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Medicina Oral, Patologia Oral Y Cirugia... Mar 2024Collagen is a component of Pyogenic Granuloma (PG) and Peripheral Ossifying Fibroma (POF) and performs different functions in these lesions. The objective of this study...
BACKGROUND
Collagen is a component of Pyogenic Granuloma (PG) and Peripheral Ossifying Fibroma (POF) and performs different functions in these lesions. The objective of this study is to evaluate the role of collagen and immunostaining for Transforming Growth Factor beta (TGF-β) in the clinical and microscopic findings of PG and POF.
MATERIAL AND METHODS
PG (n=20) and POF (n=20) were selected for clinical evaluation (sex, age, localization, size and evolution time) and microscopic analysis (picrosirius red staining for collagen analysis and immunohistochemistry for TGF-β) performed in the superficial and deep areas of the two lesions. ANOVA/Bonferroni and t-test, Pearson correlation and χ2 were used to compare the sites and parameters analyzed (p<0.05, GraphPad Prism 5.0).
RESULTS
The depth of PG presented the highest amount of collagen (p<0.001), and its surface showed the lowest amount of type 1 collagen (yellow-red strong birefringence). Type 1 collagen gradually increased in depth of PG, surface and depth of POF (p<0.001). The number of TGF-β+ cells was lower on the surface of PG compared with the depth of PG and the two areas of POF (p<0.001). Sex and localization did not affect these parameters, but the profile of collagen and immunostaining for TGF-β suffered from modifications by the time of evolution and the size of the lesion.
CONCLUSIONS
Although PG and POF are reactive gingival lesions, the expression of TGF-β and its role in collagen showed different biological behaviors in these lesions, suggesting different biological origins for its components.
Topics: Humans; Fibroma, Ossifying; Collagen Type I; Granuloma, Pyogenic; Collagen; Gingival Neoplasms; Transforming Growth Factor beta
PubMed: 38288849
DOI: 10.4317/medoral.26268 -
Asian Journal of Surgery Apr 2024
Topics: Humans; Fibroma, Ossifying; Soft Tissue Neoplasms
PubMed: 38245414
DOI: 10.1016/j.asjsur.2024.01.034 -
BMJ Case Reports Jan 2024Ossifying fibroma is a type of fibro-osseous lesion categorised into cemento-ossifying fibroma and juvenile ossifying fibroma. Malignant transformation of fibro-osseous...
Ossifying fibroma is a type of fibro-osseous lesion categorised into cemento-ossifying fibroma and juvenile ossifying fibroma. Malignant transformation of fibro-osseous lesions is documented especially for fibrous dysplasia, but scarcity is seen when we search for malignant transformation of ossifying fibroma. Thus, we are presenting an extremely rare case of cemento-ossifying fibroma transforming into osteosarcoma with long sequential radiographic details.
Topics: Humans; Fibroma, Ossifying; Cementoma; Bone Neoplasms; Bone and Bones; Skull Neoplasms; Osteosarcoma
PubMed: 38233000
DOI: 10.1136/bcr-2023-257104 -
Annals of Medicine and Surgery (2012) Jan 2024Peripheral ossifying fibroma is one of the commonly occurring reactive benign lesions that occurs in the gingiva, predominantly in females, especially in the anterior...
INTRODUCTION AND IMPORTANCE
Peripheral ossifying fibroma is one of the commonly occurring reactive benign lesions that occurs in the gingiva, predominantly in females, especially in the anterior maxillary region of young women and in pediatric patients. It causes unsatisfactory esthetics, difficulty in maintaining good oral hygiene and difficulty in mastication.The importance of this clinical case is to emphasize the interest of early management of the residual defect after the removal of the gum growth.
CASE PRESENTATION
A 39-year-old female patient was referred to the clinical department of periodontology, with the chief complaint of bleeding gingiva, unsatisfactory esthetics and gum growth on the interproximal area in relation to left maxillary canine and premolar region, with the size ~2 cm×1.5 cm.
CLINICAL DISCUSSION
This article describes an atypical case of peripheral ossifying fibroma with the clinical, histopathologic, and radiographic features in the posterior maxilla in an adult female patient. Treatment consisted of complete surgical excision, gingival curettage, and management of keratinezed gingiva by utilizing laterally displaced flap. Clinical healing was satisfactory at 2 weeks, and excellent coverage of residual mucogingival defect with no evidence of recurrence was achieved 3 weeks postoperatively. The patient was satisfied with case resolution with a follow-up of 1 year.
CONCLUSION
Although surgical excision is the treatment of choice, sometimes it may induce residual soft tissue defect, which may further precipitate functional and esthetic discrepancies if not managed.
PubMed: 38222715
DOI: 10.1097/MS9.0000000000001013 -
Cureus Dec 2023Free gingival grafts are commonly used to address mucogingival deformities and increase the zone of keratinized tissue. However, the development of bone exostosis after...
