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Environmental Science and Pollution... Jan 2023The study used scattered literature to summarize the effects of excess Cd, As, and Pb from contaminated soils on plant secondary metabolites/bioactive compounds...
The study used scattered literature to summarize the effects of excess Cd, As, and Pb from contaminated soils on plant secondary metabolites/bioactive compounds (non-nutrient organic substances). Hence, we provided a systematic overview involving the sources and forms of Cd, As, and Pb in soils, plant uptake, mechanisms governing the interaction of these risk elements during the formation of secondary metabolites, and subsequent effects. The biogeochemical characteristics of soils are directly responsible for the mobility and bioavailability of risk elements, which include pH, redox potential, dissolved organic carbon, clay content, Fe/Mn/Al oxides, and microbial transformations. The radial risk element flow in plant systems is restricted by the apoplastic barrier (e.g., Casparian strip) and chelation (phytochelatins and vacuole sequestration) in roots. However, bioaccumulation is primarily a function of risk element concentration and plant genotype. The translocation of risk elements to the shoot via the xylem and phloem is well-mediated by transporter proteins. Besides the dysfunction of growth, photosynthesis, and respiration, excess Cd, As, and Pb in plants trigger the production of secondary metabolites with antioxidant properties to counteract the toxic effects. Eventually, this affects the quantity and quality of secondary metabolites (including phenolics, flavonoids, and terpenes) and adversely influences their antioxidant, antiinflammatory, antidiabetic, anticoagulant, and lipid-lowering properties. The mechanisms governing the translocation of Cd, As, and Pb are vital for regulating risk element accumulation in plants and subsequent effects on secondary metabolites.
Topics: Antioxidants; Biodegradation, Environmental; Cadmium; Lead; Metals, Heavy; Soil; Soil Pollutants
PubMed: 36529801
DOI: 10.1007/s11356-022-24776-x -
Environmental Science and Pollution... Jan 2023Environmental pollution caused by persistent organic pollutants (POPs) has increased the challenge for the scientific communities. Polybrominated diphenyl ethers... (Review)
Review
Environmental pollution caused by persistent organic pollutants (POPs) has increased the challenge for the scientific communities. Polybrominated diphenyl ethers (PBDEs), classified as POPs, are widely applied in various materials as brominated flame retardants (BFRs). Because of the nature of these chemical compounds including toxicity, stability, and capability to bioaccumulate and biomagnify, PBDEs have posed a great challenge and risk to human health and wildlife. Therefore, the side effects of exposure to PBDEs as ubiquitous pollutants in the environment on cancer progression were investigated using a systematic review (SR) survey. To achieve this goal, forty studies were considered after defining the search terms and inclusion criteria, and/or exclusion criteria; the eligible records were collected from the international bibliographic databases. Based on the findings of the reviewed records, environmental exposure to the BFRs including PBDEs has a positive association with different mechanisms that induce cancer progression. However, the findings of the reviewed studies were not totally consistent with the mode of action and side effects are yet to be fully elucidated. Several articles have reported that BFRs can be carcinogenic and induce epithelial to mesenchymal transition via different mechanisms. The main mode of action involved in the environmental exposure to BFRs and the risk of cancer progression is endoplasmic reticulum and oxidative stress (OS). Generally, the imbalance of antioxidant mechanisms, reactive nitrogen species (RNSs) and reactive oxygen species (ROSs), during damage in cells, and stress caused OS, which increases tumorigenesis via multiple mechanisms, such as DNA damage, inflammation, and angiogenesis.
