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Frontiers in Chemistry 2024The deterioration of mild steel in an acidic environment poses a significant challenge in various industries. The emergence of effective corrosion inhibitors has drawn...
Unraveling the corrosion inhibition behavior of prinivil drug on mild steel in 1M HCl corrosive solution: insights from density functional theory, molecular dynamics, and experimental approaches.
The deterioration of mild steel in an acidic environment poses a significant challenge in various industries. The emergence of effective corrosion inhibitors has drawn attention to studies aimed at reducing the harmful consequences of corrosion. In this study, the corrosion inhibition efficiency of Prinivil in a 1M HCl solution through various electrochemical and gravimetric techniques has been investigated for the first time. The results demonstrated that the inhibition efficiency of Prinivil expanded from 61.37% at 50 ppm to 97.35% at 500 ppm concentration at 298 K. With a regression coefficient ( ) of 0.987, K value of 0.935 and E value of 43.024 kJ/mol at 500 ppm concentration of inhibitor, a strong affinity of Prinivil for adsorption onto the metal surface has been significantly found. Scanning electron microscopy (SEM) and contact angle measurement analyses further support the inhibitory behavior of Prinivil, demonstrating the production of a defensive layer on the surface of mild steel. Additionally, molecular dynamics (MD) and Monte Carlo simulations were employed to investigate the stability and interactions between Prinivil and the metallic surface (Fe (1 1 0)) at the atomic level. The computed results reveal strong adsorption of Prinivil upon the steel surface, confirming its viability as a corrosion inhibitor.
PubMed: 38947959
DOI: 10.3389/fchem.2024.1403118 -
ACS Applied Electronic Materials Jun 2024Flexible temperature sensors are becoming increasingly important these days. In this work, we explore graphene oxide (GO)/poly(vinyl alcohol) (PVA) nanocomposites for...
Flexible temperature sensors are becoming increasingly important these days. In this work, we explore graphene oxide (GO)/poly(vinyl alcohol) (PVA) nanocomposites for potential application in temperature sensors. The influence of the mixing ratio of both materials, the reduction temperature, and passivation on the sensing performance has been investigated. Various spectroscopic techniques revealed the composite structure and atomic composition. These were complemented by semiempirical quantum chemical calculations to investigate rGO and PVA interaction. Scanning electron and atomic force microscopy measurements were carried out to evaluate dispersion and coated film quality. The temperature sensitivity has been evaluated for several composite materials with different compositions in the range from 10 to 80 °C. The results show that a linear temperature behavior can be realized based on rGO/PVA composites with temperature coefficients of resistance (TCR) larger than 1.8% K and a fast response time of 0.3 s with minimal hysteresis. Furthermore, humidity influence has been investigated in the range from 10% to 80%, and a minor effect is shown. Therefore, we can conclude that rGO/PVA composites have a high potential for excellent passivation-free, humidity-independent, sensitive, and fast response temperature sensors for various applications. The GO reduction is tunable, and PVA improves the rGO/PVA sensor performance by increasing the tunneling effect and band gap energy, consequently improving temperature sensitivity. Additionally, PVA exhibits minimal water absorption, reducing the humidity sensitivity. rGO/PVA maintains its temperature sensitivity during and after several mechanical deformations.
PubMed: 38947952
DOI: 10.1021/acsaelm.4c00729 -
Frontiers in Oncology 2024Although the incidence and mortality rates of colorectal cancer exhibit significant variability, it remains one of the most prevalent cancers worldwide. Endeavors to...
INTRODUCTION
Although the incidence and mortality rates of colorectal cancer exhibit significant variability, it remains one of the most prevalent cancers worldwide. Endeavors to prevent colorectal cancer development focus on detecting precursor lesions during colonoscopy. The diagnosis of endoscopically resected polyps relies on hematoxylin and eosin staining examination. For challenging cases like adenomatous polyps with epithelial misplacement, additional diagnostic methods could prove beneficial.
METHODS
This paper aims to underscore stromal changes observed in malignant polyps and polyps with pseudoinvasion, leveraging two-photon excitation microscopy (TPEM), a technique extensively employed in the medical field in recent years.
