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International Journal of Law and... 2023The Italian mafia organizations represent a subculture with values, beliefs and goals that are antithetical to and undermining of the predominant society. The conduct of...
The Italian mafia organizations represent a subculture with values, beliefs and goals that are antithetical to and undermining of the predominant society. The conduct of individual members includes such extreme violence for material gain, it may at least superficially suggest a severe personality disorder. Since the first edition of the DSM and into the 21st century, various terms have been used, sometimes interchangeably, but over time inconsistently, to designate the mentality and practices of mafia members. Only recently has the psychology of mafia members become a focus of serious scientific study. Following broader national multicenter research, the present study aimed at investigating the possible differences in psychopathy between those mafia associates who had been convicted only of mafia association (Group A, bosses), and those who were also convicted of violent crimes (Group B, soldiers). The Psychopathy Checklist-Revised (PCL-R) was administered to n = 48 male inmates convicted of mafia association (M 45.0 years, SD 10.9, range 20-80 years); Group A consisted of n = 26 (54%) subjects, Group B n = 22 (46%). Most of the sample (73%) did not manifest psychopathy (PCL-R ≥ 25) nor Mann-Whitney U test disclosed significant differences in the total PCL-R scores between the study groups. We found significantly higher scores of PCR-R factor 1 (interpersonal / affective) in the members of the mafia association also convicted of violent crimes (PCL-R F1, group A: 5.8 ± 3.7; group B: 7.9 ± 3.5; p < 0.05), this difference appeared explainable on the basis of a higher component of affective psychopathy. These initial results add to the limited literature on mafia and psychopathy and seem to suggest the existence of a specific component of psychopathy in the subgroup of mafiosi with overtly violent conduct.
Topics: Humans; Male; Young Adult; Adult; Middle Aged; Aged; Aged, 80 and over; Socialization; Antisocial Personality Disorder; Violence; Personality Disorders; Aggression
PubMed: 37441856
DOI: 10.1016/j.ijlp.2023.101907 -
Rivista Di Psichiatria 2023Attachment styles represent a personality pattern critical to psychological health, with insecure attachment being a central factor in developing psychopathological...
INTRODUCTION
Attachment styles represent a personality pattern critical to psychological health, with insecure attachment being a central factor in developing psychopathological characteristics of psychosis. However, its downstream psychopathological pathways remain unclear. This study aimed to investigate the putative psychopathological mediators in the relationship between insecure attachment and psychotic features in a non-clinical sample of university students.
METHODS
We recruited two non-clinical samples for a total of 978 subjects, 324 males and 654 females, and administered the Relationship Questionnaire (RQ) to assess attachment styles and the Symptom Check-List 90 (SCL-90) to assess psychopathological symptoms. Moreover, the Paranoia and Psychoticism subscales of SCL-90 were combined and used as a measure of Psychosis (PSY). A mediation analysis model was carried out to establish the relationship among variables.
RESULTS
Mediation analysis showed a total effect from RQ-Preoccupied and RQ-Fearful to PSY, respectively, 0.31 and 0.28. Direct effects from the SCL-90-R factor candidate mediator to PSY ranged from 0.51 for somatization to 0.72 for depression and 0.72 for interpersonal sensitivity. Indirect effects ranged from 0.08 for RQ-Preoccupied via hostility to 0.21 for RQ-Preoccupied via depression.
DISCUSSION
Our results show that the effect of insecure attachment on psychosis features is differentially mediated by some psychopathological dimensions, being depression and interpersonal sensitivity the most relevant ones. PSY feature, therefore, is predicted by other specific symptoms in the psychological context of insecure primary relationships.
CONCLUSIONS
From a preventive and clinical point of view, our results could be relevant in informing the early-stage psychological treatment of pre-psychotic states and, in general, people experiencing sub-threshold psychotic symptoms.
