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Clinical Science (London, England :... Jul 2024Salt-sensitive hypertension (SSHTN) is associated with M1 macrophage polarization and inflammatory responses, leading to inflammation-associated lymphangiogenesis and...
Salt-sensitive hypertension (SSHTN) is associated with M1 macrophage polarization and inflammatory responses, leading to inflammation-associated lymphangiogenesis and functional impairment across multiple organs, including kidneys and gonads. However, it remains unclear whether promoting M2 macrophage polarization can alleviate the hypertension, inflammation, and end organ damage in mice with salt sensitive hypertension (SSHTN). Male and female mice were made hypertensive by administering nitro-L-arginine methyl ester hydrochloride (L-NAME; 0.5 mg/mL) for 2 weeks in the drinking water, followed by a 2-week interval without any treatments, and a subsequent high salt diet for 3 weeks (SSHTN). AVE0991 (AVE) was intraperitoneally administered concurrently with the high salt diet. Control mice were provided standard diet and tap water. AVE treatment significantly attenuated BP and inflammation in mice with SSHTN. Notably, AVE promoted M2 macrophage polarization, decreased pro-inflammatory immune cell populations, and improved function in renal and gonadal tissues of mice with SSHTN. Additionally, AVE decreased lymphangiogenesis in the kidneys and testes of male SSHTN mice and the ovaries of female SSHTN mice. These findings highlight the effectiveness of AVE in mitigating SSHTN-induced elevated BP, inflammation, and end organ damage by promoting M2 macrophage polarization and suppressing pro-inflammatory immune responses. Targeting macrophage polarization emerges as a promising therapeutic approach for alleviating inflammation and organ damage in SSHTN. Further studies are warranted to elucidate the precise mechanisms underlying AVE-mediated effects and to assess its clinical potential in managing SSHTN.
PubMed: 38949840
DOI: 10.1042/CS20240699 -
Nano Letters Jul 2024Maxwell's equations are solved when the amplitude and phase of the electromagnetic field are determined at all points in space. Generally, the Stokes parameters can only...
Maxwell's equations are solved when the amplitude and phase of the electromagnetic field are determined at all points in space. Generally, the Stokes parameters can only capture the amplitude and polarization state of the electromagnetic field in the radiation (far) zone. Therefore, the measurement of the Stokes parameters is, in general, insufficient to solve Maxwell's equations. In this Letter, we solve Maxwell's equations for a set of objects widely used in Nanophotonics using the Stokes parameters alone. These objects are lossless, axially symmetric, and well described by a single multipolar order. Our method for solving Maxwell's equations endows the Stokes parameters an even more fundamental role in the electromagnetic scattering theory.
PubMed: 38949763
DOI: 10.1021/acs.nanolett.4c01976 -
The Review of Scientific Instruments Jul 2024We developed a diamagnetic loop for the estimation of plasma stored energy in the KAIST Magnetic Mirror magnetic mirror device [Oh et al., J. Plasma Phys. 90, 975900202...
We developed a diamagnetic loop for the estimation of plasma stored energy in the KAIST Magnetic Mirror magnetic mirror device [Oh et al., J. Plasma Phys. 90, 975900202 (2024)]. Diamagnetic loops are used to estimate the plasma stored energy from measurements of the diamagnetic flux in plasma with an applied external magnetic field. However, diamagnetic flux measurements are accompanied by the vacuum flux, which generally exceeds the diamagnetic flux by over 10 000 times. Therefore, it is critical to attain a high signal-to-noise ratio with minimized noise in diamagnetic flux measurements. In this study, we employed a novel method to reduce background noise and improve the signal-to-noise ratio. Using two identical loops with opposite polarities, we successfully removed parasitic capacitive noise from the external insulation while amplifying the inductive signal two times. To eliminate the vacuum flux, we utilized two coaxial loops with different radii positioned at the same axial location. Results obtained from six paired loops confirmed the successful removal of the vacuum flux. The plasma stored energy was also found to agree well with Langmuir probe measurements, which verifies the diamagnetic flux measurements using the developed loop.