RESULTS AND DISCUSSIONS
Both the subjective and quantitative analysis of TPEM images revealed distinct distributions and densities of collagen at the invasion front in malignant polyps compared to areas of pseudoinvasion. TPEM holds potential in discerning true invasion in malignant polyps from pseudoinvasion, offering enhanced visualization of local stromal changes.
PubMed: 38947893
DOI: 10.3389/fonc.2024.1394493 -
ACS Omega Jun 2024Bituminous carbonate rocks of the Upper Cretaceous Shu'ayb Formation from the Ajloun outcrop in Northern Jordan were geochemically and petrologically analyzed in this...
Geochemical and Organic Petrological Characteristics of the Bituminous Carbonate Succession (Upper Cretaceous Shu'ayb Formation) in Northern Jordan: Implications for Organic Matter Input and Paleosalinity, Paleoredox, and Paleoclimatic Conditions.
Bituminous carbonate rocks of the Upper Cretaceous Shu'ayb Formation from the Ajloun outcrop in Northern Jordan were geochemically and petrologically analyzed in this study. This study integrates kerogen microscopy results with geochemical results (i.e., biomarker, stable carbon isotope, and major elemental compositions) to understand the organic matter (OM) inputs and to reveal the dispositional setting and its effect on the occurrence of OM. The Shu'ayb bituminous carbonate rocks have high total organic carbon (TOC) and sulfur (S) contents, with average values of 12.3 and 4.59 wt %, respectively, indicating redox conditions during their precipitation. The high abundance of alginite (i.e., ) in the Shu'ayb bituminous carbonate sediments is a further evidence for redox conditions. The finding of mainly marine-derived OM was also demonstrated by the biomarker distribution and carbon isotope composition. The biomarkers are represented by a narrow Pr/Ph ratio of up to 0.97, abundance of tricyclic terpanes, and high C regular sterane, indicating that the OM was primarily derived from phytoplankton algae, along with small amounts of land plant-derived materials, and were accumulated under reducing conditions. The studied Shu'ayb bituminous carbonate facies is composed of mainly calcium (CaO; average, 45.10 wt %), with significant amounts of silicon (SiO; avg., 9.35 wt %), aluminum (AlO; avg., 6.91 wt %), and phosphorus (PO; avg., 1.47 wt %) and low amounts of iron (FeO) and titanium (TiO) of less than 1 wt %, indicating that the detrital influx was low in an open water depth system with higher primary bioproductivity. The geochemical proxy suggests that the Shu'ayb bituminous carbonate facies was established in a saline water environment, with Ca/Ca + Fe and S/TOC values of more than 0.9 and 0.50, respectively, which could be attributed to the increase in reducing conditions of the water column. The chemical index of alteration values of more than 0.8 also indicate that the Shu'ayb bituminous carbonate facies formed during warm and humid climatic conditions, thereby resulting in intense subaerial weathering.
PubMed: 38947829
DOI: 10.1021/acsomega.4c02582 -
ACS Omega Jun 2024Oligocene-Pliocene shale reservoirs in the Western Qaidam Depression represent typical mixed shale deposits characterized by moderate organic matter (OM) abundance and...
Oligocene-Pliocene shale reservoirs in the Western Qaidam Depression represent typical mixed shale deposits characterized by moderate organic matter (OM) abundance and sufficient OM maturity, indicating substantial shale-oil resource potential. Here, a comprehensive study was conducted to analyze the reservoir characteristics of different shale types, including the Upper Xiaganchaigou (late Oligocene), Shangganchaigou (Miocene), and Xiayoushashan (early Pliocene) Formations in the Western Qaidam Depression. Our analysis focused on the pore structural characteristics of shale reservoirs, employing X-ray diffraction, casting thin sections, scanning electron microscopy, low-temperature nitrogen adsorption, and nuclear magnetic resonance (NMR) as investigative techniques. Our results show that (1) the study area comprises five typical shale types: lime shale, argillaceous shale, limestone, argillaceous limestone, and mudstone. The best hydrocarbon source rock conditions are found in the lime shale and argillaceous shale. (2) Inorganic pores, including dissolution pores, intergranular pores, bedding fractures, structural fractures, and intraparticle pores in clay minerals, are the main pore types found in the studied samples and constitute the primary reservoir space for shale oil. On the basis of fractal dimensions obtained through NMR, the pores can be classified as micropores (<100 nm), mesopores (100-1000 nm), or macropores (>1000 nm). Mesopores are the main contributors to porosity. (3) The development of micropores is positively correlated with clay mineral content. The development of mesopores and macropores is influenced by the quartz, feldspar, dolomite, and calcite contents. Calcite content exhibits a negative correlation with porosity, suggesting that later-stage pore cementation hinders shale reservoir development. (4) The five typical shale reservoirs in the study area can be categorized into three types. Type I reservoir lithologies include lime shale and argillaceous shale; type II reservoir lithologies include limestone and argillaceous limestone; and type III reservoirs comprise mudstone. Type I and II reservoirs are of better quality than type III.