Free gingival grafts are commonly used to address mucogingival deformities and increase the zone of keratinized tissue. However, the development of bone exostosis after soft tissue graft procedures, such as the free gingival graft, is infrequent. This case report presents the development of a 12x5 mm bony exostosis in the buccal region of the maxillary right canine in a 28-year-old female medical student after a free gingival graft preceding orthodontic treatment. A patient-centric treatment plan, initiated with consultation from an oral pathologist, suggested a biopsy for a definitive diagnosis of a suspected peripheral ossifying fibroma. However, the patient declined due to the absence of symptoms. Therefore, a non-invasive approach involving close monitoring through regular follow-ups has been chosen. In conclusion, this case report highlights the rarity of bony exostosis development after a free gingival graft and orthodontic treatment. The patient's asymptomatic presentation, coupled with the decision to decline the biopsy, underscores the importance of vigilant monitoring. It is significant for dentists to be knowledgeable about this potential complication and its identification to avoid misdiagnosis as oral lesions.
PubMed: 38222237
DOI: 10.7759/cureus.50500 -
BMJ Case Reports Jan 2024A man in his 20s presented with complaints of unilateral nasal obstruction for the past 6 years that progressively worsened leading to irrational use of over-the-counter...
A man in his 20s presented with complaints of unilateral nasal obstruction for the past 6 years that progressively worsened leading to irrational use of over-the-counter nasal decongestants. With the worsening of symptoms, a non-contrast CT was done. It showed a dense expansile sclerotic lesion of the right inferior turbinate, which was excised endoscopically. Cemento-ossifying fibromas of the inferior turbinate are rare and require assessment and surgical excision to relieve the symptom of nasal obstruction. It derives its name from the variable proportions of fibrous and mineralised tissue present in it and exclusively develops in the craniofacial region. It can be surgically managed by an endoscopic, an endonasal non-endoscopic (with a speculum) or an open approach (lateral rhinotomy, sublabial approach or mid-facial degloving). Here, we present how such a case was detected and managed surgically by the endoscopic approach, which is a minimally invasive option with shorter hospital stay and early recovery.
Topics: Male; Humans; Nasal Obstruction; Turbinates; Fibroma, Ossifying; Cementoma; Skull Neoplasms; Soft Tissue Neoplasms; Diagnostic Errors
PubMed: 38199659
DOI: 10.1136/bcr-2023-255881 -
Radiology Case Reports Mar 2024Ossifying fibroma is a benign fibro-osseous lesion arising from the periodontal ligament cells. The lesion may progressively enlarge with the mass affecting the mandible...
Ossifying fibroma is a benign fibro-osseous lesion arising from the periodontal ligament cells. The lesion may progressively enlarge with the mass affecting the mandible or maxilla, resulting in facial deformities and tooth displacement despite its benign nature. Here, we presented a case of an 18-year-old female with ossifying fibroma in the maxilla extending to the maxillary sinus, infraorbital area, and skull base, resulting in considerable facial asymmetry. Since the primary treatment of ossifying fibroma is surgical resection, it is essential to determine the areas where the lesion has expanded, where a 3-dimensional computed tomography scan could play a critical role in providing such information. A complete surgical excision and histopathologic examination in treating this patient are crucial, made possible by a meticulous preoperative radio imaging technique.
PubMed: 38188957
DOI: 10.1016/j.radcr.2023.10.059 -
Zhonghua Er Bi Yan Hou Tou Jing Wai Ke... Dec 2023
Topics: Humans; Fibroma, Ossifying; Orbit; Skull Base; Calcium Phosphates; Paranasal Sinuses
PubMed: 38186101
DOI: 10.3760/cma.j.cn115330-20230411-00161 -
Journal of Stomatology, Oral and... Jan 2024
PubMed: 38184197
DOI: 10.1016/j.jormas.2024.101760 -
International Journal of Surgery Case... Jan 2024Peripheral ossifying fibroma (POF) is an unusual localized, reactive benign gingival growth. POF is usually small in size, it's measure <2 cm in diameter, but rarely...
INTRODUCTION
Peripheral ossifying fibroma (POF) is an unusual localized, reactive benign gingival growth. POF is usually small in size, it's measure <2 cm in diameter, but rarely reaches important sizes. The aim of this work was to present a rare case report of a giant peripheral ossifying fibroma of the mandible measuring >2 cm in diameter, misdiagnosed as peripheral myxoma.
CASE PRESENTATION
We present the case of a 42-year-old woman with a large peripheral ossifying fibroma in the oral cavity measuring 6 × 4 cm in diameter. The patient presented with an asymptomatic, slowly growing gingival mass in the left anterior and posterior region of the mandible. It gradually increased in size for more than two years. The patient had a mild mental deficit; however, we performed biopsy surgery, which revealed a peripheral myxoma, and then treated the tumor by excision under local anesthesia. The final histopathological examination revealed a peripheral ossifying fibroma.
CLINICAL DISCUSSION
This case report shows that POF can grow and reach unusual dimensions that may contribute to occlusal problems. The diagnosis of POF is based on clinical and radiographic features. The histopathological examination of the biopsy specimen can misdiagnose the lesion; therefore, the final diagnosis is based on the histopathological examination of the complete excised lesion.
CONCLUSION
POF is usually small, but can reach a larger size. The histopathological examination of the entire lesion is of paramount importance to make a final diagnosis.
PubMed: 38157625
DOI: 10.1016/j.ijscr.2023.109161