DOI: 10.1016/bs.apar.2020.01.031