PubMed: 38947797
DOI: 10.1021/acsomega.4c03956 -
ACS Omega Jun 2024Hybrid microgels made from starch nanoparticles (SNPs) and poly(-isopropylacrylamide) p(NIPAM) were used as promising hosts for the methylene blue (MB) dye. In this...
Hybrid microgels made from starch nanoparticles (SNPs) and poly(-isopropylacrylamide) p(NIPAM) were used as promising hosts for the methylene blue (MB) dye. In this paper, these thermoresponsive microgels were characterized by dynamic light scattering (DLS), zeta potential measurements (ZP), and scanning electron microscopy (SEM) and evaluated as carriers for skin-targeted drug delivery. The hybrid microgel-MB systems in PBS solution were also studied by UV-vis spectroscopy and DLS, revealing discernible differences in spectral intensity and absorption shifts compared to microgels devoid of MB. This underscores the successful integration of methylene blue within the SNPs--p(NIPAM) microgels, signifying their potential as efficacious drug delivery vehicles.
PubMed: 38947796
DOI: 10.1021/acsomega.4c01947 -
ACS Omega Jun 2024This study conducts a systematic investigation of the creation and optimization of a rutin-loaded transethosome intended for topical use. The formulation's...
This study conducts a systematic investigation of the creation and optimization of a rutin-loaded transethosome intended for topical use. The formulation's characteristics were thoroughly assessed for vesicle size (160.45 ± 1.98 nm), polydispersity index (0.235 ± 0.067), and zeta potential (-22.89 mV), with an entrapment efficiency and drug loading of 89.99 ± 1.55% and 8.9 ± 2.11%, respectively, and found to have a spherical shape by the use of transmission electron microscopy. The conversion to a gel suitable for application on the skin was carried out. The drug release form Opt-RUT-TE formulation (73.61 ± 2.55%) was significantly higher than that of release form RUT-suspension (34.52 ± 1.19%). The drug that permeated the skin from Opt-RUT-TEG (935.25 ± 10.49 μg/cm) was significantly higher than the permeability from RUT-Suspension gel (522.57 ± 6.79 μg/cm). Notably, tape stripping analysis revealed that the Opt-RUT-TE gel effectively penetrated the skin layers, with a higher concentration observed in the epidermis-dermis than in the RUT-suspension gel. The transethosomal gel exhibited favorable characteristics, highlighting its capacity to efficiently permeate the skin and suppress the growth of microorganisms, and Opt-RUT-TEG showed a higher microorganism inhibition zone (Gram-positive bacteria) than that of RUT-suspension gel. The investigation highlights the significant therapeutic possibilities of rutin in a transethosomal gel formulation for treating dermatological diseases by improving skin permeability and exhibiting antibacterial effects.
PubMed: 38947795
DOI: 10.1021/acsomega.4c01718 -
ACS Omega Jun 2024Recently, obtaining collagen films using a cross-linking technique has been a successful strategy. The current investigation used six cross-linker extracts (CE) from six...
