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Journal of Periodontal Research Oct 2023To investigate the existence of any association between new putative periodontal pathogens and periodontitis. Two independent reviewers conducted electronic literature... (Meta-Analysis)
Meta-Analysis Review
To investigate the existence of any association between new putative periodontal pathogens and periodontitis. Two independent reviewers conducted electronic literature searches in the MEDLINE (PubMed), EMBASE, DOSS and Google Scholar databases as well as a manual search to identify eligible clinical studies prior to November 2022. Studies comparing the prevalence of microorganisms other than the already-known periodontal pathogens in subgingival plaque and/or saliva samples between subjects with periodontitis and subject with periodontal health were included. Meta-analyses were performed on data provided by the included studies. Fifty studies including a total of 2739 periodontitis subjects and 1747 subjects with periodontal health were included. The Archaea domain and 25 bacterial species (Anaeroglobus geminatus, Bacteroidales [G-2] bacterium HMT 274, Desulfobulbus sp. HMT 041, Dialister invisus, Dialister pneumosintes, Eubacterium brachy, Enterococcus faecalis, Eubacterium nodatum, Eubacterium saphenum, Filifactor alocis, Fretibacterium sp. HMT 360, Fretibacterium sp. HMT 362, Mogibacterium timidum, Peptoniphilaceae sp. HMT 113, Peptostreptococcus stomatis, Porphyromonas endodontalis, Slackia exigua, Streptococcus gordonii, Selenomonas sputigena, Treponema amylovorum, Treponema lecithinolyticum, Treponema maltophilum, Treponema medium, Treponema parvum and Treponema socranskii) were found to be statistically significantly associated with periodontitis. Network studies should be conducted to investigate the role of these newly identified periodontitis-associated microorganisms through interspecies interaction and host-microbe crosstalk analyses.
Topics: Humans; Bacteria; Periodontitis; Dental Plaque; Bacteroides; Eubacterium
PubMed: 37572051
DOI: 10.1111/jre.13173 -
Archives of Oral Biology Sep 2020To systematically review the literature regarding the microbiota composition in various peri-implant conditions as analyzed by 16S rRNA gene sequencing methods.
OBJECTIVE
To systematically review the literature regarding the microbiota composition in various peri-implant conditions as analyzed by 16S rRNA gene sequencing methods.
METHODS
Electronic searches were conducted at MEDLINE/PubMed, Scopus, Embase, ScienceDirect and Web of Science databases looking for articles published up to April 2020. Observational prospective investigations were considered with systemically healthy patients and that had presented the description of the microbiota composition of peri-implantitis (PI), peri-implant mucositis (PM) and/or health implants (HI) by using 16S rRNA gene sequencing analysis were considered eligible.
RESULTS
From 1,380 titles found, 8 studies were considered for qualitative analysis. One article was excluded due to high risk of bias, remaining 7 studies for descriptive analysis. In 6 out of 7 studies the PI microbiota was reported as being in relative abundance and variety though with a different composition from those with HI. There was no consensus regarding which condition had more diversity. The main observed phyla among PI were Firmicutes, Bacteroidetes, Actinobacteria, Fusobacteria and Spirochaetes, while the genera were mainly Actinomyces, Eubacterium, Fusobacterium, Mogibacterium, Moraxella, Treponema and Porphyromonas. Comparisons between PI and PM microbiota showed conflicting results: one study suggested that PI has greater bacterial diversity; another study reported the opposite result, while another investigation found similar variety for both conditions.
CONCLUSIONS
The microbiota of peri-implant conditions have been reported as distinct, although the available literature presents discrepancies. Nonetheless, considering the findings in most studies, it can be suggested that the relative abundance of microbiota and bacterial diversity increased with the progress of peri-implant disease.
Topics: Bacteria; Dental Implants; Humans; Microbiota; Observational Studies as Topic; Peri-Implantitis; RNA, Ribosomal, 16S
PubMed: 32512257
DOI: 10.1016/j.archoralbio.2020.104776