Topics: Humans; Halogenated Diphenyl Ethers; Epithelial-Mesenchymal Transition; Environmental Exposure; Environmental Pollutants; Flame Retardants; Carcinogenesis; Environmental Monitoring
PubMed: 36469279
DOI: 10.1007/s11356-022-24538-9 -
Frontiers in Pharmacology 2022Lonicerae Japonicae Flos has been used as a tea and medicine for more than 1,500 years. It has the functions of clearing heat, detoxification, and is often used to... (Review)
Review
Lonicerae Japonicae Flos has been used as a tea and medicine for more than 1,500 years. It has the functions of clearing heat, detoxification, and is often used to treat carbuncle, furuncle, throat arthralgia, erysipelas, heat-toxic blood dysentery, febrile fever. This paper summarizes the botany, ethnopharmacology, chemical composition and pharmacological action of Lonicerae Japonicae Flos from 1986 to 2022, and looks forward to the future research direction of Lonicerae Japonicae Flos. At present, the components isolated from Lonicerae Japonicae Flos include essential oils, organic acids, flavonoids, iridoids, saponins and other compounds. It has the effects of anti-inflammation, anti-virus, anti-bacteria, anti-oxidation, anti-tumor, protect liver and galltesticles, hypotensive, hypolipidemic, anti-thrombosis, anti-allergy, immune regulation and so on. It is often used in clinical treatment of diarrhea, hematochezia, febrile disease, exogenous wind-heat, and cold, swelling and toxin of carbuncle, sore throat and so on. The comprehensive evaluation of the quality of Lonicerae Japonicae Flos and the understanding of multi-target network pharmacology also need to be studied. As a kind of health food with high value, LJF is worthy of further promotion and development.
PubMed: 36339557
DOI: 10.3389/fphar.2022.1013992 -
Frontiers in Plant Science 2022Global climate change stress has greatly influenced agricultural crop production which leads to the global problems such as food security. To cope with global climate...
Global climate change stress has greatly influenced agricultural crop production which leads to the global problems such as food security. To cope with global climate change, nature based solutions (NBS) are desirable because these lead to improve our environment. Environmental stresses such as drought and salinity are big soil problems and can be eradicated by increasing soil organic matter which is directly related to soil organic carbon (SOC). SOC is one of the key components of the worldwide carbon (C) cycle. Different types of land use patterns have shown significant impacts on SOC stocks. However, their effects on the various SOC fractions are not well-understood at the global level which make it difficult to predict how SOC changes over time. We aim to investigate changes in various SOC fractions, including mineral associated organic carbon (MAOC), mineral associated organic matter (MAOM), soil organic carbon (SOC), easily oxidized organic carbon (EOC), microbial biomass carbon (MBC) and particulate organic carbon (POC) under various types of land use patterns (NBS), including cropping pattern, residue management, conservation tillages such as no tillage (NT) and reduced tillage (RT) using data from 97 studies on a global scale. The results showed that NT overall increased MAOC, MAOM, SOC, MBC, EOC and POC by 16.2%, 26.8%, 24.1%, 16.2%, 27.9% and 33.2% ( < 0.05) compared to CT. No tillage with residue retention (NTR) increased MAOC, MAOM, SOC, MBC, EOC and POC by 38.0%, 29.9%, 47.5%, 33.1%, 35.7% and 49.0%, respectively, compared to CT ( < 0.05). RT overall increased MAOC, MAOM, SOC, MBC, EOC and POC by 36.8%, 14.1%, 25.8%, 25.9, 18.7% and 16.6% ( < 0.05) compared to CT. Reduced tillage with residue retention (RTR) increased MAOM, SOC and POC by 14.2%, 36.2% and 30.7%, respectively, compared to CT ( < 0.05). Multiple cropping increased MAOC, MBC and EOC by 14.1%, 39.8% and 21.5%, respectively, compared to mono cropping ( < 0.05). The response ratios of SOC fractions (MAOC, MAOM, SOC, MBC, EOC and POC) under NT and RT were mostly influenced by NBS such as residue management, cropping pattern along with soil depth, mean annual precipitation, mean annual temperature and soil texture. Our findings imply that when assessing the effects of conservation tillage methods on SOC sequestration, SOC fractions especially those taking part in driving soil biological activities, should be taken into account rather than total SOC. We conclude that conservation tillages under multiple cropping systems and with retention of crop residues enhance soil carbon sequestration as compared to CT in varying edaphic and climatic conditions of the world.
