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Case Reports in Infectious Diseases 2018This is a case of in the breast abscess of a penicillin-allergic woman. The mainstay of treatment for actinomycosis is penicillin, and there is a lack of literature...
This is a case of in the breast abscess of a penicillin-allergic woman. The mainstay of treatment for actinomycosis is penicillin, and there is a lack of literature describing nonpenicillin treatment options. A 69-year-old woman presented acutely with a breast abscess which was managed with incision and drainage and antibiotic therapy to good response. 21 days after presentation, were grown from the culture of pus, so the patient was recalled and more rigorous treatment and follow-up were initiated. The penicillin allergy led to difficulty in the identification of an appropriate antimicrobial agent that was also logistically feasible to be given on an outpatient IV basis. IV tigecycline followed by oral clarithromycin was found to be effective treatment.
PubMed: 30026992
DOI: 10.1155/2018/6708614 -
Journal of Infection and Public Health 2018Actinomyces species are part of the commensal flora of the mucous membranes of the oropharynx, gastrointestinal tract and female genital tract. Actinomyces europaeus is...
Actinomyces species are part of the commensal flora of the mucous membranes of the oropharynx, gastrointestinal tract and female genital tract. Actinomyces europaeus is a short, nonmotile, facultative anaerobic rod first described in 1997, susceptible in vitro to a wide range of b-lactam antibiotics which are regarded as first choice. In this report we described the case of A. europaeus infection in a young female patient admitted to Intensive Care Unit and the possible damage of vascular endothelium due to a chronic progressive actinomycosis that at first involved neck soft tissue, then cervical lymphnodes, and finally extended to the vascular structure.
Topics: Actinomyces; Actinomycosis; Anti-Bacterial Agents; Brain; Endothelium, Vascular; Female; Humans; Intensive Care Units; Lymph Nodes; Lymphadenopathy; Nervous System Diseases; RNA, Ribosomal, 16S; Symbiosis; Tomography, X-Ray Computed; Treatment Outcome; Vasculitis; Young Adult
PubMed: 29277334
DOI: 10.1016/j.jiph.2017.12.010 -
Journal of Global Antimicrobial... Mar 2017Patterns of antimicrobial susceptibility in Actinomyces and related genera are very limited in the literature. Data of predominant susceptibility profiles could...
OBJECTIVES
Patterns of antimicrobial susceptibility in Actinomyces and related genera are very limited in the literature. Data of predominant susceptibility profiles could contribute to the establishment of an accurate empirical treatment.
METHODS
A total of 113 isolates from clinical samples were included in this study. Each isolate was identified using phenotypic methods and MALDI-TOF/MS. When discrepancies were observed, 16S rRNA gene sequencing was performed. The minimum inhibitory concentrations (MICs) of nine antimicrobial agents (penicillin, ceftriaxone, linezolid, tetracycline, clindamycin, erythromycin, ciprofloxacin, levofloxacin and vancomycin) were tested against the species Actinotignum schaalii (n=23), Actinomyces turicensis (n=18), Actinomyces europaeus (n=13), Actinomyces naeslundii/Actinomyces viscosus group (n=12), Actinomyces urogenitalis (n=11), Actinomyces radingae (n=11), Actinomyces neuii (n=9), Actinomyces odontolyticus (n=8), Bifidobacterium scardovii (n=3), Actinomyces graevenitzii (n=2), Alloscardovia omnicolens (n=2) and Varibaculum cambriense (n=1).
RESULTS
All of the isolates were susceptible to penicillin, ceftriaxone, vancomycin and linezolid. Almost all of the A. urogenitalis isolates (8/11) were resistant to clindamycin and showed susceptibility to erythromycin, suggesting an L-phenotype, however no determinants of clindamycin resistance (lnu and lsa genes) were detected by PCR. High MIC values to quinolones were observed in 54/113 isolates (47.8%). All of the A. urogenitalis isolates were highly resistant to ciprofloxacin and levofloxacin.
CONCLUSIONS
These data highlight the importance of ongoing surveillance to provide relevant information for empirical management of infections caused by these organisms.
Topics: Actinobacteria; Actinomycosis; Anti-Bacterial Agents; Bacteriological Techniques; Clindamycin; DNA, Bacterial; DNA, Ribosomal; Drug Resistance, Bacterial; Humans; RNA, Ribosomal, 16S; Sequence Analysis, DNA; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
PubMed: 28109846
DOI: 10.1016/j.jgar.2016.11.007 -
Enfermedades Infecciosas Y... May 2016
Topics: Actinomyces; Actinomycosis; Adult; Epidermal Cyst; Humans; Male
PubMed: 26358564
DOI: 10.1016/j.eimc.2015.08.001 -
First report of Actinomyces europaeus bacteraemia result from a breast abscess in a 53-year-old man.New Microbes and New Infections Sep 2015This is the first report of Actinomyces europaeus bacteraemia in a 53-year-old man. The bacteraemia was the result of a breast abscess. Identification was established by...
This is the first report of Actinomyces europaeus bacteraemia in a 53-year-old man. The bacteraemia was the result of a breast abscess. Identification was established by matrix-assisted desorption ionization-time of flight mass spectrometry and confirmed by 16S rRNA gene sequencing. The patient was treated with surgical drainage and penicillin for 4 weeks; the patient did not experience any relapse during 6 months of follow-up.
PubMed: 26110063
DOI: 10.1016/j.nmni.2015.05.001