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Microbes and Infection Jun 2024Pathogen avoidance is a crucial and evolutionarily conserved behavior that enhances survival by preventing infection in diverse species, including Caenorhabditis elegans...
Pathogen avoidance is a crucial and evolutionarily conserved behavior that enhances survival by preventing infection in diverse species, including Caenorhabditis elegans (C. elegans). This behavior relies on multiple chemosensory neurons equipped with cilia that are exposed to the external environment. However, the specific role of neuronal cilia in pathogen avoidance has not been completely elucidated. Herein, we discovered that osm-3(p802) mutants, which lack chemosensory neuronal cilia, exhibit slower avoidance of the pathogen Pseudomonas aeruginosa PA14, but not Escherichia coli OP50. This observation was consistent when osm-3(p802) mutants were exposed to P. aeruginosa PAO1. Following an encounter with PA14, the pumping, thrashing, and defecation behaviors of osm-3 mutants were comparable to those of the wild-type. However, the osm-3 mutants demonstrated reduced intestinal colonization of PA14, suggesting that they have stronger intestinal clearance ability. We conducted RNA-seq to identify genes responding to external stimuli that were differentially expressed owing to the loss of osm-3 and PA14 infection. Using RNAi, we demonstrated that three of these genes were essential for normal pathogen avoidance. In conclusion, our findings demonstrate that the loss of chemosensory neuronal cilia reduces pathogen avoidance in C. elegans while delaying intestinal colonization.
PubMed: 38843949
DOI: 10.1016/j.micinf.2024.105370 -
Alternative Therapies in Health and... Jun 2024Accelerated recovery programs have gained recognition for their potential to enhance postoperative outcomes. However, their effectiveness in gynecological oncology...
BACKGROUND
Accelerated recovery programs have gained recognition for their potential to enhance postoperative outcomes. However, their effectiveness in gynecological oncology remains understudied.
OBJECTIVE
This study aims to assess the efficacy of accelerated recovery care in enhancing postoperative outcomes and patient satisfaction following surgery.
METHODS
A quasi-experimental design was employed, and we included 72 patients undergoing cytoreductive surgery for ovarian tumors at The First Affiliated Hospital of Nanjing Medical University between October 1st, 2019, and May 31st, 2020. The patients were divided into two groups: an observation group receiving accelerated recovery care and a control group receiving standard care. Nursing staff administered comprehensive pre-and postoperative care, utilizing Mindray iPM10 monitors to monitor vital signs. Additionally, postoperative rehabilitation training and dietary guidance were provided. Complication rates, recovery indicators, and patient satisfaction were compared between the two groups.
RESULTS
The complication rate in the observation group was significantly lower at 2.78% compared to 11.11% in the control group (P < .05). Patients in the observation group exhibited significantly faster recovery indicators, including time to first flatulence, first defecation, and time to ambulation (P < .05). Moreover, patients in the observation group reported lower abdominal distension and pain scores, with 100% satisfaction rates.
CONCLUSION
Implementing accelerated recovery nursing demonstrates a notable reduction in postoperative complication rates among surgical patients, concurrently fostering an expedited recovery process and heightened patient satisfaction. The provision of comprehensive nursing attention and guidance throughout the perioperative continuum emerges as indispensable for optimizing patient recovery outcomes.
PubMed: 38843426
DOI: No ID Found -
Alternative Therapies in Health and... Jun 2024Cytoreductive surgery for gynecological ovarian cancer involves the removal of tumor masses and affected tissue, aiming to achieve optimal debulking. Accelerated...
BACKGROUND
Cytoreductive surgery for gynecological ovarian cancer involves the removal of tumor masses and affected tissue, aiming to achieve optimal debulking. Accelerated recovery nursing, a comprehensive care model, focuses on expediting post-surgical recovery and enhancing patient satisfaction. It has emerged as a vital approach to optimize post-surgical outcomes and patient satisfaction.
