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Clinics in Dermatology 2023This is the second installment of a three-part contribution that highlights the achievements of Jewish dermatologists as reflected by eponyms that honor their names. It...
This is the second installment of a three-part contribution that highlights the achievements of Jewish dermatologists as reflected by eponyms that honor their names. It covers the period 1933-1945 when the Nazis took over Germany and how the lives of 14 notable Jewish physicians, mostly in Germany, were impacted during the Holocaust. Many of them fled from the persecution, bringing their academic talents to other lands such as the United States. At least one committed suicide (Fritz Juliusberg), and three others perished in the Holocaust (Abraham Buschke, Lucja Frey-Gottesman, and Karl Herxheimer). They are remembered by eponyms including Neisser-Juliusberg pityriasis lichenoides chronica, Buschke-Ollendorff syndrome, Frey syndrome, and Jarisch-Herxheimer reaction. It made little difference to the Nazis that several of the 14 physicians had converted to Christianity. All were persecuted by the Nazis and had their professional careers destroyed. Two of the 14 physicians lived outside of the Third Reich (Bruno Bloch and Emanuel Libman) and were spared the suffering endured by the other 12. This tragic account of Jewish dermatologists during the Holocaust, and the eponyms that honor them, will continue in part three of this contribution.
Topics: Humans; United States; Jews; Dermatologists; Eponyms; Holocaust; Physicians; Germany
PubMed: 37777142
DOI: 10.1016/j.clindermatol.2023.09.006 -
JAAD Case Reports Oct 2023
PubMed: 37701883
DOI: 10.1016/j.jdcr.2023.07.038 -
Anais Brasileiros de Dermatologia 2024
Topics: Humans; Pityriasis Lichenoides; Dermoscopy; Pityriasis
PubMed: 37661463
DOI: 10.1016/j.abd.2022.04.017 -
European Journal of Dermatology : EJD Jun 2023
Topics: Humans; Pityriasis Lichenoides; Brentuximab Vedotin; Lymphoma, T-Cell, Peripheral; Exanthema
PubMed: 37594350
DOI: 10.1684/ejd.2023.4494 -
European Journal of Dermatology : EJD Jun 2023
Topics: Humans; Pityriasis Lichenoides; Antibodies, Monoclonal, Humanized
PubMed: 37594343
DOI: 10.1684/ejd.2023.4483 -
Photodermatology, Photoimmunology &... Sep 2023Pityriasis lichenoides (PL) is a papulosquamous disease affecting both children and adults, for which narrowband-UVB (NB-UVB) phototherapy is regarded as a commonly used... (Observational Study)
Observational Study
INTRODUCTION
Pityriasis lichenoides (PL) is a papulosquamous disease affecting both children and adults, for which narrowband-UVB (NB-UVB) phototherapy is regarded as a commonly used treatment option. The aim of this study was to investigate the efficacy of NB-UVB phototherapy in the management of PL and to compare response rates in pediatric and adult age groups.
MATERIALS AND METHODS
This observational, retrospective study included 20 PL patients (12 pityriasis lichenoides chronica; PLC, 8 pityriasis lichenoides et varioliformis acuta; PLEVA) who failed to respond to other treatment modalities. The data for this study were collected retrospectively from patient follow-up forms in the phototherapy unit.
RESULTS
A complete response (CR) was obtained in all pediatric patients with PL, while 53.8% of adult patients had achieved CR. The mean cumulative dose required to achieve the CR was higher in pediatric patients than adult patients with PL (p < .05). The CR was achieved in 6 (75%) of 8 PLEVA patients, while 8 (66.7%) of 12 PLC patients had reached to CR. The mean number of exposures for patients with PLC to achieve a CR was higher than patients with PLEVA (p < .05). Erythema was the most common adverse effect during phototherapy particularly in 5 (35.7%) of the patients with PL who had achieved CR.
CONCLUSIONS
NB-UVB is an effective and well-tolerated treatment option for PL especially in diffuse types. A higher response can be obtained in children with higher cumulative dose. Patients with PLC may require more exposures for CR than patients with PLEVA.