Recently, obtaining collagen films using a cross-linking technique has been a successful strategy. The current investigation used six cross-linker extracts (CE) from six different pomegranate varieties' byproducts to make and characterize collagen-tannin films using acid-soluble collagen (SC). The polymeric film has a yellow hue after CE incorporation. Fourier transform infrared spectroscopy assessed the impact of CE and its successful interaction within the matrix. The shifts verify different interactions between extracts and collagen functional groups, where they likely form new hydrogen bonds, retaining their helix structure without damaging the matrix. Scanning electron microscopy was used to analyze the morphology and fiber size. The average diameter of the fibers was found to be about 3.64 μm. Thermal behaviors (denaturation and degradation) were investigated by thermogravimetric analysis. The weight losses of cross-linked films increased by around 20% compared to non-cross-linked ones. This phenomenon was explained by the absence of telopeptide sections in the collagen helical structure, typically reinforced by lysine and hydroxylysine covalent linkages. Nanoscaled observations were also accomplished using transmission electron microscopy (TEM) on SC and SC-CE. The TEM analysis confirmed the CE polymerization degree effect on the cross-linking density via the overlap sequences, ranging up to 32.38 ± 2.37 nm on the fibril. The prepared biodegradable collagen-tannin film showed higher cross-linking density, which is expected to improve the biomaterial applications of collagen films while exploiting the underrated pomegranate byproducts.
PubMed: 38947794
DOI: 10.1021/acsomega.4c02321 -
Cureus May 2024Leukemia is a rare but fatal cancer of the blood. This cancer arises from abnormal bone marrow cells and requires prompt diagnosis for effective treatment and positive... (Review)
Review
Leukemia is a rare but fatal cancer of the blood. This cancer arises from abnormal bone marrow cells and requires prompt diagnosis for effective treatment and positive patient prognosis. Traditional diagnostic methods (e.g., microscopy, flow cytometry, and biopsy) pose challenges in both accuracy and time, demanding an inquisition on the development and use of deep learning (DL) models, such as convolutional neural networks (CNN), which could allow for a faster and more exact diagnosis. Using specific, objective criteria, DL might hold promise as a tool for physicians to diagnose leukemia. The purpose of this review was to report the relevant available published literature on using DL to diagnose leukemia. Using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, articles published between 2010 and 2023 were searched using Embase, Ovid MEDLINE, and Web of Science, searching the terms "leukemia" AND "deep learning" or "artificial neural network" OR "neural network" AND "diagnosis" OR "detection." After screening retrieved articles using pre-determined eligibility criteria, 20 articles were included in the final review and reported chronologically due to the nascent nature of the phenomenon. The initial studies laid the groundwork for subsequent innovations, illustrating the transition from specialized methods to more generalized approaches capitalizing on DL technologies for leukemia detection. This summary of recent DL models revealed a paradigm shift toward integrated architectures, resulting in notable enhancements in accuracy and efficiency. The continuous refinement of models and techniques, coupled with an emphasis on simplicity and efficiency, positions DL as a promising tool for leukemia detection. With the help of these neural networks, leukemia detection could be hastened, allowing for an improved long-term outlook and prognosis. Further research is warranted using real-life scenarios to confirm the suggested transformative effects DL models could have on leukemia diagnosis.
PubMed: 38947677
DOI: 10.7759/cureus.61379 -
Cureus May 2024Invasive Paget's disease (IPDN) is a rare phenomenon characterised by invasive carcinoma localised to the nipple. It is associated with Paget's disease of the nipple...
Invasive Paget's disease (IPDN) is a rare phenomenon characterised by invasive carcinoma localised to the nipple. It is associated with Paget's disease of the nipple (PDN) whereby Paget cells locally invade the underlying epidermis. Often in PDN, histopathological confirmation is needed, due to a lack of clear symptoms on clinical presentation. An 82-year-old female with single duct ectasia presented to the breast clinic in September 2023 with a tender, inflamed right nipple with a necrotic appearance. The lesion was excised, and an ultrasound scan showed right U2, implying no underlying malignancy. Microscopy showed Paget's disease with underlying ductal carcinoma in situ and two small (0.4 and 0.3mm) foci of dermal invasion by Paget cells in keeping with IPDN. Research suggests that dermal invasion by Paget cells has little effect on clinical outcome and prognosis depends largely on the associated underlying malignancy. However, all cases of IPDN with deep invasion or penetration of Paget cells into the dermis have the potential for regional and distant lymphatic spread. In extramammary Paget's disease, depth of invasion has been associated with poorer survival. Therefore, wide variability in clinical patterns and presentations of PDN mandates that a careful clinical approach correlated with in-depth histopathological evaluation is adopted in all cases.
PubMed: 38947628
DOI: 10.7759/cureus.61381