PubMed: 38949464
DOI: 10.1063/5.0212548 -
Advanced Materials (Deerfield Beach,... Jun 2024Heart transplantation offers life-saving treatment for patients with end-stage heart failure; however, ischemia-reperfusion injury (IRI) and subsequent immune responses...
Heart transplantation offers life-saving treatment for patients with end-stage heart failure; however, ischemia-reperfusion injury (IRI) and subsequent immune responses remain significant challenges. Current therapies primarily target adaptive immunity, with limited options available for addressing IRI and innate immune activation. Although plant-derived vesicle-like nanoparticles show promise in managing diseases, their application in organ transplantation complications is unexplored. Here, this work develops a novel reactive oxygen species (ROS)-responsive multifunctional fusion extracellular nanovesicles carrying rapamycin (FNVs@RAPA) to address early IRI and Ly6CLy6G inflammatory macrophage-mediated rejection in heart transplantation. The FNVs comprise Exocarpium Citri grandis-derived extracellular nanovesicles with anti-inflammatory and antioxidant properties, and mesenchymal stem cell membrane-derived nanovesicles expressing calreticulin with macrophage-targeting ability. A novel ROS-responsive bio-orthogonal chemistry approach facilitates the active targeting delivery of FNVs@RAPA to the heart graft site, effectively alleviating IRI and promoting the polarization of Ly6CLy6G inflammatory macrophages toward an anti-inflammatory phenotype. Hence, FNVs@RAPA represents a promising therapeutic approach for mitigating early transplantation complications and immune rejection. The fusion-targeted delivery strategy offers superior heart graft site enrichment and macrophage-specific targeting, promising improved transplant outcomes.
PubMed: 38949397
DOI: 10.1002/adma.202406758 -
Organic Letters Jul 2024A general intermolecular polarity-mismatched carboamination reaction of unactivated alkenes with unactivated alkyl halides has been developed. A series of nonactivated...
A general intermolecular polarity-mismatched carboamination reaction of unactivated alkenes with unactivated alkyl halides has been developed. A series of nonactivated alkyl-substituted aziridines were constructed in exclusive regioselectivity. The dual polarity-mismatched mechanism might be involved.
PubMed: 38949378
DOI: 10.1021/acs.orglett.4c01224 -
Physical Review Letters Jun 2024We show that excitonic resonances and interexciton transitions can enhance the probability of spontaneous parametric down-conversion, a second-order optical response...
We show that excitonic resonances and interexciton transitions can enhance the probability of spontaneous parametric down-conversion, a second-order optical response that generates entangled photon pairs. We benchmark our ab initio many-body calculations using experimental polar plots of second harmonic generation in NbOI_{2}, clearly demonstrating the relevance of excitons in the nonlinear response. A strong double-exciton resonance in 2D NbOCl_{2} leads to giant enhancement in the second order susceptibility. Our work paves the way for the realization of efficient ultrathin quantum light sources.
PubMed: 38949373
DOI: 10.1103/PhysRevLett.132.246902 -
Physical Review Letters Jun 2024Distributed quantum information in networks is paramount for global secure quantum communication. Moreover, it finds applications as a resource for relevant tasks, such...
Distributed quantum information in networks is paramount for global secure quantum communication. Moreover, it finds applications as a resource for relevant tasks, such as clock synchronization, magnetic field sensing, and blind quantum computation. For quantum network analysis and benchmarking of implementations, however, it is crucial to characterize the topology of networks in a way that reveals the nodes between which entanglement can be reliably distributed. Here, we demonstrate an efficient scheme for this topology certification. Our scheme allows for distinguishing, in a scalable manner, different networks consisting of bipartite and multipartite entanglement sources. It can be applied to semi-device-independent scenarios also, where the measurement devices and network nodes are not well characterized and trusted. We experimentally demonstrate our approach by certifying the topology of different six-qubit networks generated with polarized photons, employing active feed-forward and time multiplexing. Our methods can be used for general simultaneous tests of multiple hypotheses with few measurements, being useful for other certification scenarios in quantum technologies.
