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The American Journal of Dermatopathology Apr 2023
Topics: Humans; Buttocks; Skin; Porokeratosis; Plaque, Amyloid
PubMed: 36921311
DOI: 10.1097/DAD.0000000000002390 -
The American Journal of Dermatopathology Apr 2023
Topics: Humans; Buttocks; Skin; Porokeratosis; Plaque, Amyloid
PubMed: 36921306
DOI: 10.1097/DAD.0000000000002391 -
The Australasian Journal of Dermatology May 2023
Topics: Humans; Lichen Planus; Porokeratosis; Lower Extremity
PubMed: 36920437
DOI: 10.1111/ajd.14017 -
Diagnostics (Basel, Switzerland) Mar 2023Fordyce spots (FS) are heterotopic sebaceous glands affecting mostly oral and genital mucosa, commonly misdiagnosed with sexually transmitted infections. In a...
Fordyce spots (FS) are heterotopic sebaceous glands affecting mostly oral and genital mucosa, commonly misdiagnosed with sexually transmitted infections. In a single-center retrospective study, we aimed to assess the ultraviolet-induced fluorescencedermatoscopy (UVFD) clues of Fordyce spots and their common clinical simulants: molluscum contagiosum, penile pearly papules, human papillomavirus warts, genital lichen planus, and genital porokeratosis. Analyzed documentation included patients' medical records (1 September-30 October 2022) and photodocumentation, which included clinical images as well as polarized, non-polarized, and UVFD images. Twelve FS patients were included in the study group and fourteen patients in the control group. A novel and seemingly specific UVFD pattern of FS was described: regularly distributed bright dots over yellowish-greenish clods. Even though, in the majority of instances, the diagnosis of FS does not require more than naked eye examination, UVFD is a fast, easy-to-apply, and low-cost modality that can further increase the diagnostic confidence and rule out selected infectious and non-infectious differential diagnoses if added to conventional dermatoscopic diagnosis.
PubMed: 36900129
DOI: 10.3390/diagnostics13050985 -
Acta Dermatovenerologica Croatica : ADC Nov 2022Dear Editor, Segmental Darier disease (DD) is a rare disease with around 40 described English literature cases. It is hypothesized that one of the causes of the disease...
Dear Editor, Segmental Darier disease (DD) is a rare disease with around 40 described English literature cases. It is hypothesized that one of the causes of the disease is a post-zygotic somatic mutation for the calcium ATPase pump, only present in lesional skin. There are two types of segmental DD: type 1, where lesions follow Blaschko's lines unilaterally, and type 2, characterized by focal areas of increased severity in patients with generalized DD (1). Type 1 segmental DD is not easily diagnosed due to the lack of positive family history, the late onset of the disease in the third or fourth decade of life, and lack of DD-associated features. The differential diagnosis of type 1 segmental DD includes acquired papular dermatoses distributed in linear or zosteriform fashion, such as lichen planus, psoriasis, lichen striatus, or linear porokeratosis (2). We report two cases of segmental DD, of which the first case was a 43-year-old woman who presented with pruritic skin changes five years in duration and a history of seasonal aggravation. On examination, light brownish to reddish keratotic small papules were observed on the left abdomen and inframammary area, arranged in a swirling pattern (Figure 1, a). Dermoscopy showed polygonal or roundish yellowish/brown areas surrounded with whitish structureless areas (Figure 1, b). The histopathological correlations for dermoscopic brownish polygonal or round areas are hyperkeratosis, parakeratosis, and dyskeratotic keratinocytes, which were present in the biopsy specimen (Figure 1, c). The patient was prescribed 0.1% tretinoin gel, which led to marked improvement (Figure 1, d). The second case was a 62-year-old woman who presented with a flare of small red-brown papules, eroded papules, and some yellowish crusts arranged in a zosteriform pattern on the right side of the upper abdomen (Figure 2, a). Dermoscopy showed polygonal, roundish, yellowish areas surrounded with whitish and reddish structureless areas (Figure 2, b). Histopathology mainly revealed compact orthokeratosis and small foci of parakeratosis, marked granular layer with dyskeratotic keratinocytes, and foci of suprabasal acantholysis consistent with the diagnosis of DD (Figure 2, d, d). The patient was prescribed topical steroid cream and 0.1% adapalene cream, which also led to improvement. In both of our cases, a final diagnosis of type 1 segmental DD was established based on clinico-histopathologic correlation, since acantholytic dyskeratotic epidermal nevus could not have been ruled out only based on the histopathology report as it is clinically and histologically indistinguishable from segmental DD. However, the late age of onset and aggravation resulting from external factors such as heat, sunlight, and sweat supported the diagnosis of segmental DD. Although the final diagnosis of type 1 segmental DD is typically established based on clinico-histopathological correlation, we find dermoscopy particularly useful in aiding the diagnosis by eliminating differential diagnoses and being aware of their well-known dermoscopic patterns.
Topics: Female; Humans; Adult; Middle Aged; Darier Disease; Parakeratosis; Dermoscopy; Skin
PubMed: 36812281
DOI: No ID Found -
JAMA Dermatology Apr 2023
Topics: Humans; Porokeratosis; Simvastatin; Buttocks; Biopsy; Cholesterol
PubMed: 36811903
DOI: 10.1001/jamadermatol.2022.6591 -
Dermatology Online Journal Oct 2022Linear porokeratosis is a rare variant of porokeratosis that is characterized by unilateral lesions along the lines of Blaschko. Like all variants of porokeratosis,...
Linear porokeratosis is a rare variant of porokeratosis that is characterized by unilateral lesions along the lines of Blaschko. Like all variants of porokeratosis, linear porokeratosis is characterized by the histopathologic finding of cornoid lamellae bracketing the lesion. The underlying pathophysiology involves a two-hit post-zygotic knockdown of genes involved in mevalonate biosynthesis in embryonic keratinocytes. Although there is currently no standard or effective treatment, therapies targeted to rescue this pathway and restore keratinocyte cholesterol availability are promising. Presented here is a patient with a rare, extensive case of linear porokeratosis treated with compounded 2% lovastatin/2% cholesterol cream leading to partial resolution of the plaques.
Topics: Humans; Porokeratosis; Lovastatin; Keratinocytes; Cholesterol
PubMed: 36809136
DOI: 10.5070/D328559247 -
Indian Journal of Sexually Transmitted... 2022
PubMed: 36743090
DOI: 10.4103/ijstd.ijstd_56_22 -
Journal of the European Academy of... Jun 2023
Topics: Humans; Infant, Newborn; Connexins; Hamartoma; Keratosis; Mutation; Porokeratosis
PubMed: 36734293
DOI: 10.1111/jdv.18935 -
Clinical and Experimental Dermatology Feb 2023
Topics: Humans; Hidradenitis Suppurativa; Porokeratosis; Interleukin 1 Receptor Antagonist Protein; Skin; Mutation; Pyrin
PubMed: 36730507
DOI: 10.1093/ced/llac023