Topics: Male; Female; Humans; Depression; Object Attachment; Psychotic Disorders; Paranoid Disorders; Personality Disorders
PubMed: 37409433
DOI: 10.1708/4064.40478 -
Environmental Science and Pollution... Jul 2023While some robust artificial intelligence (AI) techniques such as Gene-Expression Programming (GEP), Model Tree (MT), and Multivariate Adaptive Regression Spline (MARS)...
While some robust artificial intelligence (AI) techniques such as Gene-Expression Programming (GEP), Model Tree (MT), and Multivariate Adaptive Regression Spline (MARS) have been frequently employed in the field of water resources, documents aimed to explore their uncertainty levels are few and far between. Meanwhile, uncertainty determination of these AI models in practical applications is highly important especially when we aimed to use the AI models for streamflow forecast due to the repercussions of poorly managed water resources. With the aid of a global daily streamflow dataset, understanding the uncertainty of GEP, MT, and MARS for forecasting streamflow of natural rivers was studied. The efficiency of uncertainty analysis was quantified by two statistical indicators: 95% Percent Prediction Uncertainty (95%PPU) and R-factor. The results demonstrated that MT had lower uncertainty (95%PPU=0.59 and R-factor=1.67) in comparison with MARS (95%PPU=0.61 and R-factor=1.92) and GEP (95%PPU=0.64 and R-factor=2.03). Overall, although the confidence interval bands of uncertainty for the AI models almost captured the mean streamflow measurements, wide bands of uncertainty were obtained and consequently remarkable uncertainty in the calculation of monthly streamflow values was met.
Topics: Artificial Intelligence; Uncertainty; Lead; Water Resources; Trees; Rivers; Forecasting
PubMed: 37369900
DOI: 10.1007/s11356-023-28236-y -
3 Biotech Jul 2023Phycobiliproteins is a family of chromophore-containing proteins having light-harvesting and antioxidant capacity. The phycocyanin (PC) is a brilliant blue coloured...
UNLABELLED
Phycobiliproteins is a family of chromophore-containing proteins having light-harvesting and antioxidant capacity. The phycocyanin (PC) is a brilliant blue coloured phycobiliprotein, found in rod structure of phycobilisome and has been widely studied for their therapeutic and fluorescent properties. In the present study, the hexameric assembly structure of phycocyanin (Syn-PC) from Sp. R42DM is characterized by X-ray crystallography to understand its light-harvesting and antioxidant properties. The crystal structure of Syn-PC is solved with 2.15 Å resolution and crystallographic -factors, / 0.16/0.21. The hexamer of Syn-PC is formed by heterodimer of two polypeptide chains, namely, α- and β-subunits. The structure is analysed at atomic level to reveal the chromophore microenvironment and possible light energy transfer mechanism in Syn-PC. The chromophore arrangement in hexamer, deviation angle and distance between the chromophore contribute to the energy transfer efficiency of protein. The structural attributes responsible for the antioxidant potential of Syn-PC are recognized and annotated on its 3-dimensional structure.
SUPPLEMENTARY INFORMATION
The online version contains supplementary material available at 10.1007/s13205-023-03665-1.
PubMed: 37366498
DOI: 10.1007/s13205-023-03665-1 -
PLoS Genetics Jun 2023Transposable elements (TE) are mobile DNA sequences whose excessive proliferation endangers the host. Although animals have evolved robust TE-targeting defenses,...
Transposable elements (TE) are mobile DNA sequences whose excessive proliferation endangers the host. Although animals have evolved robust TE-targeting defenses, including Piwi-interacting (pi)RNAs, retrotransposon LINE-1 (L1) still thrives in humans and mice. To gain insights into L1 endurance, we characterized L1 Bodies (LBs) and ORF1p complexes in germ cells of piRNA-deficient Maelstrom null mice. We report that ORF1p interacts with TE RNAs, genic mRNAs, and stress granule proteins, consistent with earlier studies. We also show that ORF1p associates with the CCR4-NOT deadenylation complex and PRKRA, a Protein Kinase R factor. Despite ORF1p interactions with these negative regulators of RNA expression, the stability and translation of LB-localized mRNAs remain unchanged. To scrutinize these findings, we studied the effects of PRKRA on L1 in cultured cells and showed that it elevates ORF1p levels and L1 retrotransposition. These results suggest that ORF1p-driven condensates promote L1 propagation, without affecting the metabolism of endogenous RNAs.
