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Clinical Rheumatology Jul 2020
Topics: Child; Family; Humans; Mucocutaneous Lymph Node Syndrome; Nail Diseases
PubMed: 32333298
DOI: 10.1007/s10067-020-05100-9 -
Journal of Clinical Virology : the... May 2020Enterovirus (EV) A71 and coxsackievirus (CV) A16 were the most frequent serotypes involved in hand, foot, and mouth disease (HFMD) outbreaks throughout Asia. In the past... (Review)
Review
BACKGROUND
Enterovirus (EV) A71 and coxsackievirus (CV) A16 were the most frequent serotypes involved in hand, foot, and mouth disease (HFMD) outbreaks throughout Asia. In the past 5 years, however, CV-A6 has emerged as a new important pathogen worldwide, and more severe and extensive dermatologic presentations has been reported.
OBJECTIVES
Identify the clinical spectrum for atypical HFMD and enterovirus serotypes in Belém, Pará, Amazon region of northern Brazil.
STUDY DESIGN
A prospective ambulatory clinic-based surveillance conducted from January to June 2019, involving patients under 15 years with symptoms of HFMD. Stool, serum, oropharyngeal, and skin swab samples were analyzed. Real-time RT-PCR was performed to detect the viral genome of enteroviruses. Positive specimens were submitted to semi-nested PCR. Physical examinations and demographic data were recorded on a standardized form.
RESULTS
48 patients with symptoms of HFMD were included in the study and collected all samples according to protocol. Enteroviruses were detected in 83 % of patients. An atypical form of HFMD with vesiculobullous exanthema was present in 70 % (28/40); desquamation of the palms and soles detected in 90 % (36/40) and onychomadesis in 30 % (12/40) of patients. The serotype was identified in 22 patients, CV- A6 occurred in 81.8 % of them.
CONCLUSION
This is the first ambulatory surveillance and virologic investigation involving HFMD performed in outpatients from Amazon region, Brazil. The detection of CV-A6 was related to atypical forms HFMD. Desquamation of the palms and soles and nail changes occurred with frequency, such as a late sequel in the HFMD disease.
Topics: Adolescent; Antibodies, Viral; Brazil; Child; Child, Preschool; Disease Outbreaks; Enterovirus; Enterovirus Infections; Female; Genome, Viral; Genotype; Hand, Foot and Mouth Disease; Humans; Infant; Infant, Newborn; Male; Phylogeny; Prospective Studies; Serogroup; Skin Diseases, Vesiculobullous
PubMed: 32302950
DOI: 10.1016/j.jcv.2020.104307 -
The Veterinary Record Apr 2020
Review
Topics: Administration, Oral; Animals; Dog Diseases; Dogs; Fatty Acids, Essential; Foot Dermatoses; Hoof and Claw; Treatment Outcome
PubMed: 32299980
DOI: 10.1136/vr.m967 -
Journal of the American Academy of... Dec 2020Carpal tunnel syndrome (CTS) is commonly seen by general practitioners and often presents with neurologic symptoms of nocturnal pain and paresthesia along the median... (Review)
Review
Carpal tunnel syndrome (CTS) is commonly seen by general practitioners and often presents with neurologic symptoms of nocturnal pain and paresthesia along the median nerve distribution. Approximately 20% of patients also present with cutaneous findings (ulcerations, blistering, sclerodactyly, nail dystrophy) characterizing a severe form called necrotic CTS. Necrotic CTS can also be associated with bone changes (acro-osteolysis). In the author's practice, combined nail and skin findings are not an uncommon presentation of CTS, although this form remains overlooked and underreported in the dermatological textbooks and studies. This manuscript aims to review the literature on CTS cases, with a specific focus on using associated nail findings as diagnostic clues. The literature review along with a few additional recent cases from the author's practice demonstrate that CTS is frequently accompanied by a variety of nail changes including koilonychia, longitudinal fissuring, Beau's lines, onychomadesis, melanonychia, nail thickening, hyperkeratosis, and ischemic ulcerations with paronychia. Furthermore, when these changes are limited to the second and third fingernails, they should prompt the diagnosis of CTS. Once suspected, diagnostic evaluation is not difficult and surgical management can resolve cutaneous findings and prevent irreversible changes such as acro-osteolysis.
