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The Journal of Dermatological Treatment Aug 2022Clear cell acanthoma (CCA) is a rare, benign epidermal lesion of clear glycogen-containing keratinocytes. The exact etiology is unknown. Although CCA usually appear as...
Clear cell acanthoma (CCA) is a rare, benign epidermal lesion of clear glycogen-containing keratinocytes. The exact etiology is unknown. Although CCA usually appear as solitary lesions, cases of multiple CCAs have also been described. The rare eruptive CCA variant describes cases with more than 30 lesions.Current therapeutic evidence for the management of multiple CCAs is limited. CO2 laser remains the most widely used laser in clinical practice. However, literature describing its effectiveness on CCA is sparse, and previous reports have described its use for a maximum of three lesions. To our knowledge, this is the first report of successful CO2 laser treatment of the multiple eruptive CCA variant with an excellent cosmetic outcome.Our case adds to the evidence that CO2 laser is an effective treatment for this condition. Particularly in those patients with refractory or multiple eruptive CCAs, or for those who may not tolerate repeated courses of cryotherapy, or who are concerned about scarring and cosmetic outcome.
Topics: Acanthoma; Carbon Dioxide; Exanthema; Humans; Laser Therapy; Lasers, Gas; Skin Neoplasms
PubMed: 35238268
DOI: 10.1080/09546634.2022.2049587 -
Journal Der Deutschen Dermatologischen... Apr 2022
Topics: Acanthoma; Antiviral Agents; Humans; Interferon alpha-2; Interferon-alpha; Polyethylene Glycols; Recombinant Proteins; Skin Neoplasms
PubMed: 35188707
DOI: 10.1111/ddg.14719 -
The American Journal of Dermatopathology Jun 2022Pilomatrical differentiation can be observed in a variety of benign and malignant tumors, with the most common prototype being pilomatricoma. Pilomatricoma often...
Pilomatrical differentiation can be observed in a variety of benign and malignant tumors, with the most common prototype being pilomatricoma. Pilomatricoma often presents in the deep dermis or subcutis, and the sole involvement of epidermis is extremely rare. In our current case series, specimens from 5 patients were included with an average age of 68 years. All lesions presented as solitary verrucous or keratotic papules on the extremities, with 1 lesion having a prominent horn. All lesions have a variable mixture of basaloid matrical cells and shadow cells, and all lesions express β-catenin (strong nuclear and cytoplasmic), lymphoid enhancer-binding factor 1 within the matrical component, and pleckstrin homology-like domain family A member 1. The histomorphology and immunoprofile of all lesions are of pilomatrical differentiation, confined to the level of the epidermis. Based on these findings and analogous to the terminology used for other benign intraepidermal proliferations (hidroacanthoma simplex and epidermolytic acanthoma), we propose the term "pilomatrical acanthoma" for these rare lesions.
Topics: Acanthoma; Aged; Hair Diseases; Humans; Pilomatrixoma; Skin Neoplasms; Sweat Gland Neoplasms
PubMed: 35120037
DOI: 10.1097/DAD.0000000000002147 -
Journal of Cutaneous Pathology Dec 2022
Topics: Humans; Porokeratosis
PubMed: 35075675
DOI: 10.1111/cup.14195 -
Dermatology Practical & Conceptual Oct 2021The differential diagnosis of lesions excised to exclude melanoma include a variety of benign and malignant melanocytic and non-melanocytic lesions.
INTRODUCTION
The differential diagnosis of lesions excised to exclude melanoma include a variety of benign and malignant melanocytic and non-melanocytic lesions.
OBJECTIVES
We examined the variability between pathologists in diagnosing non-melanocytic lesions.
METHODS
As part of a larger study prospectively examining the diagnosis of lesions excised to exclude melanoma in 198 patients at a primary care skin cancer clinic in Newcastle, Australia, we compared diagnosis made by 5 experienced dermatopathologists, of 44 non-melanocytic lesions in 44 patients aged 22-90.
RESULTS
Forty-four lesions (out of 217 in total) were non-melanocytic. Among the 5 pathologists who examined each case there was marked variability in the terminology used to diagnose each case. The most common variability was found between seborrheic keratosis, large cell acanthoma, solar lentigo, and lichenoid keratosis. The diagnosis made by the majority of the pathologists was deemed to be the reference diagnosis. Versus majority diagnosis, 4% of benign lesions were considered malignant, and 7% of malignant diagnoses were considered as benign.
CONCLUSIONS
The different terminology adopted and lack of consensus in the diagnosis of these non-melanocytic lesions in this setting suggests that training AI systems using gold standards may be problematic. We propose a new management classification scheme called MOLEM (Management of Lesions Excised to exclude Melanoma) which expands the previously described MPATH-dx to include non-melanocytic lesions.
PubMed: 35024222
DOI: 10.5826/dpc.1104a94 -
Journal of the European Academy of... Apr 2022
Topics: Acanthoma; Humans; Nail Diseases; Skin Neoplasms
PubMed: 34753213
DOI: 10.1111/jdv.17800 -
Cornea Jul 2022The purpose of this study was to describe a case of conjunctival melanoacanthoma, an exceedingly rare condition that has yet to be fully described in the literature.
PURPOSE
The purpose of this study was to describe a case of conjunctival melanoacanthoma, an exceedingly rare condition that has yet to be fully described in the literature.
METHODS
Melanoacanthomas are most commonly seen on the skin or oral mucosa and are believed to result from local irritation or trauma. A 34-year-old Hispanic man presented with a painless, solitary, pigmented conjunctival lesion, in addition to bilateral pterygia suggesting chronic solar damage. The lesion was excised and sent for analysis.
RESULTS
Histopathologic analysis of tissue samples demonstrated melanocyte proliferation and epithelial dysplasia, yielding a final pathologic diagnosis of conjunctival melanoacanthoma with dysplastic and acantholytic-type features. The patient is being closely followed and has not had recurrence of the lesion.
CONCLUSIONS
Only 1 prior case of conjunctival melanoacanthoma has been documented. As such, there is no standard of care regarding appropriate management.
Topics: Acanthoma; Adult; Conjunctiva; Humans; Male; Mouth Mucosa; Pterygium; Skin Neoplasms
PubMed: 34723861
DOI: 10.1097/ICO.0000000000002850 -
Dermatologic Surgery : Official... Nov 2021
Topics: Acanthoma; Dermatologic Surgical Procedures; Humans; Male; Middle Aged; Nerve Compression Syndromes; Peripheral Nervous System Diseases; Postoperative Complications; Skin Neoplasms; Sural Nerve
PubMed: 34608085
DOI: 10.1097/DSS.0000000000003234 -
JAAD Case Reports Oct 2021
PubMed: 34522750
DOI: 10.1016/j.jdcr.2021.08.016 -
Dermatology Practical & Conceptual Jul 2021
PubMed: 34414014
DOI: 10.5826/dpc.1103a89