Topics: Humans; Male; Mice; Animals; Retroelements; Ribonucleoproteins; Piwi-Interacting RNA; Spermatocytes; Long Interspersed Nucleotide Elements; RNA; RNA, Messenger; Cytoplasm; RNA, Small Interfering
PubMed: 37307272
DOI: 10.1371/journal.pgen.1010797 -
Plasmid Jul 2023Plasmid families harbor different maintenances functions, depending on their size and copy number. Low copy number plasmids rely on active partition systems, organizing... (Review)
Review
Plasmid families harbor different maintenances functions, depending on their size and copy number. Low copy number plasmids rely on active partition systems, organizing a partition complex at specific centromere sites that is actively positioned using NTPase proteins. Some low copy number plasmids lack an active partition system, but carry atypical intracellular positioning systems using a single protein that binds to the centromere site but without an associated NTPase. These systems have been studied in the case of the Escherichia coli R388 and of the Staphylococcus aureus pSK1 plasmids. Here we review these two systems, which appear to be unrelated but share common features, such as their distribution on plasmids of medium size and copy number, certain activities of their centromere-binding proteins, StbA and Par, respectively, as well as their mode of action, which may involve dynamic interactions with the nucleoid-packed chromosome of their hosts.
Topics: Humans; Plasmids; DNA Copy Number Variations; Nucleoside-Triphosphatase; Escherichia coli; Bacterial Proteins; Chromosome Segregation
PubMed: 37301314
DOI: 10.1016/j.plasmid.2023.102694 -
The Science of the Total Environment Sep 2023In this study, we used a large national database to assess the rainfall erosivity (RE) patterns in time and space over the Brazilian territory. Thereby, RE and erosivity...
In this study, we used a large national database to assess the rainfall erosivity (RE) patterns in time and space over the Brazilian territory. Thereby, RE and erosivity density (ED) values were obtained for 5166 rainfall gauges. Also, the concentration of the RE throughout the year and the RE's gravity center locations were analyzed. Finally, homogeneous regions regarding RE values were delimited and estimative regression models were established. The results show that Brazil's mean annual RE value is 5620 MJ mm ha h year, with considerable spatial variation over the country. The highest RE magnitudes were found for the north region, while the northeast region shows the lowest values. Regarding the RE's distribution throughout the year, in the southern region of Brazil, it is more equitable, while in some spots of the northeastern region, it is irregularly concentrated in specific months. Further analyses revealed that for most of the months, the RE's gravity centers for Brazil are in the Goiás State and that they present a north-south migration pattern throughout the year. Complementarily, the ED magnitudes allowed the identification of high-intensity rainfall spots. Additionally, the Brazilian territory was divided into eleven homogeneous regions regarding the RE patterns and for each defined region, a regression model was established and validated. These models' statistical metrics were considered satisfactory and, thus, can be used to estimate RE values for the whole country using monthly rainfall depths. Finally, all database produced are available for download. Therefore, the values and maps shown in this study are relevant for improving the accuracy of soil loss estimates in Brazil and for the establishment of soil and water conservation planning on a national scale.
PubMed: 37286003
DOI: 10.1016/j.scitotenv.2023.164557 -
BMC Urology May 2023Collecting system entry in robot-assisted partial nephrectomy may occur even in cases showing a low N factor in the R.E.N.A.L nephrometry score. Therefore, in this...
BACKGROUND
Collecting system entry in robot-assisted partial nephrectomy may occur even in cases showing a low N factor in the R.E.N.A.L nephrometry score. Therefore, in this study, we focused on the tumor contact surface area with the adjacent renal parenchyma and attempted to construct a novel predictive model for collecting system entry.
