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Photodermatology, Photoimmunology &... Nov 2023
Review
Topics: Humans; Acanthoma; Dermoscopy; Skin Neoplasms
PubMed: 37587661
DOI: 10.1111/phpp.12906 -
Skin Appendage Disorders Aug 2023Onychocytic matricoma (OCM) is a benign acanthoma of the nail matrix that presents with longitudinal melanonychia and nail thickening. Only 18 previously reported cases...
INTRODUCTION
Onychocytic matricoma (OCM) is a benign acanthoma of the nail matrix that presents with longitudinal melanonychia and nail thickening. Only 18 previously reported cases of OCM are in the literature since it was first described in 2012.
CASE PRESENTATION
The purpose of this case report was to report a unique presentation of OCM in the toenail of a Black patient as well as to review the clinical presentation, histologic features, and management of this rare entity. Previously described cases presented on the fingernails and were predominantly in white males.
CONCLUSION
OCM is a benign entity that may mimic a nail unit melanoma or squamous cell carcinoma especially when pachyonychia is present. Despite some clinical clues to suggest a diagnosis of OCM, a nail matrix biopsy is often required to rule out malignancy.
PubMed: 37564690
DOI: 10.1159/000530470 -
Indian Journal of Dermatology,... 2023
Topics: Humans; Acanthoma; Skin Neoplasms; Acantholysis
PubMed: 37317765
DOI: 10.25259/IJDVL_970_2022 -
Italian Journal of Dermatology and... Apr 2023
Topics: Humans; Acanthoma; Skin Neoplasms; Skin; Colonic Neoplasms
PubMed: 37153955
DOI: 10.23736/S2784-8671.23.07493-5 -
Actas Dermo-sifiliograficas Sep 2023Clear cell acanthoma (CCA) is an uncommon lesion histologically characterized by the presence of epidermal acanthosis with keratinocytes containing clear cytoplasm....
BACKGROUND AND OBJECTIVE
Clear cell acanthoma (CCA) is an uncommon lesion histologically characterized by the presence of epidermal acanthosis with keratinocytes containing clear cytoplasm. Although many single cases of CCA have been described, few case series have been published. The aim of this study was to describe the clinical characteristics of CCA in our practice setting.
MATERIAL AND METHODS
Retrospective study of patients diagnosed with CCA at Hospital Universitario de Bellvitge in Barcelona, Spain, between 1995 and 2021. We conducted a chart review to record age, sex, number and location of lesions, diameter, time since onset, clinical characteristics, suspected clinical diagnosis, and treatment.
RESULTS
Seventy patients (30 women and 40 men) with a mean (SD) age of 62 (13) years were diagnosed with CCA during the study period. Median (interquartile range) time since onset was 2 (4) years and median lesion diameter was 6 (5) mm. One woman had multiple lesions. Lesions were located on the lower extremities in 57 patients (81%), the posterior aspect of the trunk in 8 (11%), the anterior aspect of the trunk in 4 (5%), and the upper extremities in 1 (1%). CCA was clinically suspected in 40% of patients seen by dermatologists.
CONCLUSIONS
CCA presents as an erythematous, dome-shaped lesion with pinpoint vessels and an epidermal collarette. The accuracy of clinical diagnosis has improved relative to earlier series, possibly due to a better clinical understanding of this lesion and a greater use of dermoscopy.
Topics: Male; Humans; Female; Middle Aged; Acanthoma; Skin Neoplasms; Retrospective Studies; Keratinocytes; Dermoscopy
PubMed: 37127205
DOI: 10.1016/j.ad.2023.04.028 -
Actas Dermo-sifiliograficas Mar 2024
Topics: Humans; Female; Acanthoma; Nipples; Skin Neoplasms; Eczema; Mammaplasty; Breast Neoplasms
PubMed: 36965773
DOI: 10.1016/j.ad.2022.06.028 -
Dermatopathology (Basel, Switzerland) Feb 2023Post-pemphigus acanthomas have been rarely discussed in the literature. A prior case series identified 47 cases of pemphigus vulgaris and 5 cases of pemphigus foliaceus,...
Post-pemphigus acanthomas have been rarely discussed in the literature. A prior case series identified 47 cases of pemphigus vulgaris and 5 cases of pemphigus foliaceus, out of which 13 developed acanthomata as a part of the healing process. Additionally, a case report by Ohashi et al. reported similar recalcitrant lesions on the trunk of a patient with pemphigus foliaceus being treated with prednisolone, IVIG, plasma exchange, and cyclosporine. Some view post-pemphigus acanthomas as variants of hypertrophic pemphigus vulgaris, being difficult to diagnose when they present as only single lesions, with a clinical differential of an inflamed seborrheic keratosis or squamous cell carcinoma. Here, we present a case of a 52-year-old female with a history of pemphigus vulgaris and four months of only topical therapy (fluocinonide 0.05%) who presented with a painful, hyperkeratotic plaque on the right mid-back that was found to be a post-pemphigus acanthoma.
PubMed: 36810570
DOI: 10.3390/dermatopathology10010012 -
Actas Dermo-sifiliograficas Dec 2022
Topics: Humans; Acanthoma; Skin Neoplasms; Sebaceous Glands
PubMed: 36543467
DOI: 10.1016/j.ad.2021.08.010