PubMed: 38949362
DOI: 10.1103/PhysRevLett.132.240802 -
Physical Review Letters Jun 2024We report the creation of ultracold ground state ^{6}Li^{40}K polar molecules with high efficiency. Starting from weakly bound molecules, stimulated Raman adiabatic...
We report the creation of ultracold ground state ^{6}Li^{40}K polar molecules with high efficiency. Starting from weakly bound molecules, stimulated Raman adiabatic passage is adopted to coherently transfer the molecules to their singlet rovibrational ground state |X^{1}Σ^{+},v=0,J=0⟩. By employing a singlet stimulated Raman adiabatic passage pathway and low-phase-noise narrow-linewidth lasers, we observed a one-way transfer efficiency of 96(4)%. Held in an optical dipole trap, the lifetime of the ground state molecules is measured to be 5.0(3) ms. The large permanent dipole moment of LiK is confirmed by applying a dc electric field on the molecules and performing Stark shift spectroscopy of the ground state. With recent advances in the quantum control of collisions, our work paves the way for exploring quantum many-body physics with strongly interacting ^{6}Li^{40}K molecules.
PubMed: 38949353
DOI: 10.1103/PhysRevLett.132.243401 -
Physical Review Letters Jun 2024Gaussian states with nonclassical properties such as squeezing and entanglement serve as crucial resources for quantum information processing. Accurately quantifying...
Gaussian states with nonclassical properties such as squeezing and entanglement serve as crucial resources for quantum information processing. Accurately quantifying these properties within multimode Gaussian states has posed some challenges. To address this, we introduce a unified quantification: the "classical-nonclassical polarity," represented by P. For a single mode, a positive value of P captures the reduced minimum quadrature uncertainty below the vacuum noise, while a negative value represents an enlarged uncertainty due to classical mixtures. For multimode systems, a positive P indicates bipartite quantum entanglement. We show that the sum of the total classical-nonclassical polarity is conserved under arbitrary linear optical transformations for any two-mode and three-mode Gaussian states. For any pure multimode Gaussian state, the total classical-nonclassical polarity equals the sum of the mean photon number from single-mode squeezing and two-mode squeezing. Our results provide a new perspective on the quantitative relation between single-mode nonclassicality and entanglement, which may find applications in a unified resource theory of nonclassical features.
PubMed: 38949343
DOI: 10.1103/PhysRevLett.132.240201 -
Physical Review Letters Jun 2024Novel critical phenomena beyond the Landau-Ginzburg-Wilson paradigm have been long sought after. Among many candidate scenarios, the deconfined quantum critical point...
Novel critical phenomena beyond the Landau-Ginzburg-Wilson paradigm have been long sought after. Among many candidate scenarios, the deconfined quantum critical point (DQCP) constitutes the most fascinating one, and its lattice model realization has been debated over the past two decades. Here we apply the spherical Landau level regularization upon the exact (2+1)D SO(5) nonlinear sigma model with a topological term to study the potential DQCP therein. We perform a density matrix renormalization group (DMRG) simulation with SU(2)_{spin}×U(1)_{charge}×U(1)_{angular-momentum} symmetries explicitly implemented. Using crossing point analysis for the critical properties of the DMRG data, accompanied by quantum Monte Carlo simulations, we accurately obtain the comprehensive phase diagram of the model and find various novel quantum phases, including Néel, ferromagnet (FM), valence bond solid (VBS), valley polarized (VP) states and a gapless quantum disordered phase occupying an extended area of the phase diagram. The VBS-disorder and Néel-disorder transitions are continuous with non-Wilson-Fisher exponents. Our results show the VBS and Néel states are separated by either a weakly first-order transition or the disordered region with a multicritical point in between, thus opening up more interesting questions on the two-decade long debate on the nature of the DQCP.
PubMed: 38949334
DOI: 10.1103/PhysRevLett.132.246503