Topics: Administration, Topical; Carpal Tunnel Syndrome; Decompression, Surgical; Fingers; Glucocorticoids; Humans; Injections, Intralesional; Median Nerve; Nails; Nails, Malformed; Necrosis; Nitroglycerin; Severity of Illness Index; Splints; Treatment Outcome
PubMed: 32199899
DOI: 10.1016/j.jaad.2020.03.023 -
Anais Brasileiros de Dermatologia 2020
Topics: Blister; Child; Child, Preschool; Female; Hand, Foot and Mouth Disease; Humans; Male; Nail Diseases; Remission, Spontaneous
PubMed: 32165023
DOI: 10.1016/j.abd.2019.06.011 -
Rheumatology (Oxford, England) Sep 2020
Topics: Amputation Stumps; Anti-Inflammatory Agents, Non-Steroidal; Child; Female; Finger Phalanges; Hereditary Sensory and Autonomic Neuropathies; Humans; Iodophors; Osteolysis; Radiography; Surface-Active Agents
PubMed: 31990336
DOI: 10.1093/rheumatology/keaa007 -
European Journal of Cancer (Oxford,... Feb 2020
Topics: Aged; Antibodies, Monoclonal, Humanized; Antineoplastic Agents, Immunological; Carcinoma, Transitional Cell; Female; Foot Dermatoses; Humans; Male; Neoplasm Metastasis; Onychomycosis; Urologic Neoplasms
PubMed: 31923731
DOI: 10.1016/j.ejca.2019.12.009 -
The British Journal of Dermatology May 2020
Topics: Humans; Immunoglobulin A; Linear IgA Bullous Dermatosis; Nail Diseases; Nails, Malformed
PubMed: 31867716
DOI: 10.1111/bjd.18744 -
Reviews in Medical Virology Mar 2020Coxsackievirus A6 (CV-A6) has been associated with increasingly occurred sporadic hand-foot-mouth disease (HFMD) cases and outbreak events in many countries. In order to... (Meta-Analysis)
Meta-Analysis Review
Coxsackievirus A6 (CV-A6) has been associated with increasingly occurred sporadic hand-foot-mouth disease (HFMD) cases and outbreak events in many countries. In order to understand epidemiological characteristics of CV-A6, we collected the information describing HFMD caused by CV-A6 to describe the detection rate, severe rate and onychomadesis rate, which is defined as one or more nails defluvium, caused by CV-A6 from 2007 to 2017. The results showed that there was an outbreak of CV-A6 every other year, and overall trend of the epidemic of CA6-associated HFMD was increasing in China. The detection rate of CV-A6 in other countries was 32.0% (95% CI: 25.0%~40.0%) before 2013 and 28.0% (95% CI: 20.0%~36.0%) after 2013, respectively. Although the severe rate of HFMD caused by CV-A6 was low (0.10%, 95% CI: 0.01%~0.20%), CV-A6 can cause a high incidence of onychomadesis (28.0%, 95%CI: 21.9%-34.3%). Thus, it would be worthwhile to research and develop an effective multivalent vaccine for CV-A6 to achieve a more powerful prevention of HMFD.
Topics: Comorbidity; Disease Outbreaks; Disease Susceptibility; Enterovirus A, Human; Global Health; Hand, Foot and Mouth Disease; Humans; Incidence; Molecular Epidemiology; Public Health Surveillance
PubMed: 31811676
DOI: 10.1002/rmv.2087 -
Contact Dermatitis Apr 2020
Topics: Adult; Amoxicillin-Potassium Clavulanate Combination; Anti-Bacterial Agents; Antifungal Agents; Clobetasol; Dermatitis, Allergic Contact; Drug Therapy, Combination; Female; Glucocorticoids; Humans; Imidazoles; Male; Nail Diseases; Toes
PubMed: 31800097
DOI: 10.1111/cod.13446