PubMed: 36212308
DOI: 10.3389/fpls.2022.1007222 -
Environmental Research Jan 2023Volatile organic compound (VOC) emissions have attracted wide attention due to their impacts on atmospheric quality and public health. However, most studies reviewed... (Review)
Review
Volatile organic compound (VOC) emissions have attracted wide attention due to their impacts on atmospheric quality and public health. However, most studies reviewed certain aspects of natural VOCs (NVOCs) or anthropogenic VOCs (AVOCs) rather than comprehensively quantifying the hotspots and evolution trends of AVOCs and NVOCs. We combined the bibliometric method with the evolution tree and Markov chain to identify research focus and uncover the trends in VOC emission sources. This study found that research mainly focused on VOC emission characteristics, effects on air quality and health, and VOC emissions under climate change. More studies concerned on AVOCs than on NVOCs, and AVOC emissions have shifted with a decreasing proportion of transport emissions and an increasing share of solvent utilization in countries with high emissions and publications (China and the USA). Research on AVOCs is imperative to develop efficient and economical abatement techniques specific to solvent sources or BTEX species to mitigate the detrimental effects. Research on NVOCs originating from human sources risen due to their application in medicine, while studies on sources sensitive to climate change grew slowly, including plants, biomass burning, microbes, soil and oceans. Research on the long-term responses of NVOCs derived from various sources to climate warming is warranted to explore the evolution of emissions and the feedback on global climate. It is worthwhile to establish an emission inventory with all kinds of sources, accurate estimation, high spatial and temporal resolution to capture the emission trends in the synergy of industrialization and climate change as well as to simulate the effects on air quality. We review VOC emissions from both anthropogenic and natural sources under climate change and their effects on atmospheric quality and health to point out the research directions for the comprehensive control of global VOCs and mitigation of O pollution.
Topics: Humans; Volatile Organic Compounds; Air Pollutants; Ozone; Air Pollution; Solvents; China; Environmental Monitoring
PubMed: 36162470
DOI: 10.1016/j.envres.2022.114386 -
Minerva Dental and Oral Science Aug 2022Compare through case-control studies, the salivary characteristics of patients with and without BMS.
INTRODUCTION
Compare through case-control studies, the salivary characteristics of patients with and without BMS.
EVIDENCE ACQUISITION
Searches in Embase, PubMed, Web of Science, Scopus, Cochrane, and BIREME were conducted for the identification of case-controls studies reported.
EVIDENCE SYNTHESIS
Thirty-three studies were included, of which 26 articles evaluated OSB, 17 SRF, and 7 SE. Nineteen organic biomarkers showed higher levels in BMS patients, the two most indicated being α-amylase and cortisol. Ten organic biomarkers, including Tumor Necrosis Factor-alpha (TNF-α) and IL-6, showed lower levels in BMS patients. Regarding salivary flow rate (SFR), five articles indicated that BMS patients have less unstimulated SFR (uSRF)Two articles indicate that stimulated SFR (sSRF) is lower in BMS patients nevertheless, but eight did not show differences. Sialochemical analysis revealed that sodium (Na), chloride (Cl), potassium (K), sodium (Na), and calcium (Ca), showed higher levels in BMS patients according to three studies, but two studies did not establish any differences. Two study established that BMS patients have lower Mg salivary levels.
CONCLUSIONS
Qualitative salivary characteristics suggest that BMS has neuropathic, inflammatory, emotional, immune, and hormonal involvements. BMS can be associated with changes in salivary biomarkers of inflammation and oxidative stress, is related to anxiety and degree of pain.