OBJECTIVE
This study evaluates the impact of accelerated recovery care on surgical patients to enhance recovery outcomes and patient satisfaction post-surgery.
METHODS
The study utilized an observational and control group design and selected 72 patients undergoing ovarian tumor cytoreductive surgery at The First Affiliated Hospital of Nanjing Medical University between October 1st, 2019, and May 31st, 2020. These patients were divided into two groups: an observation group and a control group, each comprising 36 patients, with one group receiving standard care and the other accelerated recovery care. Nursing staff provided comprehensive pre-and post-operative care, monitoring patients' vital signs using Mindray iPM10 monitors. Postoperative rehabilitation training and dietary guidance were administered. Complication rates, recovery indicators, and patient satisfaction were compared between the groups.
RESULTS
The observation group exhibited a significantly lower complication rate (2.78%) compared to the control group (11.11%) (P < .05). Patients in the observation group demonstrated faster recovery indicators, including time to first flatulence, first defecation, and first mobilization from bed (P < .05). Additionally, abdominal distension and pain scores were lower in the observation group, with 100% patient satisfaction.
CONCLUSIONS
Implementation of accelerated recovery nursing significantly reduces surgical patient complication rates, facilitates recovery, and enhances patient satisfaction. Nursing attention and guidance throughout the surgical process are crucial for optimal patient outcomes. This study emphasizes the importance of thorough care protocols in improving surgical recovery.
PubMed: 38843421
DOI: No ID Found -
Archivos Espanoles de Urologia May 2024Predictive care in patients undergoing ureteroscopic stone surgery has emerged as a promising approach. Thus, this study aims to enhance personalised nursing plans and...
OBJECTIVE
Predictive care in patients undergoing ureteroscopic stone surgery has emerged as a promising approach. Thus, this study aims to enhance personalised nursing plans and reduce the risk of complications by conducting predictive analysis of possible risks early in the treatment and nursing process.
METHODS
Clinical data were collected from 108 patients who underwent ureteroscopic stone surgery and were admitted to our hospital between January 2020 and January 2023. Patients were divided into a control group (conventional nursing, n = 53) and an observation group (predictive care, n = 55) based on the nursing method, and various clinical indicators were compared between the two groups of surgical patients.
RESULTS
No significant difference in general data was found between the two groups ( > 0.05). Compared with the control group, the first time to exhaust gas ( < 0.05), the first time to get out of bed ( < 0.05), the time to exhaust stone ( < 0.05), the first time to defecate ( < 0.05) and the length of hospital stay ( < 0.05) in the observation group were shorter; 1 day after surgery, no significant differences in all dimensions of the general comfort questionnaire (GCQ) score were found; 2 days after surgery, the GCQ score in all dimensions of the observation group was significantly higher than that of the control group ( < 0.05). The incidence of postoperative complications in the observation group was significantly lower than that in the control group ( < 0.05).
CONCLUSIONS
Predictive nursing can effectively improve the patients with ureteral calculi, accelerate the process of postoperative recovery and reduce the occurrence of complications; Thus, this process is worthy of widespread clinical promotion.
Topics: Humans; Retrospective Studies; Male; Ureteral Calculi; Female; Middle Aged; Postoperative Complications; Adult; Ureteroscopy; Recovery of Function; Aged
PubMed: 38840288
DOI: 10.56434/j.arch.esp.urol.20247704.59 -
Scientific Reports Jun 2024Free Fecal Liquid (FFL), also termed Fecal Water Syndrome (FWS), is an ailment in horses characterized by variable solid and liquid (water) phases at defecation. The...
