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Journal of Neurophysiology Jun 2024Previous research has shown that action effects of self-generated movements are internally predicted before outcome feedback becomes available. To test whether these...
Previous research has shown that action effects of self-generated movements are internally predicted before outcome feedback becomes available. To test whether these sensorimotor predictions are used to facilitate visual information uptake for feedback processing, we measured eye movements during the execution of a goal-directed throwing task. Participants could fully observe the effects of their throwing actions (ball trajectory, and either hitting or missing a target) in most of the trials. In a portion of the trials, the ball trajectory was not visible, and participants only received static information about the outcome. We observed a large proportion of predictive saccades, shifting gaze toward the goal region before the ball arrived and outcome feedback became available. Fixation locations after predictive saccades systematically covaried with future ball positions in trials with continuous ball flight information, but notably also in trials with static outcome feedback and only efferent and proprioceptive information about the movement that could be used for predictions. Fixation durations at the chosen positions after feedback onset were modulated by action outcome (longer durations for misses than for hits) and outcome uncertainty (longer durations for narrow vs. clear outcomes). Combining both effects, durations were longest for narrow errors and shortest for clear hits, indicating that the chosen locations offer informational value for feedback processing. Thus, humans are able to use sensorimotor predictions to direct their gaze toward task-relevant feedback locations. Outcome-dependent saccade latency differences (miss vs. hit) indicate that also predictive valuation processes are involved in planning predictive saccades.
PubMed: 38919149
DOI: 10.1152/jn.00052.2024 -
Advances in Experimental Medicine and... 2024Temporal information processing in the range of a few hundred milliseconds to seconds involves the cerebellum and basal ganglia. In this chapter, we present recent... (Review)
Review
Temporal information processing in the range of a few hundred milliseconds to seconds involves the cerebellum and basal ganglia. In this chapter, we present recent studies on nonhuman primates. In the studies presented in the first half of the chapter, monkeys were trained to make eye movements when a certain amount of time had elapsed since the onset of the visual cue (time production task). The animals had to report time lapses ranging from several hundred milliseconds to a few seconds based on the color of the fixation point. In this task, the saccade latency varied with the time length to be measured and showed stochastic variability from one trial to the other. Trial-to-trial variability under the same conditions correlated well with pupil diameter and the preparatory activity in the deep cerebellar nuclei and the motor thalamus. Inactivation of these brain regions delayed saccades when asked to report subsecond intervals. These results suggest that the internal state, which changes with each trial, may cause fluctuations in cerebellar neuronal activity, thereby producing variations in self-timing. When measuring different time intervals, the preparatory activity in the cerebellum always begins approximately 500 ms before movements, regardless of the length of the time interval being measured. However, the preparatory activity in the striatum persists throughout the mandatory delay period, which can be up to 2 s, with different rate of increasing activity. Furthermore, in the striatum, the visual response and low-frequency oscillatory activity immediately before time measurement were altered by the length of the intended time interval. These results indicate that the state of the network, including the striatum, changes with the intended timing, which lead to different time courses of preparatory activity. Thus, the basal ganglia appear to be responsible for measuring time in the range of several hundred milliseconds to seconds, whereas the cerebellum is responsible for regulating self-timing variability in the subsecond range. The second half of this chapter presents studies related to periodic timing. During eye movements synchronized with alternating targets at regular intervals, different neurons in the cerebellar nuclei exhibit activity related to movement timing, predicted stimulus timing, and the temporal error of synchronization. Among these, the activity associated with target appearance is particularly enhanced during synchronized movements and may represent an internal model of the temporal structure of stimulus sequence. We also considered neural mechanism underlying the perception of periodic timing in the absence of movement. During perception of rhythm, we predict the timing of the next stimulus and focus our attention on that moment. In the missing oddball paradigm, the subjects had to detect the omission of a regularly repeated stimulus. When employed in humans, the results show that the fastest temporal limit for predicting each stimulus timing is about 0.25 s (4 Hz). In monkeys performing this task, neurons in the cerebellar nuclei, striatum, and motor thalamus exhibit periodic activity, with different time courses depending on the brain region. Since electrical stimulation or inactivation of recording sites changes the reaction time to stimulus omission, these neuronal activities must be involved in periodic temporal processing. Future research is needed to elucidate the mechanism of rhythm perception, which appears to be processed by both cortico-cerebellar and cortico-basal ganglia pathways.