Topics: Biomarkers; Burning Mouth Syndrome; Humans; Hydrocortisone; Saliva; Sodium
PubMed: 35920290
DOI: 10.23736/S2724-6329.22.04647-2 -
Neurotoxicology Sep 2022Investigation of the toxicity triggered by chemicals on the human brain has traditionally relied on approaches using rodent in vivo models and in vitro cell models... (Review)
Review
Investigation of the toxicity triggered by chemicals on the human brain has traditionally relied on approaches using rodent in vivo models and in vitro cell models including primary neuronal cultures and cell lines from rodents. The issues of species differences between humans and rodents, the animal ethical concerns and the time and cost required for neurotoxicity studies on in vivo animal models, do limit the use of animal-based models in neurotoxicology. In this context, human cell models appear relevant in elucidating cellular and molecular impacts of neurotoxicants and facilitating prioritization of in vivo testing. The SH-SY5Y human neuroblastoma cell line (ATCC® CRL-2266™) is one of the most used cell lines in neurosciences, either undifferentiated or differentiated into neuron-like cells. This review presents the characteristics of the SH-SY5Y cell line and proposes the results of a systematic review of literature on the use of this in vitro cell model for neurotoxicity research by focusing on organic environmental pollutants including pesticides, 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin (TCDD), flame retardants, PFASs, parabens, bisphenols, phthalates, and PAHs. Organic environmental pollutants are widely present in the environment and increasingly known to cause clinical neurotoxic effects during fetal & child development and adulthood. Their effects on cultured SH-SY5Y cells include autophagy, cell death (apoptosis, pyroptosis, necroptosis, or necrosis), increased oxidative stress, mitochondrial dysfunction, disruption of neurotransmitter homeostasis, and alteration of neuritic length. Finally, the inherent advantages and limitations of the SH-SY5Y cell model are discussed in the context of chemical testing.
Topics: Adult; Animals; Cell Line, Tumor; Cell Survival; Child; Environmental Pollutants; Flame Retardants; Fluorocarbons; Humans; Neuroblastoma; Neurotoxicity Syndromes; Parabens; Pesticides; Polychlorinated Dibenzodioxins
PubMed: 35914637
DOI: 10.1016/j.neuro.2022.07.008 -
Human Reproduction Update Jan 2023Air pollution is both a sensory blight and a threat to human health. Inhaled environmental pollutants can be naturally occurring or human-made, and include...
BACKGROUND
Air pollution is both a sensory blight and a threat to human health. Inhaled environmental pollutants can be naturally occurring or human-made, and include traffic-related air pollution (TRAP), ozone, particulate matter (PM) and volatile organic compounds, among other substances, including those from secondhand smoking. Studies of air pollution on reproductive and endocrine systems have reported associations of TRAP, secondhand smoke (SHS), organic solvents and biomass fueled-cooking with adverse birth outcomes. While some evidence suggests that air pollution contributes to infertility, the extant literature is mixed, and varying effects of pollutants have been reported.
OBJECTIVE AND RATIONALE
Although some reviews have studied the association between common outdoor air pollutants and time to pregnancy (TTP), there are no comprehensive reviews that also include exposure to indoor inhaled pollutants, such as airborne occupational toxicants and SHS. The current systematic review summarizes the strength of evidence for associations of outdoor air pollution, SHS and indoor inhaled air pollution with couple fecundability and identifies gaps and limitations in the literature to inform policy decisions and future research.
SEARCH METHODS
We performed an electronic search of six databases for original research articles in English published since 1990 on TTP or fecundability and a number of chemicals in the context of air pollution, inhalation and aerosolization. Standardized forms for screening, data extraction and study quality were developed using DistillerSR software and completed in duplicate. We used the Newcastle-Ottawa Scale to assess risk of bias and devised additional quality metrics based on specific methodological features of both air pollution and fecundability studies.
OUTCOMES
The search returned 5200 articles, 4994 of which were excluded at the level of title and abstract screening. After full-text screening, 35 papers remained for data extraction and synthesis. An additional 3 papers were identified independently that fit criteria, and 5 papers involving multiple routes of exposure were removed, yielding 33 articles from 28 studies for analysis. There were 8 papers that examined outdoor air quality, while 6 papers examined SHS exposure and 19 papers examined indoor air quality. The results indicated an association between outdoor air pollution and reduced fecundability, including TRAP and specifically nitrogen oxides and PM with a diameter of ≤2.5 µm, as well as exposure to SHS and formaldehyde. However, exposure windows differed greatly between studies as did the method of exposure assessment. There was little evidence that exposure to volatile solvents is associated with reduced fecundability.
WIDER IMPLICATIONS
The evidence suggests that exposure to outdoor air pollutants, SHS and some occupational inhaled pollutants may reduce fecundability. Future studies of SHS should use indoor air monitors and biomarkers to improve exposure assessment. Air monitors that capture real-time exposure can provide valuable insight about the role of indoor air pollution and are helpful in assessing the short-term acute effects of pollutants on TTP.