METHODS
Among 190 patients who underwent robot-assisted partial nephrectomy at our institution from 2015 to 2021, 94 patients with a low N factor (1-2) were analyzed. Contact surface was measured with three-dimensional imaging software and defined as the C factor, classified as C1, < 10 cm [2]; C2, ≥ 10 and < 15 cm [2]; and C3: ≥ 15 cm [2]. Additionally, a modified R factor (mR) was classified as mR1, < 20 mm; mR2, ≥ 20 and < 40 mm; and mR3, ≥ 40 mm. We discussed the factors influencing collecting system entry, including the C factor, and created a novel collecting system entry predictive model.
RESULTS
Collecting system entry was observed in 32 patients with a low N factor (34%). The C factor was the only independent predictive factor for collecting system entry in multivariate regression analysis (odds ratio: 4.195, 95% CI: 2.160-8.146, p < 0.0001). Models including the C factor showed better discriminative power than the models without the C factor.
CONCLUSIONS
The new predictive model, including the C factor in N1-2 cases, may be beneficial, considering its indication for preoperative ureteral catheter placement in patients undergoing robot-assisted partial nephrectomy.
Topics: Humans; Nephrectomy; Retrospective Studies; Robotic Surgical Procedures; Robotics; Carcinoma, Renal Cell; Kidney Neoplasms
PubMed: 37158841
DOI: 10.1186/s12894-023-01247-0 -
Advances in Health Sciences Education :... Dec 2023Q methodology is a unique, yet underutilized methodology designed specifically to scientifically study subjectivity. Q, as it is most often referred to, is an...
Q methodology is a unique, yet underutilized methodology designed specifically to scientifically study subjectivity. Q, as it is most often referred to, is an appropriate methodology whenever a researcher is interested in uncovering and describing the multiple divergent viewpoints on any topic. Such discovery of viewpoints provides insight into the subjectivities related to policies, values, priorities, judgements, opinions, and decisions. The disciplines where Q has been used for research are many, and include health sciences, education, and other social science / behavioral science fields. Because of its rather idiosyncratic place in research, however, many Q methodologists are self-taught or seek education through a few select universities that offer graduate level Q courses. The key to successfully approaching a Q study is to embrace its unique approach to studying subjectivity such that it is a powerful tool in health science education and other fields. It is common to find inconsistencies related to Q terminology, analyses, and decision making across studies. There is often an over reliance on concepts that come from purely quantitative methodologies such as R factor analysis rather than embracing the qualitative-quantitative hybridity of Q. This article is written as a primer with a focus on understanding Q at a deeper level rather than a step-by-step guide.
Topics: Health Education; Research Design
PubMed: 37071262
DOI: 10.1007/s10459-023-10214-1 -
The Journal of Nervous and Mental... Aug 2023Spirituality/religion (S/R) is clinically relevant to recovery from alcohol use disorders (AUDs)/substance use disorders (SUDs) and also associated with less...
Spirituality/religion (S/R) is clinically relevant to recovery from alcohol use disorders (AUDs)/substance use disorders (SUDs) and also associated with less self-injury; however, the interplay of these factors has not been adequately evaluated. Participants ( n = 1443) were culled from a larger study among psychiatric patients. We assessed for S/R using self-report measures, and medical records were reviewed for demographics, clinical diagnoses, psychiatric medications, and self-harm engagement. Self-harm engagement was significantly higher among patients without AUD/SUD. S/R distress was higher among participants with AUD/SUD, but S/R community activity and importance of religion were lower. Interest in discussing S/R in treatment did not significantly differ across patients. Religious affiliation, importance of religion, and belief in God were associated with less self-harm, but effects were not moderated by presence of AUD/SUD. S/R factors are associated with lower self-harm, irrespective of the presence or absence of AUD/SUD. In contrast with clinical lore, S/R may be equally salient to psychiatric patients with AUD/SUD versus other disorders.
Topics: Humans; Spirituality; Alcoholism; Religion; Substance-Related Disorders; Self-Injurious Behavior
PubMed: 37015109
DOI: 10.1097/NMD.0000000000001655