Topics: Animals; Cerebellum; Basal Ganglia; Time Perception; Saccades; Time Factors; Humans
PubMed: 38918348
DOI: 10.1007/978-3-031-60183-5_6 -
Otology & Neurotology : Official... Jun 2024The purpose of this study was to evaluate the value of asymmetry values, gain, and pathological saccades of the video head impulse test (vHIT) in sudden sensorineural...
OBJECTIVE
The purpose of this study was to evaluate the value of asymmetry values, gain, and pathological saccades of the video head impulse test (vHIT) in sudden sensorineural hearing loss (SSNHL).
STUDY DESIGN
Retrospective study.
SETTING
Tertiary referral center.
PATIENTS
A total of 226 individuals diagnosed with unilateral definite SSNHL were hospitalized. The assessment included a comprehensive evaluation of medical history, pure-tone test, acoustic impedance, positional test, video nystagmography (VNG), vHIT, vestibular evoked myogenic potentials (VEMPs) and magnetic resonance.
INTERVENTIONS
vHIT, VNG, cVEMP, oVEMP. Statistical analysis was performed with SPSS version 22.0 for Windows.
MAIN OUTCOME MEASURES
The asymmetry values, gain, and pathological saccades of the vHIT.
RESULTS
The abnormal gain of vHIT in anterior, horizontal, and posterior canal in SSNHL patients with vertigo were revealed in 20 of 112 (17.9%), 24 of 112 (21.4%), and 60 of 112 (53.6%), respectively. The vHIT pathological saccades (overt + covert) of anterior, horizontal, and posterior canal in SSNHL patients with vertigo were observed in 5 of 112 (4.6%), 52 of 112 (46.4%), and 58 of 112 (51.8%), respectively. Multivariate analysis indicated that the prognosis of patients with vertigo was correlated with vHIT gain of posterior canal, pathological saccade in horizontal canal, asymmetric ratio of horizontal canal gain, asymmetric ratio of posterior canal gain, Canal paresis (%) on caloric test and spontaneous nystagmus.
CONCLUSION
In the vHIT of patients with SSNHL with vertigo, the posterior canal is most easily affected. Reduced gain of posterior canal, pathological saccade of horizontal canal, and larger asymmetric gain of posterior canal and horizontal canal may be negative prognostic factors.
PubMed: 38918071
DOI: 10.1097/MAO.0000000000004247 -
Current Biology : CB Jun 2024With every movement of our eyes, the visual receptors in the retina are swiped across the visual scene. Saccades are the fastest and most frequent movements we perform,...
With every movement of our eyes, the visual receptors in the retina are swiped across the visual scene. Saccades are the fastest and most frequent movements we perform, yet we remain unaware of the self-produced visual motion. Previous research has tried to identify a dedicated suppression mechanism that either actively or passively cancels vision at the time of saccades. Here, we investigated a novel theory, which states that saccadic omission results from habituation to the predicted sensory consequences of our own actions. We experimentally induced novel, i.e., artificial visual consequences of saccade performance by presenting gratings that were drifting faster than the flicker fusion frequency and that became visible only when participants performed saccades. We asked participants to perform more than 100 saccades in each session across these gratings to make the novel contingencies predictable for the sensorimotor system. We found that contrast sensitivity for intra-saccadic motion declined drastically after repeated exposure of such motion. The reduction in sensitivity was even specific to the saccade vector performed in habituation trials. Moreover, when subjects performed the same task in fixation, no reduction in sensitivity was observed. In a motion speed comparison task, we found that the reduction in contrast sensitivity is the consequence of silencing-predicted intra-saccadic visual motion. Our data demonstrate that the sensorimotor system selectively habituates to recurring intra-saccadic visual motion, suggesting an efficient prediction mechanism of visual stability.
PubMed: 38917799
DOI: 10.1016/j.cub.2024.05.063 -
Journal of Neurology Jun 2024Saccadic oscillations (SOs) mostly occur spontaneously, but can be occasionally triggered by various stimuli. To determine clinical characteristics and underlying...