Free Fecal Liquid (FFL), also termed Fecal Water Syndrome (FWS), is an ailment in horses characterized by variable solid and liquid (water) phases at defecation. The liquid phase can be excreted before, during, or after the solid defecation phase. While the underlying causes of FFL are unknown, hindgut dysbiosis is suggested to be associated with FFL. Three European studies investigated dysbiosis in horses with FFL using 16S rRNA sequencing and reported results that conflicted between each other. In the present study, we also used 16S rRNA sequencing to study the fecal microbial composition in 14 Canadian horses with FFL, and 11 healthy stable mate controls. We found no significant difference in fecal microbial composition between FFL and healthy horses, which further supports that dysbiosis is not associated with FFL.
Topics: Horses; Animals; Feces; RNA, Ribosomal, 16S; Dysbiosis; Horse Diseases; Male; Canada; Female; Gastrointestinal Microbiome
PubMed: 38839848
DOI: 10.1038/s41598-024-63868-1 -
Surgery Jun 2024Rectal cancer surgery risks causing bowel dysfunction, which has an important impact on health-related quality of life. The validity of generic tools used to measure...
BACKGROUND
Rectal cancer surgery risks causing bowel dysfunction, which has an important impact on health-related quality of life. The validity of generic tools used to measure health-related quality of life after bowel dysfunction is unclear. This study aims to determine the content validity of health-related quality-of-life measurement tools in rectal cancer.
METHODS
This was a qualitative single-center study in which adult patients who underwent rectal cancer surgery with sphincter preservation from July 2017 to October 2020 were recruited. Patients were excluded if they developed local metastasis, required a permanent stoma, or had surgery <1 year since recruitment. Telephone-based semi-structured interviews were conducted. Bowel dysfunction was measured using the Low Anterior Resection Syndrome score. Content analysis was achieved using the International Classification of Functioning framework.
RESULTS
Recurrent bowel dysfunction-related concepts included "Mental functions," "Defecation functions," "Emotional functions," "Recreation and leisure," "Intimate relationships," and "Remunerative employment." A mean of 7.5 recurrent bowel dysfunction-related concepts were identified within the health-related quality of life instruments analyzed. The European Organization for Research and Treatment of Cancer Quality-of-Life Questionnaire-C30 (n = 11) and the 36-Item Short Form Health Survey (n = 9) covered the greatest number of recurrent bowel dysfunction-related concepts. Concepts such as "Mental functions," "Urination functions," "Sexual functions," "Driving," and "Mobility" were not covered by any instrument.
CONCLUSION
The content of traditional health-related quality-of-life instruments is missing important areas that represent the impact of bowel dysfunction after rectal cancer surgery on health-related quality of life. These findings could help improve patient-centered care in rectal cancer surgery.
PubMed: 38839434
DOI: 10.1016/j.surg.2024.04.038 -
BMC Public Health Jun 2024Poor sanitation and/or open defecation are a significant public health problem in Ethiopia, where access to improved sanitation facilities is still limited. There is a...
BACKGROUND
Poor sanitation and/or open defecation are a significant public health problem in Ethiopia, where access to improved sanitation facilities is still limited. There is a growing body of literature about the effect of open defecation on children's linear growth failure. However, very few studies about the effects of open defecation on child anemia exist. In this study, we examine whether childhood undernutrition (i.e. stunting, wasting, and underweight) mediates the relationship between open defecation and childhood anemia in children aged 6-59 months in Ethiopia.
METHODS
We used pooled Ethiopia Demographic and Health Survey data (2005-2016) comprising 21,918 (weighted data) children aged 6-59 months. Anemia was defined as an altitude-adjusted hemoglobin (Hb) level of less than 11 g/deciliter (g/dl) for children under 5 years. Childhood undernutrition was assessed using height-for-age Z-scores (HAZ), weight-for-age Z-scores (WAZ), and weight-for-height Z-scores (WHZ) for stunting, wasting, and underweight respectively. Mediation effects were calculated using the bootstrap and the indirect effect was considered significant when the 95% bootstrap confidence intervals (95% CI) did not contain zero. Moreover, separate multilevel regression analyses were used to explore the statistical association between open defecation and child anemia, after adjusting for potential confounders.