Topics: Adult; Humans; Child; Pityriasis Lichenoides; Retrospective Studies; Ultraviolet Therapy; Phototherapy; Ultraviolet Rays
PubMed: 37340660
DOI: 10.1111/phpp.12895 -
Boletin Medico Del Hospital Infantil de... 2023Pityriasis lichenoides et varioliformis acuta (PLEVA) is a rare dermatosis recognized as a benign condition of unknown etiopathogenesis. It is more common in pediatric... (Review)
Review
BACKGROUND
Pityriasis lichenoides et varioliformis acuta (PLEVA) is a rare dermatosis recognized as a benign condition of unknown etiopathogenesis. It is more common in pediatric patients and young adults and is characterized by multiple small or large erythematous plaques spread over the trunk and extremities.
CASE REPORT
We describe the case of a 5-year-old male, previously healthy, with multiple erythematous lesions that disappeared leaving hypopigmented macules. The biopsy reported histological changes suggestive of mycosis fungoides. After a second revision of lamellae in this hospital, lymphocytic vasculitis (LV) with focal epidermal necrosis consistent with acute pityriasis lichenoides (PL) was identified.
CONCLUSIONS
The existing knowledge about PLEVA lacks a consensus in specifying its classification, etiopathogenesis, diagnosis, and treatment, so this clinical condition represents a medical challenge. The diagnosis is made by clinical suspicion and confirmed by histology. The objective of this article was to report a case of PLEVA with an atypical presentation due to its histopathological findings, being the first report showing LV in children, as well as a review of the literature.
Topics: Male; Young Adult; Humans; Child; Child, Preschool; Pityriasis; Pityriasis Lichenoides; Skin Diseases
PubMed: 37155724
DOI: 10.24875/BMHIM.22000043 -
Cureus Mar 2023A rare subtype of mycosis fungoides (MF) known as pityriasis lichenoides-like mycosis fungoides (PL-like MF) manifests as recurrent crops of erythematous scaly papules...
A rare subtype of mycosis fungoides (MF) known as pityriasis lichenoides-like mycosis fungoides (PL-like MF) manifests as recurrent crops of erythematous scaly papules with the histological findings of MF. We report a 64-year-old male with recurrent crops of psoriasiform papules with mild scales on his trunk and extremities. Skin biopsy results were consistent with CD8+ cutaneous T-cell lymphoma (CTCL). Our patient had clinical features of pityriasis lichenoides and histological findings consistent with CD8+ MF. A differential diagnosis of PL, lymphomatoid papulosis (LyP), and PL-like MF was considered. Counseling patients with CD8+ cutaneous T-cell lymphoma can be challenging, as there is an aggressive variant named primary cutaneous aggressive epidermotropic CD8+ CTCL. However, with the ability to recognize PL-like MF, a rare indolent type of CD8+ CTCL, physicians can counsel patients appropriately.
PubMed: 37113344
DOI: 10.7759/cureus.36665 -
JAAD Case Reports May 2023
PubMed: 37078017
DOI: 10.1016/j.jdcr.2023.02.006 -
Acta Dermato-venereologica Apr 2023Febrile ulceronecrotic Mucha-Habermann disease (FUMHD) is a rare fulminant variant of pityriasis lichenoides et varioliformis acuta (PLEVA) that is characterized by a... (Review)
Review
Febrile ulceronecrotic Mucha-Habermann disease (FUMHD) is a rare fulminant variant of pityriasis lichenoides et varioliformis acuta (PLEVA) that is characterized by a large ulceronecrotic appearance with high fever and a variety of systemic symptoms. We report here a case of FUMHD in a 17-year-old male Chinese patient who was treated successfully with a combination therapy of methotrexate, methylprednisolone, and intravenous immunoglobulin. In addition, a literature review was conducted to summarize the key characteristics of paediatric FUMHD cases.
Topics: Male; Humans; Child; Adolescent; Pityriasis Lichenoides; Herpes Simplex; Methotrexate; Methylprednisolone
PubMed: 37073962
DOI: 10.2340/actadv.v103.4806