Saccadic oscillations (SOs) mostly occur spontaneously, but can be occasionally triggered by various stimuli. To determine clinical characteristics and underlying mechanisms of triggered SOs, we analyzed the clinical features and quantitative eye-movement recordings of six new patients and 10 patients in the literature who exhibited with triggered SOs. Eleven of the 16 patients (69%) had a lesion involving cerebellum and/or brainstem such as cerebellar degeneration, cerebellitis, or cerebellar infarction. The other causes were vestibular migraine (n = 2), multiple sclerosis (n = 1), Krabbe disease (n = 1), and idiopathic (n = 1). Vestibular stimulation was the most common trigger (n = 11, 69%), followed by removal of visual fixation (n = 4, 25%), hyperventilation (n = 1), light (n = 1), and blink (n = 1). The types of triggered SOs were varied which included ocular flutter (n = 13), opsoclonus (n = 3), vertical SOs (n = 2), and macrosaccadic oscillations (n = 1). Three patients exhibited downbeat nystagmus either before (n = 1) or after (n = 2) the onset of SOs. The frequency of triggered SOs ranged from 4 to 15 Hz, and oscillations with smaller amplitudes had higher frequencies and smaller peak velocities. SOs can be triggered by the modulation of unstable saccadic neural networks through vestibular and visual inputs in lesions of the brainstem and cerebellum.
PubMed: 38916677
DOI: 10.1007/s00415-024-12533-8 -
BioRxiv : the Preprint Server For... Jun 2024Hering's Law of binocular eye movement control guides most oculomotor research and supports diagnosis and treatment of clinical eye misalignment (strabismus). The law...
Hering's Law of binocular eye movement control guides most oculomotor research and supports diagnosis and treatment of clinical eye misalignment (strabismus). The law states that all eye movements are controlled by a unitary conjugate signal and a unitary vergence signal that sum. Recent evidence of temporally asynchronous inter-eye rotations during vergence (Chandna et al., 2021) challenges the viability of a unitary vergence signal. An alternative theory that might explain these anomalous results posits that the eyes are controlled independently. Yet independent control fails to explain a phenomenon known as "Remarkable Saccades" where an inappropriate saccade occurs from an eye aligned on a target during asymmetric vergence (Enright, 1992). We introduce a new model formulated to describe the Chandna et al. (2021) midline vergence result that generates remarkable saccades as an emergent property. The Hybrid Binocular Control model incorporates independent controllers for each eye with a cortical origin that interact with a unitary conjugate controller residing in brainstem. The model also accounts for behavioral variations in remarkable saccades when observers attend to an eye. Furthermore, it suggests more generally how the eyes are controlled during vergence and other voluntary eye movements, thus challenging documented oculomotor neural circuitry and suggesting that refinements are needed for clinical oculomotor interventions.
PubMed: 38915723
DOI: 10.1101/2024.06.14.599100 -
Optometry and Vision Science : Official... Jun 2024Prior studies with large, highly visible targets report low smooth pursuit gains in individuals with macular degeneration (MD). We show that lower gains persist even...
SIGNIFICANCE
Prior studies with large, highly visible targets report low smooth pursuit gains in individuals with macular degeneration (MD). We show that lower gains persist even when observers are pursuing a target that requires discrimination at the acuity limit. This low gain causes retinal slip, potentially leading to motion blur and target disappearance in the scotoma, which further compromise the visibility of moving object.
PURPOSE
In this study, we examine whether the characteristics of smooth pursuit (pursuit gain and placement of the fixational locus relative to the target) change when the task requires dynamic visual acuity.
METHODS
Using the scanning laser ophthalmoscope, we recorded smooth pursuit eye movements in 10 eyes of 6 MD participants and 7 eyes of 4 age-matched controls in response to leftward- or rightward-moving annular targets (O) that briefly (300 milliseconds) changed to a Landolt C at one of several time points during the pursuit trial. Participants were asked to pursue the target and indicate the direction of the C opening.
RESULTS
Individuals with MD had lower pursuit gains and fewer saccades during the C presentation than during the O, compared with their age-matched peers. Further, pursuit gain, but not the distance of the retinal pursuit locus from the target, predicted task performance in the MD group.
CONCLUSIONS
Our findings suggest that compromised pursuit gain in MD participants likely further compromises their dynamic visual acuity and thus ability to view moving targets.
PubMed: 38913934
DOI: 10.1097/OPX.0000000000002144 -
ELife Jun 2024Autism spectrum disorder (ASD) presents a range of challenges, including heightened sensory sensitivities. Here, we examine the idea that sensory overload in ASD may be...
