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FASEB Journal : Official Publication of... May 2024Mesenchymal stromal cells (MSCs) have been shown to modulate the function of various subsets of T cells such as naïve CD4 T cells and IFNγCD4 Th1 cells; however,...
Mesenchymal stromal cells (MSCs) have been shown to modulate the function of various subsets of T cells such as naïve CD4 T cells and IFNγCD4 Th1 cells; however, mechanisms underlying this regulation have not been fully deciphered. Our in vitro culture assays demonstrate that MSCs suppress the activation and function of CD4 T cells by secreting interleukin 11, and neutralization of IL11 abrogates MSC-mediated suppression of CD4 T cell function. Moreover, delayed-type, exogenous supplementation of IL11 significantly suppressed IFNγ expression by Th1 cells. Th1 and CD8 cells play central roles in T cell-mediated tissue damage. Using a murine model of hypersensitivity response to study T cell-mediated tissue damage, we show that silencing IL11 in MSCs significantly abates the capacity of MSCs to suppress the generation of IFNγ-secreting CD4 and CD8 cells, failing to prevent T cell-mediated tissue inflammation and tissue damage.
Topics: Animals; Mesenchymal Stem Cells; Th1 Cells; Mice; Interleukin-11; Mice, Inbred C57BL; CD8-Positive T-Lymphocytes; Interferon-gamma; CD4-Positive T-Lymphocytes; Cells, Cultured; Female
PubMed: 38758184
DOI: 10.1096/fj.202400078R -
The British Journal of Dermatology May 2024
Topics: Humans; Dermatitis, Allergic Contact; Female; Male; Adult; Middle Aged; Dental Materials; Patch Tests; Aged
PubMed: 38758061
DOI: 10.1093/bjd/ljae160 -
Allergologie Select 2024Allergic contact dermatitis is one of the most frequent occupational skin diseases. Targeted allergen avoidance can only be achieved by identification of the causative... (Review)
Review
Allergic contact dermatitis is one of the most frequent occupational skin diseases. Targeted allergen avoidance can only be achieved by identification of the causative allergen. Therefore, patch testing is of utmost importance in occupational dermatology, not only in terms of assessing causal relationships but also regarding the implementation of prevention measures and evaluation of the legal criteria for an occupational skin disease in Germany (statutory occupational disease BK 5101). The lack of commercial patch test preparations poses a great diagnostic challenge. Patch testing of patient's own materials from their workplace is therefore very important to reduce diagnostic gaps. The performance and documentation of the patch test should be in line with current guidelines and recommendations to ensure the necessary test quality and comprehensibility of the test results.
PubMed: 38756208
DOI: 10.5414/ALX2483E -
Allergy and Asthma Proceedings May 2024Concern of metal sensitization in pre- and postsurgical evaluation is growing, with the recent guidelines remaining the criterion standard for consideration of patch...
Concern of metal sensitization in pre- and postsurgical evaluation is growing, with the recent guidelines remaining the criterion standard for consideration of patch testing. Information remains scarce on surgical screening in the groups of patients who reported a history of metal sensitivity versus those with no reported history. The objective of this study was to assess the utility of patch testing in surgical candidates based on reported metal allergy history. The secondary objective was to evaluate the utility and outcomes in postsurgical patch testing. Nine hundred and thirty-one patient charts of patients with the diagnosis of "contact dermatitis" who underwent an evaluation at a single allergy clinic site between January 2013 and December 2022 were identified and reviewed as part of a retrospective chart review study. Patients were included in subgroups based on the time of patch testing and history of reported metal allergy. In all, 67 patients underwent patch testing, 10 (14.9%) of whom were surgical candidates without a history of metal sensitivity, 31 (46.2%) of whom were surgical candidates with a history of metal sensitivity, and 26 (38.8%) of whom were postsurgical patients. Twenty-nine (43.3%) of patients had positive patch testing results, with only one (10%) in the presurgical group, 17 (54.8%) in the presurgical with a history of metal sensitivity, and 11 (42.3%) in the postsurgical group. Zero patients in our cohort without metal sensitivity who were undergoing the Nuss procedure had positive reactions on patch testing, whereas two of four (50%) with reported metal sensitivity who were undergoing the Nuss procedure had positive relevant metal reactions. Ambiguity in the utility of patch testing for surgical decision making remains, despite common utilization. Recent guidelines along with coordination of care among the surgeon, allergist, and patient remains the criterion standard of care.