RESULTS
Our analysis revealed that nearly half (49.6%) of children aged 6 to 59 months were anemic, 46.8% were stunted, 9.9% were wasted, and 29.5% were underweight. Additionally, 45.1% of children belonged to households that practiced open defecation (OD). Open defecation was associated with anemia (AOR: 1.28; 95% CI: 1.18-1.39) and it positively predicted anemia with direct effect of β = 0.233, p < 0.001. Childhood undernutrition showed a partial mediating role in the relationship between OD and anemia. Analyzing the indirect effects, results revealed that child undernutrition significantly mediated the relationship between open defecation and anemia (stunting (βindirect = 0.014, p < 0.001), wasting (βindirect = 0.009, p = 0.002), and underweight (βindirect = 0.012, p < 0.001)). When the mediating role of child undernutrition was accounted for, open defecation had a positive impact on anemia with a total effect of βtotal = 0.285, p < 0.001.
CONCLUSION
Open defecation showed a significant direct effect on anemia. Child undernutrition remarkably mediated the relationship between OD and anemia that further magnified the effect. This finding has an important programmatic implication calling for strengthened, accelerated and large-scale implementation of strategies to end open defecation and achieve universal access to sanitation in Ethiopia.
Topics: Humans; Ethiopia; Infant; Child, Preschool; Female; Male; Cross-Sectional Studies; Anemia; Malnutrition; Defecation; Growth Disorders; Sanitation; Child Nutrition Disorders; Thinness; Health Surveys
PubMed: 38831296
DOI: 10.1186/s12889-024-18931-x -
Sultan Qaboos University Medical Journal May 2024This study aimed to compare the effects of green cumin (Cuminum cyminum) and nettle (Urtica dioica L.) oral drops on the indicators of breast milk adequacy in lactating... (Randomized Controlled Trial)
Randomized Controlled Trial
OBJECTIVES
This study aimed to compare the effects of green cumin (Cuminum cyminum) and nettle (Urtica dioica L.) oral drops on the indicators of breast milk adequacy in lactating mothers. Due to the presence of phytoestrogens in the combinations of cumin and nettle, it is stipulated that they may have milk-increasing properties.
METHODS
A triple-blind, randomised, controlled clinical trial was conducted on 117 lactating mothers who had given birth to healthy infants aged 10-15 days and who received cumin oral drops (n = 39), nettle oral drops (n = 39) or placebo (n = 39) from August 2020 to March 2021. The participants were recruited from a regional public health care centre affiliated with Iran University of Medical Sciences of Tehran, Tehran, Iran. The 3 study groups received 15 drops thrice a day for 4 weeks. Infant weight, breastfeeding frequency, number of wet diapers, diaper weight and frequency of infant defecation were evaluated before and after the intervention.
RESULTS
At the beginning of the trial, no statistically significant differences were observed between the 3 groups for infant weight ( = 0.891), breastfeeding frequency ( = 0.921), number of wet diapers ( = 0.783), diaper weight ( = 0.841) and frequency of infant defecation ( = 0.898). However, following the intervention, the mean scores of all indicators were significantly higher in the experimental groups than in the placebo group ( <0.001). In addition, all the indicators in the cumin group increased significantly compared to those in the nettle group ( <0.001).
CONCLUSION
Considering the effectiveness of cumin and nettle drops in increasing milk and the availability of these native plants in Iran, it is suggested that they, especially cumin, be used postpartum to increase breast milk production.
Topics: Humans; Iran; Female; Cuminum; Milk, Human; Adult; Infant, Newborn; Breast Feeding; Lactation; Mothers; Infant
PubMed: 38828258
DOI: 10.18295/squmj.3.2024.022 -
Journal of Neurogastroenterology and... Jun 2024Chronic constipation is an important public health problem and significantly affects women's lives. It is important to investigate non-pharmacological applications that...