Autism spectrum disorder (ASD) presents a range of challenges, including heightened sensory sensitivities. Here, we examine the idea that sensory overload in ASD may be linked to issues with efference copy mechanisms, which predict the sensory outcomes of self-generated actions, such as eye movements. Efference copies play a vital role in maintaining visual and motor stability. Disrupted efference copies hinder precise predictions, leading to increased reliance on actual feedback and potential distortions in perceptions across eye movements. In our first experiment, we tested how well healthy individuals with varying levels of autistic traits updated their mental map after making eye movements. We found that those with more autistic traits had difficulty using information from their eye movements to update the spatial representation of their mental map, resulting in significant errors in object localization. In the second experiment, we looked at how participants perceived an object displacement after making eye movements. Using a trans-saccadic spatial updating task, we found that those with higher autism scores exhibited a greater bias, indicating under-compensation of eye movements and a failure to maintain spatial stability during saccades. Overall, our study underscores efference copy's vital role in visuo-motor stability, aligning with Bayesian theories of autism, potentially informing interventions for improved action-perception integration in autism.
Topics: Humans; Male; Female; Autism Spectrum Disorder; Adult; Young Adult; Eye Movements; Psychomotor Performance; Visual Perception; Adolescent; Saccades; Autistic Disorder
PubMed: 38913073
DOI: 10.7554/eLife.94946 -
Journal of Vision Jun 2024Humans saccade to faces in their periphery faster than to other types of objects. Previous research has highlighted the potential importance of the upper face region in...
Humans saccade to faces in their periphery faster than to other types of objects. Previous research has highlighted the potential importance of the upper face region in this phenomenon, but it remains unclear whether this is driven by the eye region. Similarly, it remains unclear whether such rapid saccades are exclusive to faces or generalize to other semantically salient stimuli. Furthermore, it is unknown whether individuals differ in their face-specific saccadic reaction times and, if so, whether such differences could be linked to differences in face fixations during free viewing. To explore these open questions, we invited 77 participants to perform a saccadic choice task in which we contrasted faces as well as other salient objects, particularly isolated face features and text, with cars. Additionally, participants freely viewed 700 images of complex natural scenes in a separate session, which allowed us to determine the individual proportion of first fixations falling on faces. For the saccadic choice task, we found advantages for all categories of interest over cars. However, this effect was most pronounced for images of full faces. Full faces also elicited faster saccades compared with eyes, showing that isolated eye regions are not sufficient to elicit face-like responses. Additionally, we found consistent individual differences in saccadic reaction times toward faces that weakly correlated with face salience during free viewing. Our results suggest a link between semantic salience and rapid detection, but underscore the unique status of faces. Further research is needed to resolve the mechanisms underlying rapid face saccades.
Topics: Humans; Saccades; Male; Female; Reaction Time; Adult; Young Adult; Facial Recognition; Photic Stimulation; Individuality; Fixation, Ocular; Adolescent
PubMed: 38913016
DOI: 10.1167/jov.24.6.16 -
Accident; Analysis and Prevention Jun 2024Partially automated systems are expected to reduce road crashes related to human error, even amongst professional drivers. Consequently, the applications of these...
Partially automated systems are expected to reduce road crashes related to human error, even amongst professional drivers. Consequently, the applications of these systems into the taxi industry would potentially improve transportation safety. However, taxi drivers are prone to experiencing driving anger, which may subsequently affect their takeover performance. In this research, we explored how driving anger emotion affects taxi drivers' driving performance in various takeover scenarios, namely Mandatory Automation-Initiated transition (MAIT), Mandatory Driver-Initiated transition (MDIT), and Optional Driver-Initiated transition (ODIT). Forty-seven taxi drivers participated in this 2·3 mixed design simulator experiment (between-subjects: anger vs. calmness; within-subjects: MAIT vs. MDIT vs. ODIT). Compared to calmness, driving anger emotion led to a narrower field of attention (e.g., smaller standard deviations of horizontal fixation points position) and worse hazard perception (e.g., longer saccade latency, smaller amplitude of skin conductance responses), which resulted in longer takeover time and inferior vehicle control stability (e.g., higher standard deviations of lateral position) in MAIT and MDIT scenarios. Angry taxi drivers were more likely to deactivate vehicle automation and take over the vehicle in a more aggressive manner (e.g., higher maximal resulting acceleration, refusing to yield to other road users) in ODIT scenarios. The findings will contribute to addressing the safety concerns related to driving anger among professional taxi drivers and promote the widespread acceptance and integration of partially automated systems within the taxi industry.
PubMed: 38909484
DOI: 10.1016/j.aap.2024.107686