Topics: Pregnancy; Female; Humans; Air Pollution; Air Pollutants; Tobacco Smoke Pollution; Particulate Matter; Fertility; Environmental Pollutants
PubMed: 35894871
DOI: 10.1093/humupd/dmac029 -
International Journal of Environmental... Jul 2022Air pollution affects health, but much of the focus to this point has been on outdoor air. Higher indoor pollution is anticipated due to increasingly energy-efficient... (Review)
Review
Indoor Air Pollution and the Health of Vulnerable Groups: A Systematic Review Focused on Particulate Matter (PM), Volatile Organic Compounds (VOCs) and Their Effects on Children and People with Pre-Existing Lung Disease.
Air pollution affects health, but much of the focus to this point has been on outdoor air. Higher indoor pollution is anticipated due to increasingly energy-efficient and less leaky buildings together with more indoor activities. Studies of indoor air pollution focusing on children and people with respiratory disease from the database Web of Science (1991-2021) were systemically reviewed according to the PRISMA guidelines, with 69 studies included in the final selection. Emissions from building materials affected indoor air quality, and ventilation also had an influence. The main indoor air pollutants are Volatile Organic Compounds (VOCs) and Particulate Matter (PM). PM sources included smoking, cooking, heating, candles, and insecticides, whereas sources of coarse particles were pets, housework and human movements. VOC sources included household products, cleaning agents, glue, personal care products, building materials and vehicle emissions. Formaldehyde levels were particularly high in new houses. Personal exposure related to both indoor and outdoor pollutant levels, highlighting home characteristics and air exchange rates as important factors. Temperature, humidity, educational level, air purifiers and time near sources were also related to personal exposure. There was an association between PM and Fractional exhaled Nitric Oxide (FeNO), lung function, oxygen saturation, childhood asthma and symptoms of chronic obstructive pulmonary disease (COPD) patients. High VOCs were associated with upper airways and asthma symptoms and cancer. Effective interventional studies for PM in the future might focus on human behavior together with air purifiers and increased ventilation, whereas VOC interventions might center more on building materials and household products, alongside purification and ventilation.
Topics: Air Pollutants; Air Pollution, Indoor; Asthma; Child; Environmental Monitoring; Humans; Lung; Lung Diseases; Particulate Matter; Volatile Organic Compounds
PubMed: 35886604
DOI: 10.3390/ijerph19148752 -
Environmental Research Nov 2022Biochar is the solid material produced from the carbonization of organic feedstock biomass. This material has several unique characteristics such as greater carbon...
Biochar is the solid material produced from the carbonization of organic feedstock biomass. This material has several unique characteristics such as greater carbon content, good electrical conductivity, high stability and large surface area, which can be applied in several research areas such as generation of power and wastewater treatment. In connection with this, recently, the investigations on biochar significantly focus on the removal of toxic heavy metals since the biochar material is easily available and environmentally friendly. According to an environmental analytical device, biochar-derived carbonaceous material has been additionally applied to the synthesis of an effective, sensitive, and low-cost electrochemical sensor. Biochar with an assessment of electrochemical properties has engaged with different redox reactions in water. In this survey, electrochemical ways of behaving of biochar in light of the electrochemical structures were analytically compiled as well as the impact from biomass sources and manufacturing process including carbonization strategies, pre-treatment/changed techniques. This review emphasizes the various synthesis methods of biochar form organic feedstock, properties and different modulations of biochar for the bioremediation of heavy metals. This review study emphasizes the utilization of biochar as sensing platform and supercapacitor for electrode fabrication in electrochemical biosensor to enhance the remediation of toxic contaminants from water streams and by switching the less ecological traditional materials. Brief information on the techniques employed for packaging biochar as carbon electrode is summarized. Scope in the aspect of environmental concern of biochar, future challenges and prospects are proposed in detail.
Topics: Biodegradation, Environmental; Charcoal; Metals, Heavy; Water
PubMed: 35835170
DOI: 10.1016/j.envres.2022.113857