Topics: Humans; Retrospective Studies; Patch Tests; Metals; Male; Female; Middle Aged; Prostheses and Implants; Adult; Dermatitis, Allergic Contact; Aged; Allergens
PubMed: 38755777
DOI: 10.2500/aap.2024.45.240005 -
American Journal of Clinical Dermatology Jul 2024Drug reaction with eosinophilia and systemic symptoms (DReSS) is known to cause mortality and long-term sequelae in the pediatric population, however there are no... (Review)
Review
Drug reaction with eosinophilia and systemic symptoms (DReSS) is known to cause mortality and long-term sequelae in the pediatric population, however there are no established clinical practice guidelines for the management of pediatric DReSS. We conducted a scoping review, according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, to summarize the currently available data on treatment, mortality, and long-term sequelae of DReSS in children (aged 0-18 years). Data from 644 individuals revealed that various treatment strategies are being used in the management of pediatric DReSS, and strategies were often used in combination. The diversity in treatment approaches cannot be solely attributed to age or disease severity and reflects the lack of evidence-based management guidelines for DReSS. Children are also at risk of developing autoimmune sequelae following DReSS, most commonly thyroid disease and type 1 diabetes mellitus. We found that the eventual development of autoimmune disease was more often associated with DReSS caused by antibiotics, especially minocycline and sulfamethoxazole, in comparison with individuals who did not develop sequelae. In this study, we identify strengths and weaknesses in the currently available literature and highlight that future prospective studies with structured and long-term follow-up of children with DReSS are needed to better understand potential risk factors for mortality and development of sequelae after DReSS.
Topics: Humans; Drug Hypersensitivity Syndrome; Child; Adolescent; Child, Preschool; Infant; Risk Factors; Anti-Bacterial Agents; Treatment Outcome; Autoimmune Diseases; Severity of Illness Index
PubMed: 38755503
DOI: 10.1007/s40257-024-00867-y -
Journal of the American Academy of... Jul 2024
Topics: Etanercept; Humans; Stevens-Johnson Syndrome; Treatment Outcome
PubMed: 38754630
DOI: 10.1016/j.jaad.2024.04.072 -
Current Opinion in Allergy and Clinical... Aug 2024Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN) are severe cutaneous adverse drug reactions (SCARs) characterized by widespread epithelial detachment and... (Review)
Review
Greater mechanistic understanding of the cutaneous pathogenesis of Stevens-Johnson syndrome/toxic epidermal necrolysis can shed light on novel therapeutic strategies: a comprehensive review.
PURPOSE OF REVIEW
Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN) are severe cutaneous adverse drug reactions (SCARs) characterized by widespread epithelial detachment and blistering, which affects the skin and mucocutaneous membranes. To date, therapeutic interventions for SJS/TEN have focused on systematic suppression of the inflammatory response using high-dose corticosteroids or intravenous immunoglobulin G (IgG), for example. No targeted therapies for SJS/TEN currently exist.
RECENT FINDINGS
Though our understanding of the pathogenesis of SJS/TEN has advanced from both an immunological and dermatological perspective, this knowledge is yet to translate into the development of new targeted therapies.
SUMMARY
Greater mechanistic insight into SJS/TEN would potentially unlock new opportunities for identifying or repurposing targeted therapies to limit or even prevent epidermal injury and blistering.
Topics: Stevens-Johnson Syndrome; Humans; Immunoglobulins, Intravenous; Skin; Adrenal Cortex Hormones; Animals; Molecular Targeted Therapy
PubMed: 38753537
DOI: 10.1097/ACI.0000000000000993 -
JAMA Jun 2024
Topics: Humans; Toxicodendron; Dermatitis, Toxicodendron
PubMed: 38753316
DOI: 10.1001/jama.2023.26355 -
The New England Journal of Medicine May 2024
Topics: Aged; Female; Humans; Diagnosis, Differential; Exanthema; Skin; Pain; Tomography, X-Ray Computed; Exudates and Transudates; Anal Canal; Anti-Bacterial Agents; Stevens-Johnson Syndrome; Amoxicillin-Potassium Clavulanate Combination; Doxycycline; Perineum; Abdomen; Black or African American; Biopsy; Lymphoma, Follicular; Immunoblastic Lymphadenopathy
PubMed: 38749037
DOI: 10.1056/NEJMcpc2312736 -
Food and Chemical Toxicology : An... Jul 2024Wearable devices are in contact with the skin for extended periods. As such, the device constituents should be evaluated for their skin sensitization potential, and a...
Wearable devices are in contact with the skin for extended periods. As such, the device constituents should be evaluated for their skin sensitization potential, and a Point of Departure (PoD) should be derived to conduct a proper risk assessment. Without historical in vivo data, the PoD must be derived with New Approach Methods (NAMs). To accomplish this, regression models trained on LLNA data that use data inputs from OECD-validated in vitro tests were used to derive a predicted EC3 value, the LLNA value used to classify skin sensitization potency, for three adhesive monomers (Isobornyl acrylate (IBOA), N, N- Dimethylacrylamide (NNDMA), and Acryloylmorpholine (ACMO) and one dye (Solvent Orange 60 (SO60)). These chemicals can be used as constituents of wearable devices and have been associated with causing allergic contact dermatitis (ACD). Using kinetic DPRA and KeratinoSens™ data, the PoDs obtained with the regression model were 180, 215, 1535, and 8325 μg/cm for IBOA, SO60, ACMO, and NNDMA, respectively. The PoDs derived with the regression model using NAMs data will enable a proper skin sensitization risk assessment without using animals.
Topics: Wearable Electronic Devices; Humans; Dermatitis, Allergic Contact; Risk Assessment; Skin; Acrylates; Adhesives
PubMed: 38744418
DOI: 10.1016/j.fct.2024.114725