BACKGROUND/AIMS
Chronic constipation is an important public health problem and significantly affects women's lives. It is important to investigate non-pharmacological applications that can be used in the treatment of chronic constipation. The aim is to assess how abdominal massage and kinesio taping impact constipation severity, quality of life (QOL), and perception of subjective improvement in women with chronic constipation.
METHODS
Following Rome IV diagnostic criteria, women with constipation were randomly sorted into three distinct groups for study: massage group (lifestyle recommendations+abdominal massage, n:22), taping group (lifestyle recommendations+kinesio taping, n:22), and control group (lifestyle recommendations, n:22). Constipation Severity Instrument (CSI) (for constipation severity), 7 days bowel diary (for bowel function), Patient Assessment of Constipation QOL (PAC-QOL) questionnaire (for QOL), 4-item Likert-type scale (for perception of subjective improvement) was used.
RESULTS
The group x time interaction effect was significant in all CSI, bowel diary and PAC-QQL parameters, except for incomplete evacuation and PAC-QOL-worries/concerns, and a large effect size was found (Partial η2 > 0.14). Improvement scores of all parameters (except CSI-obstructive defecation, incomplete evacuation, PAC-QOL-worries/concerns) were similar in the massage and taping groups and were better than the control group. Noteworthy perceptions of subjective improvement and normalization of stool type predominantly manifested in the massage group (p<0.05).
CONSLUSION
Abdominal massage and kinesio taping are recommended as initial conservative interventions for managing chronic constipation within the therapeutic spectrum.
PubMed: 38826075
DOI: 10.5056/jnm23131 -
Zhonghua Yi Xue Za Zhi Jun 2024To investigate the clinical characteristics of metastatic tumors in small intestine. The clinical manifestations, imaging and endoscopic findings, treatment methods and...
To investigate the clinical characteristics of metastatic tumors in small intestine. The clinical manifestations, imaging and endoscopic findings, treatment methods and follow-up of patients with small bowel metastatic tumors admitted to the First Affiliated Hospital of Zhengzhou University from January 1, 2018 to December 31, 2022 were retrospectively analyzed. A total of 10 patients were included, including 7 males and 3 females, aged 33-77 (56.4±12.6) years. The main clinical manifestations were intestinal obstruction (8 cases), such as abdominal pain, abdominal distension, nausea, vomiting, and reduced defecation. Some patients had intussusception (abdominal pain, vomiting, black stool and other symptoms, 1 case) or gastrointestinal bleeding (1 case) with early symptoms imperceptible. The primary tumors include gastric cancer (3 cases), malignant melanoma (2 cases), ovarian cancer (2 cases), colon cancer (1 case), rectal cancer (1 case), and lung cancer (1 case). Most of the primary tumors were poorly differentiated (6 cases) or moderately to poorly differentiated (2 cases). The median time from primary tumor surgery to detection of small bowel metastasis [ ()] was 22 (18, 28) months.The metastatic lesions were single (6 cases) or multiple (4 cases), in both jejunum and ileum. Positron emission tomography-computed tomography (PET-CT, 3 cases) and endoscopy (2 cases) were helpful for detection of small intestinal metastases. The main treatment methods were surgical resection (9 cases), supplemented by radiotherapy, targeted drugs, immunotherapy, etc. Postoperative recurrence and metastasis occurred in some patients (5 cases). Most patients died within 4 to 29 months after diagnosis. Metastatic tumors in small intestine are rare in clinical practice with atypical early symptoms. The patients often present with complications such as intestinal obstruction, which is prone to delayed diagnosis and poor prognosis.
Topics: Humans; Female; Middle Aged; Male; Aged; Intestine, Small; Adult; Retrospective Studies; Intestinal Neoplasms; Intestinal Obstruction; Melanoma; Stomach Neoplasms
PubMed: 38825945
DOI: 10.3760/cma.j.cn112137-20240311-00551